Articles tagged with Personalized Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
Researchers conducted genomic evaluations of advanced malignancies to develop matched, individualized combination therapies. The study found that precision cancer therapy improved median overall survival rate by 3.9 months compared to standard care.
Researchers conducted a functional test to identify effective therapies for advanced hematological cancers, achieving significant positive outcomes with 56 patients receiving individually tailored treatment. The study demonstrates the clinical feasibility and efficacy of personalized medicine in breaking resistance to prior therapies.
A University of Alberta-led study found that anemia can generate different immune responses in males versus females, making females more prone to infections. The research highlights the importance of considering sex as a variable in prevention, diagnostic, and therapeutic strategies for immune-related conditions.
Researchers have developed a federated analytics system, FAMHE, that enables healthcare providers to collaborate on statistical analyses and machine learning models without exchanging underlying datasets. The system has been proven mathematically secure and accurately reproduced published studies in multi-centric settings.
Researchers at the University of Arizona have created custom-fitted wearable devices that can monitor physiological parameters without needing recharging. The biosymbiotic devices use wireless power transfer and compact energy storage to enable continuous operation, providing accurate data on body temperature, strain, and muscle deform...
Researchers created a customized device that targets unique brain circuits associated with depression, providing immediate relief. The approach uses neural biomarkers to personalize therapy and has shown long-term efficacy in treatment-resistant patients.
The MAP Virtual Congress 2021 focuses on integrating tumour sample analysis into daily practice, enabling personalized treatment. Key findings include actionable mutations in patient DNA and the role of the tumour microenvironment in metastasis.
Researchers create a novel magnetoelastic generator that can convert human body motions into electricity, outperforming existing technology. The device is flexible, waterproof, and generates significant electrical currents, opening up new avenues for wearable and implantable diagnostic sensors.
Researchers mapped cancer through protein interactions, revealing biomarkers and potential new treatments for breast and head and neck cancers. The study provides a new definition of biomarkers based on large, multi-protein complexes, offering a more precise way to explain mutation effects.
New targeted therapies are being developed to target genetic alterations in cancer cells, such as the ARID1A mutation found in 10-50% of solid tumours. Early clinical trials suggest that these agents may be effective in treating multiple cancers, including breast, ovarian, and gastric cancer.
The VCU Massey Cancer Center has established a Translational Research Center in Lung Cancer Disparities (TRACER) to address racial disparities in lung cancer. TRACER will investigate the interaction between stress, smoking, and gene expression to raise lung cancer risk in Black men.
A survey of 5,589 cancer patients found widespread unawareness about immunotherapy's mechanism, efficacy, and cost. Non-oncology doctors also face challenges in keeping up with the latest developments in oncology.
A new algorithm, Phe2vec, accurately identified patients with certain diseases, outperforming traditional methods in classifying diagnoses. The study suggests that this automation will facilitate further research in clinical informatics.
A pan-Canadian randomized controlled trial is using digital communication to target common reasons for vaccine hesitancy, including age, language, and education level. Family physicians will receive tailored information to share with patients through email and text message, aiming to improve vaccine uptake.
Researchers at Texas A&M University designed a new framework to create the most optimal oxygen concentrator, capable of producing high-purity oxygen and adapting to changing patient needs. The LiLSX-based system outperformed other zeolites in simulation tests.
Researchers at RMIT University have discovered a Teflon-like molecule on the womb's surface that decreases at a certain point in the menstrual cycle, opening the 'golden window' for pregnancy success. This finding could lead to improved IVF success rates and potentially treat underlying causes of infertility.
Fels and Fox Chase researchers found specific TET2 and DNMT3A mutations in leukemia patients that affect DNA repair pathways. These mutations make leukemia cells sensitive to PARP inhibitors, a type of targeted therapy, while others are resistant. The study aims to develop personalized therapies for patients with these mutations.
Researchers discovered that almost half of patients who received personalized information about community resources shared them with at least one other person. Individuals in poorer health were more likely to report sharing the information, and those who visited or used a resource on their list were also more likely to share it.
A new app called selfBACK has been developed to help people deal with back pain in a better way. The app uses artificial intelligence and draws on other people's experiences with back pain to provide tailored advice and feedback.
Researchers at University of Colorado Boulder have developed a blood test that can assess the timing of an individual's internal circadian clock, potentially leading to personalized medicine breakthroughs. The study found that analyzing a combination of molecules in a single blood draw can determine the timing of a person's biological ...
Researchers developed a comprehensive tool to explore disease development patterns, identifying main highways of disease progression. The Danish Disease Trajectory Browser analyzes 25 years of public health data to discover frequent disease trajectories.
Scientists have developed biocompatible TeSex nano-alloys that eliminate toxicity and enhance theranostic performances for precision medicine. The nano-alloys enable high-efficacy photothermal therapy under multimodal imaging guidance.
The human genome's complexity hinders personalized medicine by having an immense ability to change and cope with issues, context matters in our genome. Researchers conclude that precision medicine is crucial but must consider the full genomic blueprint including 'unnecessary' elements.
CURATE.AI is an AI-derived mechanism-independent technology platform that profiles individual patients based on their data and recommends optimal drug doses. This approach aims to improve treatment efficacy while reducing toxicity levels and addressing the challenges of personalized dosing.
Researchers have developed a method to monitor and predict the progression of atrial fibrillation using cardiac electrical signals from implantable devices. This technology enables personalized treatment timing, optimizing medical intervention for individual patients.
This special issue focuses on advancements in technologies that enable predictive, preventative, and personalized medicine. The articles cover various topics such as biomicrofluidic systems, purification and enrichment of extracellular vesicles, and electrochemical sensors.
A study by San Diego State University researcher Rob Edwards found a country-specific biomarker for the crAssphage virus in humans, which rapidly changes with travel. The research analyzed over 32,000 sequences from 65 countries and revealed the phage's global distribution.
New research highlights the importance of diverse genetic data in understanding complex traits and diseases. By studying a large number of groups together, scientists have discovered dozens of discoveries that would not have been possible in single-population studies.
The EU-STANDS4PM forum aims to develop standardized transnational frameworks for data integration and in silico modeling in personalized medicine. This will facilitate the use of life science data in clinical research and accelerate growth of the European data-driven economy.
A review paper highlights the transformative potential of precision and personalized medicine for cancer treatment. The traditional approach focuses on general treatments, while PPM allows for individualized treatments tailored to specific tissues and gene mutations.
The Quadratic Phenotypic Optimization Platform (QPOP) uses AI to analyze small datasets and design optimal drug combinations based on real experimental data. This approach can optimize and personalize combination therapy for individual patients with complex diseases, such as multiple myeloma.
A KAIST research team has developed a flexible drug delivery device with controlled release, blurring the path toward theragnosis. The device boasts fewer side effects and uniform therapeutic results compared to oral ingestion, making it suitable for smart contact lenses and brain disease treatments.
The research aims to assess the cost-effectiveness of LHSC's personalized medicine program, which uses pharmacogenomics to predict patient responses to medications. The study will compare patient outcomes with those in the province using provincial health care data.
Researchers have developed a novel omics tool to explore the interaction between genetics, environment, and disease. By integrating large datasets from the BXD mouse population, scientists can identify gene-phenotype associations and make personalized treatment predictions.
Computational biologists discover that protein variations have a significant impact on cell functions, even in healthy individuals. The study's findings could lead to advances in personalized medicine and better understanding of individual responses to environmental influences.
A new study found that generous health insurance plans with low deductibles and copays can lead to unnecessary treatments for chronically ill patients. The study suggests that personalized medicine interventions, providing more information about treatment effectiveness, can reduce healthcare costs and improve patient outcomes.
Researchers have developed a new approach to create integration-free, Myc- and Lin28-free human induced pluripotent stem cells. This breakthrough method reduces the neoplastic risk associated with IPSC generation, enabling their utility in regenerative medicine and personalized medicine.
Personalized Medicine in Psychiatry aims to increase treatment efficacy and reduce adverse effects by considering individual patient characteristics. The journal will publish research on endophenotypes, pharmacologic approaches, and education, with the goal of identifying predictors of response and tailoring treatments.
Seventy percent of patients who kept their gallbladders despite experiencing biliary pancreatitis had no recurrence four years later. A large database analysis found that many patients who did not undergo surgery within 30 days still had no recurrences over a four-year follow-up period.
Researchers at Boston University School of Medicine have developed a novel approach to generate airway cells from stem cells using the Wnt signaling pathway. These cells can be grown into three-dimensional spheres and used to study lung diseases such as cystic fibrosis.
Researchers have discovered significant differences in cells derived from dura mater and skin samples across the lifespan, highlighting the importance of considering the cell's original location and donor age. These findings necessitate further exploration into epigenetic patterns in stem cells used for new tissue and organ generation.
A global research team has identified 52 genetic variants associated with age-related macular degeneration (AMD), a disease affecting 150 million people worldwide. The discovery may lead to personalized medicine approaches and new treatments for this debilitating condition.
More than 120 US engineering schools pledged to graduate 20 'Grand Challenge Engineers' per year, trained through special programs with a focus on hands-on research, global perspectives, and service-learning. The goal is to train over 20,000 engineers to address societal challenges.
Researchers at U of MD will implement genomic screening in various healthcare settings to detect monogenic diabetes, tailor treatments, and identify at-risk family members. The goal is to enhance diagnosis and treatment for individuals with genetic forms of diabetes.
Researchers have made progress in designing therapies for patients with specific genetic traits, particularly in cancer treatment. However, the field still faces significant hurdles, including a need to incorporate individuals' health histories and environmental factors into personalized medicine.
The Mount Sinai Hospital is launching the first-ever genetic testing program in primary care settings to identify genetic risk for kidney disease in patients with hypertension. This $3.7 million grant will provide genomic information to individualize treatment, testing, and monitoring, with a focus on African Americans who are four to ...
Research by Northwestern Medicine cardiologist Jeffrey Goldberger combines evidence-based guidelines with tailored treatment for patients, reducing over-treatment and under-treatment. By analyzing clinical data and individual characteristics, physicians can make more precise decisions, leading to better patient care.
A recent study found that vaginal microbes change in some healthy women over short periods, while remaining stable in others. These changes can impact a woman's susceptibility to infections and diseases. Researchers hope this research will lead to personalized medicine for women.
The Canadian Institutes of Health Research will lead a landmark research competition to develop personalized treatments for various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. The investment aims to transform the delivery of healthcare through predictive, preventive, and precision care.
Researchers propose using personalized medicine to identify individuals at highest risk for developing type 2 diabetes, allowing for targeted prevention efforts. Current methods are inefficient, but new biomarkers and approaches hold promise for preventing and controlling the disease.
A new study found that more than 85% of US states have inadequate genetics standards for preparing high school students for personalized medicine. The study, published by the American Society of Human Genetics, rates only seven states as 'adequate' in genetic literacy.
The American Chemical Society honors Keith H. Gibson, Andrew J. Barker, and George L. Trainor for their contributions to personalized medicine and genetic sequencing. The trio developed a new drug that helped pioneer the era of 'personalized medicine' for cancer patients.
Despite genomics' promise in treating cancer and cardiovascular disease, personalized medicine's complexities limit tailored interventions. The authors advocate for a more holistic approach focusing on the person as a whole, rather than abstract scientific manipulations.
The Research Institute of the McGill University Health Centre (RI-MUHC) has been awarded a $1.4M grant to develop Personalized Medicine for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH). The project aims to identify new biomarkers and disease predictors to improve diagnosis and treatment options.
A recent study published in PLOS ONE found that ancestral genetic heritage is not fixed at the individual level for African-American and Hispanic patients, but rather varies widely within each group. This research challenges traditional ethnic labels and highlights the importance of considering individual genotypes in personalized medi...
This special issue of Perspectives on Psychological Science investigates the potential of genetics research, personalized medicine, and behavioral intervention to improve patient care. The articles examine the intersection of behavior and genetics, with a focus on tailoring treatments to individual genetic characteristics.
A series of essays examines the challenges in determining effective treatments, benefits and drawbacks for patients, as well as consumers' right to their genetic information. The articles discuss controversies surrounding direct-to-consumer tests, genetically customized drug treatments and biospecimen use.
This special edition of The Hastings Center Report examines the promise and pitfalls of personalized medicine, from direct-to-consumer genetic testing to hospice care. Key findings include the need for thousands of human biospecimens for genetic studies, as well as debates over individual mandates in healthcare reform.
Experts in pathology are advocating for a comprehensive training program to integrate genomics and personalized medicine into daily practices. The proposed curriculum would cover laboratory medicine, genetic counseling, and health information technology, enabling pathologists to serve as primary consultants for physicians and patients.