Articles tagged with Personalized Medicine
Researchers have discovered a way to enhance awake brain mapping, allowing neurosurgeons to remove more cancerous tissue while minimizing disruptions to patients' quality of life. The new technique uses subtle changes in patient behavior to inform surgical decisions.
A new study from Duke University Medical Center suggests that a simple blood test can accurately predict short-term survival in older adults by detecting specific piRNA molecules. Lower levels of these molecules are linked to longer survival, echoing patterns seen in simple organisms where reducing them can extend lifespan.
Researchers have developed a definitive guide to safely navigating health information on AI-powered chatbots, addressing the risk of 'hallucinated' or factually incorrect advice. The Health Chatbot Users’ Guide focuses on harm reduction and maximises benefits to users, offering a pragmatic and neutral approach.
Researchers have made significant advancements in nuclear medicine by developing a new reporting framework for PET/CT scans, using targeted radiation therapy to treat sarcoma, and investigating how genetic mutations affect prostate cancer treatment outcomes. These studies aim to improve diagnosis and treatment for various cancers.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers propose a new framework to detect chronic diseases earlier by tracking individual biological changes. Advances in technology and AI enable the analysis of complex patterns from wearable devices and biological samples.
A 23andMe Research Institute study found that people with increased genetic risk for serious health conditions took positive actions after learning of their risk through direct-to-consumer genetic testing. Eighty-six percent received medical recommendations, and 88% adhered to them.
A study by University of Virginia Health System researchers found that Medicare Advantage patients had better access to preventive care and rehabilitation after a stroke, leading to faster recovery times. In contrast, traditional Medicare patients were less likely to receive these services due to prior authorization requirements.
Researchers developed a vascularized liver tissueoid-on-a-chip that recapitulates key structural, functional, and immunological features of human liver tissue. The platform enabled the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
Researchers from UC San Francisco successfully decoded brain activity patterns associated with walking, enabling the development of personalized neural biomarkers for movement state classification. This breakthrough could lead to more effective adaptive DBS systems that adjust stimulation in response to a patient's activity state.
Researchers are testing new targeted radiation approaches for early colorectal cancer, HER2-positive breast cancer, and advanced prostate cancer. Imaging tools track treatment movement and help evaluate dosing and safety.
The Global Exposome Forum is a global initiative that aims to understand the complex interplay between biological, chemical, and environmental exposures and human health. The project has partnered with national governments, scientific institutions, and large membership-led organizations to advance exposomics science.
Ken Herrmann will lead the journal for five years, focusing on global engagement and impact. He succeeds Johannes Czernin, who guided JNM through significant growth and expansion.
A new online tool provides information and tools for clinicians to respond to emerging patient care needs, enhancing trauma-informed healthcare for individuals with C-PTSD. The resource was co-developed by researchers and survivors, aligning with best practices and patient-centered research.
Researchers used advanced PET imaging techniques to study the effects of traumatic spinal cord injuries on nerve cells. Additionally, whole-body PET scans were used to map brain-body immune cross-talk during immune responses.
Researchers discovered that collaborative care programs improve quality of life, reduce costs, and alleviate caregiver burden for dementia patients. Adding lecanemab to treatment increased healthcare costs but was offset by the savings from collaborative care.
The National Comprehensive Cancer Network (NCCN) has committed to updating its robust information resources for cancer patients and caregivers annually, available in both English and Spanish. The updated resources will provide factual, trustworthy information to guide patients and caregivers towards their best possible outcome.
A retrospective analysis of 94 adult patients who underwent PEEK cranioplasty found that surface architecture may influence postoperative healing, with smooth implants associated with higher rates of wound complications and infections. Perforated implants showed lower rates of major fluid collections, especially in trauma patients.
A rare genetic mutation has been discovered that can explain why some people do not respond to newer schizophrenia treatments. The mutation, known as C182F, removes a structural bond in the TAAR1 receptor, blocking its binding site and rendering drugs ineffective.
A recent systematic review has compiled and catalogued publicly available omics data on pituitary tumours, highlighting the need for standardisation and clinical annotation. The resulting catalogue facilitates the reuse of data for future research projects and precision medicine initiatives.
Researchers have developed new CXCR4-targeting radiolabeled peptides for cancer imaging and therapy, producing clear tumor images and extending survival in preclinical testing studies. Additionally, PET scans are being used to predict prostate cancer outcomes, identify primary aldosteronism, and guide treatment decisions.
A UBC study found that exercise physiology research predominantly focuses on male bodies and voices, while women are underrepresented as participants and researchers. The study highlights the need for greater equity in exercise physiology research to improve understanding of sex-based differences in physiology and treatment.
Long COVID shows self-reported data strengths over objective data, calls to de-stigmatize self-reporting in healthcare research. PLOS article highlights need for reevaluation of what counts as 'objective' data.
The ISSCR is hosting a summit on access and affordability in cell and gene therapies to explore pricing, manufacturing, regulation, and reimbursement strategies. Experts will examine key barriers and emerging solutions across the access landscape.
Researchers at Salk Institute debut an epigenetic catalog that shows genetic inheritance and life experiences have distinct effects on various types of immune cells, shedding light on individual differences in immune responses and potential new personalized therapeutics.
This study introduces a new FAP-targeting peptide that shows strong tumor uptake and effective tumor growth inhibition when paired with lutetium-177. Additionally, researchers have identified distinct metabolic and structural brain patterns that differentiate probable LATE, Alzheimer disease, and their frequent overlap.
Researchers are expanding options for patients with hard-to-treat cancers using a personalized approach that identifies effective therapies by testing large libraries of drugs on living tumor cells. The approach has shown stronger responses than initial findings, suggesting it can reveal opportunities missed by traditional methods.
A study from Flinders University found that patients with progressive disease, which describes the way cancer grows, have varying survival rates depending on whether their existing tumours re-grow or new ones appear. Understanding this progression can help doctors make better decisions about future treatment strategies.
Researchers identify circulating extracellular vesicles produced in diseased kidneys as the culprit behind toxicity in the heart. The discovery could lead to the development of a blood test to identify patients at high risk for serious heart problems and novel treatments to prevent and treat heart failure.
Recent studies published in The Journal of Nuclear Medicine explore the use of interim PET scans to predict treatment response and survival in patients with large B-cell lymphoma. Additionally, a phase 2 trial evaluates the safety and effectiveness of a radiopharmaceutical targeting prostate-specific membrane antigen (PSMA) in advanced...
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
A newly developed radiopharmaceutical pair can precisely detect and effectively treat gastric and pancreatic tumors, completely eradicating tumors in preclinical models. Claudin-18.2-based theranostics could meaningfully change patient care by enabling non-invasive tumor identification and targeted radiation therapy.
A major U.S. clinical trial has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Researchers found that men who carry a specific version of the gene SULT2A1 clear abiraterone from their bodies more slowly, which could affect how well it w...
ACCESS-AD aims to address Alzheimer's disease challenges with a coordinated framework for diagnosis, treatment and monitoring. The project combines advanced neuroimaging with digital biomarkers to support early patient identification and personalized treatment pathways.
A study published in PNAS found that over 60% of pairs of damaging genetic variants can restore enzyme activity when combined, challenging long-held assumptions about genetics. This phenomenon, known as intragenic complementation, has implications for rare disease diagnosis and treatment.
Researchers developed new imaging approaches using specialized amino acid PET tracers to visualize aggressive breast, lung, and glioma cancers. The studies showed promising results, highlighting the potential of these tools for future cancer imaging and guiding targeted therapies.
The collaboration aims to integrate AI-powered analytics with clinical expertise to accelerate data-driven cancer care. MD Anderson researchers will leverage SOPHIAs AI technologies to develop bioinformatics pipelines for rapid RNA-sequencing data interpretation.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
The Baveno VII consensus guidelines have reshaped portal hypertension management, focusing on early intervention and noninvasive diagnostics. Nonselective beta-blockers and transjugular intrahepatic portosystemic shunt (TIPS) are recommended for clinically significant portal hypertension diagnosis.
CORAL accurately predicts genetic subtypes and patient outcomes in multiple myeloma without costly genomic tests. The technology could be applied to other cancers, opening the door to personalized, faster and widely accessible cancer care.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
Researchers at Kobe University developed a method to preserve iPS cells directly in their culture dishes using D-proline as a cryoprotectant. This allows for easy automation of the process, reducing costs and increasing efficiency in regenerative medicine and drug discovery research. The breakthrough enables the direct freezing, thawin...
A University of Arizona study found that most people who fill out the Patient Health Questionnaire (PHQ) are confused by its instructions, leading to inaccurate data. The study highlights a problematic phrasing in the questionnaire's instructions, which asks patients to indicate the frequency with which they've been bothered by symptoms.
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
Recent studies explored novel biomarkers for kidney cancer spread detection, heart scans for ATTR amyloidosis diagnosis, and radiation therapy delivery for neuroendocrine tumors. Additionally, researchers developed a new PET tracer to track heart-healing cells after a heart attack.
A study found that only 6% of FDA-approved drugs reflect the US racial and ethnic makeup, with a decline in Black and Hispanic enrollment between 2021 and 2023. The researchers recommend setting diversity goals at preclinical stages and collecting biological samples to understand how people's bodies react to medications.
A multicenter study found that higher-intensity rehabilitation in the ICU is linked to faster recovery and lower risk of delayed recovery for critically ill patients on mechanical ventilation. Purposeful mobilization preserves muscle strength and function, supporting faster return to independence.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
The ISSCR symposium highlights new clinical trial results and emerging technologies advancing PSC-derived cell therapies. Key findings include breakthrough approaches for treating drug-resistant epilepsy and geographic atrophy, as well as durable remission in type 1 diabetes.
Researchers at Florida Atlantic University have developed a deep learning model that detects and evaluates Alzheimer's disease (AD) and frontotemporal dementia (FTD) using EEG brainwave analysis. The model achieved over 90% accuracy in distinguishing individuals with dementia from cognitively normal participants.
This supplement highlights key areas of focus for theranostics, including clinical lessons, education, science, multidisciplinary collaboration, and equity. It also explores new frontiers beyond oncology and examines finance, sustainability, policy, strategy, and future directions.
Researchers measured dyadic alliance in support groups using computational algorithms and found verbal and nonverbal communication features, such as head poses and facial expressions, to be strong predictors of connection. The study suggests that AI can potentially identify behavioral markers of alliance and may have a role in mental h...
Researchers analyzed AI methods for detecting pulse rates from facial video recordings and found significant errors at elevated heart rates. The study highlights weaknesses in remote photoplethysmography (rPPG) technique under challenging conditions.
A first-in-human study found that a single dose of the alpha-emitting radionuclide <sup> 211 </sup> At was both well-tolerated and effective in achieving disease control without molecularly targeted drugs. The therapy has potential to reduce treatment burden and broaden access to effective care for patients with refractory disease.
Recent studies explore new PET/CT imaging methods for prostate cancer staging and detection. Researchers assess improved performance of these advanced scans in detecting lymph node or bone spread, as well as their impact on treatment plans. Additionally, researchers examine the effectiveness of peptide receptor radionuclide therapy (PR...
Researchers at CU Anschutz have discovered a novel therapy combination to offer new hope to ovarian cancer patients who do not respond to existing treatments. The combination of a PARP inhibitor and SM08502 boosts the effectiveness of treatment, even for patients resistant to PARP inhibitors.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
University of Missouri researchers are combining in-home sensor technology with artificial intelligence to monitor daily changes in ALS patients' health. The system uses machine learning to estimate a patient's score on the ALS Functional Rating Scale Revised, predicting potential problems before they occur.
Researchers at Newcastle University have led the way in redefining Dementia with Lewy bodies as a distinct cause of dementia. Their work has improved outcomes and offered hope to those affected, thanks to breakthroughs in disease mechanisms, stem-cell models, blood-based tests, and personalized therapies.