Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study published in Preventive Medicine found that 94% of 14-15 year olds watched R-rated movies and 38.5% watched weekly, suggesting the R rating may not prevent teen smoking. The study suggests glamorization of smoking in movies can be a significant risk factor for youth smoking.
A study of deceased men found that prostate cancer diagnosis depends more on the biopsied area than sample number, suggesting a new approach to design biopsies. Alternative trial designs and targeting tumor microenvironments may also improve cancer treatment outcomes.
A study of black and white patients with asthma found that blacks were more likely to visit the emergency department or be hospitalized for the condition, even after adjusting for socioeconomic status. The researchers suggest that genetic differences may underlie these racial disparities in asthma outcomes.
Patients seeking urgent health care have highest satisfaction with their own family physicians; new models of care can inform improved access and continuity. Treating anger and psychological stress may slow progression from prehypertension to hypertension and coronary heart disease, research suggests.
A new topical lotion has shown high degree of safety and tolerability in treating toenail fungus. The treatment avoids systemic absorption, reducing risks of cardiac and liver toxicity associated with current oral medications.
A new study found that individuals with a family history of alcoholism are more likely to reduce their drinking when prescribed naltrexone. However, those without a family history of alcoholism may experience increased drinking with higher doses of naltrexone.
New research supports the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits in improving blood glucose and lipid levels. The study found that therapies including pioglitazone are associated with significant reductions in the risk of stroke or myocardial infarction compared to non-thiazolidinedione therapies.
A recent study suggests that an abnormal amount of inflammatory cells in the duodenum may be responsible for nonulcer dyspepsia, a condition characterized by chronic or recurrent abdominal pain. The researchers propose targeted anti-inflammatory medicine as a potential treatment option.
A single dose of tolvaptan significantly increased urine volume and reduced pulmonary artery pressure, with more pronounced effects at higher doses. The study found no significant differences in cardiac output or other secondary outcomes.
A study found that half of women prescribed medications linked to birth defects do not receive contraceptive counseling. Women filling prescriptions for these medications are no more likely to use contraception than other women, highlighting the need for increased awareness among physicians and women who may become pregnant.
Researchers reanalyzed data from the Prostate Cancer Prevention Trial, finding that prostate shrinkage may be responsible for the excess prevalence of high-grade cancer in the drug-treated group. Adjusting for changes in gland size due to finasteride use eliminated all excess high-grade tumors.
A study published in Neurology found that people with multiple sclerosis who stop taking natalizumab may develop more brain lesions, indicating increased disease activity. The results suggest that discontinuing the drug can lead to a rebound increase in disease activity, particularly for those who take it for a short time.
A new Mayo Clinic study published in Value in Health found no significant difference between abciximab and eptifibatide in hospital stay length or cardiovascular event rates. The study provides data to guide treatment decisions for heart patients undergoing angioplasty.
Researchers found an antidepressant (citalopram) may perform as well as a commonly-prescribed antipsychotic (risperidone) in reducing psychosis and agitation in patients with dementia. The study also showed citalopram was associated with significantly lower adverse side effects.
A Harvard study found that socioeconomic status influences antiretroviral treatment effectiveness, even among those adhering to treatment schedules. Lower education levels were associated with faster regimen failure, while higher adherence self-efficacy reduced this risk.
An international team of researchers has identified three new genes associated with rheumatoid arthritis, including TRAF-C5 and STAT4. The study analyzed the genomes of over 1,500 patients and 1,850 controls, revealing a broader understanding of the disease's genetic mechanisms.
A new study at the University of Rochester Medical Center found that parents' beliefs about their children's asthma medications play a significant role in treatment adherence. The study revealed that parents who perceived a stronger need for their child's medication were more likely to adhere strictly to the prescribed regimen.
The SCAI has announced that its leaders are available for comment on numerous studies, trials, and data releases at the upcoming European Society for Cardiology Congress. These studies focus on interventional cardiology, percutaneous intervention, angioplasty, and stents.
A new nasal spray treatment has been shown to be safe and effective in rapidly treating cluster headaches, considered the most painful type of headache. The study involved 52 people with cluster headaches who used zolmitriptan nasal spray or placebo to treat 151 separate attacks.
Researchers found that vitamin E's antioxidant effect is only significant at high doses, exceeding previously used amounts in clinical trials. The optimal dose was determined to be around 1600 IU/day for maximum suppression of oxidative stress.
Leading researchers from IAVI, CDC and USMHRP presented final results of independent studies reexamining medical criteria for African volunteers in AIDS vaccine trials. The findings suggest that many healthy Africans have been excluded due to laboratory reference ranges developed for Western populations.
A new study reveals that pharmacy disparities disproportionately impact elderly African-American patients with multiple medications for chronic diseases. Despite seeking a close relationship with pharmacists, many participants felt uncomfortable initiating discussions due to lack of knowledge or perceived busyness.
A new review suggests that only modest evidence supports the use of most medications to raise high-density lipoprotein (HDL) levels, which is often referred to as 'good' cholesterol. Lifestyle changes such as weight loss, exercise, and moderate alcohol consumption are recommended as safe and effective strategies to increase HDL levels.
Research at the University of Iowa suggests that a patient-centered approach can be detrimental for patients who prefer a more traditional 'doctor-centered' style. The study found that when these patients are matched with patient-centered doctors, they are less likely to follow treatment recommendations and feel satisfied with their care.
Research suggests that female gender is associated with slower progression rates in certain renal diseases, possibly due to the protective effects of estrogen on kidney health. Estrogen inhibits the activity of transforming growth factor beta (TGF-β), which promotes scarring in the kidneys.
A three-year observational study at Wake Forest University Baptist Medical Center found that a combination of strategies, including reclassifying brand-name drugs and removing non-essential medications from the formulary, resulted in significant cost savings. The plan's approach preserved members' use of medications for chronic conditi...
The Hypertension in the Very Elderly Trial (HYVET) found that lowering blood pressure significantly reduces both stroke and mortality in patients aged 80 and over. The trial, which began in 2001, involved 3,845 patients from across the world and stopped early due to significant reductions in overall mortality.
A study found that long-term use of histamine2 receptor antagonists increases the risk of cognitive impairment in older African-Americans. Nearly 18% of users exhibited signs of cognitive impairment after controlling for other factors.
A Dutch study found that starting statin therapy at age 8 safely delays early artery damage caused by FH. The study showed that earlier initiation of statin treatment results in smaller carotid intima-media thickness at a later age, with no serious clinical or laboratory adverse events reported.
A study found that 81% of visits for children with sleep difficulties resulted in a medication prescription. The most commonly prescribed medications were often not FDA-approved for this age group, highlighting the need for better labeling and safety guidelines.
A study by the National Institute of Mental Health found that people with a variation in the GRIK4 gene are more likely to respond to citalopram, an antidepressant medication. Researchers also discovered that variations in another gene, HTR2A, make people more likely to respond as well.
A recent study published in Mayo Clinic Proceedings found that patients prescribed cholesterol-lowering medications do not necessarily adopt unhealthy diets. Despite taking statins, patients made good faith efforts to improve their health through lifestyle changes.
Researchers at the University of Cincinnati will use functional MRI and MRS to study brain chemistry in response to different treatments. The goal is to better understand the disease, identify early warning signs, and personalize treatment plans.
A new study by PECARN reveals that steroid treatment does not prevent hospitalization or improve symptoms in infants with bronchiolitis, the most common cause of infant hospitalization. The study's findings provide solid evidence for treating bronchiolitis with simple supportive care.
Researchers at UT Southwestern Medical Center have found that a drug called tetrabenazine (TBZ) prevents death of brain cells in mice genetically engineered to mimic Huntington's disease. The study sheds light on the biochemical mechanisms involved in the disease and suggests new avenues of study for preventing brain-cell death.
Immediate license suspension for DWI saves 800 lives each year by deterring drunk driving, with more severe penalties after conviction having little impact. Laws allowing immediate suspensions reduce fatalities among light, moderate and heavy drinkers.
Researchers found a 15% reduction in colorectal cancer diagnosis among patients with osteoarthritis who took NSAIDs, consistent with previous findings on pre-cancerous polyps. The study supports the need for further research to identify safe NSAID agents for regular preventive therapy.
A major follow-up study found that most children treated for ADHD showed sustained improvement after three years, but behavioral problems persisted. Children who responded well to medication initially were more likely to deteriorate over time, highlighting the need for continued treatment.
A new study by Weill Cornell Medical College found that young rats given Ritalin injections from week-old age showed significant brain changes linked to higher executive functioning and addiction. Changes resolved with time, but the findings suggest doctors must be careful in diagnosing ADHD before prescribing Ritalin.
A new therapy, certolizumab pegol, has been found to be effective in easing symptoms of patients with active Crohn's disease. The treatment was shown to improve clinical symptoms in both short-term and long-term maintenance therapies, offering a potential new option for managing the condition.
Two studies found that elevated nonfasting triglyceride levels are associated with an increased risk of heart attacks, ischemic heart disease, and death. The findings suggest that remnant lipoproteins play a dominant role in postprandial atherosclerosis, and may predict the risk of cardiovascular events in women.
The Lancet Series explores inappropriate prescribing in elderly people, with evidence suggesting overprescription of drugs and inadequate patient involvement. Drug-drug interactions are also a significant concern, with 46% of elderly outpatients at risk of potentially significant interactions.
Researchers found that patients treated with single-drug therapy had shorter overall survival, but those receiving sequential treatment had similar survival rates to combination therapy regimens. The study results challenge conventional clinical practice and suggest a more gentle approach for some patients.
A $2 million federal grant will help the OHSU Cardiac Arrhythmia Center pinpoint those at greatest risk of sudden cardiac arrest due to left ventricular hypertrophy. The study aims to improve identification and prediction methods, potentially averting disaster before it happens.
A new study found that patients treated with HCQ were less likely to develop diabetes, and those who did were more likely to manage their disease without medications. The medication may also be suitable for people at high risk of developing diabetes as a preventive therapy.
A meta-analysis of 29 studies found that incretin-based therapy improves glycemia, particularly postprandial glycemia, and has a favorable or neutral effect on weight. However, glucagon-like peptide 1 analogues are associated with gastrointestinal adverse effects, while DPP4 inhibitors have an increased risk of infection.
A new drug candidate, abiraterone, has shown significant anti-tumor activity in early trials for patients with advanced prostate cancer whose tumors have continued to grow despite medical or surgical castration. The drug reduced PSA levels and shrunk tumors in both pre- and post-chemotherapy patients.
A new NNRTI etravirine has been shown to be effective in suppressing HIV viral load in treatment-experienced patients with documented resistance to non-nucleoside reverse transcriptase inhibitors. The DUET trials 1 and 2 found that 56% and 62% of patients achieved viral loads below 50 copies/mL, respectively.
A randomized trial found that darunavir-ritonavir reduced HIV RNA levels by 77% compared to lopinavir-ritonavir at week 48. The treatment was well-tolerated with mild side effects in both groups.
Two studies published in The New England Journal of Medicine found taking SSRIs during pregnancy increases the risk of rare birth defects, including withdrawal symptoms and pulmonary hypertension. However, most birth defects were not associated with antidepressant use.
Two new studies investigated patients' decisions regarding therapy for rheumatoid arthritis (RA) and glucosamine use for osteoarthritis, finding that most RA patients prefer to maintain their current treatment as long as their condition doesn't worsen. The studies also highlighted discrepancies in clinical trial results for glucosamine...
A recent study published in Complementary Health Practice Review found Rescue Remedy to be an effective all-natural stress reliever comparable to pharmaceutical drugs without adverse side effects. The remedy, containing five flower essences, was administered to 111 individuals and showed significant reduction in situational anxiety.
The use of computerized physician order entry systems has been shown to significantly reduce medication errors, with a 66% decrease in prescription errors reported. The systems also improve patient safety and ease the workload for pharmacists by reducing the need for deciphering handwritten prescriptions.
A review of 12 studies found that computerized physician order entry systems can reduce medication errors by up to 66%. However, the incidence of one type of error, prescribing the wrong drug, did not decrease. The study highlights the importance of implementing CPOE systems in hospitals to improve patient safety.
Researchers investigated the effect of finasteride on sexual function in over 17,000 men, finding minimal impact. A new trial design aims to better evaluate targeted therapies by identifying a molecular cutoff point for responsive patients.
Two studies by OHSU scientists found that elderly men taking SSRIs have lower bone mineral density, while elderly women taking the drugs experience a higher rate of yearly bone loss. The researchers caution against drawing conclusions about causality but suggest screening and extra protection may be needed.
A study by Georgetown University Medical Center researchers highlights the issue of inconsistent medical standards across US states, with some relying on local rules rather than national standards. This can lead to inadequate patient care, as doctors may be unsure about what constitutes standard practice in their specific jurisdiction.
Women with diabetes experienced a decline in death rates, but at a cost: their bone density and endometrial thickness may have increased. In contrast, a study on soy products found that genistein supplements boosted bone mineral density and improved markers of bone metabolism.
A recent study from the University of Missouri-Columbia found that exercise alone led to significant improvements in blood glucose levels for people with diabetes, outperforming diet and medication changes. The meta-analysis of 10,455 subjects showed that physical activity had equal benefits across age groups and genders.
A study at EULAR 2007 found that early treatment with a combination of methotrexate and infliximab can induce clinical remission and reduce joint damage in rheumatoid arthritis patients. Almost one-fifth (17%) of patients reached clinical remission, while 51% were able to discontinue infliximab treatment.