Articles tagged with Drug Studies
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Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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Researchers have designed a sensor necklace called MagneTrace that records the exact time and date when specially-designed pills are swallowed, helping to increase drug compliance and reduce unnecessary healthcare costs. The device can notify both the patient and their doctor if prescribed dosage is not taken at the proper time.
A study found that adding gemcitabine to chemoradiation improved survival rates for pancreatic cancer patients who had surgery, but the benefit was not statistically significant. The treatment reduced local relapse and systemic metastasis in patients.
Researchers found that tamoxifen significantly reduced mania scores and improved patient outcomes in a three-week clinical trial. The study suggests that tamoxifen's effects on protein kinase C may be beneficial for treating bipolar disorder.
Researchers found a significant link between alcohol intake and increased blood pressure, even among moderate drinkers with the *1 *1 genotype. This study challenges previous findings and suggests that alcohol may be a more significant risk factor for hypertension than previously thought.
A new study, ALTTO, is testing two targeted medications to treat aggressive breast cancer in 8,000 participants across 50 countries. The trial will compare four different regimens of targeted therapy and provide insights into individualized patient care.
Computer simulations revealed that a defective gene causes cystic fibrosis by misfolding the CFTR protein. The study identifies critical amino acid pairs essential for proper protein folding, providing guidance for designing small molecule drugs.
Researchers at Michigan Medicine have developed an oil-based nanoemulsion vaccine that produces strong immunity against smallpox and HIV in animal studies. The vaccine uses a mixture of soybean oil, alcohol, water, and detergents emulsified into ultra-small particles to trigger the body's immune response.
A Northwestern University study found that cancer patients taking erythropoiesis-stimulating agents (ESAs) have a 10% increased risk of death compared to those who did not take the drugs. The study's findings suggest that ESAs may stimulate the growth of cancer cells, leading to shorter survival rates.
A study published in The Lancet Neurology found that donepezil improved measures of executive function in patients with CADASIL vascular dementia, but not their cognitive scores. The drug showed therapeutic potential for this specific population.
A new study found that patients who prefer a highly active role in their treatment do not necessarily have better luck managing chronic health conditions. Those who preferred an active role had higher blood pressure and cholesterol levels over a 12-month period compared to those with a less active approach.
Researchers found that a new 'top-down' therapy approach significantly improved disease remission rates and reduced steroid use in Crohn's patients. The two-year study showed 60% of top-down subjects were symptom-free by week 26, compared to 36% on traditional step-up treatment.
Researchers found that calling a doctor's office instead of 9-1-1 can delay patients from reaching the emergency room during the critical three-hour window for acute stroke treatment. Calling an emergency number or ambulance is the quickest way to receive timely treatment and potentially avoid serious post-stroke disability.
A multidisciplinary symposium will address evidence of paternal exposure to toxins affecting fetal development, producing deficits in offspring, and expressing in subsequent generations. The event aims to raise awareness and stimulate research on the significant impact of male parents on reproductive success.
Researchers found that Hispanic patients with diabetes have approximately 0.5% higher levels on the A1C test compared to non-Hispanic white patients. This study highlights the need for strategies to reduce disparities in diabetes control among minority groups.
Researchers present studies on the relationship between smoking and neuropathic pain, the benefits of physical conditioning in chronic pain patients, and the effectiveness of pain rehabilitation programs in reducing medication costs. These findings highlight the importance of addressing underlying causes of chronic pain and exploring n...
A new study by the National Institutes of Health found that a stent designed to open clogged brain arteries was successfully deployed in nearly all cases and reduced arterial blockage, but long-term benefits compared to medical treatment alone were inconclusive. A large-scale randomized trial is expected to provide definitive results.
A small clinical trial found that rituximab dramatically reduced inflammatory lesions and clinical symptoms in patients with relapsing-remitting MS. The study suggests that therapies targeting B-cells may provide an important treatment strategy for multiple sclerosis.
Patients with refractory asthma experienced longer term improvement in pulmonary function, improved quality of life, and reduced rescue medication use after undergoing bronchial thermoplasty. The procedure resulted in a significant reduction in corticosteroid use, particularly among those who were able to wean off medication completely.
A specific gene variant associated with a better response to naltrexone in treating alcohol dependence has been identified, according to a large-scale analysis of the COMBINE Study. Patients carrying the variant experienced significantly improved clinical outcomes compared to those without it.
A recent study found a significant association between the combination of aprotinin and angiotensin-converting enzyme (ACE) inhibitors during off-pump cardiac surgery and postoperative renal dysfunction. The study, published in The Lancet, analyzed data from over 9,700 patients undergoing cardiac surgery between 2000 and 2007.
Researchers at the University of Alabama at Birmingham found that PTC124 restored normal function in up to 29 percent of abnormal cystic-fibrosis protein cases. The drug works by rescuing faulty proteins that lead to illnesses, including cystic fibrosis and over 2,400 genetic diseases.
A recent study found that patients who stop taking clopidogrel after a heart attack are at higher risk of a heart attack or death in the first 90 days. The risk is nearly twice as high during this period compared to later periods, suggesting a possible 'rebound effect' on thrombotic events.
A multi-center study of 500 women found that more women preferred the contraceptive ring over the skin patch due to lower complication rates and higher satisfaction. The ring was also reported to have fewer side effects compared to the patch.
A meta-analysis found that former substance abusers have a low rate of relapse after organ transplantation, with significant associations between relapse and poor social support and family alcohol history. The study included over 3,600 individuals who received transplants and examined the rates of alcohol and drug relapse.
A study of patients with chronic hepatitis C found that silymarin, a popular herbal supplement, had no effect on HCV virus activity or liver inflammation. However, users reported fewer symptoms and improved quality of life compared to non-users.
Women with irritable bowel syndrome (IBS) who experienced sexual and/or physical abuse may have a heightened brain response to pain, making them more sensitive to abdominal discomfort. Researchers found that patients with IBS background of abuse were less effective in turning off a pain modulation mechanism in the brain.
A clinical trial shows that romiplostim significantly improved platelet levels in patients with chronic immune thrombocytopenic purpura (ITP), a hematologic disorder that can cause uncontrolled bleeding. The novel drug duplicates the action of a natural hormone discovered by MGH investigator, offering low toxicity and high response rates.
A study comparing sirolimus-eluting and paclitaxel-eluting stents found no significant differences in heart attack or cardiac death rates among patients undergoing percutaneous coronary interventions. The use of drug-eluting stents may be safe for the general population, with low rates of serious adverse events at 18 months of follow-up.
A new study reveals that certain over-the-counter earwax softeners can cause severe inflammation and damage to the eardrum and inner ear. The products should be used with extreme caution due to their toxic potential.
The use of clinical trials to inform Medicare coverage decisions disproportionately affects older women with comorbid conditions, differing significantly from the target population. This disparity highlights the need for more representative trial populations to ensure better value and improved outcomes for Medicare beneficiaries.
A large-scale drug comparison trial involving 23,077 people with both high blood pressure and metabolic syndrome found that diuretics significantly reduced the risk of heart disease. Diuretics were particularly effective in reducing cardiovascular disease in black patients, who have a higher incidence of hypertension.
Researchers have discovered a new ALS drug target by identifying an unexpected protein-protein interaction between SOD1 and Rac1. This interaction, which is impaired in familial ALS, leads to excessive ROS production and oxidative stress, contributing to the disease's progression.
Researchers at University at Buffalo found that Celebrex reduces heart rate and induces arrhythmia by inhibiting potassium channels, which are present in the heart, brain, and other tissues. The study suggests that the drug's mechanism of action may be relevant to its cardiovascular side effects.
A new study has discovered a link between gene variations and the effectiveness of blood pressure medications. Patients with certain gene variations experienced varying results with different types of medication, suggesting that tailoring treatment to an individual's genotype may lead to more favorable outcomes.
A study of pharmacists reveals that drive-through windows lead to increased processing times, reduced efficiency, and dispensing errors. The survey found that automated dispensing systems can reduce errors and enhance efficiency by minimizing workflow interruptions.
A saline nasal wash solution improved nasal symptoms and reduced the recurrence of respiratory infections in children with the common cold. Children using the saline group had fewer days of illness, missed school days, or complications compared to those receiving standard medication.
A study found that selective publication in antidepressant trials significantly overstates their effectiveness, with nearly all positive studies being published and most negative ones not. However, when combining all studies using meta-analysis, each drug was superior to a placebo, but less effective than reported.
A study by Johns Hopkins Medicine found that lingering doubts and fears among African Americans are major obstacles to their participation in medical research. Blacks were only 60% as likely as whites to participate in a mock study, highlighting the need for improved communication and mutual respect between patients and physicians.
A new protocol combining daily spontaneous awakening trials with spontaneous breathing trials results in better outcomes for mechanically ventilated patients, including shorter ventilation periods and earlier discharge. The study found that this approach improved clinical outcomes without increasing adverse events.
Researchers have made significant advances in treating and diagnosing LAM through the use of sirolimus and serum VEGF-D test, showing improved lung function and reduced tumor growth. These studies provide hope for patients suffering from this deadly disease, paving the way for targeted therapies.
A new study has found that widely used asthma medication long-acting beta-agonists may not be associated with adverse events based on a patient's genotype. The study analyzed data from two clinical trials and found no differences in asthma symptoms or control between patients with different beta-2 adrenergic receptor genotypes.
A new study found that reducing drug co-pays for employees with chronic illnesses increased the use of preventive medicines, leading to fewer hospitalizations and emergency room visits. The study involved over 35,000 employees and showed significant increases in use of important medications.
A study published in Clinical Cancer Research examines the antitumor efficacy and safety of various combinations of reovirus and cyclophosphamide. The findings support investigation in human clinical trials to modulate, but not ablate, the immune system before systemic reovirus administration.
Research from the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) found that chemotherapy safely reduced recurrence, breast cancer mortality, and death from any cause in women with hormone-resistant breast cancer. The study showed a 10-year risk reduction of 25% in younger women and 39% in women aged 50-69 years.
Researchers investigated college parties, observing environments, behaviors, and blood-alcohol concentrations to identify key predictors of excessive drinking. Young women drank more heavily at themed events with sexualized themes and costumes, while students who socialized without drinking games had lower levels of consumption.
A physician-scientist is urging improved drug regulation to ensure the cardiovascular safety of non-heart drugs. This includes earlier testing and continued evaluation of drug effects post-approval.
The WIN-R study found weight-based REBETOL plus PEG-INTRON improves sustained virologic response and lowers relapse rates, particularly in African-Americans with genotype 1 HCV. Weight-based dosing is also justified for very heavy patients.
A new clinical trial results in a proof-of-principle for personalized molecular medicine, with the potential to treat muscular dystrophies and other disorders. The treatment uses an 'exon-skipping' approach to restore dystrophin protein production in muscle tissue.
A systematic review of published research explores the benefits of seven key behaviors (AADE7) in diabetes management. The studies were rigorously reviewed to identify effective strategies and remaining gaps in knowledge, providing direction for future researchers.
The ATAC trial confirms anastrozole's superior efficacy over tamoxifen, with increased disease-free survival and reduced cancer recurrence. Long-term benefits of anastrozole treatment persist even after completion.
Researchers at Cedars-Sinai Medical Center are conducting a five-year study to test the safety and effectiveness of docosahexanoic acid (DHA) and eicosapentanoic acid (EPA) as treatments for major depressive disorder. The study aims to determine whether these two omega-3 fatty acids can help alleviate symptoms of depression in adults.
The PREVENT study found that nearly 80% of patients with recurrent major depressive disorder achieved an adequate therapeutic response to venlafaxine extended-release or fluoxetine, with almost none relapsing after 6 months. The results suggest a subgroup of depressed patients may benefit from early and sustained treatment.
Researchers found that telmisartan completely protected rats from stroke when used alone or with ramipril, with no strokes noted in either group. The study suggests that telmisartan's ability to pass through the blood-brain barrier is likely behind its neuroprotective effect.
Older patients taking thiazolidinediones (TZDs) like rosiglitazone have a significantly increased risk of heart attack, congestive heart failure, and death compared to other hypoglycemic drugs. This study suggests that TZDs may cause more harm than good, particularly in older adults who are already at higher risk.
A new 3-drug combination of bortezomib, lenalidomide, and dexamethasone has achieved an impressive overall response rate of 98% in newly diagnosed multiple myeloma patients. The regimen has also shown a high-quality response rate of 52%.
A new study suggests that a vaccine targeting Epstein-Barr virus may prevent infectious mononucleosis, commonly known as “mono” or “glandular fever.” The vaccine was found to reduce the proportion of symptomatic EBV infections from 10% in control groups to 2% in vaccinated individuals.
Two studies found that consuming a Mediterranean diet and engaging in moderate to vigorous physical activity were associated with reduced mortality rates over five years. The Mediterranean diet was linked to a lower risk of death from any cause, cancer, and cardiovascular disease.
A study suggests that combining a medication for multiple sclerosis with an antibiotic may slow the disease's progression. The treatment combination showed promising results in reducing lesions and disability scores.
A clinical trial by Mayo Clinic found a lower dose of steroids to be as effective as the standard high-dose treatment in improving overall survival rates for multiple myeloma patients. The new regimen, lenalidomide plus low-dose dexamethasone, showed significantly better results with less toxicity.
Research suggests that maintaining consistent sleep schedules and regular physical activity can help balance the circadian system and reduce symptoms of bipolar disorder. Studies found that patients who participated in interpersonal and social rhythm therapy experienced longer periods without new episodes of mania or depression.