Articles tagged with Drug Therapy
Researchers identified 35-63 proteins affecting severe COVID-19, hospitalization, SARS-COV2 infection, and 4-32 proteins for healthspan and lifespan. Novel proteins involved in inflammation, immunity, apoptosis and metabolism were also found.
A new study published in the Journal of Clinical Oncology identified NECTIN4 amplification as a potential genomic biomarker for predicting treatment response to enfortumab vedotin in patients with advanced urothelial carcinoma. The study found that over 90% of patients with NECTIN4 amplification showed tumor response to EV therapy.
A team of Purdue researchers has developed a novel immunotherapy to combat glioblastoma, a type of brain tumor with limited treatment options. The treatment uses genetically engineered stem cell-derived natural killer cells that can target and eliminate tumors without the need for blood sourcing.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
A clinical trial found that video-only hand therapy is non-inferior to in-person therapy after thumb CMC arthroplasty, offering a more patient-driven approach with reduced travel burden. Video-administered therapy provided similar outcomes and significantly reduced travel distance and time for patients.
Researchers have developed an AI pipeline to identify molecular interactions crucial for developing new treatments and understanding diseases. The AF-CBA Pipeline offers unparalleled accuracy and speed in pinpointing the strongest peptide binders to specific proteins.
A new study developed two machine learning models to quantify CD8+ cell positivity and classify the immunophenotype of cancer specimens in patients with non-small cell lung cancer. The models hold promise for identifying patients who may benefit from immunotherapy.
Researchers found that ~60% of tissues exhibit a significant negative correlation between age and stemness score, indicating a pan-tissue decline in stemness. This study adds weight to the idea that stem cell deterioration contributes to human aging, with hematopoietic stem cells from older individuals showing higher stemness scores.
Researchers from Osaka University have discovered a way to deliver antisense oligonucleotides to their targets inside cancer cells by opening specific calcium permeable channels. The new compound, L687, promotes efficient uptake of ASO into cancer cells, suppressing target gene activity and enhancing ASO efficacy.
Researchers have developed a new treatment that uses tailored doses of anti-cancer drugs released directly into the surgical cavity to treat liver cancer. The approach has shown promise in reducing recurrence rates and minimizing chemotherapy side effects, with potential applications for other types of cancer.
Researchers analyzed blood stem cells in mice with prior sepsis and found they were fully recovered but failed to respond to a second inflammatory stimulus, leading to inefficient immune cell production.
A new study shows that a massive effort to reduce the overuse of proton pump inhibitors (PPIs) led to a nearly 30% reduction in prescriptions, but also resulted in some veterans missing out on protective use. The intervention, which imposed limits on PPI prescription size and refills, was carried out in one region of the Veterans Healt...
Researchers deciphered the molecular structure of bulevirtide in complex with HBV/HDV receptor NTCP, revealing a unique 'plug' that inhibits virus entry. The study also sheds light on evolutionary adaptation of HBVs to host species and provides insights for developing smaller, more effective active agents.
Researchers highlight the role of post-transcriptional RNA modifications in AML pathogenesis, identifying m6A and m7G regulators as potential therapeutic targets. Targeted therapies, including selective inhibitors and Traditional Chinese Medicine compounds, show promise in promoting cell differentiation and reversing AML phenotypes.
The St. Jude survivorship portal provides a rich dataset for researchers to study childhood cancer survivors, including genomic and clinical information. The portal facilitates breakthroughs in pediatric cancer survivorship research through dynamic visualization and customizable charts.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
A comprehensive Scandinavian study has found no evidence that popular diabetes medications GLP-1 analogues increase the risk of thyroid cancer. The research analysed data from over 145,000 patients treated with these drugs and compared them to other patient groups.
A new study published in the New England Journal of Medicine found that half of patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. The study shows that these patients have suffered a small heart attack and have retained heart function afterwards.
Cadanilimab plus chemotherapy improved progression-free and overall survival in HER2-negative, locally advanced or metastatic gastric/GEJ cancer patients with PD-L1-low tumors. The treatment showed a significant survival benefit in these patients.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.
Researchers developed a nanosized polymer that selectively delivers chemotherapeutic drugs to blood vessels supporting tumor growth. The treatment eliminates colorectal cancer liver metastases and prolongs mice survival after a single dose-therapy.
Researchers found that medical cannabis legislation in the US improves mental health for individuals with chronic pain and those using marijuana for medical reasons. However, no negative impact was observed on recreational users or younger populations.
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
Researchers discovered compounds with untapped therapeutic potential for treating BPH, melanogenesis, and nerve damage. Metformin restored sex hormone homeostasis, epimedin B stimulated pigmentation function, and hydralazine suppressed ferroptosis to aid in axon regeneration.
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
Researchers outline ferroptosis mechanisms and regulatory networks in lung cancer, highlighting potential therapeutic targets. The study suggests ferroptosis as a novel approach to overcome treatment resistance in lung cancer, providing hope for improving clinical outcomes.
Researchers at the University of Toronto have found that two enzymes, APOBEC3C and APOBEC3D, promote resistance to chemotherapy drug gemcitabine in pancreatic cancer cells. Removing these enzymes can kill cancer cells by stymieing DNA repair.
A study published in Critical Care identified eight different trauma phenotypes associated with lower in-hospital mortality when treated with tranexamic acid. The researchers used a machine learning model to analyze data from over 50,000 patients and found subgroups of patients who received no benefit from treatment.
Researchers at Yokohama National University found that cinnamic acid activates oxytocin receptor expression, increasing hair growth gene expression in human dermal papilla cells. The compound showed a similar hair growth effect to oxytocin, with a 1.25-fold increase in hair shaft-like structures.
A team of researchers at Weill Cornell Medicine has discovered a critical protein sensor called SEL1L that regulates collagen clearance from tissue. This finding provides new insights into the development of therapeutic strategies for diseases like lung fibrosis, which currently have no effective treatments.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
A new task force formed under C-Path's Rare Disease Cures Accelerator-Data and Analytics Platform aims to advance therapeutic development for Progressive Supranuclear Palsy (PSP). The collaboration leverages collective expertise to foster innovation, identify critical gaps in research, and expedite treatment advancements.
Researchers at RCSI have identified a new treatment option for multiple myeloma by combining venetoclax with 5-azacytidine. This combination shows enhanced efficacy across various patient samples and has the potential to expand treatment options for those resistant to standard care.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Research reveals that FoxO6 upregulates ApoC3, leading to increased lipid accumulation and liver damage in aged rats on a high-fat diet. The study suggests that targeting this pathway may offer therapeutic strategies against hepatic steatosis.
A study published in Genome Medicine uses digital twins to computationally treat thousands of medications in individual patients with autoimmune diseases, finding promising results in mice and human tissue samples. The technology has the potential to revolutionize precision medicine by providing tailored medication for each patient.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
Researchers identify mitochondrial priming as a key driver of multi-drug resistance in relapsed acute myeloid leukemia. A new technique called dynamic BH3 profiling reveals anti-cancer drugs capable of overcoming resistance.
A new genetic test has identified patients with triple negative early-stage breast cancer who are unlikely to respond to immunotherapy drugs. The test, called ImPrintTN, can predict a patient's likelihood of responding to these treatments and help avoid severe side effects.
A new multitasking substance has been identified to prevent and treat both flu and COVID-19 infections concurrently. The long-acting recombinant cytokine protein rhIL-7-hyFc demonstrated therapeutic and preventive effects against various respiratory diseases, including COVID-19, influenza virus, and respiratory syncytial virus.
Researchers have identified a potential therapeutic target for Borjeson-Forssman-Lehman Syndrome, a neurodevelopmental disorder characterized by seizures and intellectual disability. The study found that PHF6 gene mutations impair Ephrin receptor regulation, leading to neural stem cell misregulation.
Researchers have identified a subset of T-cells that acts like stem cells and continuously generates effector T-cells that attack transplanted organs. Targeting the transcription factor IRF4 may lead to innovative therapies for patients with chronic infections, cancers, autoimmune diseases and transplanted organs.
A new study from the University of Colorado Anschutz Medical Campus suggests that managing circadian rhythms through intense light and chronologically timed therapy can help prevent or treat various circulatory system conditions, including heart disease. The research found that intense light stabilizes the PER2 gene and increases level...
Resmetirom, a new medication, has been approved to treat metabolic dysfunction-associated steatohepatitis (MASH), a more advanced stage of MASLD characterized by liver inflammation and scarring. The drug was shown to improve fibrosis and reduce disease progression in patients with MASLD.
A scoping review of literature found associations between cannabis use and non-cancerous urogenital illnesses like acute kidney injury and urinary retention. However, the data also suggest a therapeutic role of cannabis in certain urological conditions.
Researchers have deciphered trabectedin's precise mechanism of action, revealing its ability to induce persistent DNA breaks in cancer cells. This disruption of the transcription-coupled nucleotide excision repair (TC-NER) pathway leads to long-lasting DNA breaks that ultimately kill cancer cells.
A new study suggests that mushroom extract containing psilocybin demonstrates superior efficacy in stimulating neuroplasticity and promoting new connections between nerve cells. The research found that the extract had a more potent and prolonged impact on synaptic plasticity compared to chemically synthesized psilocybin.
Scientists from the University of Cologne developed threofuranosyl nucleic acid (TNA) with a new base pair, offering improved stability and function compared to natural DNA and RNA. This breakthrough could enable targeted drug delivery, diagnostics, and recognition of viral proteins or biomarkers.
Research reveals oestrogen's protective role in preventing fatty liver disease by targeting the TEAD1 protein. The discovery could lead to a new treatment for fatty liver and liver cancer, as well as earlier detection methods.
Researchers at the University of Cincinnati Cancer Center have identified a new protein called p47 that helps prevent breast cancer metastasis. The study found that lower p47 expression was correlated with higher breast cancer metastasis, and that increasing p47 function could potentially lead to new therapies.
Researchers have designed a candidate drug to target the K-Ras G12D mutation, responsible for nearly half of all pancreatic cancer cases. The molecule permanently modifies the mutation, stopping tumor growth in cancer cell lines and animal models.
Researchers have made a breakthrough in developing genetic treatments for hereditary conditions like cystic fibrosis and inherited vision loss. They created a new type of lipid nanoparticle, called Thio-lipids, that can deliver therapeutic payloads to the lungs and retina.
UCSF scientists discover delivering therapeutic molecules to amniotic fluid can effectively treat Angelman syndrome and other neurological conditions. The treatment uses antisense oligonucleotides, which can alter gene expression, and has shown improved motor function and learning outcomes in mice.
Researchers analyzed access to new treatments for early-stage lung cancer in Europe, highlighting existing disparities in healthcare systems and reimbursement structures. The study calls for a collective European approach to reduce inequalities in access to care.
Researchers discovered a potential treatment for Alzheimer's disease also prevents Type 2 diabetes by blocking the formation of toxic IAPP clusters. A synthetic peptide was shown to bind and neutralize these clusters, keeping beta cells alive.
The American Gastroenterological Association has proposed a 12-point plan to enhance IBD care in the US, focusing on insurer-mandated barriers such as prior authorization and step therapy. The plan aims to improve treatment access and quality for over three million Americans living with IBD.
A new study found that high-dose inhaled nitric oxide improves oxygenation and reduces mortality risk among critically ill Black patients with COVID-19. The treatment was more effective for Black patients, who have a suppressed nitric oxide system at baseline.
Researchers found that rapamycin extends lifespan by regulating the activity of protein S6K, which influences the endolysosomal system. This leads to improved immune function and clearance of bacterial infections at old age.