Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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In a new analysis, rituximab shows promising results in treating chronic immune thrombocytopenic purpura (ITP), a bleeding disorder that destroys blood cells. The treatment promotes long-term response in approximately one quarter of patients, with normalized platelet counts lasting at least five years.
A one-year study has found that Avastin and Lucentis have similar effectiveness in treating the most common cause of blindness in developed countries. The treatment approach, where drugs are administered as needed rather than monthly, resulted in almost identical levels of vision improvement.
A new UCSF study questions the previous analysis of varenicline's safety, finding no clinically or statistically significant increase in serious adverse cardiovascular events. The researchers analyzed data from 22 trials with over 9,200 participants, concluding that the risk difference is only 0.27 percent.
Carnegie Mellon and McGill researchers argue that current research ethics frameworks fail to prevent biased evidence in phase IV drug trials. They propose policy options to expand FDA review authority and empower oversight systems to detect scientific bias.
A new study from the University of Pennsylvania School of Medicine confirms that COX-2 inhibitors, such as Vioxx and Celebrex, increase cardiovascular risk by disrupting prostacyclin production. This disruption leads to hardening of the arteries and amplifies the effects of COX-2 inhibition on the cardiovascular system.
A new randomized controlled trial found that memantine, a commonly prescribed medication for Alzheimer's disease, is no more effective in reducing significant agitation than a placebo. The study suggested improvements in cognitive functioning and neuropsychiatric symptoms, but failed to provide relief from severe agitation.
A landmark clinical trial found that aspirin and warfarin are equally effective in preventing a combined risk of death, stroke, and cerebral hemorrhage in heart failure patients. The WARCEF trial, which involved over 2,300 patients, showed that the overall risks and benefits of the two medications are similar.
A study found that varenicline significantly reduced average number of drinks per week by 36% in participants assigned to take the drug. The effects on drinking behavior were separate from its effects on smoking.
A large-scale analysis found that most clinical trials are small and have significant methodological differences, leading to concerns about the quality of evidence. The study's findings highlight the need for better trial design and data collection practices to ensure high-quality evidence for medical decision-making.
Researchers discovered a link between ACE inhibitors and ARBs and lower PTSD symptom scores in patients taking these medications. The findings suggest that these blood pressure medications could be valuable tools for treating or preventing post-traumatic stress disorder.
The CATT study found that Avastin and Lucentis were similarly effective in maintaining vision for AMD patients, with two-thirds of patients retaining 20/40 or better vision after two years. However, the study highlights the need for further research on dry form AMD and a stronger national commitment to funding eye research.
A study examining registered clinical trials found that many small, single-center trials were submitted between 2007-2010, leading to heterogeneity in methodological approaches. The majority of trials had an anticipated enrollment of 1,000 or fewer participants, and only 44% were funded by industry.
A study in Cell Metabolism resolves controversy over resveratrol's life-extending effects by demonstrating that the ingredient's benefits require the SIRT1 gene. The research also clarifies resveratrol's dose-dependent action on SIRT1 and other proteins.
Scientists at Ohio State University found that excessive beta-carotene consumption can lead to the production of anti-vitamin A molecules, disrupting metabolism and immune function. This paradoxical effect may explain a decades-old clinical trial's unexpected outcome where beta-carotene supplementation increased lung cancer risk.
Researchers confirm that Avastin and Lucentis yield similar improvements in vision for patients receiving monthly or as-needed treatment. The year-two results of the Comparison of AMD Treatment Trials (CATT) support the findings from the first year of the study.
A landmark study found that bevacizumab (Avastin) is equivalent to ranibizumab (Lucentis) in treating wet age-related macular degeneration through two years, with monthly dosing producing slightly more vision gain. The study showed similar visual results regardless of dosing frequency, with 60% of patients achieving driving vision.
The study found a nearly 5-fold increase in maternal opiate use and a 3-fold increase in newborns diagnosed with neonatal abstinence syndrome (NAS) between 2000 and 2009. NAS is associated with increased hospital charges, longer hospital stays, and adverse neonatal outcomes.
A study presented at the Pediatric Academic Societies annual meeting found that nearly one-third of parents have low reading skills and 83% have poor numeracy skills. Parents who scored below the third grade level on a math test were five times more likely to make dosing errors.
A study found a large discrepancy between global disease burden in children and the amount of clinical trial research devoted to this population. Only 12% of clinical drug trials are pediatric trials, despite children bearing nearly 60% of the disease burden for high-priority conditions.
A newly launched clinical trial at URMC is testing whether lower doses of an established blood pressure medication can provide the same benefits as a standard dose, potentially reducing side effects and costs. The study aims to learn how varying amounts of the medication affect patients with mild hypertension.
A groundbreaking study found that effective HIV treatment and transmission reduction are thwarted by patients' unmet basic living needs such as housing, food, and hygiene. The research suggests that addressing these subsistence needs is crucial to improving public health outcomes.
A new study published in PLOS ONE found that addressing subsistence needs is crucial for improving the health of HIV-infected individuals living in poverty. The research, conducted by UCSF scientists, revealed that unmet basic needs like housing and food significantly undermine the benefits of HIV medication delivery.
Researchers examine interaction between Ibudilast, a phosphodiesterase inhibitor, and MA, an addictive stimulant, in the first Phase I clinical safety trial. The study aims to determine the effects of Ibudilast on heart rate and blood pressure when combined with relevant doses of MA.
A systematic review of 13 studies found that electronic reminders, including text messages, boosted patients' ability to stick to their drug dosing schedules, with significant differences reported in eight studies. However, the effectiveness of these reminders may decrease over time due to habituation.
Research identifies enzyme essential for M. globosa's growth, making it a prime target for developing better anti-dandruff medicines. Sulfonamides show greater effectiveness than ketoconazole in preventing the fungus's growth.
A review of previous studies found that Botox injections are associated with a small to modest benefit for patients with chronic migraine and chronic daily headaches, but not for episodic migraines or tension-type headaches. The treatment was linked to improved frequency of chronic conditions, such as headache reduction from 19.5 to 17.2.
Research suggests that dietary changes can help alleviate ADHD symptoms in some children, but more studies are needed to understand the benefits and limitations.
Researchers found gabapentin significantly reduces cannabis use and withdrawal symptoms, improving cognitive skills. The study suggests gabapentin could become first FDA-approved treatment for cannabis dependence.
A study published in Archives of Internal Medicine found that treatment with levothyroxine reduced ischemic heart disease events and mortality in younger patients with subclinical hypothyroidism. However, the findings were not evident in older patients, highlighting the need for further research to confirm these results.
Researchers found a significant relationship between decreased CSF αβ 1-42 and clinical decline in participants with elevated CSF p-tau 181p, suggesting p-tau as an important marker of AD-associated degeneration. The study suggests that targeting tau may be crucial for therapy development.
Researchers found that salicylate increases AMPK activity, leading to reduced liver fat and improved fat burning in obese mice. The study suggests a potential link between aspirin and preventing type 2 diabetes.
Researchers have identified potential biomarkers for personalized medicine in lung cancer, such as a test that predicts patient response to certain treatments. The findings suggest that these innovative approaches could lead to more effective treatment strategies for patients with lung cancer.
A new analysis of the TORCH trial found that erlotinib is most effective in patients with EGFR mutations, while those with wild-type tumors should receive standard chemotherapy first. The study confirms the importance of biomarker testing to guide treatment decisions.
Two University at Buffalo studies found that giving children more toy choices increases their physical play time by nearly 200% for girls. The research also showed that providing autonomy and mastery in toy selection motivates children to be physically active, especially when combined with exergames.
Researchers found that adding lime juice to water treated with solar disinfection removed detectable levels of E. coli significantly faster than solar disinfection alone. The treatment time was comparable to boiling and other household methods, making it a potential effective solution for improving water quality in low-income regions.
Researchers from the Microbicide Trials Network reported two new findings from HPTN 035 data, presenting contradictory results to previous studies on hormonal contraception and HIV risk. The analysis of nearly 3,000 women found no association between hormonal contraceptive use and increased risk of HIV infection.
A new study by Lawson Research Institute found that one in 10 older fibrate users experienced a 50% increase in serum creatinine, an indicator of kidney health. The study suggests further research is needed to understand the mechanism behind fibrates' impact on kidney function.
A Canadian study found that off-label prescribing is common in primary care, with 11% of medications prescribed for indications not approved by regulators. The study also identified medications with multiple approved indications as having lower rates of off-label use.
A study led by University of Michigan physicians shows a single dose of indomethacin can prevent post-ERCP pancreatitis, reducing hospitalizations and costs. The medication is part of a category of non-steroid anti-inflammatory drugs that inhibits an inflammatory response in the pancreas.
Leading experts argue that full clinical study reports of authorized drugs should be made publicly available to allow independent re-analysis. The authors use Tamiflu as an example, highlighting discrepancies in regulatory evidence and advocating for open access to clinical trial data.
A nationwide Danish registry study found no significant association between losartan and increased all-cause mortality in heart failure patients compared to candesartan. However, lower doses of losartan were associated with increased mortality risk, while high doses showed no increased risk compared to candesartan.
A study published in the American Journal of Preventive Medicine found that obese dieters who reported eating less fat and exercising more were more likely to lose weight. Diet foods and products were less successful, while prescription weight loss medications showed an association with successful weight loss.
A recent study by Beth Israel Deaconess Medical Center found that exercising more and eating less fat were significantly associated with successful weight loss among obese individuals. Meanwhile, the use of popular diets was not linked to weight loss success.
A team of University of Missouri researchers used a groundbreaking computer algorithm to compare the genomes of six plants and six animals, finding identical DNA sequences for the first time. The discovery could help solve mysteries of plant evolution and improve techniques for creating medicines and crops.
Researchers identified CHD8, SNC2A, and KATNAL2 gene mutations as risk factors for autism. The studies provide a better understanding of the genetic changes and biological pathways involved in autism spectrum disorders.
A study published in Neuropsychopharmacology found that low doses of olanzapine improved survival in mice with exercise-based anorexia, a common condition in people with the eating disorder. The antidepressant fluoxetine was ineffective in improving survival rates.
A cholesterol drug commonly prescribed to reduce cardiovascular disease risk restores blood vessel function in a mouse model of Alzheimer's disease. The drug also improves learning and memory in adult mice, but not aged mice.
A study found that adding cetuximab to a regimen of drugs after stage III colon cancer surgery did not improve disease-free survival. The trial tested the combination in patients with resected stage III wild-type KRAS colon cancer and showed no benefit.
Researchers found a decrease in cerebrospinal fluid biomarker P-tau following treatment with bapineuzumab, suggesting potential benefits for Alzheimer's patients. However, further examination is needed to determine if these changes correlate with clinical improvements.
A three-year clinical trial found that intermittent preventive treatment (IPT) reduced malaria infections among infants by up to 30%. The treatment regime protected against malaria for at least six weeks after treatment, showing an ongoing protective effect.
A prospective controlled study of 309 mother-infant pairs found that prenatal antipsychotic exposure was associated with significantly lower scores on a standardized neuromotor screening measure. Infants exposed to antidepressants also showed lower scores, while those with no psychotropic exposure scored highest. The study highlights t...
A Phase 1 study demonstrated galeterone's tolerability and efficacy in patients with castration-resistant prostate cancer, with minimal toxicities reported. The study showed significant reductions in tumor size and prostate-specific antigen levels in nearly half of the patients evaluated.
A study by Regenstrief Institute and U.S. Department of Veterans Affairs investigators found that prescribers are sometimes unsure why an alert appears and that alert designs are more pharmacist-oriented than physician- or nurse practitioner-oriented.
The iDEAL study is a Phase II clinical trial evaluating the safety and efficacy of iCo-007 in treating diabetic macular edema. The trial aims to improve visual acuity in patients with DME, a leading cause of blindness in working Americans.
A meta-analysis found that non-HDL-C levels are strongly associated with the risk of major cardiovascular events in patients taking statins, more so than LDL-C. Non-HDL-C was also shown to explain a larger proportion of the atheroprotective effect of statin therapy.
A recent US study found that higher out-of-pocket costs for children's medication are associated with reduced medication use and increased hospitalizations. The study, which analyzed data from over 8,000 patients, suggests that parents may be less sensitive to cost when making decisions for their younger children.
A study found that higher out-of-pocket costs for asthma medications in children were associated with lower medication use and increased asthma-related hospitalizations. The findings highlight the need for strategies to improve medication adherence, such as routine access to primary care and pulmonary specialists.
A new clinical trial aims to determine whether intravenous antibiotics are more effective than traditional therapies in tackling Pseudomonas aeruginosa, a common germ causing destructive lung infections in CF patients. The study will assess the treatment's success over a year and potentially inform national guidelines.
Researchers found that many dementia patients' delusions have logical explanations and can be treated through behavioral therapy. The study suggests a better understanding of delusions can lead to more humane and compassionate treatment, considering the patient's context and circumstances.
New studies reveal lower fetal/infant death risks among planned repeat caesarean sections, while higher uterine rupture risk found in women with multiple previous caesarean sections. Research emphasizes pragmatic studies to improve maternal and infant care.