Articles tagged with Personalized Medicine
The American College of Lifestyle Medicine has published a position paper calling for the implementation of lifestyle medicine as a scalable and sustainable approach to address chronic disease burden and unsustainable healthcare costs. The framework includes training, board certification, clinical practice toolkits, and numerous resour...
An international team led by Lehigh University researcher Hannah Dailey is building predictive models to understand and eventually prevent bone healing complications. The team aims to incorporate biological differences into the model, using a library of imaging data from Switzerland's AO Research Institute Davos.
Several studies examine imaging tools for detecting prostate cancer, testing new PET tracers for spotting aggressive tumors. Researchers also explored a new scan to detect gastrointestinal stromal tumors and improved imaging agents for pancreatic cancer diagnosis.
A study at Technical University of Munich found that AI-simplified CT reports reduced reading time to two minutes and improved patient comprehension. Patients rated the simplified texts as more helpful and informative, with 82% finding them easier to read and understand.
A UCSF study found that a combination of outreach methods, including texts and live phone calls, significantly improves follow-up care for hard-to-reach patients. The integrated approach increased engagement among African American patients to 76.4% and improved overall reach rate by 3.5%, supporting their recovery and treatment outcomes.
A nationwide telehealth clinical trial is now open at Ohio State University Wexner Medical Center for adults with advanced or metastatic pancreatic cancer with specific mutations in the fibroblast growth factor receptor (FGFR) gene. The study will test pemigatinib, a smart drug targeting these genetic mutations.
Despite national policy, palliative care is often not equally accessible to all, with most people dying in hospitals or nursing homes rather than at home. The researchers emphasize the need for systematic implementation and integration of person-centred palliative care across different care settings.
Research suggests that health apps, wearables, and interactive programs can improve physical activity, diet, and weight outcomes for children and teens. Mobile apps had the greatest impact on diet and weight outcomes, while wearables were most effective for reducing sedentary time.
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
Researchers have made significant advancements in detecting and treating prostate cancer and ALS using innovative imaging techniques. A new PET tracer has been developed to track Huntington disease protein aggregates, offering a potential noninvasive monitoring tool. Additionally, studies have compared two types of PET scans for spotti...
Artificial intelligence is being used to improve diagnostic accuracy in molecular pathology, with studies showing 93% accuracy for cancer diagnosis. Researchers are also using AI to analyze chromosomal changes in blood cancer patients and provide personalized treatment plans.
The Society of Nuclear Medicine and Molecular Imaging emphasizes the importance of education, training, and experience for safe and effective delivery of radiopharmaceutical therapy. Specialized expertise is needed to handle radioactive compounds and ensure patient safety.
A new report from Northwestern University offers six practical strategies to improve the doctor-patient bedside encounter in an era dominated by AI. By employing these strategies, clinicians can strengthen patient-physician relationships, combat inequities, and reduce burnout, ultimately leading to better patient outcomes.
Researchers have summarized recent breakthroughs in theranostic nanomaterials, engineered nanoparticles that can both diagnose and treat TBI. These materials can deliver drugs precisely where damage occurs while monitoring biological changes inside the brain.
Researchers at Tohoku University shared key findings from their 10-year genome cohort study, highlighting effective techniques for analyzing and managing genomic data. The study's unique approaches to whole-genome sequencing, including qMiSeq and iDeal protocols, have been widely adopted by institutions worldwide.
A doctor warns of critical treatment gaps in eating disorders, highlighting the dangers of ignoring physical warning signs and behavioral indicators. Dr. Jennifer Gaudiani advocates for integrated medical and psychological care to address the urgent need for effective treatment.
A new genetic risk score combines rare and common gene variants with non-coding genome information to predict arrhythmia risk. This comprehensive framework can be applied to other genetically influenced diseases like cancer and Parkinson's Disease.
Exercise promotes angiogenesis and lymphangiogenesis through molecular signaling pathways, enhancing vascular function and immune response. This process offers potential interventions to combat age-related decline and disease, including cardiovascular diseases, muscle atrophy, and metabolic disorders.
Researchers have identified three distinct immunotypes in EPTB patients, revealing new insights into disease mechanisms. Additionally, gene expression-based biomarkers have been developed to reliably diagnose both pulmonary and extrapulmonary tuberculosis.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
Researchers at UVA School of Medicine found that the breakdown of protective brain structures called perineuronal nets leads to social memory loss in Alzheimer's patients. Preventing the degradation of these nets may lead to new treatments to prevent or delay the disease.
A new radioimmunotherapy approach has been developed to treat HER2-positive breast cancer, resulting in complete and histologic cures with minimal toxicities. The treatment uses a pretargeted approach to directly target tumors, reducing the risk of radiation toxicity to healthy tissues.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
A new USC study identified five genes linked to aggressive prostate cancer in people of African descent, including ATM, BRCA2, CHEK2, HOXB13 and PALB2. The researchers developed a method combining genetic risk scores with family history and specific variant presence for personalized monitoring and treatment strategies.
A study at the University of Gothenburg found that intensive treatment with remote monitoring of glucose levels and weekly healthcare contact significantly improved long-term blood glucose control in people with type 1 diabetes. The treatment also increased patient satisfaction and proved to be safe, with no serious events reported.
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
The Lehigh University team created a computational model to predict the hemodynamic response of patients with AFib, helping tailor neurostimulation dosages. The model validated against clinical data and predicted accurate effects on blood pressure, heart rate, and stroke volume.
A novel 3D chromosome mapping method has been developed to detect hidden structural variants in DNA, revealing new discoveries for genetic disorders. The study successfully identified known large chromosomal variants with 100% concordance and uncovered 12 novel structural variants missed by standard clinical tests.
Researchers at the University of Connecticut have developed two fast tests for early markers of Alzheimer's disease using CRISPR technology. The tests recognize microRNA molecules associated with Alzheimer's, allowing for quick identification in doctor's offices.
A systematic review by ECU and US universities reveals cognitive-based interventions as the most effective in managing perinatal anxiety, depression, and stress, while counselling-based interventions show moderate impact on anxiety and quality of life. Occupational therapy can help women transition to new roles, providing strategies fo...
A University of East Anglia study found that treating patients at home with IV antibiotics can save the NHS over £3,500 per patient and potentially free-up vital hospital beds. The treatment involves having antibiotics prepared at home and continuously delivered into the bloodstream by an elastomeric pump.
The Bezos Earth Fund has awarded a $2 million grant to researchers at UC Davis and the American Heart Association to advance AI-designed food research. The funding will support scientists in developing an AI-powered recipe formulation tool called Swap it Smart, which aims to redesign foods for sustainability and nutritional value.
The FDA has approved elinzanetant for treating hot flashes and night sweats in postmenopausal women. The drug significantly reduces the frequency and severity of symptoms while improving sleep quality and quality of life.
The Association for Molecular Pathology recognized Dr. Laposata's contributions to clinical laboratory practice and his role in challenging the FDA's rule on laboratory-developed test regulation. The award preserves diagnostic innovation, ensures patient access, and avoids escalating healthcare costs.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
A study published in the British Journal of Health Psychology reveals that commercial fitness apps can have negative themes such as quantifying diet and physical activity challenges, oversimplified algorithms, and aversive emotional responses. The findings suggest a need for user-centered design prioritizing wellbeing over rigid goals.
The John Shufeldt School of Medicine and Medical Engineering will train students to blend multiple disciplines for innovative healthcare leadership. Graduates will receive dual degrees and leverage new tools like AI and data science to connect with patients and develop innovative practices.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Researchers found a targeted immunotherapy regimen yielded promising survival outcomes for patients with B-cell ALL, outperforming historical results. The treatment was well-tolerated, with more than half completing the full course of therapy, and responded similarly in patients with complex medical histories.
The US needs a new strategy for insurance coverage and access to cell and gene therapies due to high up-front costs. In contrast, Europe has approved 19 CGTs with most being reimbursed within two years of approval based on demonstrated added therapeutic value.
Researchers at the University of Pittsburgh and UPMC developed a new treatment for patients with drug-resistant epilepsy. The approach uses deep brain stimulation (DBS) targeted to each patient's unique brain wiring, resulting in a significant reduction in seizures, with some patients becoming seizure-free for months.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Researchers developed an ultra-sensitive hydrogel for human-machine interaction, achieving high-accuracy collaboration in remote surgical operations and virtual reality. The AirCell Hydrogel boasts a smooth surface and porous interior structure, allowing it to detect various human motions with exceptional accuracy.
A landmark study analyzed health data from over 600,000 patients across 10 countries to assess patient risk for non-ST-elevation acute coronary syndrome (NSTE-ACS). The AI-powered model GRACE 3.0 predicts risk more accurately and guides personalized treatment decisions.
Researchers developed TAMENDOX to supplement (Z)-endoxifen in patients with CYP2D6 enzyme deficiency, improving drug concentration and effectiveness. The new therapy was well-tolerated, showing promise as an alternative to aromatase inhibitors for premenopausal women.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
A new RNA-based therapy targeting Marfan syndrome shows promise in treating the genetic disorder, which can lead to aortic aneurysms and be fatal. The therapy, developed by Mizzou researcher Dunpeng Cai, aims to correct mutated RNA for those with Marfan syndrome.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
The University of Surrey is part of a global research project to create an 'Immune Digital Twin', a virtual model of the human immune system. This could help scientists tackle autoimmune disorders and infectious diseases by simulating how different drugs or treatments work for individual patients.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Researchers use AI, omics, and systems biology to design targeted drugs for cardiovascular disease pathways. The tools could transform heart drug development and save lives, but global health policy leadership is urgently needed.
A new review in Frontiers in Science calls for a fundamental shift in how heart drugs are discovered and tested using AI, omics, and big data. This approach could drive the development of personalized treatments for cardiovascular disease, which currently relies on broad-brush treatments that don't account for individual variability.
A new analysis found that virtual reality effectively reduced anxiety during coronary angiography and had more stable vital signs than standard care. VR was superior to standard care in reducing anxiety and associated with significantly lower changes in heart rate and blood pressure.
Researchers designed and lab-validated synthetic proteins using generative AI tools, outperforming natural proteins in editing the human genome. The study's findings have significant implications for improving gene editing tools and developing new therapies for cancer and rare diseases.
Colin Hill joins C-Path's Board of Directors with experience in AI, drug development, and translational acceleration. He aims to bring precision medicine focus to advance treatments worldwide.
A groundbreaking study aims to improve genetic services for adolescent and young adult (AYA) cancer survivors by integrating digital tools and chatbot technology. Participants will receive tailored communication, digital education tools, and genetic testing, with the goal of increasing uptake of genetic counseling and testing.
Liberate AI project develops an AI model capable of predicting long-term outcomes and potential complications in ischemic stroke patients. The model will be trained using Swarm Learning technology, aiming for explainability and transparency, while striking a balance between these features and accuracy.
A randomized clinical trial found that parents who received remote motivational counseling and mobile-based support improved their use of appropriate child car seats. The intervention included tailored web content, periodic text messages, and personalized feedback.
A portable device using machine learning can detect signs of concussions in real-time, providing a more objective way to assess injuries. The Mizzou Point-of-Care Assessment System combines a force plate, depth camera and interface board to track movement, balance and reaction times.