Articles tagged with Drug Studies
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Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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Researchers found that patients who experienced damage to their residences were nearly twice as likely to fail to completely follow their medicine regimen. The study suggests opportunities for improving disaster planning and prescription refill processes to increase medication adherence in older adults.
A study by Duke University Medical Center researchers found that depression is independently associated with worse outcomes in heart failure patients. Symptoms of depression were common in this population and depressed patients were over 50% more likely to die or be hospitalized for their heart condition than non-depressed patients.
Researchers from UNC and Dana Farber Cancer Institute found that industry-funded breast cancer trials are more likely to have positive outcomes compared to non-pharmaceutical funded studies. The study also revealed significant differences in clinical trial design and outcome between industry-supported and non-industry studies.
A study found that pharmaceutical industry-sponsored breast cancer trials are more likely to report positive results than non-sponsored studies. These trials also tend to use single-arm designs, targeting patients with advanced disease, which may not answer questions about optimal treatment outcomes.
A clinical trial enrolling over 2,700 uncircumcised men found that circumcision reduced the risk of acquiring HIV by 53% compared to uncircumcised men. The study's results suggest that circumcision can be an effective addition to other prevention and reproductive health services in sub-Saharan Africa.
Researchers found that a drug called trichostatin A can increase SMN2 gene activity, improving symptoms and extending survival in SMA mice. Treatment started after symptoms appeared led to a 19% longer lifespan on average.
Researchers have identified several genes linked to nicotine dependence, including CHRNA5 and NRXN1, which play a role in regulating communication between nerve cells. These findings could lead to the development of more effective smoking cessation therapies tailored to an individual's genetic traits.
The exclusivity of clinical trial data could jeopardize efforts to create generic versions of life-saving medicines, harming public health. Karin Timmermans warns that data exclusivity can delay generic competition and drive up prices.
The trial will evaluate a candidate HIV vaccine on the African continent, aiming to determine its effectiveness and potential protection against different strains of HIV. The study will enroll healthy HIV-negative males and females aged 18-35, exploring how the vaccine works in a predominantly heterosexual epidemic.
A new study reveals Pycnogenol, a French maritime pine tree extract, is 190 times more potent in delaying glucose absorption than prescription medication Precose. This natural extract has been shown to suppress carbohydrate absorption in diabetes, making it an effective alternative for managing type 2 diabetes.
The Pediatric Exclusivity Program has generated over 300 pediatric studies and labeling changes for more than 115 products. The program's economic return is highly variable among products, with blockbuster medications producing substantial profits while others yield modest returns.
A clinical trial found that nearly 600 adults with newly diagnosed epilepsy experienced few to no seizures while taking levetiracetam as a single therapy. The study also showed that patients remained seizure-free for at least six months at the lowest dose level.
A new study at Wake Forest University School of Medicine found that women's conflicting attitudes towards participating in clinical trials are rooted in fears, distrust, and hopes for future benefits. The researchers called for greater involvement of academic medical centers with minority communities to address health concerns.
A Phase III trial of cellulose sulfate, a topical microbicide gel, has been halted due to preliminary results indicating an increased risk of HIV infection in women. The Independent Data Monitoring Committee will conduct a review of the data to better understand the findings and determine implications for future research.
A nationwide study found that despite high insurance coverage rates, many individuals with MS struggle financially due to unaffordable healthcare costs. The study revealed a significant proportion of participants made lifestyle changes, skipped medication doses, or went without essential necessities to pay for healthcare needs.
The National Institutes of Health has awarded Temple University Hospital a $1 million grant to participate in the Neurological Emergencies Treatment Trials Network. The five-year study series aims to facilitate high-quality clinical trials for various emergency neurological disorders, including traumatic brain injuries and seizures.
A study found that three-fourths of cardiovascular clinical trials published in leading medical journals did not provide sex-based analysis, highlighting the lack of data on women's heart health. Researchers urge more women to be included in trials and for journal editors to require sex-specific reporting.
A new national research network, NETT, aims to improve treatment outcomes for neurological emergencies. The network will gather data from patients at multiple hospitals nationwide to test new treatments in real-world settings.
A study published in JAMA found that citalopram was superior to placebo in reducing depressive symptoms in patients with coronary artery disease. The treatment also improved perceived social support and daily function.
A new study published in the Journal of Allergy and Clinical Immunology found that inhaled corticosteroids are the most effective initial daily therapy for children with mild to moderate persistent asthma. The study also showed no significant adverse growth effects among any of the medicines studied.
A study of 5,008 adults found that daily use of selective serotonin reuptake inhibitors (SSRIs) is associated with a doubled risk of certain fractures. The use of SSRIs was also linked to an increased risk of falls and decreased bone mineral density.
Researchers at University at Buffalo are testing a nasal spray anesthetic and ozone delivery device to eliminate drilling and injections in dental procedures. The studies aim to improve patient comfort and reduce pain associated with dental care.
A recent study found that nearly a quarter of women treated with tamoxifen for breast cancer stop taking the medication within one year, leading to concerns about treatment efficacy. The study also revealed that over one-third of women have ceased tamoxifen treatment after three and a half years.
Researchers at Rush University Medical Center found significant differences between antihypertensive drugs and their risk of new-onset diabetes. ACE-inhibitors and ARBs prevent diabetes, while diuretics and beta-blockers increase the risk. The study analyzed 22 long-term randomized clinical trials and included 143,153 patients.
The University of Pittsburgh has been awarded a five-year, $13 million NIH grant to study chronic obstructive pulmonary disease (COPD) and develop novel treatment options. Researchers will investigate the molecular and cellular characteristics of COPD to better understand its progression and potential treatments.
Researchers found that adding cetuximab to radiation therapy and chemotherapy improved local regional control and overall survival in patients with locally advanced squamous cell carcinoma of the head and neck. Seventy-two percent achieved a complete response two months after completion of therapy, while 95 percent were disease-free.
AZD2171, a new angiogenesis inhibitor, has shown significant promise in treating glioblastomas by reducing tumor size and alleviating debilitating brain swelling. The treatment also appears to normalize blood vessels, creating a window of opportunity for other therapies to be more effective.
The FDA has approved LIALDA (mesalamine), the first oral once-daily mesalamine for patients with active, mild to moderate ulcerative colitis. Clinical trials found LIALDA effective in inducing remission compared to placebo after eight weeks of treatment.
A study of 44 industry-initiated trials found that ghost authorship was present in 33 trials, with statisticians being the most common ghost authors. This practice undermines scientific integrity and highlights the need for stricter guidelines to prevent it.
A study led by doctors at Beth Israel Deaconess Medical Center shows that patients treated with the endoscopic Plicator procedure experience a sustained reduction in gastro esophageal reflux disease (GERD) symptoms and medication use. Over half of the patients were able to stop medication completely three years post-procedure.
The Society for Cardiovascular Angiography and Interventions (SCAI) released a clinical alert on the risks of late thrombosis associated with drug-eluting stents. The alert provides practical advice for physicians to minimize this risk, including careful patient selection and use of dual anti-clotting medications.
Researchers at Penn School of Medicine have shown a 51% reduction in low-density lipoprotein (LDL) cholesterol levels in patients with homozygous familial hypercholesterolemia. The new therapy, which targets the microsomal triglyceride transfer protein, also decreased total cholesterol and triglyceride levels.
Two Mayo Clinic studies found no strong evidence supporting testosterone's safety from cardiovascular harm and inconsistent results regarding its impact on sexual dysfunction. The research highlights the need for large-scale trials to inform clinicians' decisions about prescribing testosterone.
New research suggests that taking prescribed medications like statins and beta-blockers following a heart attack is associated with longer survival. Adherence to these medications was found to be linked to improved mortality outcomes, with the strongest association observed for patients who took their medication as prescribed.
Researchers at Stanford University School of Medicine have used the antiviral drug valganciclovir to treat patients with chronic fatigue syndrome, with significant improvement in 21 out of 25 cases. The therapy has shown promise in reducing inflammation and improving symptoms.
Recent analysis found that nutrition studies funded solely by industry were four to eight times more likely to have favorable conclusions than those with no industry funding. The study's findings suggest a pervasive bias in the field, which may have significant implications for public health and dietary guidelines.
JDRF is providing up to $2 million in funding for the 'Protégé' trial of teplizumab, a proprietary MacroGenics compound that has shown promise in slowing type 1 diabetes progression. The trial aims to assess teplizumab's capacity to reduce insulin requirements and maintain normal blood sugar levels.
A phase 3 trial found that pexelizumab did not significantly reduce the risk of death from STEMI when used with primary PCI. The study, which included over 5,700 patients, suggests that new treatments targeting inflammation may be needed for this patient population.
Researchers at the University of California - San Francisco have discovered two novel treatments that may prevent brain damage caused by stroke, administered through the nose to reduce brain cell death. The studies found that nicotinamide adenine dinucleotide (NAD+) reduced brain cell death by 70-86% and significantly reduced motor imp...
Researchers found that inactivating TNFa significantly reduced blood vessel impairment and cell death in aged vessels, suggesting a link between increased TNFa levels and cardiovascular disease. The study's findings could lead to the development of new treatments for age-related vascular diseases.
A large-scale study found that prolonged use of proton pump inhibitors (PPIs) increases the risk of hip fractures by 44%. Long-term users of high-dose PPIs face a significantly higher risk, highlighting the need for further research into the underlying mechanism.
A new study found that postmenopausal women who stop taking the osteoporosis drug alendronate after 5 years do not increase their risk of nonvertebral fractures, suggesting a lasting effect. The research also shows that BMD and bone marker levels remain at or above pretreatment levels 10 years after discontinuation.
Researchers analyzed 1,200 genome-wide polymorphisms in 432 Indian individuals, revealing low levels of genetic divergence across geographically and linguistically diverse populations. The study provides a foundation for future research on the genetic basis of common diseases in Asian Indians.
A study by Dr. Xuemei Huang found that participants with lower LDL cholesterol had a 3.5-fold higher occurrence of Parkinson's disease compared to those with higher LDL levels. The results suggest a link between low LDL cholesterol and an increased risk of developing the neurodegenerative disorder.
Recent studies have investigated the cost-effectiveness of drug-eluting stents compared to bare-metal stents. Two articles found that drug-eluting stents were used more frequently in private hospitals, but studies' quality and funding sources influenced their conclusions. The clinical indications for PCI have also been questioned due t...
A $1.7 billion North American study aims to answer whether reopening narrowed kidney arteries benefits patients. Researchers will compare medical management with medicines coupled with stents, stainless steel scaffolds inserted into blood vessels.
A Phase II trial found that 86% of patients with inflammatory breast cancer responded to lapatinib-chemotherapy, offering new hope for treatment. The study also showed that 25-30% of patients responded within two weeks of treatment alone.
A clinical trial combining bortezomib with Doxil has shown promising results in treating relapsed or refractory multiple myeloma, a type of bone marrow cancer. The combination treatment demonstrated a better response rate compared to standard therapy alone, with a median time to progression of 9.3 months.
AkaRx Inc. presents Phase I clinical data of AKR-501, a TPO receptor agonist that mimics the effect of thrombopoietin to stimulate platelet production, with a 50% increase in platelet count in healthy volunteers. The results suggest potential for safe and effective treatment of thrombocytopenia in various diseases.
Researchers at M.D. Anderson Cancer Center report clinical activity of MK-0457 against T315I BCR-ABL mutation in CML and ALL, and JAK-2 mutation in myeloproliferative disorders. The drug shows minimal side effects and has potential to benefit patients with these rare and aggressive cancers.
The study found that AVN944 significantly inhibited the IMPDH enzyme and induced biomarkers associated with cancer cell death. The gene HspA1A marker was elevated even at low doses of the drug, indicating potential for tumor cell apoptosis.
A study by Yale University researchers found that Swedish massage therapy significantly improved symptoms in adults with osteoarthritis of the knee, including reduced pain and increased flexibility. The treatment was shown to be safe and effective, with benefits persisting after completion of the massage intervention.
In a Phase III study, eculizumab provided clinically and statistically significant improvements in intravascular hemolysis, anemia, fatigue and quality of life in patients with paroxysmal nocturnal hemoglobinuria. Eculizumab therapy also reduced adverse events and showed significant benefits in patient-reported outcomes.
A clinical trial has found that a combination of nifurtimox-eflornithine offers a cure rate over twice that of current treatments for second-stage African trypanosomiasis. This combination also resulted in lower rates of adverse events, suggesting potential as a future therapy.
A new study found that patients who initiate general discussions about antidepressant medication are more likely to be thoroughly evaluated for depression than those with brand-specific requests or no request. This increase in history-taking also leads to better provision of initial care and diagnostic accuracy.
Abstracts on Soliris (eculizumab) will be presented at the ASH Annual Meeting, highlighting its potential to reduce thrombosis in paroxysmal nocturnal hemoglobinuria (PNH) patients. The therapy has shown promise in clinical trials with significant reductions in anemia and intravascular hemolysis.
A University of Rochester study published in Obstetrics and Gynecology journal found that low doses of mifepristone shrink uterine fibroid tumors and greatly improve the quality of life in women who suffer from pain and heavy bleeding. The treatment resulted in a 135% improvement in quality of life for women taking mifepristone compare...
A recent study published in The Journal of Clinical Pharmacology found that palifermin clearance and tolerability are not affected by renal function. No dose adjustment is indicated for patients with impaired kidney function, allowing the drug to be used without restrictions.
A study found that schizophrenia patients respond equally well to older psychiatric drugs as newer, costlier alternatives. The NHS-funded trial revealed little benefit from switching to second-generation anti-psychotics despite their higher market share.
A new study suggests that older antipsychotic medication perphenazine is less expensive and equally effective as newer medications for treating schizophrenia. The study, funded by the National Institutes of Health, found that total monthly health costs were up to 30% lower for patients taking perphenazine compared to those taking secon...