Articles tagged with Personalized Medicine
A meta-analysis of over 1.5 million patients reveals associations between autoimmune diseases like coeliac disease and increased risks of stomach, bowel, pancreatic, oesophageal, and rectal cancers.
Researchers developed a neoAg mRNA-based vaccine that induces higher frequency of neoAg-specific cytotoxic T cells in mice, leading to tumor regression and eradication. The combination with anti-PD-1 therapy enhances antitumor efficacy, especially against peritoneal metastasis.
A new study finds that up to 18% of women are advised to stop breastfeeding due to medication, while chronic illness increases this number to 58%. The research highlights the need for accurate and balanced information about medication safety during breastfeeding.
Researchers developed pH-responsive graphene-based nanocarriers that can target cancer cells, achieving efficient and safe drug delivery. The material's surface charge adapted to the acidic tumor environment, allowing it to bind and enter cancer cells while avoiding healthy tissues.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Researchers are developing an AI imaging approach to distinguish between tumor progression and treatment effects in glioblastoma patients, promising to improve care and outcomes. The AI approach has already shown accuracy rates of up to 74% in initial testing.
Dr. Adekemi Adeniyan's innovative solutions to tackle oral health disparities in underserved communities have earned her the IHME's 2025 Roux Prize. Her work, using local data and community feedback, has expanded access to dental care for over 100,000 people.
Researchers at Syracuse University have identified a new target for treating obesity and diabetes, reducing nausea and vomiting associated with existing treatments. A molecule called tridecaneuropeptide (TDN) produced by brain support cells suppresses appetite and improves glucose processing without adverse effects.
A three-year follow-up study of a personalized program of cognitive functional therapy (CFT) found clinically significant improvements in pain-related activity and pain intensity compared to usual care. The treatment produced large benefits that were sustained over time, offering potential for major human and economic impact.
Researchers developed a novel framework using generative AI and musculoskeletal simulation to create synthetic gait data. This approach enables more robust and generalizable gait analysis across various patient populations and clinical environments.
Researchers developed a novel radioimmunotherapy that successfully eliminated cancer stem cells (CSCs) in preclinical models of ovarian cancer. The therapy, targeting CSC-associated biomarkers L1CAM + /CD133 + , showed significantly increased cytotoxicity compared to existing treatments.
A technology expert predicts AI-based medicine will revolutionise care for Alzheimer’s and diabetes, but access must be made available to all patients. The author highlights key innovations such as diagnostic imaging and surgical robots that will aid in more accurate diagnoses and treatments.
This article reviews bronchiectasis phenotypes and endotypes, exploring their impact on disease management and treatment strategies. Recent research has identified distinct inflammatory endotypes, guiding targeted therapies and improving patient outcomes through personalized approaches.
A large-scale study analyzing over 1 million individuals has identified 57 distinct genomic regions associated with 48 genes linked to stuttering. The findings suggest a shared genetic architecture with autism, depression, and musicality, providing a foundation for early identification and therapeutic advances in stuttering.
Researchers at The University of Osaka have developed a novel technology to unzip DNA's double helix structure, allowing for efficient and accurate genetic testing. The device uses a nano-sized platinum coil and precise heating to minimize DNA damage and read information from the DNA molecule.
New research highlights the transformative power of digital technology in shaping the e-patient era, enabling active participation and co-production in healthcare. Key technological innovations have built upon each other, providing patients with unprecedented tools for self-care and interaction with the healthcare system.
A study by Kaunas University of Technology reveals that digital mental health platform start-ups prioritize simple, scalable services and use subscription models to achieve success. State funding can hinder development rather than encouraging it to become a unicorn.
Researchers have identified a novel diagnostic tool that can predict patient outcomes for head and neck squamous cell carcinoma. The LIMA1-alpha protein reliably identifies patients who can be cured with surgery alone, avoiding unnecessary oncological treatments.
A new study reveals that the human gut microbiota can pinpoint an individual's city of residence with high accuracy, strongly linked to each city's characteristic diet. The researchers identified unique microbial signatures and interaction networks between cities in China, shedding light on how local environments shape our inner biology.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
Bioengineers at Harvard John A. Paulson School of Engineering and Applied Sciences have developed a computational model called BrainFlow that simulates cerebrospinal fluid flow in the presence of shunt implants, providing insight into optimal shunt design and placement for hydrocephalus patients.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers have developed a groundbreaking technique that maps temperature in three dimensions within biological tissue using invisible light and artificial intelligence. This new technology has the potential to improve early disease detection and treatment monitoring without the need for costly or invasive imaging technologies.
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
A survey from the Orlando Health Spine Center found that Americans often opt for short-term relief methods such as rest (44%), over-the-counter pain relievers (42%), and hot/cold therapies (29%) when dealing with neck and back pain. In contrast, only 5% consider surgery as a top option for pain relief.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
Recent studies have revealed significant improvements in patient prognosis for chronic thromboembolic pulmonary hypertension (CTEPH) over the past few decades. Advances in surgical techniques, drug development, and multimodal therapies have led to increased treatment rates and improved survival rates among patients.
The Mount Sinai Hospital has implemented the American Orthopaedic Association’s Own the Bone program to improve patient care for fragility fracture patients. The program offers a fracture liaison service to document and track individualized care, and incorporates 10 prevention measures to improve patient outcomes.
A special issue of Journal of Intensive Medicine provides key insights into selecting optimal non-invasive respiratory support strategies for AHRF, featuring review articles and original research. The collection offers guidance on the efficacy of HFNC, CPAP, NIV, and awake prone positioning to improve patient outcomes.
A study published in Neurobiology of Disease found that melanin degradation is impaired in genetically engineered mice lacking the SLC26A4 gene, leading to chronic inflammation and macrophage activation. The researchers propose a novel pathological cascade where melanin accumulation exacerbates hearing loss in pigmented individuals.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
Researchers discovered that slowing down intracellular transport of RNA-based drugs increases their effectiveness in treating genetic diseases. The study identified key genes involved in endosomal transport and found that selectively switching off a specific gene can prolong ASO residence time, boosting therapeutic efficacy.
A study by Carnegie Mellon University researchers found that the closures resulted in a 4% reduction in physicians per capita and declines in infant, non-infant, and total mortality rates. The Flexner Report era reforms led to significant changes in the US medical education landscape.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
A new gene therapy delivery device called NANOSPRESSO could revolutionize how hospitals treat rare diseases by allowing them to create personalized nanomedicines in-house. This democratized approach to precision medicine could boost access to low-cost bespoke gene and RNA therapies, especially in low-resource settings.
A new book written by an international team from Carnegie Mellon University and the University of Oxford argues that data-driven decision-making can improve healthcare outcomes. The authors explain how analytics can be used to optimize hospital operations, manage bed allocation, and improve treatment efficiency.
A new approach enables hospital pharmacists to rapidly create bespoke medicine cartridges for rare disease patients, boosting access to personalized treatment. The NANOSPRESSO platform could open up treatments for underfunded and underserved rare conditions worldwide.
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.
Current risk-based regulatory approaches to AI in healthcare fall short, ignoring individual patient preferences and potential for bias. Authors call for introduction of patient rights relating to AI-generated diagnosis or treatment planning to protect patients' autonomy and trust.
A new study found that over 1.74 million patients in Ontario are attached to family physicians aged 65 or older, with many having complex medical needs. The study highlights a decline in the number of early career physicians and an aging workforce nearing retirement.
The Association for Molecular Pathology publishes guidelines for detecting homologous recombination deficiency (HRD) in cancer. The report includes recommendations for clinical laboratories, addressing technical aspects of genomic instability and HRD analysis.
A dual-protective approach using Botox and an anti-nausea patch significantly reduces salivary gland toxicity in prostate cancer patients undergoing PSMA-targeted radiopharmaceutical therapy. This strategy led to a 30% decrease in PSMA uptake by the salivary glands without affecting the treatment's cancer-fighting efficacy.
Researchers at University of Cologne have discovered a previously unknown mechanism that explains why many patients with aggressive B-cell lymphoma don't respond to CAR-T cell therapy. Combining this innovative treatment with CSF1R inhibitors improves its effectiveness, according to the study published in Cancer Cell.
The Association for Molecular Pathology (AMP) has announced the election results for 2026-2027 leadership positions, including President-Elect Yassmine M.N. Akkari and Secretary-Treasurer Jonathan A. Nowak. The newly elected leaders will drive AMP's mission to advance molecular diagnostics.
Researchers have developed a test that can predict chemotherapy resistance in cancer patients, based on chromosomal instability signatures. This test has the potential to personalize treatment and reduce side effects for patients.
Researchers developed a dual-targeting radiopharmaceutical therapy that targets two key markers simultaneously, delivering radiation directly to tumors. The therapy showed strong and lasting uptake in tumors, allowing for high doses of targeted radiation to be delivered to cancer cells, resulting in 88.9% positive responses.
Researchers developed a new laboratory method that helps diagnose patients with suspected immune system disorders like activated-PI3Kδ syndrome (APDS). The method identified dozens of additional genetic variations associated with the condition, enabling rapid diagnosis and treatment. This breakthrough may also help identify more patien...
A new online toolkit developed by the University of Ottawa and Health Canada aims to educate healthcare providers on managing opioid-related issues. The toolkit's co-creation model involves patient input, leading to a deeper understanding of chronic pain and opioid use, and a more compassionate approach to care.
Mount Sinai Health System will participate at the 2025 Aspen Ideas: Health festival, discussing emerging science of aging and inflammation, and harnessing AI for healthcare innovation. The system will also provide complimentary dermatologic screenings for attendees.
Researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine aim to reduce falls and adverse drug events among older adults by using personalized approach tailored to individual genetic profiles.
A recent survey by Ateneo de Manila University researchers highlights the challenges faced by young Filipino nursing and medicine graduates in finding stable employment and meaningful roles. Many new graduates feel lost and unsupported, with restricted hiring rules and budget ceilings forcing them to take on multiple roles without addi...
The Human Exposome Moonshot initiative aims to map the physical, chemical, biological and psychosocial exposures driving 80% of chronic diseases. The exposome project integrates advanced technologies to create a comprehensive understanding of environmental influences on health.
New radioimmunotherapy approaches show promise against advanced breast cancer and prostate cancer. Additionally, new imaging tools enhance cancer detection and diagnosis, while a proposed standard improves lesion interpretation. Cost-effectiveness studies also support novel therapies for rare digestive cancers.
Researchers developed an AI model that uses real-time data to diagnose nystagmus, a condition linked to vestibular or neurological disorders. The system allows patients to record their eye movements using a smartphone and receive remote diagnostic analysis.
A global study by UniSA researchers found that 94% of people who use wearable activity trackers are open to sharing their health information with healthcare providers. This could lead to more personalized and responsive care. The demand for personalized healthcare is on the rise, and wearable activity tracker market is increasing.
The Ochsner Health system implements pharmacogenomics to fine-tune treatments based on individual genetic profiles, transforming patient care through personalized medicine. Pharmacists play a pivotal role in spearheading these innovations, overcoming barriers and maximizing impact.
A University of the Basque Country study found that Bilbao's urban elements significantly impact physical activity levels. Citizens prioritized green areas, multi-purpose facilities, and accessibility, highlighting the importance of proper management and maintenance. The research also emphasized the need for pedestrian-friendly infrast...
Researchers discovered biomarkers in gut bacteria and metabolites that can help diagnose and treat gastrointestinal diseases. The study found that certain biomarkers could predict multiple diseases, including gastric cancer and inflammatory bowel disease.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
The ISSCR has assembled an international consortium to support the adoption of human stem cell-derived disease models for drug discovery and development. This initiative aims to reduce R&D costs and accelerate therapy development, aligning with efforts by regulatory bodies such as the FDA, NIH, and European Commission.