Articles tagged with Personalized Medicine
New research shows that music therapy significantly decreases heart rate, systolic blood pressure, and patient-ventilator asynchronies for patients admitted to the cardiac intensive care unit (ICU). Music therapy is a safe, low-cost, non-pharmacological intervention that complements conventional treatments.
A UCLA research team led by Dr. Donald Kohn has developed a one-time stem cell gene therapy treatment for alpha thalassemia major that could be curative. The therapy involves adding the missing alpha-globin gene to patient cells using a viral vector, enabling them to produce functional hemoglobin.
A new study shows that remote perioperative monitoring significantly improves recovery for cancer surgery patients, with a 6% greater functional recovery rate by day 14 after surgery. The study also found fewer major complications and improved symptom management.
Mayo Clinic researchers developed a genetic test that can predict how people will respond to weight loss medications. The test estimates an individual's calories to satiation, linking it to treatment success and providing personalized estimates of expected satiation threshold.
A new biotechnical vector, VIBV, combines viral mimicry with synthetic nanotechnology to deliver targeted RNA therapies for cancer treatment. The vector uses a spindle-shaped nanostructure and polyethylene glycolylated liposomal coat to evade immunity and extend circulation.
The American Society for Radiation Oncology, American Society of Clinical Oncology, and Society of Surgical Oncology jointly published a guideline outlining when post-mastectomy radiation therapy (PMRT) is appropriate based on new evidence. PMRT reduces cancer recurrence risk in patients with node-positive disease or high-risk features.
A new white paper from the USC Schaeffer Center recommends FDA reforms to streamline clinical trials, provide clearer guidance on newer technologies, and improve agency efficiency. This could reduce development time and costs, pushing down prices and improving patient access.
Dr Oliver Pain develops GenoPred platform advancing personalized mental healthcare worldwide through accessible genetic tools, democratizing access to cutting-edge genomic methodologies. His work aims to reduce global health inequities by developing inclusive polygenic scoring methods that perform accurately across all ancestry groups.
The Longevity Education Hub has launched a new chapter in Brazil, offering a free accredited course in Healthy Longevity Medicine. The course, developed by Dr. Fabiano Serfaty and Fernanda Calvo-Fortes, aims to equip physicians with the latest tools and knowledge to close the gap between lifespan and healthspan.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
A global study surveyed 14,000 patients across 43 countries, finding that those in poorer health were more likely to reject AI. Patients preferred explainable AI and wanted clinicians to make final decisions.
Researchers have identified a new therapeutic target, ABHD18, which can restore mitochondrial health and improve heart function in preclinical models of Barth syndrome. By blocking this gene, the body can bypass the problem caused by the faulty TAFAZZIN gene, offering a potential path to targeted therapies.
A UMD-led research team is working to improve the sharing of patients' outside health records with clinicians, aiming to reduce healthcare costs and duplicative paperwork. The study will examine how doctors make clinical decisions with outside data and its impact on patient health.
A study by BSC-CNS analyzed molecular data from over 4,000 patients and 45 diseases using a newly developed computational method. The results show that 64% of medically known connections are related by similarities in gene expression, providing clues about the biological mechanisms linking them.
A new online calculator helps doctors determine the most effective treatment plan for each patient based on their blood pressure needs. By categorizing treatments as low, moderate, or high intensity, the tool enables personalized treatment plans and potentially improves patient outcomes.
Researchers designed an ideal primary care visit scenario that emphasizes patient-centered communication, respect, and inclusivity. A survey of 250 adults with obesity found that most preferred this approach, citing doctors who listen attentively and treat weight issues sensitively.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
A new cross-national study finds that older adults with disabilities are less likely to receive preventive care, but higher government health spending closes the gap. Investing in public healthcare promotes equitable access to preventive services, particularly among vulnerable populations.
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
A new article by Dr. Leonard Berry of Texas A&M University argues that values-driven listening can improve care and heal the healthcare system. The authors identify six types of listening, including proximate, curious, earning trust, aided by design, empowering, and fostering resilience, which contribute to better care.
Weill Cornell Medicine leads a $14.9M NIH grant program to remove latent HIV from cells, aiming for effective cures. Researchers will use a personalized approach to develop tailored immunotherapies and broadly neutralizing antibodies against HIV.
Washington State University researchers developed an AI model that can accurately identify everyday activities from smartwatch data, achieving an accuracy rate of 78%. This breakthrough has potential applications in assessing cognitive health, rehabilitation, disease management, and surgical recovery.
A meta-analysis of over 1.5 million patients reveals associations between autoimmune diseases like coeliac disease and increased risks of stomach, bowel, pancreatic, oesophageal, and rectal cancers.
Researchers developed a neoAg mRNA-based vaccine that induces higher frequency of neoAg-specific cytotoxic T cells in mice, leading to tumor regression and eradication. The combination with anti-PD-1 therapy enhances antitumor efficacy, especially against peritoneal metastasis.
A new study finds that up to 18% of women are advised to stop breastfeeding due to medication, while chronic illness increases this number to 58%. The research highlights the need for accurate and balanced information about medication safety during breastfeeding.
Researchers developed pH-responsive graphene-based nanocarriers that can target cancer cells, achieving efficient and safe drug delivery. The material's surface charge adapted to the acidic tumor environment, allowing it to bind and enter cancer cells while avoiding healthy tissues.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Researchers are developing an AI imaging approach to distinguish between tumor progression and treatment effects in glioblastoma patients, promising to improve care and outcomes. The AI approach has already shown accuracy rates of up to 74% in initial testing.
Dr. Adekemi Adeniyan's innovative solutions to tackle oral health disparities in underserved communities have earned her the IHME's 2025 Roux Prize. Her work, using local data and community feedback, has expanded access to dental care for over 100,000 people.
Researchers at Syracuse University have identified a new target for treating obesity and diabetes, reducing nausea and vomiting associated with existing treatments. A molecule called tridecaneuropeptide (TDN) produced by brain support cells suppresses appetite and improves glucose processing without adverse effects.
A three-year follow-up study of a personalized program of cognitive functional therapy (CFT) found clinically significant improvements in pain-related activity and pain intensity compared to usual care. The treatment produced large benefits that were sustained over time, offering potential for major human and economic impact.
Researchers developed a novel framework using generative AI and musculoskeletal simulation to create synthetic gait data. This approach enables more robust and generalizable gait analysis across various patient populations and clinical environments.
Researchers developed a novel radioimmunotherapy that successfully eliminated cancer stem cells (CSCs) in preclinical models of ovarian cancer. The therapy, targeting CSC-associated biomarkers L1CAM + /CD133 + , showed significantly increased cytotoxicity compared to existing treatments.
A technology expert predicts AI-based medicine will revolutionise care for Alzheimer’s and diabetes, but access must be made available to all patients. The author highlights key innovations such as diagnostic imaging and surgical robots that will aid in more accurate diagnoses and treatments.
This article reviews bronchiectasis phenotypes and endotypes, exploring their impact on disease management and treatment strategies. Recent research has identified distinct inflammatory endotypes, guiding targeted therapies and improving patient outcomes through personalized approaches.
Researchers at The University of Osaka have developed a novel technology to unzip DNA's double helix structure, allowing for efficient and accurate genetic testing. The device uses a nano-sized platinum coil and precise heating to minimize DNA damage and read information from the DNA molecule.
A large-scale study analyzing over 1 million individuals has identified 57 distinct genomic regions associated with 48 genes linked to stuttering. The findings suggest a shared genetic architecture with autism, depression, and musicality, providing a foundation for early identification and therapeutic advances in stuttering.
New research highlights the transformative power of digital technology in shaping the e-patient era, enabling active participation and co-production in healthcare. Key technological innovations have built upon each other, providing patients with unprecedented tools for self-care and interaction with the healthcare system.
A study by Kaunas University of Technology reveals that digital mental health platform start-ups prioritize simple, scalable services and use subscription models to achieve success. State funding can hinder development rather than encouraging it to become a unicorn.
Researchers have identified a novel diagnostic tool that can predict patient outcomes for head and neck squamous cell carcinoma. The LIMA1-alpha protein reliably identifies patients who can be cured with surgery alone, avoiding unnecessary oncological treatments.
A new study reveals that the human gut microbiota can pinpoint an individual's city of residence with high accuracy, strongly linked to each city's characteristic diet. The researchers identified unique microbial signatures and interaction networks between cities in China, shedding light on how local environments shape our inner biology.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
Bioengineers at Harvard John A. Paulson School of Engineering and Applied Sciences have developed a computational model called BrainFlow that simulates cerebrospinal fluid flow in the presence of shunt implants, providing insight into optimal shunt design and placement for hydrocephalus patients.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers have developed a groundbreaking technique that maps temperature in three dimensions within biological tissue using invisible light and artificial intelligence. This new technology has the potential to improve early disease detection and treatment monitoring without the need for costly or invasive imaging technologies.
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
A survey from the Orlando Health Spine Center found that Americans often opt for short-term relief methods such as rest (44%), over-the-counter pain relievers (42%), and hot/cold therapies (29%) when dealing with neck and back pain. In contrast, only 5% consider surgery as a top option for pain relief.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
Recent studies have revealed significant improvements in patient prognosis for chronic thromboembolic pulmonary hypertension (CTEPH) over the past few decades. Advances in surgical techniques, drug development, and multimodal therapies have led to increased treatment rates and improved survival rates among patients.
The Mount Sinai Hospital has implemented the American Orthopaedic Association’s Own the Bone program to improve patient care for fragility fracture patients. The program offers a fracture liaison service to document and track individualized care, and incorporates 10 prevention measures to improve patient outcomes.
A special issue of Journal of Intensive Medicine provides key insights into selecting optimal non-invasive respiratory support strategies for AHRF, featuring review articles and original research. The collection offers guidance on the efficacy of HFNC, CPAP, NIV, and awake prone positioning to improve patient outcomes.
A study published in Neurobiology of Disease found that melanin degradation is impaired in genetically engineered mice lacking the SLC26A4 gene, leading to chronic inflammation and macrophage activation. The researchers propose a novel pathological cascade where melanin accumulation exacerbates hearing loss in pigmented individuals.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
Researchers discovered that slowing down intracellular transport of RNA-based drugs increases their effectiveness in treating genetic diseases. The study identified key genes involved in endosomal transport and found that selectively switching off a specific gene can prolong ASO residence time, boosting therapeutic efficacy.
A study by Carnegie Mellon University researchers found that the closures resulted in a 4% reduction in physicians per capita and declines in infant, non-infant, and total mortality rates. The Flexner Report era reforms led to significant changes in the US medical education landscape.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
A new gene therapy delivery device called NANOSPRESSO could revolutionize how hospitals treat rare diseases by allowing them to create personalized nanomedicines in-house. This democratized approach to precision medicine could boost access to low-cost bespoke gene and RNA therapies, especially in low-resource settings.
A new book written by an international team from Carnegie Mellon University and the University of Oxford argues that data-driven decision-making can improve healthcare outcomes. The authors explain how analytics can be used to optimize hospital operations, manage bed allocation, and improve treatment efficiency.
A new approach enables hospital pharmacists to rapidly create bespoke medicine cartridges for rare disease patients, boosting access to personalized treatment. The NANOSPRESSO platform could open up treatments for underfunded and underserved rare conditions worldwide.
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.