Articles tagged with Drug Studies
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A new study shows that an implantable microchip can deliver medication on command, improving bone formation and reducing the risk of bone fracture in women with osteoporosis. The device, which is roughly the size of a pacemaker, releases medication via a wireless signal and has shown to be effective and safer than traditional injections.
A new study by Wayne State University reveals that an autoinjector delivering midazolam can effectively stop prolonged seizures in patients, with 73% of participants seizure-free upon hospital arrival. This method is faster and more reliable than traditional intravenous treatment.
A new study has found that an autoinjector pen is a faster and more effective way to treat serious seizures, with 73% of patients becoming seizure-free upon arrival at the hospital. The treatment involves delivering medication directly into the thigh muscle via intramuscular injection, reducing precious time for paramedics.
A study sponsored by NIH found that intramuscular injection of anticonvulsant drugs, like midazolam, is as safe and effective as giving medicine directly into a vein. This method may be faster and more reliable, especially for patients having convulsions, reducing the risk of severe consequences if seizures are not stopped quickly.
A nationwide study has shown that injecting anticonvulsant medication into the thigh muscle using an autoinjector is as safe and more effective than traditional intravenous administration. The method resulted in 73% of patients being seizure-free upon arrival at the hospital, compared to 63% for those receiving IV treatment.
Lung cancer patients face geographic challenges to access clinical trials due to molecular preselection. Researchers propose using online patient communities and innovative trial approaches to inform patients about trials, accelerate research, and address practical challenges in conducting personalized medicine trials.
A national trial has shown that autoinjectors are quicker and more effective in stopping seizures than traditional IV line treatment. The study found that patients who received midazolam via an autoinjector were 73% seizure-free upon arrival at the hospital, compared to 63% of those receiving IV lorazepam.
A 30-year study by University of Zurich researchers reveals a strong correlation between self-rated health and mortality risk, even after controlling for various factors. The study suggests that people with excellent health ratings have better chances of survival, indicating the importance of holistic approaches to healthcare.
A study found that over half of prescription medications inhibit 17-alpha-hydroxyprogesterone caproate (17-OHPC) metabolism by 50 percent or more. This indicates that certain medications may need to be adjusted if taken with 17-OHPC, potentially affecting its effectiveness.
Two U.S. Army studies found that patients with a history of shoulder instability are more likely to experience future instability, while arthroscopic surgery has better outcomes than open repairs. The studies also identified risk factors associated with surgical failure and found that arthroscopic Bankart repair has a lower failure rate.
Researchers found a significant correlation between coronary artery disease and prostate cancer in a large study, suggesting that heart disease may be a risk factor for the malignancy. Lifestyle changes such as weight loss, exercise, and a healthy diet may help combat both conditions.
The partnership aims to reduce cancer health disparities in Hispanic populations through outreach education projects and pilot research studies. The collaboration has already learned valuable lessons, including the importance of a patient-centered approach and culturally specific dissemination routes for information.
A clinical trial found that cefpodoxime was less effective than ciprofloxacin in treating uncomplicated cystitis, with a higher rate of E coli colonization. The study suggests that cefpodoxime may not be a suitable alternative to fluoroquinolones for this condition.
A study by Brigham and Women's Hospital found that computer order entry systems significantly reduced preventable adverse drug events (ADEs) in community hospitals. The system showed a 34% reduction in preventable ADEs, but an increase in potential ADEs or near-misses following implementation.
Researchers at UT Southwestern Medical Center found that fibroblast growth factor 21 (FGF21) causes significant and rapid bone loss in mice, promoting fat cell growth but inhibiting bone cells. The study suggests a potential tradeoff between the anti-obesity benefits of FGF21 and its risk of osteoporosis.
Researchers found that using LABAs in combination with ICS reduces asthma attacks as well as or better than corticosteroids alone. The study showed the greatest benefits to African-American patients, males, and those with moderate to severe asthma.
The SOLITAIRE Flow Restoration Device outperformed the standard mechanical treatment in removing blood clots from blocked brain arteries in stroke patients. The new device resulted in a 61% success rate compared to 24% for the older device, leading to better survival rates and reduced mortality.
The Solitaire With the Intention for Thrombectomy (SWIFT) trial showed that the new device opened blocked vessels without causing symptomatic intracranial hemorrhage in 61% of patients, compared to 24% with the MERCI retriever. The device also led to better survival three months after stroke, with a 17.2% mortality rate versus 38.2% wi...
A new analysis of hundreds of doctor-patient visits found that physicians and nurse practitioners frequently use lecturing and ordering instead of engaging in open-ended discussions to address medication non-adherence. Problem-solving conversations were rare, even among patients who acknowledged lapses in adherence.
A recent study found that the STAT3 gene is activated in some non-small cell lung cancer cell lines by the JAK2 protein, which may not be effectively inhibited by drugs targeting specific mutations. This suggests a potential role for combination therapy to combat NSCLC driven by STAT3-JAK2 signaling.
The study found that commercial electronic prescribing systems substantially reduced procedural prescribing error rates in hospital patients, with a significant decline in serious clinical errors. However, the introduction of new system-related errors requiring close attention from designers and users.
A new clinical trial combines two medications to address anxiety and physiological stress before, during, and after surgery. This approach aims to increase long-term survival rates by up to 300 percent in cancer patients.
A new study found that patients who quickly stop taking immunosuppressive prednisone after receiving a kidney transplant avoid experiencing serious prednisone-related side effects. The study also showed that rapid discontinuation of prednisone does not jeopardize the long-term survival of patients and their new organs.
Two clinical trials launched by NIH aim to improve survival rates for out-of-hospital cardiac arrests. The trials compare different CPR approaches and treatments with medications, such as amiodarone or lidocaine, to determine which are most effective.
A study published in the Journal of the National Cancer Institute found that telephone counseling services doubled the odds of quitting smoking among Chinese-, Korean-, and Vietnamese-speaking smokers. In contrast, a second study on bupropion SR showed promise for African American light smokers during medication phase but lacked long-t...
A new study found that lansoprazole, an acid reflux drug, does not improve asthma symptoms or lung function in children. The medication may actually increase the risk of upper respiratory infections and other adverse events in young patients.
The new guidelines provide a contemporary, evidence-based approach for investigators conducting randomised, controlled migraine clinical trials. Key findings include the importance of patient selection, trial design, and evaluation of results in both acute and preventive settings.
A genetic variation has been found to increase the risk of metabolic syndrome in children taking second-generation anti-psychotic medications, characterized by high blood pressure and elevated fasting blood sugar levels. The study aims to prevent and manage metabolic complications associated with these medications in childhood.
Researchers found that daily positive affect and self-affirmation strategies helped patients make better decisions about their health. The interventions increased physical activity for coronary artery disease patients and improved medication adherence for those with high blood pressure.
Two studies published in scientific journals provide the most detailed picture yet of how psilocybin affects brain activity. The research suggests that psilocybin suppresses activity in 'hub' regions of the brain, leading to a state of heightened perception and memory vividness.
A new study by NYU School of Medicine reveals that positive affirmation, combined with patient education, improves medication adherence rates among hypertensive African-Americans. The study found a 22% increase in adherence rates among participants who received the intervention.
A randomized controlled trial found that patient education plus positive-affirmation induction and self-affirmation improved medication adherence in hypertensive African-Americans compared to patient education alone. The PA group had a 42% medication adherence rate at 12 months, whereas the PE group had a 36% rate.
A new study published in Psychotherapy and Psychosomatics found that regular exercise can significantly reduce anxiety symptoms in patients with Generalized Anxiety Disorder (GAD). Women who underwent six weeks of strength or aerobic exercise training experienced remission rates higher than those in a control group.
A Cochrane Review found inconsistencies with published reports of oseltamivir's efficacy and safety profile, raising questions about its use. The analysis showed that the drug did not reduce hospital treatment needs despite reducing symptom alleviation time.
Researchers found that regorafenib slowed tumor progression and lengthened patient lives by 29% compared to placebo. The median survival time increased from 5 months to 6.5 months, with a 23% reduced risk of cancer-related death.
A Scripps-led study published in JAMA finds that the new drug cangrelor successfully 'bridges' patients with recent stents to cardiac surgery without excessive bleeding. The trial showed 99% of cangrelor-treated patients maintained target levels of platelet inhibition.
A recent UBC study reveals that 9.6% of Canadians report not filling their prescriptions due to cost concerns, with those without drug insurance facing significant challenges. Individuals without insurance are 4.5 times more likely to avoid prescribed medications, while those with low incomes are 3.3 times more likely to skip doses.
New studies published in The Lancet Oncology and The Lancet show that combining lapatinib with trastuzumab is almost twice as effective as single-agent therapy, but causes more side effects. Lapatinib is less beneficial than trastuzumab for single-agent therapy.
Two studies published in Nature demonstrate the power of multi-isotope imaging mass spectrometry (MIMS) in tracking cell division, lipid metabolism, and protein turnover in various organisms, including humans. MIMS enabled researchers to non-invasively track biological processes with high resolution.
A study led by UCSF researchers found that drinking releases endorphins in areas of the brain associated with pleasure and reward. This discovery provides a possible approach to improving treatment for alcohol abuse through more effective medications targeting the Mu opioid receptor.
A study from Rhode Island Hospital found that collaborative behavioral management can reduce substance abuse among convicted marijuana users who are paroled. The intervention, called Step'n Out, provided incentives for good behavior through a system of points and positive reinforcers.
A study published in Archives of Internal Medicine found dabigatran to be associated with a higher risk of myocardial infarction and acute coronary syndrome. The research suggests that clinicians should consider the potential cardiovascular risks when using dabigatran, particularly in high-risk populations.
Researchers found that delaying effective hypertension treatment for up to a year results in small-quality adjusted life expectancy loss, but longer delays cause significant damage. The study suggests patients and providers focus on diabetes self-management and lifestyle modification within the first year after diagnosis.
A recent study by Harvard School of Public Health found that nicotine replacement therapies are no more effective in helping smokers quit than quitting on their own. The study suggests that the FDA should only approve medications proven to be effective in long-term smoking cessation, and lower nicotine levels to reduce addiction.
A small clinical trial found that taking varenicline (Chantix) for four weeks before quitting increased tobacco-free rates by 27% compared to one week. Women showed the greatest improvement, reducing smoking by over 50%. The study suggests a longer treatment period may lead to better outcomes.
A study found that genital herpes can reactivate in 'breakthrough episodes' even when taking high dose antiviral therapy, highlighting the need for new treatments to prevent onward transmission. Current antiviral therapies only reduce shedding by 50%, but don't eliminate breakthrough episodes.
A new study suggests that home monitoring strategies, including self-care, phone calls from nurses, and telemedicine, can effectively track heart failure disease-management and early identification. The authors recommend a multi-pronged approach, combining monitoring with patient follow-up and feedback to improve outcomes.
Researchers have identified a 90% accuracy biomarker that increases the risk of developing Alzheimer's by 10 years. Patients with low levels of beta-amyloid and high tau protein levels are at highest risk, indicating potential therapeutic targets for early intervention.
A systematic review and meta-analysis found no significant association between the CYP2C19 genotype and cardiovascular events in patients taking clopidogrel. The study suggests that genetic testing may not be necessary to determine individual response to the medication.
The study emphasizes the importance of disclosing site investigators' recruitment performance to ensure transparency in multicentre clinical trials. By publishing this information, sponsors can provide insights into potential issues affecting recruitment, enabling a better understanding of treatment outcomes.
The HPTN 052 study found that early treatment with antiretroviral therapy can reduce HIV transmission in couples by at least 96%. The research has been recognized as a scientific breakthrough of the year, inspiring efforts to end the world's AIDS epidemic.
The HPTN 052 clinical trial found that HIV-infected individuals who start antiretroviral therapy when their immune systems are healthy have a 96% reduced risk of transmitting the virus to their uninfected partners. This groundbreaking study demonstrates the effectiveness of treatment as prevention in reducing HIV transmission.
A new UCSF study shows a popular antibiotic treatment for trachoma can be administered every six months, reducing treatment costs and potentially treating twice as many patients. Researchers found a significant decrease in trachoma prevalence, even elimination in some villages, regardless of treatment frequency.
Most patients need several sequential treatment steps to achieve remission from major depression. The Lancet review highlights the importance of primary care providers recognizing and addressing depression in chronic physical disorders. Deep brain stimulation holds promise as a future treatment option.
Phthalates, including dibutyl phthalate (DBP) and diethyl phthalate (DEP), are used in FDA-approved medications to target delivery of active ingredients. The study found over 100 products containing phthalates, with potential health effects of human exposure unknown.
A new UBC study found that 63.5% of pregnant women in B.C. took at least one prescription medication, including those with known risks. The study highlights the need for more research on safe and effective treatment options during pregnancy.
The RTOG is launching a phase I trial testing ganitumab for locally advanced pancreatic cancer. The trial will investigate the safety and efficacy of ganitumab when combined with chemoradiation treatment. By targeting the IGF-1R pathway, ganitumab may offer a new approach to treating this aggressive form of cancer.
The REMOVAL study aims to test whether metformin can prevent or reduce the risk of cardiovascular complications in people with type 1 diabetes. The five-year trial will follow 500 patients and examine the effects of metformin on blood glucose control, treatment satisfaction, and other complications.
A multicenter study found ruxolinitib significantly reduces symptoms of myelofibrosis, including pain and enlarged spleen, compared to placebo. The study also showed ruxolinitib is more effective than best available chemotherapies in reducing symptoms.
Researchers found that patients who consistently take their prescribed dose of inhaled corticosteroid (ICS) medication can prevent up to a quarter of severe asthma attacks. Taking at least 75% of the prescribed dose is crucial, according to the study.