Articles tagged with Drug Studies
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Cedars-Sinai researchers found that rifaximin and lubiprostone are effective treatments for irritable bowel syndrome (IBS) with low side-effect profiles. The study analyzed over two dozen clinical trials and compared various drug therapies, concluding that these two drugs offer the best options for IBS patients.
A meta-analysis of 32,053 patients found warfarin to be effective in preventing strokes and non-central nervous system embolism in patients with nonvalvular atrial fibrillation. However, elderly patients, women, and those with previous stroke or TIA were at higher risk.
A study published by Cleveland Clinic found that bariatric surgery significantly improved blood sugar control, with 42.6% of gastric bypass patients achieving normal levels without medication. Sleeve gastrectomy also showed promising results, with 36.7% of patients reaching normal blood sugar levels.
New research from Brigham and Women's Hospital shows that ticagrelor significantly reduces the time to a second cardiovascular event or death, in addition to reducing total events. The study found that continued use of ticagrelor after a cardiac event is both safe and effective in preventing further cardiac events.
A new study found that the novel oral anti-coagulant rivaroxaban is as effective as traditional treatment for blocked lung blood vessels, with lower rates of major bleeding. The EINSTEIN-PE trial compared rivaroxaban to standard therapy and demonstrated its non-inferiority in treating pulmonary embolism.
Stanford researchers found a disconnect between reported cardiac toxicities in journal articles and FDA labeling for sunitinib, a kidney cancer treatment. The authors argue that the current method of measuring adverse events is inadequate, leading to under-reporting of side effects.
A study found that antipsychotic medication is associated with a modest and time-limited increased risk of heart attack among older patients treated for dementia. The risk was highest at the beginning of treatment, decreasing after the first month.
A study found bariatric surgery to be superior to intensive medical management in achieving glycemic control and weight loss for obese patients with uncontrolled type 2 diabetes. The surgery resulted in a significant reduction of medications and improved glycemic control after one year.
A new U-M study finds that US employment downturns affect remittance payments to chronically ill patients in Central America, leading to reduced access to healthcare. Patients with lower education and multiple chronic health problems face significant financial strain.
A new study has found that a three-drug regimen is as safe and effective as a double-dose two-drug treatment in preventing blood clots after angioplasty. The study compared the effectiveness of adding cilostazol to conventional dual anti-platelet therapy versus doubling the dose of clopidogrel.
Researchers discovered that abciximab significantly decreased heart muscle damage in ST-segment-elevation myocardial infarction patients. Clot aspiration did not show similar benefits.
A new study has shown that delivering abciximab directly to the site of a heart attack can significantly reduce damage to the heart muscle. The treatment was found to be effective in reducing infarct size by up to 15% compared to no treatment or aspiration thrombectomy.
A randomized controlled trial found that consuming three servings of raisins per day can significantly reduce systolic and diastolic blood pressure in people with mild hypertension. Raisins' high potassium content is believed to be the key factor behind this effect.
A multifaceted intervention improved the use of evidence-based therapies among patients with acute coronary syndromes in public hospitals in Brazil. The study found significant improvements in medication usage and overall quality of care, particularly in low- and middle-income countries.
Internet-based telemedicine systems lead to more timely treatment decisions and medication adjustments for patients with high blood pressure. Patients who reported frequent blood pressure readings via a web-based portal received more appropriate pharmacotherapy and an overall reduction in cardiovascular risk.
A study published in the British Medical Journal found that offering free nicotine patches and proactive counselling to smokers calling an NHS quitline did not increase the number of people who successfully quit smoking. The trial compared the effectiveness of this extra support against standard reactive quitline support, with no signi...
A systematic review of monkey studies found limited evidence for an association between social status and coronary artery disease. The study concludes that generalizing findings from monkeys to human societies is not warranted due to methodological limitations.
Two studies suggest that opioids can stimulate tumor growth and spread in cancer patients, with laboratory research indicating the mu opioid receptor plays a key role. Medications blocking this receptor may reduce cancer growth and metastasis.
Researchers found that dexmedetomidine reduced the duration of mechanical ventilation compared to midazolam, improved patients' ability to communicate pain, and offered benefits in terms of reduced mechanical ventilation and ICU stay. The study suggests that dexmedetomidine may provide clinically relevant benefits for long-term sedation.
A study found that four premarketing trials for second-generation antipsychotics remained unpublished and yielded unflattering results. The researchers suggest that publication bias can blur distinctions between effective and ineffective drugs, potentially obscuring the true efficacy of these medications.
A study found that selective reporting of trials enhances apparent clinical effectiveness, potentially misleading clinicians. The results of published trials influence prescribing decisions.
The university will lead the clinical trials, which aim to determine if Alzheimer's disease can be halted or delayed before symptoms appear. Researchers plan to give promising pharmaceuticals to family members with early-onset Alzheimer's gene and biological markers of disease.
A landmark clinical trial found that plugging a hole in the heart is no more effective than medication in preventing strokes. The study enrolled 909 patients with patent foramen ovale (PFO) and suffered previous strokes or transient ischemic attacks, and found that closure device was not superior to drug therapy alone.
Research presented at the American Heart Association's Scientific Sessions found that children living in a neighborhood with a specially-designed bike trail were three times more likely to engage in vigorous physical activity. The study compared two low-income neighborhoods in Chattanooga, Tenn., one with a wide trail/sidewalk for biki...
Researchers used the Cardiochip gene analysis tool to investigate a specific gene variant linked to inflammation and heart disease. They found that an existing anti-inflammatory drug may offer a new potential approach for preventing CHD by targeting the interleukin-6 receptor.
A combined therapy of Epiduo Gel containing adapalene and benzoyl peroxide with doxycycline proved more effective in reducing acne lesions compared to other regimens. Patients who received this treatment experienced significant improvement, with 50% reporting nearly clear or cleared acne.
A new international multi-site randomized study found that a catheter procedure to close a hole in patients' hearts was not more effective than medical therapy in preventing recurrent strokes. The study, led by Anthony Furlan, M.D., of University Hospitals Case Medical Center, enrolled 909 patients and showed no statistically significa...
The NIH and Lilly are collaborating to create a publicly available resource profiling thousands of approved and investigational medicines. This comprehensive database will enable researchers to better predict treatment outcomes and improve drug development.
A cancer compound called epothilone D has been found to slow neurological damage and improve memory in a mouse model of Alzheimer's disease. The treatment prevented tau tangle formation and improved learning and memory tests, suggesting potential therapeutic benefits.
Researchers have discovered that administering FTY720, an oral drug shown promise for multiple sclerosis, significantly improves motor function recovery in mice with spinal cord injuries. The study suggests targeting sphingosine 1-phosphate receptors may be a new avenue to counteract the degeneration of the spinal cord in human SCI.
Topical aganirsen shows efficacy equivalent to Lucentis in models of AMD and ischemic retinopathy, inhibiting neovascularization by blocking IRS-1. The study demonstrates a novel compound with excellent safety profile for treating retinal neovascular disease.
A study published in the Journal of Psychopharmacology found that a single dose of LSD improved outcomes for 59% of patients compared to 38% of those receiving other treatments. Patients who received LSD showed greater self-acceptance, openness and motivation to address their alcohol problem.
A recent study has successfully flushed latent HIV infection from hiding using a drug used to treat certain types of lymphoma. The results show that targeting the biological mechanism that keeps the HIV virus hidden can be effective in providing a cure.
A new meta-analysis of LSD trials found that 59% of patients showed improvement in alcohol misuse, with lasting effects for at least six months. LSD interacts with serotonin receptors to stimulate new connections and open the mind, offering a promising treatment approach for alcoholism.
Researchers at the Neuroscience Institute of Alicante have discovered that manipulating CB2 receptors can reduce impulsive behavior in mice with high impulsivity levels. The study suggests that future clinical trials could utilize drugs selectively targeting CB2 to modulate impulsivity without psychoactive effects.
Researchers at Beth Israel Deaconess Medical Center have identified a key molecular player that can reverse kidney damage in mouse models of diabetes and other kidney injuries. The targeted experimental drug has shown to suppress inflammation, cell death, and fibrosis formation, allowing normal tissue to regenerate.
Pasireotide significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease, cutting secretion by 50% and returning some patients' levels to normal. The drug, which blocks ACTH secretion by binding to somatostatin receptors on the pituitary tumor, showed promise in treating this rare endocrine disorder.
Researchers at the Mayo Clinic have found that the blood pressure drug prazosin is an effective treatment for PTSD-related nightmares. The medication was shown to be well-tolerated and take effect rapidly, within days to weeks, in a systematic literature review of 12 prazosin studies.
A major Australian study of transcranial direct current stimulation (tDCS) has found up to half of depressed participants experienced substantial improvements after receiving the treatment. The largest randomized controlled trial to date confirms previous reports of significant antidepressant effects, with results showing improved atte...
A study found that 73% of patients with mesial temporal lobe epilepsy who underwent surgery were seizure-free after two years. The procedure, called anteromesial temporal resection, also improved quality of life for those patients. Early diagnosis and referral to specialized centers are crucial for optimal treatment outcomes.
A study published in CMAJ found that younger children are 39% more likely to be diagnosed and 48% more likely to be treated with medication for ADHD if born in December compared to January. This discrepancy is due to the relative age effect, where children born in December may appear less mature than their older peers.
A new study found an increase in ADHD diagnoses and medication use among Canadian school-age children, with boys taking more medications than girls. The study suggests that school environment plays a role in the increased use of medications, raising questions about whether children with ADHD are over-medicated.
A report in Mayo Clinic Proceedings calls for abstinence-based recovery for HCPs with opioid addiction due to concerns over drug diversion and abuse. The authors argue that abstinence is the criterion standard for HCPs in recovery and recommend delaying their return to clinical practice until studies demonstrate safety.
Researchers at Linköping University have developed a new method for stronger dental implants by using a drug coating that allows titanium screws to adhere to the bone better and faster. After six months, 15 out of 16 patients showed significantly improved fixation of their treated implants.
Academics at the University of Nottingham are recruiting patients with relapsing remitting multiple sclerosis to test the effect of a low dose of the helminth parasite Necator americanus on their immune system. The study aims to prove that hookworms can reduce MS symptoms and prevent relapses.
A new phase-3 trial confirms that ruxolitinib reduces spleen volume and alleviates symptoms in patients with intermediate or advanced myelofibrosis. The study, led by Stanford Medicine, found significant improvements in patients taking the drug compared to those on placebo.
A Kaiser Permanente study of over 681,000 children found that obesity is associated with asthma, but the link varies by race and ethnicity. Hispanic youth had the strongest association between body mass index and asthma, while African Americans had a weaker connection.
A large-scale genomic study in Bangladesh has found genetic variants that increase the risk of skin lesions from arsenic exposure. The discovery could lead to new screening and intervention options.
Research suggests that daily or nightly dialysis sessions at home or in the clinic may provide more benefits for some patients with kidney failure, improving their health and survival. However, additional research is needed to determine if extended or more frequent treatments are beneficial for all dialysis patients.
A recent review highlights the growing concern of counterfeit medicines being sold online and turning up in legitimate supply chains. The study found that nearly 75 billion dollars worth of fake drugs are sold globally each year, putting millions of lives at risk.
A randomized controlled clinical trial found that varenicline significantly improved the walking ability of patients suffering from SCA3, a genetic disorder causing progressive difficulty with coordination. The drug was effective in improving symptoms associated with standing and walking straight.
A new melanoma drug, vemurafenib (Zelboraf), has been shown to nearly double the median overall survival of patients with metastatic melanoma. The Phase 2 trial found that 53% of patients responded to treatment and experienced improved survival rates.
LA BioMed investigators are making significant strides in cardiovascular medicine, with a focus on early detection of heart disease and treatment of pulmonary hypertension. Drs. Matthew Budoff and Ronald Oudiz are leading efforts to develop new therapies and improve symptoms for patients with these conditions.
A study led by University of Nottingham found that pharmacist-led intervention schemes can significantly reduce prescribing errors in general practices. The scheme involves a pharmacist working with GPs to identify and correct medication errors, resulting in reductions of up to 50 percent in errors related to specific medications.
A pharmacist-led, information technology-based intervention reduced prescribing errors by 42% in primary care, with significant reductions in specific medication errors. The intervention was found to be cheap and easy to implement, costing $75 per error avoided, making it a cost-effective solution for reducing medication errors.
Researchers found that clazosentan decreased the effects of TBI on blood flow by 25% at four hours and 23% at 48 hours. The drug was most effective when given at two hours post-injury and again at 24 hours after trauma.
Researchers have developed a reformulated imatinib that prevents and reverses morphine tolerance in rats, offering new hope for treating chronic intractable pain. The study's findings suggest the potential to reduce debilitating side effects associated with morphine use.
A study examining clot-busting drugs in children with ischemic stroke found that these medications can be safely administered, with a higher risk of bleeding but similar mortality rates compared to adults. Researchers believe further studies are needed to optimize treatment effectiveness in pediatric patients.
A comprehensive review found that switching brand-name antiepileptic drugs for generic equivalents can lead to increased hospitalizations and longer stays. The studies suggest that the switching aspect, rather than the drug itself, may be causing the problem, but more research is needed to confirm.
The study validated the use of a microchip-based device to deliver teriparatide for osteoporosis treatment, with results comparable to standard injections. The implant showed biocompatibility and was well-tolerated by patients, providing proof-of-concept for long-term device viability.