Articles tagged with Drug Studies
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A new study finds that higher doses of statins are cost-effective for patients with recent heart attacks, but may not provide significant benefits for those with stable coronary artery disease. The analysis could help evaluate the cost-effectiveness of other medications and treatments.
A Georgetown University expert reveals how drug reps manipulate physicians with finely-tuned doses of friendship and financial incentives. The authors found that friendly doctors are the easiest to influence, while those who refuse are often wooed with gifts and flattery.
A community-based study found that women with a lifetime history of migraine performed worse on cognitive tests initially but showed a 17% less decline in performance over time compared to those without migraines. Lifestyle factors such as diet and behavior may play a role in protecting memory.
A study of 4,681 older adults found that those with high levels of depressive symptoms were more likely to develop type 2 diabetes over a 10-year period. The researchers followed participants for 10 years, tracking changes in depressive symptom scores and the development of diabetes.
The Prescription Opiate Addiction Treatment Study aims to assess the effectiveness of buprenorphine/naloxone combination tablets and different models of drug counseling in patients addicted to prescription opioids. The study will enroll 648 participants and test various treatment approaches to treat addiction to opioid painkillers.
A meta-analysis of 27 major studies found antidepressants effective in treating anxiety, OCD, and depression in children and adolescents. The study suggests that while there is a small risk of suicidal thoughts, it is outweighed by the benefits of treatment.
A University of Georgia study found that giving commonly prescribed blood pressure medications within 24 hours of a stroke can significantly reduce brain damage. The finding may revolutionize emergency stroke care by adding these medications to clot-busting and blood thinners as front-line treatments.
A new study found that antidepressants are effective in treating pediatric major depressive disorder and anxiety disorders, with a lower risk of suicidal thoughts compared to FDA estimates. The study suggests antidepressants should be considered as first-line treatment options for children under 19.
A randomized controlled trial of high-risk gastric cancer patients showed no significant difference in survival between two treatment groups. The five-year survival rate was around 50%, higher than previous studies, suggesting that the quality of surgery and potential toxicity of postoperative chemotherapy may be factors.
A phase III trial of 1,298 patients found that a combination of cetuximab and irinotecan increased progression-free survival over irinotecan alone. The treatment also showed a higher tumor response rate.
Researchers found that natalizumab significantly reduces vision loss and likelihood of sustained vision loss in patients with relapsing MS. The drug's potential benefits must be weighed against its risks, including progressive multifocal leukoencephalopathy.
A study found that a generic drug called prazosin improves sleep quality and reduces trauma nightmares in veterans with posttraumatic stress disorder (PTSD). The drug, already used for high blood pressure and prostate problems, was shown to improve overall well-being and functioning.
MacroChem Corporation has completed patient enrollment in a Phase II efficacy study for EcoNail, a topical antifungal treatment for onychomycosis. The company aims to assess early signs of efficacy and collect 24-week interim data later this year.
A systematic review of studies published over four decades confirms that good doctor-patient communication significantly impacts patient outcomes, including resolution of chronic headaches and improved blood pressure readings. The review highlights the importance of clarifying instructions and checking for understanding to ensure effec...
A meta-analysis of 10 previous studies found that consuming cocoa products reduces systolic and diastolic blood pressure, comparable to the effects of blood pressure-lowering medications. However, drinking tea was not associated with a reduction in blood pressure in any of the trials.
The number of certified geriatricians in the US is declining, with only 67% of fellowship positions filled in 2005-06. Geriatric students are deterred by lower salaries and smaller work schedules.
A retrospective analysis found patients taking risedronate (Actonel) had a lower incidence of hip fractures compared to those taking alendronate. The REAL study used a health service utilization database and provided valuable insights into the clinical effectiveness of these osteoporosis treatments.
A study published in Archives of General Psychiatry found that intensive psychotherapy was more effective than brief therapy in treating bipolar depression. Patients who received intensive psychotherapy had a faster recovery rate and were more likely to stay well over time.
A study led by Children's Hospital Boston found that lesbian/gay adolescents were three to four times more likely to report having been bullied than heterosexuals. The study analyzed data from over 7,500 adolescents aged 14 to 22 and found nearly half of the lesbian and gay youth had been bullied in the past year.
Bifeprunox demonstrates a favorable weight and lipid profile, comparable to placebo, in patients with stable schizophrenia. The treatment also showed decreases in body weight and minor reductions in BMI in patients with acute exacerbations of schizophrenia.
A new report published in the New England Journal of Medicine shows that bronchial thermoplasty significantly improves asthma control, reducing symptoms and medication use. The procedure, which reduces airway smooth muscle, demonstrates promising results for patients with moderate or severe asthma.
The COURAGE trial found that PCI reduces neither mortality nor heart attack in patients with chronic stable angina when added to optimal drug therapy. SCAI leaders emphasize the importance of discussing treatment options and goals with patients, as therapy may not be suitable for every patient.
According to two studies, disease management programs designed with repetitive education and close monitoring can reduce hospital visits and increase heart failure patients' chances of long-term survival. The REMADHE study found that patients who received a nurse-based program spent an average of nine fewer days in the hospital.
Researchers at the University of Guadalajara have developed a natural drug carrier derived from tequila that shows promise in targeting colon diseases. The microspheres, made from fructans, can protect drugs from stomach acid and improve their effectiveness.
A randomized study of 2,287 patients found that percutaneous coronary intervention plus optimal medical therapy did not improve outcomes compared to medical therapy alone. Lifestyle changes and medication management were effective in managing symptoms.
The EVEREST trial showed that tolvaptan improved signs and symptoms of acutely decompensated heart failure, with significant reductions in body weight and improvements in dyspnea. Long-term use did not differ from placebo on survival endpoints, but tolvaptan may be a potential therapy for patients with heart failure.
A new five-year study published in the New England Journal of Medicine found that stable heart patients received no significant benefit from undergoing angioplasty compared to those treated with medication alone. The study showed a 19.5% rate of death, heart attack, and stroke among medication-only patients versus 20% for PCI recipients.
A study assessed whether adding succinobucol, a novel agent with antioxidant and anti-inflammatory properties, to optimal medical therapy reduces coronary events and death. The trial achieved a 19% relative risk reduction in hard atherosclerotic clinical endpoints, including cardiovascular death, myocardial infarction, and stroke.
A study found that most first-time DWI offenders have high rates of other substance-use disorders and psychiatric disorders, requiring enhanced services in intervention programs. The research suggests that treatment approaches may need to be modified to better serve this more severe subtype of DWI offenders.
A combination of aliskiren and valsartan showed improved blood pressure control compared to individual treatments or placebo. The dual renin system blocking drug combo reduced systolic and diastolic blood pressure, achieving a goal blood pressure of 140/90 mmHg in 49.3% of patients.
A 5-year study found that giving nitroglycerin to mothers in preterm labor led to significant improvement in their baby's health, especially those born between 24-28 weeks. This therapy resulted in cost savings and longer-term health benefits for premature babies.
Long-term safety of drug-eluting stents in off-label use shows low mortality rates, with cardiac mortality at 0.8%, but high risk of late stent thrombosis among non-responders to clopidogrel. The MATRIX Registry found that 34% of patients had diabetes and 33% a history of heart attack.
Researchers studied the effectiveness of estradiol and rapamycin-eluting stents in reducing in-stent restenosis. However, they found no significant difference between the two groups, indicating that adding estradiol to rapamycin-coated stents may not provide a measurable benefit.
Researchers present three studies highlighting advances in clinical cardiology, including a new drug-exercise combination that improves image quality and reduces side effects. The studies also explore the best medical and interventional treatment for patients with acute coronary syndromes.
A Phase 2 clinical trial for ranibizumab is enrolling patients with diabetic macular edema to assess its long-term safety and effectiveness. The trial aims to investigate the use of ranibizumab in combination with laser photocoagulation for treating DME.
Researchers found that combining torcetrapib with atorvastatin did not slow the progression of atherosclerosis, contrary to expectations. The study also noted significant increases in HDL-C and decreases in LDL-C levels.
Research on silent myocardial ischemia shows that anti-anginal therapy, combined with risk factor control, improves outcomes and preserves left ventricular function. Additionally, faster door-to-balloon time for STEMI patients leads to reduced healthcare costs, heart attack rates, and hospital stays.
A study published in the New England Journal of Medicine found that pairing percutaneous coronary interventions (PCI) with optimal medical therapy (OMT) is no more effective than OMT alone in preventing heart attacks and other cardiac events. The study showed similar rates of death, heart attack, or stroke between patients who received...
A new study found that CSL-111, a drug that mimics HDL, did not significantly reduce plaque in coronary arteries, but showed improvement in two indexes assessing blood vessel changes. The trial involved 183 patients with acute coronary syndromes and used intravenous ultrasound to assess coronary artery changes.
Researchers have identified promising new drug combinations that can improve survival rates among patients with severe heart disease. Studies show that using imaging technologies like PET-guided therapy can also help doctors make more accurate decisions about therapies for these high-risk patients.
A study published in JAMA found that tilarginine, a medication believed to benefit cardiogenic shock patients after a heart attack, had no effect on mortality rates. The trial tested the drug's efficacy in 398 patients and showed no difference in 30-day death rates between those who received tilarginine and placebo.
A study found that tolvaptan improves symptoms such as congestion and breathing difficulty, but has no effect on long-term mortality or re-hospitalization rates. The medication also showed promise in reducing fluid accumulation and improving sodium levels in patients with hyponatremia.
A community-based study found that intensive dietary therapy and early dosing with a medication blocking harmful hormonal effects in the heart can improve cardiovascular health and survival rates after a heart attack. The Mediterranean diet was equally beneficial as a low-fat, low-cholesterol diet.
The study found that the novel PPAR-alpha agonist LY518674 decreased triglycerides and increased HDL-C levels, but also raised safety concerns such as increased serum creatinine levels and cardiovascular toxicity. The results were generally similar to those of existing drugs like fenofibrate.
Studies found that ramipril and rosiglitazone slow atherosclerosis progression, while rosuvastatin treatment reduces arterial plaque buildup in low-risk individuals. Additionally, high-dose atorvastatin improves outcomes in patients with acute coronary syndromes undergoing percutaneous coronary intervention
A Phase 1 study evaluating a novel protein kinase C inhibitor, KAI-9803, suggests potential benefit in healing time and tissue function for heart attack patients. The trial showed improved tissue perfusion and reduced infarct size at lower dose levels.
The SPIRIT-III trial shows that the Xience V Everolimus Eluting Coronary Stent System reduces target vessel failure, ischemic-driven revascularization procedures, and major adverse cardiac events compared to paclitaxel-eluting stents. This suggests a potential enhancement of outcomes for patients with coronary artery disease.
A new study attributes long-term survival rates after cardiac surgery to the rising use of cardiac drugs, including low-dose aspirin. Researchers found that lower doses of therapies may be just as beneficial while lowering side effects.
A promising pilot study has led to a larger clinical trial of estriol as a treatment for multiple sclerosis. The trial aims to recruit 150 women and measure relapse rates over two years, potentially providing a new, affordable option with dual benefits of reducing inflammation and protecting the brain from damage.
The NIH is launching a large-scale clinical trial to explore the potential of creatine as a treatment for Parkinson's disease. The study aims to slow the progression of the disease and improve quality of life for patients.
Dr. Bruce J. Baum is recognized for his significant contributions to oral medicine and pathology, including the discovery of xerostomia's importance in clinical practice. His research has led to the development of novel treatments for salivary gland damage and single-protein-deficiency disorders.
A small clinical trial of escitalopram, an antidepressant medication, found no conclusive benefit in treating kleptomania. However, the results suggest that some medications may still be effective for certain patients.
Only 20% of children with persistent asthma have optimal control, according to a survey-based study published in Ambulatory Pediatrics. The study found that 43% of children receiving medications still experienced poor symptom control, highlighting the need for improved education and trigger avoidance strategies.
A recent study found that financial constraints hinder heart attack patients from seeking healthcare services or taking vital medications, resulting in poorer health outcomes. Patients with unaffordable medications had a 50% higher chance of being re-hospitalized for cardiac conditions.
A study found no difference in the relapse rate of people with compulsive-buying disorder when taking escitalopram compared to those on a placebo, contradicting previous research findings. The results may be due to differences in biological roots among individuals with the disorder.
A UCLA study reports that over half of patients with idiopathic pulmonary fibrosis improved their walking distance by at least 20% after taking Viagra. The medication may help breathing by opening or dilating blood vessels to allow more blood flow to the lungs.
The CATIE study found that treatment needs to be targeted and individualized for patients with schizophrenia. More intensive psychosocial therapies are needed to make meaningful gains in work, home, and community functioning.
A new US study found that nearly four out of five hospitalized children receive medications approved for adults, highlighting the need for further research on pediatric drug approval. The study also revealed that children who undergo surgery or have severe illnesses are more likely to receive off-label drugs.
A study found that feeding mice copper relieved heart disease and restored proper heart function, even when the animals' hearts were continually stressed. Increasing copper intake, especially in those pre-disposed to heart disease, might reduce mortality rates associated with this condition.
Two new studies from the CATIE trial provide more insights into comparing treatment options and their impact on people with schizophrenia. The trials found that newer antipsychotic medications like quetiapine and olanzapine may be more effective than older medications, but patient responses varied significantly.