Articles tagged with Vaccination
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Researchers analyzed vaccine failures and found that leaky vaccines lead to higher infection rates in the long run. The study also showed that all-or-nothing and waning vaccines have distinct dynamics following mass vaccination, providing an alternative explanation for disease resurgence.
Researchers have determined that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. This knowledge could help identify an earlier clinical outcome measure of disease severity, enabling doctors to provide more aggressive supportive care for patients.
Researchers have discovered that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. A new clinical parameter has been identified, which could help manage cases of yellow fever, allowing for earlier diagnosis and treatment.
Researchers created a 24-atom protein assembly that self-assembles into a porous molecular cube. This breakthrough could lead to the development of synthetic vaccines and targeted medicine delivery inside human cells. The discovery was made by UCLA biochemists led by Todd Yeates.
A national poll reveals that most parents want strong policies to ensure children in daycare are up-to-date on vaccines. In response to a scenario where 1 in 4 children were not vaccinated, 74% of parents would consider removing their child from the daycare.
A study of over 26,000 women found that Tdap vaccination during pregnancy was not associated with an increased risk of preterm delivery or small-for-gestational-age birth. However, a higher risk of chorioamnionitis was observed among vaccinated women.
A new pneumonia vaccine has led to a 27% decline in hospital admissions among children under 2 in Tennessee, with an overall 72% reduction since introduction of the first vaccine in 2000. The success of pneumococcal vaccines challenges common assumptions about antibiotic treatments for childhood pneumonia.
A new University of Michigan analysis reveals that less than half of Michigan birthing hospitals provide prevention information on their websites about Tdap vaccination and whooping cough. The Centers for Disease Control and Prevention recommends Tdap vaccination during pregnancy to protect newborns from this potentially deadly disease.
A non-injectable vaccine has been shown to provide long-term protection for non-human primates against the Ebola virus. The breathable vaccine overcomes logistical obstacles of storing and administering injectable vaccines in affected areas.
A nasal vaccine in development has been shown to provide long-term protection for non-human primates against the deadly Ebola virus. The vaccine platform has significant global implications in controlling future outbreaks, which could have a fatality rate as low as 25-90%.
Researchers highlight gaps in vaccination due to skepticism about childhood vaccines and international travel bringing measles into the country. Experts call for accessible vaccination and research on addressing public concerns about vaccine safety.
The International Union of Immunology Societies is urging urgent funding and implementation of Ebola vaccine trials. Several promising vaccine candidates, including Cad3 Ebola and rVSV-ΔG-ZEBOV, are being tested in phase 1 clinical trials, showing safe and efficient results in non-human primates.
A new vaccine is being developed to help smokers quit by blocking the physiological pleasure that nicotine elicits in the brain. The vaccine uses biodegradable nanoparticles to prevent nicotine molecules from entering the brain, reducing cravings and addiction.
The NIH is conducting an early phase trial to evaluate the VSV-ZEBOV vaccine candidate, which was developed by researchers at Canada's National Microbiology Lab. The trial will enroll 39 healthy adults aged 18-65 and assess the vaccine's safety and ability to generate an immune response.
A recent study published in JAMA Neurology found no long-term link between vaccine administration and the development of multiple sclerosis (MS) or other central nervous system demyelinating syndromes. However, a short-term increased risk was observed in younger patients, which may be attributed to existing disease.
A growing body of evidence links metal fumes to a heightened risk of bacterial lobar pneumonia in welders. New data shows welders are more than 3.5 times as likely to die from pneumococcal pneumonia compared to other workers.
Researchers discovered a paradoxical immune protein that both helps and hinders the immune system response, leading to increased susceptibility to rare bacterial infections and predisposition to autoimmune diseases. The protein ISG15 plays a crucial role in resolving inflammation and preventing autoinflammatory disorders.
Researchers at Case Western Reserve University are working on two projects to deliver protection from aggressive breast cancer and deadly heart attacks using plant viruses. The first project aims to create a vaccine that tricks the immune system into attacking HER2 proteins, while the second project targets blood clots by delivering cl...
Researchers developed stealthy nanoparticles that successfully deliver cancer vaccines to a subset of macrophages deep inside lymph nodes, hindering tumor growth. The nanoparticles bypass circulating immune cells and enter the lymph nodes' core, where they are engulfed by special kind of macrophage.
Researchers are developing a fingerprint-based recognition method to track vaccination schedules for infants and toddlers, increasing immunization coverage in developing countries. Fingerprints can accurately record immunizations, overcoming issues with lost or destroyed paper documents.
Researchers found Streptococcus pneumoniae physically damages the heart, leaving tiny lesions that can permanently scar the myocardium. A candidate vaccine has been developed to protect against this damage.
Neglected tropical diseases (NTDs) affect 14-15% of cases in Bolivia, Ecuador, Nicaragua, and Venezuela, despite the countries' small population. The US could work with these countries to implement disease control programs and develop lifesaving vaccines through joint efforts.
A mass dog vaccination program can stop agonizing rabies deaths worldwide by targeting the virus's primary source: dogs. By vaccinating 70% of dogs in high-risk areas, transmission from dogs to humans can be broken, leading to a significant decline in human cases.
Grand Challenges Canada announces $2.4 million in grants for 22 innovative projects addressing maternal, newborn and child health globally. These projects include programs improving infant nutrition, malaria diagnosis, and vaccine storage, as well as initiatives to combat iron deficiency and improve access to healthcare.
Researchers have identified a better measure of predicting cancer neoepitopes, which are specific protein sequences recognized by immune cells. This new approach has the potential to improve current methods for generating anticancer vaccines, increasing their effectiveness in combating cancer.
Researchers at LA BioMed are developing a vaccine to protect patients from healthcare-related infections such as Candida and MRSA. The NIH grant will support the study of samples from patients enrolled in an ongoing clinical trial to assess the efficacy of the vaccine.
A study found that measles illness lasts for almost 14 days and causes people to miss nearly 10 days at work or school on average. The analysis also showed that the average number of quality-adjusted life years (QALYs) lost due to measles is 0.019 per patient, equivalent to 6.9 QALYs.
Researchers have successfully tested a new vaccine regimen that provides rapid protection against Ebola virus in monkeys, with some animals remaining protected for up to 10 months after vaccination. The experimental ChAd3 Ebola vaccine demonstrated strong immune responses in both single-dose and prime-boost regimens.
A study from the University of Sydney reveals a 61% decrease in genital wart management among young women since the introduction of the free HPV vaccination program. The vaccine has been effective in reducing genital warts and their treatment costs, with no significant change in other sexually transmitted infections.
Researchers at Technical University of Munich have discovered a new site where T lymphocytes can be programmed to attack pathogens. The liver plays a key role in this process, and synthetic messenger Hyper-IL-6 has been found to efficiently activate T cells, offering a promising new adjuvant for vaccine formulations.
A new vaccine candidate, GP2, has shown a 57% reduction in recurrence rates among high-risk breast cancer patients. The vaccine targets CD8+ cells and was combined with an immune stimulant to enhance its effectiveness.
A blend of three monoclonal antibodies has been shown to protect monkeys against a lethal dose of Ebola virus for up to 5 days after infection. This treatment, ZMAPP, was found to be effective in a study published in Nature.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched an initial human safety study for an Ebola vaccine candidate. The trial is the first in a series of Phase 1 clinical trials that will examine the investigational NIAID/GSK Ebola vaccine, which is designed to induce an immune response in healthy adults.
A CU Denver study reveals that vaccine refusal is more common among children from higher-income families with educated mothers. These parents often rely on alternative practices like breastfeeding and social monitoring to prevent disease, rather than vaccinations. In contrast, lower-income families face barriers to accessing healthcare...
A new report by Princeton University researchers suggests that expanding the age of eligibility for measles vaccination from 12 to 15 months could significantly increase coverage in Africa. The study found that increasing the age range would have the most impact on countries with high rates of unvaccinated children.
The 2009 H1N1 outbreak at Washington State University provided valuable data for researchers to study the rapid spread of the virus. A computer model revealed that only a few initial infected individuals sparked the outbreak, with a high transmissibility rate among close-knit student communities.
Two commentaries in Annals of Internal Medicine emphasize the need for immediate Ebola vaccine deployment and cautious approach to containment plans. The authors argue that safety risks from vaccines are negligible compared to healthcare worker risks, while excessive measures can foster mistrust and increase risk.
A new vaccine, rBCG30, offers superior protection against tuberculosis in animal models and cross-protection against leprosy. Boosting rBCG30 with the Antigen 85B protein significantly enhances its effectiveness against leprosy.
Researchers found that personal biases and communication styles of providers played a significant role in decreasing HPV vaccination rates among teens. Providers who believed their patients were at low risk for sexual activity delayed vaccine administration, often without readdressing the decision.
Two new vaccines have been shown to prevent the transmission of meningitis bacteria from person to person, reducing carriage rates by up to 39% and 20-30%. This discovery could provide a degree of herd protection against meningitis if implemented in a campaign.
A new experimental chikungunya vaccine performed well in an early clinical trial, eliciting neutralizing antibodies in all participants and providing durable protection for at least 11 months. The vaccine, a virus-like particle (VLP) vaccine, was delivered without an adjuvant and prompted a robust immune response.
A new virus-like particle vaccine has shown promising results in a human trial, generating antibodies that provide long-term protection against chikungunya. The vaccine, composed of non-infectious VLP particles, was well-tolerated and effective across different doses.
The HPV vaccine has resulted in a dramatic drop in genital warts among young Australians, with a 90% decrease in girls aged 12-17 and a 73% decrease in women between 18-26. The vaccine also showed an indirect protective effect among young men, leading to a 38% drop in genital warts.
A Kaiser Permanente study found that older adults vaccinated against shingles are 42% less likely to develop the disease after undergoing chemotherapy. The vaccine also prevented hospitalizations for shingles among vaccinated patients, highlighting its importance in preventing long-term complications.
The BCG vaccine has a 60-80% protective efficacy against severe forms of tuberculosis in children. Research found that the vaccine is effective against TB infection, with a 19% effectiveness rate among vaccinated children after exposure.
The study found that the HPV vaccine Cervarix provided 100% protection against HPV-16/18 infections over a period of 9.4 years, with high and sustained levels of IgG antibodies observed. The results suggest that the vaccine offered excellent persistence of protective immunity.
A new C. difficile vaccine has been shown to be 100 percent effective in protecting animal models from the deadly intestinal disease caused by Clostridium difficile. The vaccine protects against bacterial toxins and could prevent deadly complications such as severe diarrhea and bowel perforation.
A dedicated website for the MMR vaccine is proposed as a simple yet effective way to boost vaccination rates. The study found that providing parents with online information reduces concerns and is more cost-effective than traditional methods like leaflets or face-to-face consultations.
A website providing information on the measles, mumps and rubella (MMR) vaccine is the most cost-effective way to increase its uptake, with a potential saving of £9.20 per vaccination for the NHS. This method is also more convenient for parents seeking additional information about the vaccine.
A study found that minority women who received HPV vaccination even after becoming sexually active had lower rates of abnormal Pap test results. The study suggests that incomplete HPV vaccination may still offer some protection against cervical cancer and its precursors.
A new vaccine developed by researchers at the University of Iowa reduces lung inflammation caused by dust-mite allergens in both lab and animal tests. The vaccine uses a booster called CpG to alter the body's immune response, producing antibodies that dampen the damaging effects of dust-mites.
Researchers from NYU Langone will present new findings on tau immunotherapy and its potential for treating Alzheimer's disease. The presentations focus on the role of mitochondria and death receptors in amyloid toxicity, which may lead to improved treatment options for patients.
A novel AD vaccine, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG, was administered via nasal mucosal inhalation to AD transgenic mouse models, producing strong T helper 2 humoral immune responses and reducing Aβ1-42-induced cytotoxicity. This approach offers a promising therapeutic strategy for Alzheimer's disease.
A recent study of over 500,000 Danish women found no increased risk of venous thromboembolism following quadrivalent HPV vaccination. The research, published in JAMA, used data from national registers to evaluate the potential link between the vaccine and blood clots.
A survey of 1,000 incoming Grand Valley State University students found that moral or religious beliefs were the primary obstacle to receiving the Human Papillomavirus (HPV) vaccine. The study, led by graduate physician assistant researchers, aimed to understand the influence of media on HPV and vaccine compliance.
Endemic infectious diseases continue to affect millions of individuals in the US, with racial and ethnic minorities disproportionately affected. Emerging vector-borne and zoonotic disease infections are threatening new areas and populations.
Scientists expect progress in developing an effective TB vaccine, with Phase IIa clinical trials underway. The new vaccine aims to activate both killer and helper cells for improved immune response.
A study found that a fifth of UK school age children visiting their doctor with a persistent cough could have whooping cough, even if they have been fully vaccinated. The research suggests that an adolescent booster vaccination is needed to protect against pertussis infection.
Researchers developed a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, reprogramming these intractable cancers. The vaccine, GVAX, consists of irradiated tumor cells modified to recruit immune cells, and boosted activity of molecular mechanisms that inhibit cancer-fighting immune cells.
Pertussis cases are rising globally, with an estimated 50 million cases and 300,000 deaths worldwide. Nurses can educate patients and the public on the importance of follow-up booster vaccinations to maintain immunity. Partnerships between healthcare organizations, schools, and communities can also help increase vaccination rates.