Articles tagged with Drug Studies
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The lack of transparency in clinical trials has been criticized by Ben Goldacre, who calls for the sharing of Clinical Study Reports to ensure informed decisions about medicines. The problem of missing trials is one of the greatest ethical challenges facing medicine today.
A study led by the University of Exeter found that 27% of over-70s with type 2 diabetes achieved better glycaemic control through individualized care alone. Researchers introduced a 'one-size-fits-all' approach for older patients, which proved ineffective due to multiple complications.
A phase III trial found that adding chemotherapy to surgery after curative D2 gastrectomy improved 5-year survival by 34% compared to surgery alone. The study, CLASSIC, added combination chemotherapy (XELOX) to standard treatment, showing a significant reduction in cancer-related death.
A study found that home blood pressure telemonitoring with pharmacist management improved BP control and maintained it for 6 months. The intervention group had a higher proportion of patients with controlled BP at both 6- and 12-month visits compared to the usual care group.
Joslin scientists found that salsalate effectively lowers blood glucose and improves glycemic control in type 2 diabetes. The study involved 286 participants with inadequately controlled diabetes, who showed significant reductions in hemoglobin A1c levels and fasting glucose concentration.
A new technique called 'renal denervation' has shown significant reductions in blood pressure and improved long-term stability. The procedure involves removing nerves connecting the kidney to the brain using radio-frequency energy, with minimal side effects and no need for tablets.
A single systemic dose of dendritic cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation. The treatment successfully regulated the immune system without side effects, allowing for longer organ survival.
Research found that longer initial prescriptions for cardiac medications after hospital discharge are associated with long-term adherence in elderly patients. The study suggests that longer prescriptions are more patient-centered and effective in preventing further cardiac events.
The ISSUE III registry study found that cardiac pacing is more effective in patients with presumed neurally mediated syncope (NMS) and asystolic episodes, than in patients with positive tilt table testing. The registry showed that oral anticoagulation therapy is now widely used in patients with atrial fibrillation.
A new study published in Gastroenterology reveals a significant increase in drug-induced liver injury cases worldwide. The most common culprits were antibiotics like amoxicillin-clavulante, immunosuppressants such as azathioprine and biologics like infliximab.
A study has found that human and canine B-cell lymphoma expression profiles are similar, providing a new model for understanding the disease. This discovery may facilitate faster development of new therapies for both humans and dogs with lymphoma.
The GAP-AF study found that complete ablation with complete linear lesions around pulmonary veins was more effective than incomplete lesions in preventing AF recurrence. This approach resulted in higher success rates and longer periods of sinus rhythm compared to incomplete procedures.
A new study by UCSF researchers identified a brain pathway linked to addiction cravings and found that deactivating it could prevent relapse in rats. The study suggests that targeting the molecular pathway mediated by mTORC1 could lead to a treatment option for people with alcohol abuse disorders.
Patients with paroxysmal atrial fibrillation (AF) show signs of depression, sleeping disorders, and low levels of physical activity, despite physicians rating their quality of life higher. Good communication between physicians and patients is crucial for adherence to medications and long-term prognosis.
The First-HD study examines the efficacy and safety of SD-809, a novel drug for treating chorea associated with Huntington Disease. The trial aims to test the tolerability of the drug in patients who have not previously taken tetrabenazine.
A large clinical trial shows that clopidogrel does not effectively reduce shunt-related blood flow issues in infants with congenital heart diseases. Aspirin alone may be effective in reducing the risk of clot formation, while switching to Plavix is not recommended.
A study of over 3000 patients found that those who received rt-PA within six hours of a stroke had fewer problems with self-care and mobility, experienced less pain, and needed less help from others 18 months later. The drug significantly improved life after stroke in the long-term for elderly patients as well.
A phase Ib/II trial showed an overall response rate of 71% for CLL patients and a 68% response rate for MCL patients, with estimated progression-free survival rates of 75% and 58% respectively. Ibrutinib has been shown to target Bruton's tyrosine kinase, a protein critical in B-cell receptor pathway for tumor cell survival.
A meta-analysis study found that insulin degludec has a similar or reduced risk of recurrent hypoglycemia compared to insulin glargine. The study, involving nearly 3,400 adults with type 2 diabetes, suggests that insulin degludec may offer benefits in reducing the major side effect of insulin therapy.
Researchers analyzed data from over 50,000 stroke patients to determine the critical time gap between stroke onset and treatment initiation. For every 15-minute faster interval of treatment, patients were more likely to go home, walk at discharge, and have fewer symptoms.
A large-scale study published in JAMA Internal Medicine found that consuming more red meat over time increases the risk of developing Type 2 diabetes. The research followed over 149,000 participants and documented a 48% elevated risk for those who increased their red meat intake by more than 0.50 servings per day.
The study found that the median time to activation of phase 1-2 trials decreased from 541 to 442 days, and for phase 3 trials from 727 to 395 days. The reforms led to faster initiation of NCI-sponsored trials, ultimately benefiting patients in need of new treatments for cancer.
A recent review conducted by Oregon Health & Science University found that a bone growth product used in spinal surgeries offers no real benefit over traditional bone grafts and comes with potential harms. The review also identified reporting bias in studies funded by the product's manufacturer, Medtronic.
A pooled analysis of two clinical trials found that lorcaserin improves hemoglobin A1c levels and fasting blood sugar levels in nondiabetic, overweight patients. The study suggests that the drug's serotonin receptor activation may play a role in regulating glucose metabolism.
A group of experts proposes restoring unpublished and misreported clinical trials to publish previously confidential trial documents, ensuring accurate treatment information. The effort aims to address the issue of unreported trials that have misled public health decisions and wasted public money.
The Journal of Pharmaceutical Policy and Practice has transferred to BioMed Central, supporting its growth and development. The new focus will cover high-income economies and provide a platform for researchers to share evidence and perspectives on global pharmaceutical policy.
A new study found that a daily oral dose of tenofovir significantly reduces the risk of HIV infection in people who inject drugs, with 17 participants infected out of 1204 on the drug versus 33 on placebo. Adherence to the treatment was key to its effectiveness.
A study found specific patterns of brain activity can indicate whether a patient will respond to medication or psychotherapy for depression. Low activity in the anterior insula region was associated with remission through CBT, while high activity was linked to improved response to medication.
The lack of hard data on drug safety during pregnancy is leading to a doubling of deaths among mothers with underlying health conditions. Pregnant women are hesitant to take medications due to concerns about their developing baby, while doctors are also reluctant to prescribe due to limited evidence.
Researchers from La Jolla Institute, Dana-Farber and BloodCenter of Wisconsin are launching Phase II clinical trials to investigate a potential new therapy for reducing sickle cell anemia symptoms. The trial is testing Lexiscan, an existing drug with anti-inflammatory effects.
A UCLA study found that women with hyperemesis gravidarum (HG) who take antihistamines are more likely to experience bad outcomes, including low birth weight babies and premature births. The study also showed that these medications are not effective in treating HG symptoms
A recent study found that approximately 40% of designated drivers have consumed alcohol, with many having blood alcohol levels that impair their driving skills. The researchers emphasize the importance of complete abstinence as a designated driver to ensure safety on the road.
Researchers found that rapamycin improved cardiac function and reduced inflammation in aged mice, slowing down heart dysfunction. The study suggests potential benefits for humans with heart disease, as it is already FDA-approved for other indications.
A joint investigation by BMJ and Channel 4 Dispatches found that evidence of potential harm from new diabetes drugs has not been fully published. This has led to millions of patients worldwide being under-informed about possible risks. Regulators in Europe and the US have faced criticism for their slow response to emerging concerns.
Scientists at Scripps Research Institute have identified an extraordinary family of cow antibodies that could lead to breakthroughs in human medicine. The unique structure and mechanism of these antibodies may allow for the creation of new therapeutic proteins.
A new drug has been shown to prevent PTSD-like symptoms in mice by targeting the Oprl1 receptor, a gene variant linked to increased risk of developing PTSD in humans. The results suggest that the drug could have a similar preventive effect on PTSD in humans.
Research reveals higher diversity in gut microbiota enables more robust immune responses to vaccines. Scientists found that diverse gut bacteria may help humans resist enteric pathogens like Salmonella and Shigella.
Researchers have identified a genetic variation that can help estimate the correct dose of warfarin for African-Americans. This discovery may improve the predictability of warfarin dosing by 21 percent, reducing hospitalizations for adverse drug reactions.
A systematic review of over 50 studies found bariatric surgery associated with greater short-term weight loss and improved blood glucose levels in non-morbidly obese adults with diabetes. However, the evidence is limited, and long-term benefits are unknown.
Researchers have discovered the functional importance of enhancer-directed RNAs, also known as eRNAs, which boost or enhance nearby genes. The discovery could provide a new way to alter gene expression in a cell-specific manner, potentially treating diseases.
A randomized phase III trial found sorafenib stops tumor growth and provides effective treatment for thyroid cancer patients who progress following standard therapies. The therapy also thwarts disease progression even among those whose tumors do not regress, with median progression-free survival of 10.8 months.
A Phase III study by MD Anderson Cancer Center found no overall survival (OS) or progression-free survival (PFS) benefits for bevacizumab in newly diagnosed glioblastoma patients. However, patients on bevacizumab experienced higher rates of toxicities and symptom burden compared to placebo.
A new gene panel may help personalize therapy for newly diagnosed glioblastoma patients by identifying those most likely to benefit from bevacizumab. Researchers observed a significant association between lower mesenchymal signatures and better survival in patients taking the drug.
The GRACE study found that access to treatment was the most positive factor for patient enrollment, while difficulties in adherence included being a primary caregiver and transportation issues Women of color reported feeling differently about their health after participating in the trial
A new study found that only one-fifth of rheumatoid arthritis patients took their oral medications at 80% or greater. Researchers emphasize the importance of following the prescribed regimen to manage disease symptoms and prevent progression. Patients with better mental health status were more likely to adhere to their medication regimen.
A comprehensive study by UCLA researchers found that children with ADHD who take medications like Ritalin are not at greater risk of using alcohol, marijuana, nicotine, or cocaine later in life. The study analyzed over 2,500 children and concluded that medication use has no significant association with future substance abuse.
In a large, international randomized trial, initial radiotherapy was compared to temozolomide chemotherapy. No significant difference in progression-free survival was observed between the two treatment strategies, with radiotherapy numerically favored. Molecular tumor characterization may allow personalized treatment approaches.
The study analyzes benefits and risks of non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 inhibitors (coxibs), finding that naproxen may have the best benefit-to-risk ratio on cardiovascular disease, while high-dose diclofenac and ibuprofen pose comparable vascular risks.
A randomized clinical trial found that higher-dose radiotherapy did not improve overall survival in patients with stage III non-small-cell lung cancer. The study suggested that a standard dose of 60Gy is superior to 74Gy, and that adaptive radiotherapy may be more effective.
A new study found that disabled Medicare patients under 65 who face cost barriers to medication adherence are more likely to have emergency department visits. The study revealed that 38.3% of patients with severe cost-related non-adherence had at least one ER visit, compared to 27.5% without CRN.
An Indiana University study found that a unique omega-3 supplement, Lyprinol/Omega XL, significantly improved lung function and reduced airway inflammation in asthmatics. The supplement, derived from the New Zealand green-lipped mussel, was effective in reducing symptoms and potentially improving athletic performance.
A national survey found that adults often did not make informed medical decisions due to insufficient shared decision-making. Healthcare providers need to improve patient engagement by balancing discussions on pros and cons and regularly seeking patient input.
A synthetic compound ShK-186, derived from a sea anemone toxin, enhances metabolic activity and shows potential as a treatment for obesity. The compound selectively blocks the activity of a protein that promotes inflammation through the Kv1.3 potassium channel.
The RELAX-AHF trial demonstrated serelaxin's efficacy in relieving dyspnea in HFpEF patients, particularly within the first 24 hours. The VIVIDD trial also showed vildagliptin to be non-inferior to placebo in improving LVEF in HFrEF patients with type 2 diabetes.
Researchers found that an anti-cancer drug, bexarotene, did not reduce amyloid plaques in the brains of mice, despite initial claims of its effectiveness in reversing Alzheimer's-like symptoms. The study suggests that further research is needed to understand the nuances of this potential treatment.
A population-based study suggests that high-potency statins like atorvastatin and rosuvastatin increase the risk of developing new-onset diabetes. In contrast, fluvastatin and lovastatin appear to have a lower risk. Researchers recommend considering individual patient risk when prescribing statins.
A study of older patients with chronic obstructive pulmonary disease (COPD) found that new use of long-acting bronchodilators was associated with an increased risk of cardiovascular events. The study suggests that close monitoring of COPD patients taking these medications is necessary to mitigate this risk.
A study published in JAMA Network found that patient-preferred music significantly reduced anxiety and sedation frequency and intensity in critically ill patients receiving acute ventilatory support. The intervention resulted in a 19.5-point lower anxiety score compared to usual care.
A clinical trial shows that listening to favorite music lowers anxiety by 36.5% and reduces the need for sedative medications in ICU patients on mechanical ventilators. The study also found that patients who listened to music spent more time being liberated from the ventilator than those in other groups.
Researchers at NYU Langone Health found that combat veterans with PTSD exhibit abnormal brain activity in key fear and anxiety regions even at rest. The study sheds light on which areas of the brain provoke traumatic symptoms and represents a critical step toward better diagnostics and treatments for PTSD.