Research on treating disease with medication. Covers psychedelics, combination cancer therapy, opioid treatment in pregnancy, and personalized guidelines.
Researchers from Penn Medicine's Abramson Cancer Center and Perelman School of Medicine will present results from clinical trials for esophageal cancer, CAR T cell therapy, and ovarian cancer. The meeting will feature more than 200 sessions on AI in cancer care.
Weo electrolyzed water (WEW) has been shown to attenuate cellular senescence in both normal fibroblasts and breast cancer cells. The study found that WEW modulated markers of cellular senescence, inflammation, and stress response genes in a cell type-dependent manner.
Researchers found that miR-377 reduces MYC mRNA levels, leading to increased Bax and PTEN expression and decreased CDK4. This results in induced apoptosis, inhibited proliferation, and arrested cell cycle in prostate cancer cells.
The FDA committee voted unanimously to approve minimal residual disease (MRD) as a new clinical endpoint for evaluating proposed drugs to treat multiple myeloma. A meta-analysis led by C. Ola Landgren shows a strong correlation between MRD and clinical outcomes in newly diagnosed and relapsed patients.
A novel therapy has been developed to reprogram macrophage immune cells, shifting their balance toward antitumor activity. The treatment, JHU083, blocks the use of glutamine in tumors, reducing growth and triggering cell death. It also boosts immune-activating macrophages, recruiting tumor-killing T-cells and natural killer cells.
Only 14.5% of adult patients with moderate or severe asthma are prescribed the recommended Single Maintenance and Reliever Therapy (SMART) combination inhaler regimen. Older age and Medicare insurance are associated with not being prescribed SMART, suggesting providers may resist changing treatment regimens for these groups.
A phase 3 trial found that pamrevlumab did not significantly improve lung function in patients with idiopathic pulmonary fibrosis. The study's results underscore the need for effective treatments to slow disease progression and improve patient outcomes.
University of Minnesota researchers found that immunotherapy improves CD8+ T-cell responses in older mice, reducing mortality from infections. The treatment, PD1 blockade, enhances the ability of T cells to kill harmful cells infected with a virus.
Researchers investigated molecular changes in aging mouse sweat glands, finding 171 mRNAs enriched in secretory cells. Altered mRNA and protein abundance were associated with age-related declines in sweat gland function.
Researchers found a significant association between neighborhood deprivation and DNA methylation in brain tissue, which may be linked to immune response. The study identified one CpG site (cg26514961, PLXNC1 gene) significantly associated with neighborhood deprivation after controlling for covariates.
Researchers Polina A. Loseva and Vadim N. Gladyshev challenge the existing definition of human life, suggesting a new meaning for the 14-day stage in organismal life grounded in recent mechanistic advances and insights from aging studies. This stage defines the separation of soma from the germline and marks the boundary between rejuven...
Researchers discovered that IL-6 signaling in CD4-positive T cells promotes pulmonary hypertension development and progression. Treating mice with IL-6 inhibitors improved symptoms and decreased damage to the lungs and heart.
Three FAU researchers have received $1M in FDOH grants to develop innovative approaches against Alzheimer's disease. Mare Cudic aims to explore the link between glycosylation and neuroinflammation, while Ruth Tappen develops an online screening tool for older drivers with cognitive decline.
Starting people with opioid use disorder on extended-release, injectable naltrexone within five to seven days of seeking treatment is more effective than the standard method. This rapid treatment protocol requires closer medical supervision and could make XR-naltrexone a more viable option for treating opioid use disorder.
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
Increasing varenicline dosage enhanced abstinence rates in individuals who initially failed with the medication. For non-abstainers, a dosage increase or switch to varenicline also showed promise as rescue strategies.
Researchers designed a new AI model that accurately predicts treatment outcomes for stroke prevention in people with heart disease. The model, called CURE, was trained on a massive dataset of de-identified patient information and fine-tuned to focus on specific health conditions and treatments.
Researchers investigate senescence phenotypes of human corneal endothelial cells upon treatment with ultraviolet (UV)-A. Cells exhibit enlarged morphology, increased β-galactosidase activity and decreased proliferation. UV-A-induced senescent cells show similar gene expression profiles to ionizing radiation (IR)-induced cells.
A new study suggests that the withdrawal of a prescription stop-smoking pill could lead to thousands fewer people quitting each year in England, resulting in avoidable deaths. The disruption to varenicline supply may have caused smokers to rely on less effective smoking cessation aids or no medication at all.
Robert A. Harrington, MD, will be honored for his groundbreaking work in clinical research and clinical excellence. He has made extraordinary contributions to the field of interventional cardiology, transforming cardiovascular care through his pioneering research and mentorship.
Researchers identified a spectrum of effects on sodium channel function due to SCN2A variants, with hyperactive channels linked to early seizure onset and underactive channels associated with autism. The study provides insights into the relationship between genetic changes, disease severity, and age of seizure onset.
Researchers found that spinal cord injury triggers abnormal neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs. A short course of gabapentin, commonly prescribed for nerve pain, prevented this damaging metabolic effect.
Researchers identified 35-63 proteins affecting severe COVID-19, hospitalization, SARS-COV2 infection, and 4-32 proteins for healthspan and lifespan. Novel proteins involved in inflammation, immunity, apoptosis and metabolism were also found.
A new study published in the Journal of Clinical Oncology identified NECTIN4 amplification as a potential genomic biomarker for predicting treatment response to enfortumab vedotin in patients with advanced urothelial carcinoma. The study found that over 90% of patients with NECTIN4 amplification showed tumor response to EV therapy.
A team of Purdue researchers has developed a novel immunotherapy to combat glioblastoma, a type of brain tumor with limited treatment options. The treatment uses genetically engineered stem cell-derived natural killer cells that can target and eliminate tumors without the need for blood sourcing.
Scientists have identified a consistent signature of multiple sclerosis in the blood of patients years before they develop symptoms. The discovery, published in Nature Medicine, could lead to earlier diagnosis and treatment of the disease, affecting nearly 1 million people in the US.
A clinical trial found that video-only hand therapy is non-inferior to in-person therapy after thumb CMC arthroplasty, offering a more patient-driven approach with reduced travel burden. Video-administered therapy provided similar outcomes and significantly reduced travel distance and time for patients.
Researchers have developed an AI pipeline to identify molecular interactions crucial for developing new treatments and understanding diseases. The AF-CBA Pipeline offers unparalleled accuracy and speed in pinpointing the strongest peptide binders to specific proteins.
A new study developed two machine learning models to quantify CD8+ cell positivity and classify the immunophenotype of cancer specimens in patients with non-small cell lung cancer. The models hold promise for identifying patients who may benefit from immunotherapy.
Researchers found that ~60% of tissues exhibit a significant negative correlation between age and stemness score, indicating a pan-tissue decline in stemness. This study adds weight to the idea that stem cell deterioration contributes to human aging, with hematopoietic stem cells from older individuals showing higher stemness scores.
Researchers from Osaka University have discovered a way to deliver antisense oligonucleotides to their targets inside cancer cells by opening specific calcium permeable channels. The new compound, L687, promotes efficient uptake of ASO into cancer cells, suppressing target gene activity and enhancing ASO efficacy.
Researchers have developed a new treatment that uses tailored doses of anti-cancer drugs released directly into the surgical cavity to treat liver cancer. The approach has shown promise in reducing recurrence rates and minimizing chemotherapy side effects, with potential applications for other types of cancer.
A new study shows that a massive effort to reduce the overuse of proton pump inhibitors (PPIs) led to a nearly 30% reduction in prescriptions, but also resulted in some veterans missing out on protective use. The intervention, which imposed limits on PPI prescription size and refills, was carried out in one region of the Veterans Healt...
Researchers analyzed blood stem cells in mice with prior sepsis and found they were fully recovered but failed to respond to a second inflammatory stimulus, leading to inefficient immune cell production.
Researchers deciphered the molecular structure of bulevirtide in complex with HBV/HDV receptor NTCP, revealing a unique 'plug' that inhibits virus entry. The study also sheds light on evolutionary adaptation of HBVs to host species and provides insights for developing smaller, more effective active agents.
Researchers highlight the role of post-transcriptional RNA modifications in AML pathogenesis, identifying m6A and m7G regulators as potential therapeutic targets. Targeted therapies, including selective inhibitors and Traditional Chinese Medicine compounds, show promise in promoting cell differentiation and reversing AML phenotypes.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
A comprehensive Scandinavian study has found no evidence that popular diabetes medications GLP-1 analogues increase the risk of thyroid cancer. The research analysed data from over 145,000 patients treated with these drugs and compared them to other patient groups.
The St. Jude survivorship portal provides a rich dataset for researchers to study childhood cancer survivors, including genomic and clinical information. The portal facilitates breakthroughs in pediatric cancer survivorship research through dynamic visualization and customizable charts.
A new study published in the New England Journal of Medicine found that half of patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. The study shows that these patients have suffered a small heart attack and have retained heart function afterwards.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.
Researchers developed a nanosized polymer that selectively delivers chemotherapeutic drugs to blood vessels supporting tumor growth. The treatment eliminates colorectal cancer liver metastases and prolongs mice survival after a single dose-therapy.
Cadanilimab plus chemotherapy improved progression-free and overall survival in HER2-negative, locally advanced or metastatic gastric/GEJ cancer patients with PD-L1-low tumors. The treatment showed a significant survival benefit in these patients.
Researchers found that medical cannabis legislation in the US improves mental health for individuals with chronic pain and those using marijuana for medical reasons. However, no negative impact was observed on recreational users or younger populations.
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
Researchers discovered compounds with untapped therapeutic potential for treating BPH, melanogenesis, and nerve damage. Metformin restored sex hormone homeostasis, epimedin B stimulated pigmentation function, and hydralazine suppressed ferroptosis to aid in axon regeneration.
Researchers outline ferroptosis mechanisms and regulatory networks in lung cancer, highlighting potential therapeutic targets. The study suggests ferroptosis as a novel approach to overcome treatment resistance in lung cancer, providing hope for improving clinical outcomes.
Researchers at the University of Toronto have found that two enzymes, APOBEC3C and APOBEC3D, promote resistance to chemotherapy drug gemcitabine in pancreatic cancer cells. Removing these enzymes can kill cancer cells by stymieing DNA repair.
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
A study published in Critical Care identified eight different trauma phenotypes associated with lower in-hospital mortality when treated with tranexamic acid. The researchers used a machine learning model to analyze data from over 50,000 patients and found subgroups of patients who received no benefit from treatment.
Researchers at Yokohama National University found that cinnamic acid activates oxytocin receptor expression, increasing hair growth gene expression in human dermal papilla cells. The compound showed a similar hair growth effect to oxytocin, with a 1.25-fold increase in hair shaft-like structures.
A team of researchers at Weill Cornell Medicine has discovered a critical protein sensor called SEL1L that regulates collagen clearance from tissue. This finding provides new insights into the development of therapeutic strategies for diseases like lung fibrosis, which currently have no effective treatments.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
The International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis have issued new guidelines for managing osteoporosis in men. These recommendations cover disease burden, fracture risk assessment, treatment thresholds, and interventions to reduce the substantial morbidity and mortality ass...
A new task force formed under C-Path's Rare Disease Cures Accelerator-Data and Analytics Platform aims to advance therapeutic development for Progressive Supranuclear Palsy (PSP). The collaboration leverages collective expertise to foster innovation, identify critical gaps in research, and expedite treatment advancements.
Researchers at RCSI have identified a new treatment option for multiple myeloma by combining venetoclax with 5-azacytidine. This combination shows enhanced efficacy across various patient samples and has the potential to expand treatment options for those resistant to standard care.