Articles tagged with Vaccination
Researchers found that carbohydrate polymers control the physical behavior of vaccines and provide a protective cloud against protein denaturation. The conjugates were over 50 times larger than the protein, with flexible properties that retained the highly flexible nature of the carbohydrates.
Two investigational vaccines against Ebola virus disease induced an immune response among 1,000 participants in the Phase 2 PREVAIL I trial. The cAd3-EBOZ and rVSV-ZEBOV vaccines were well-tolerated and elicited measurable and demonstrable antibodies, respectively.
A new Penn study reveals that fish induce production of a specific antibody, IgT, in response to pathogen exposure on their gills. The researchers found that IgT coats the microbiota in the gills, helping control the community of friendly microbes.
A new vaccination scheme is projected to reduce the frequency of Hand, Foot, and Mouth Disease (HFMD) in China. The study suggests that serotype replacement will not significantly impact the benefits of a HFMD vaccination campaign, with cross-protection lasting an average of 6.77 weeks.
Researchers present an experimental Ebola vaccine with 100% efficacy against the virus in West Africa and propose a novel vaccination strategy using ring vaccination. This innovative approach could be adapted to combat other emerging threats like Zika virus.
University of Leeds researchers will run computer software to identify compounds that could be the basis of antivirals for Ebola. The project focuses on finding effective anti-viral drugs, as vaccines are not yet available to treat infected patients.
Development assistance for vaccines in low- and middle-income countries increased from $822m in 2000 to $3.6bn in 2014, driven by the creation of Gavi and US/UK contributions.
Researchers at Columbia University's Mailman School of Public Health review vaccination policies, finding that states like Mississippi and West Virginia have high immunization rates with strict exemption laws. The authors suggest alternatives to eliminating nonmedical exemptions entirely, including making them more difficult to obtain.
A Kaiser Permanente study found moderate protection against whooping cough during the first year after vaccination, but effectiveness dwindles to less than 9% after four years among teenagers vaccinated with newer acellular pertussis vaccine as infants and children. Targeted rounds of vaccination may be necessary for adolescents.
A study by the University of Pennsylvania School of Nursing found that voucher promotions and celebrity PSAs did not increase Tdap vaccination among caregivers. The researchers discovered that financial barriers were a significant factor, but so were perceptions about the risk and severity of whooping cough.
UC Davis researchers have created virus-like particles based on Hepatitis E proteins to target breast cancer. These particles can carry vaccines or drugs, potentially delivered through food or drink.
A new study found that 75% of vaccine-related posts on Pinterest are negative towards vaccination, highlighting the need for better communication about vaccination. The researchers argue that institutions need to value public engagement and advocacy to effectively promote vaccines.
Researchers at Colorado State University are developing a multiplayer game to plan for disease outbreaks. The game uses powerful software to predict and analyze the severity of an outbreak, providing real-time visualizations such as heat maps of potential danger zones.
A follow-up study found most vaccinated children maintained anti-hepatitis A antibodies until age 15-16 years, suggesting protection for at least 30 years. The findings support current US vaccine recommendations and do not require booster doses.
Researchers show that large groups of people sharing in a conspiracy will very quickly give themselves away, using equation to estimate time before exposure. For instance, moon landing hoax would be revealed in just 3 years and 8 months.
Human monoclonal antibodies isolated from Ebola survivors can neutralize multiple species of the virus, including Bundibugyo, Sudan, and Zaire viruses. These findings suggest a common therapeutic or vaccine strategy could solve all Ebola viruses.
Researchers have found a link between the chickenpox and shingles vaccine and corneal inflammation in rare instances. Primary care physicians should discuss this potential side effect with susceptible patients before vaccination.
A new study published in Nature Communications has identified predictors and response mechanisms to the hepatitis B vaccine. Researchers found that elevated levels of inflammatory response transcripts correlate with weaker responses, while augmented B-cell responses are linked to stronger reactions.
BioMARC, a high-containment biopharmaceutical unit at CSU, has been awarded $4.6 million to develop and manufacture vaccines for three additional viruses causing severe long-term disease. The facility will produce vaccines using VRP technology, which works to better immunize individuals.
A large-scale clinical trial has been launched in Brazil to evaluate a candidate vaccine for dengue fever, which affects half the world's population and causes 500,000 hospitalizations annually. The vaccine, TV003, aims to prevent the mosquito-borne illness with a robust antibody and cellular immune response.
A $3.82 million NIH grant will prepare the Schistosomiasis Vaccine (SchistoShield) for human clinical trials, aiming to reduce infections in millions worldwide. The vaccine has potential impact on up to one billion people and is part of a broader research effort with over $11.5 million in total funding.
Researchers developed a vaccine effective in protecting dromedaries against MERS-CoV, reducing nasal excretion and transmission. Vaccination may also protect humans at high risk of infection, but further studies are needed to determine duration of protection.
Researchers have developed a new vaccine candidate that significantly reduces the virus load in infected camels, offering a promising method to prevent human infections. The vaccine also provides dual activity, protecting camels from another disease similar to smallpox.
A US$200,000 grant from the Bill & Melinda Gates Foundation will support the development of a one-shot vaccine for tapeworms, reducing deaths from neurocysticercosis in developing countries. The vaccine aims to break the lifecycle of the parasite, causing brain cysts and seizures.
The La Jolla Institute will characterize immune responses to dengue virus and Mycobacterium tuberculosis with the HIPC grant. The research aims to identify effective gene signatures for vaccines against these diseases, which are major global health challenges.
Recent studies identified five distinct lineages of MERS-CoV in camels, with low barrier for interspecies transmission. A vaccine was found to be effective in preventing clinical symptoms and reducing virus levels in vaccinated camels.
A Kaiser Permanente study found that elderly patients with end-stage renal disease who received the shingles vaccine were half as likely to develop shingles. The vaccine was most effective when given shortly after beginning dialysis, reducing the risk by nearly 70%.
A study found a transient increased risk of ischemic stroke and myocardial infarction after herpes zoster diagnosis, peaking within the first week. The risk gradually decreased over six months.
A £5.7 million grant from the Biotechnology and Biological Sciences Research Council (BBSRC) will support the development of cheap and effective vaccines for poultry. The project aims to reduce infections in humans and minimize antibiotics in the food chain, with potential applications for cattle, sheep, and goats.
Researchers have found novel mechanisms to inhibit chikungunya virus at multiple stages of infection, including entry and release from cells. The discovery could lead to the development of a single vaccine that protects against multiple alphaviruses.
The article provides recommendations for primary care physicians to screen for mental health issues in Syrian refugees, such as anxiety and post-traumatic stress disorder. It also highlights the importance of vaccinations, including measles, mumps, and rubella, as well as screening for chronic Hepatitis B and tuberculosis.
A study in Tanzania found that using incentives increased dog vaccination turnout by 34 dogs per village, while a household questionnaire underestimated coverage by 6.6%. The researchers recommend using incentives and the questionnaire as a reliable method to assess post-vaccination coverage.
A Phase 2 clinical trial is underway to test a chikungunya vaccine in 400 healthy adult volunteers. The trial aims to assess the safety and immune response of the vaccine, which has shown promising results in previous studies.
A recent study by the CDC and University of Georgia found that 75% of first-time expectant mothers planned to follow the recommended childhood immunization schedule. Most undecided mothers had low levels of confidence in vaccines, suggesting targeted outreach may be needed.
A content analysis of nearly 500 anti-vaccination websites found that over two-thirds used misinformation and pseudoscience to claim vaccines are dangerous. The sites also promoted positive behaviors like eating healthy and breastfeeding, often using these tactics to sway vaccine-hesitant parents.
Research by University of Colorado School of Medicine faculty found that one in five pediatricians dismiss families who refuse vaccines. The study suggests that states with philosophical exemption laws and easier exemption processes have lower vaccination rates and higher rates of vaccine-preventable diseases.
A Cancer Research UK survey found that around 20% of unvaccinated ethnic school girls believe they don't need the HPV vaccine. Reasons cited include lack of sexual activity and perceived side effects, highlighting barriers to vaccination uptake.
Saint Louis University's Vaccine and Treatment Evaluation Unit will study the safety and effectiveness of vaccines using omics technologies, including transcriptomics, proteomics, lipidomics, and metabolomics. The research aims to understand the immune system's response to infectious diseases.
Researchers have developed a new way to enhance the effectiveness of antigen-based vaccines by mimicking the natural arrangement of multiple TLR agonists. This triply-linked activator more effectively triggers an immune response than mixing individual components, paving the way for improved vaccine design.
A new study by the American Academy of Pediatrics found that nearly three-quarters of mothers and fathers start developing vaccine preferences for their newborns before they know they are having a baby. Parents who were more educated and had previously discussed vaccines with their partner were more likely to form these early preferences.
A study found that many pediatricians and primary care physicians report communicating about HPV vaccination in ways that discourage parents from getting their children vaccinated. The researchers recommend improving communication practices, such as recommending HPV vaccination for all 11- to 12-year-olds and suggesting same-day vaccin...
Researchers at Boston Medical Center have been awarded a $1.04 million grant to expand an education-based pilot program improving communication between pediatric physicians and their patients about the Human Papillomavirus (HPV) vaccine. The intervention has shown significant increases in HPV vaccination rates among pilots.
A study examining the safety of Tdap vaccination in pregnant women found no significant differences in acute adverse events or adverse birth outcomes between those vaccinated recently and those not. The researchers' findings provide reassurance for patients and clinicians regarding the use of Tdap vaccine during pregnancy.
Researchers at Duke Medicine have discovered that rhesus monkeys can transmit the virus across the placenta to their unborn offspring, establishing a first primate model to study mother-to-fetus CMV infections. The discovery aims to spur development of potential vaccine approaches against congenital CMV infections.
The Global Health Vaccine Center of Innovation (GHVCI) aims to accelerate vaccine development and make vaccines more accessible globally. The GHVCI combines IDRI's vaccine design technologies with Sanofi Pasteur's expertise in vaccine development, formulation, and production.
Researchers at Tulane National Primate Research Center are working on a new tuberculosis vaccine by modifying Mycobacterium tuberculosis to lose stress response gene SigmaH. Monkeys vaccinated with the modified strain showed better resistance to infection and protective immune responses in their lungs.
A recent study found that over half of eligible Americans visiting a travel clinic did not receive the recommended measles vaccine, putting them at risk for infection. Vaccination is also essential for preventing hepatitis A outbreaks in areas with inadequate sanitation, such as Mexico's Tulum resort destination.
A new review of the literature identifies four types of people who decide not to vaccinate due to issues of complacency, convenience, confidence, and calculation. Strategies include increasing awareness about vaccine effectiveness, debunking myths, and adding incentives for calculating individuals.
Researchers at University of Zurich and University Hospital Zurich develop new treatment methods for rare brain disease PML. A vaccine against the disease could be developed using specific antibodies that recognize the most important mutants of the JC virus.
Researchers at Scripps Florida Institute have been awarded $6 million to develop an innovative HIV/AIDS vaccine that has shown promise in animal models. The approach works by blocking key sites on the virus's surface, preventing it from attaching and invading human immune cells.
Researchers uncover interesting revelations about the vaccinia virus through DNA sequencing data and historical accounts. The study suggests that the Brazilian VACV-IOC strain may have originated from a French Beaugency strain, challenging previous assumptions.
Researchers mapped antigenic differences in dengue virus strains, finding overlap among previously thought distinct groups. The findings suggest a continuum rather than separate groups, making vaccine development harder.
In a clinical trial, a genetically engineered vaccine successfully eradicated high-grade precancerous cervical lesions in 48.2% of women who received the vaccine, compared to 30% of those who received saline injections. The vaccine also cleared the virus from the cervixes of 56 women, reducing the risk of cancer recurrence.
A systematic review of animal studies on MVA85A vaccine found insufficient evidence to support its effectiveness as a BCG booster. The delay in publishing the largest monkey trial with the longest follow-up also raised concerns about scientific integrity.
The American College of Physicians recommends policies for the use of telemedicine in primary care settings, aiming to improve access to care while balancing benefits and risks. The position paper offers more than a dozen policy statements and recommendations for utilization and reimbursement.
Researchers at VIB discovered that exposure to farm dust reduces the severity of allergic reactions in mice. In humans, a deficiency in the protective protein A20 is found in those who suffer from allergies and asthma. The study paves the way for the development of an asthma vaccine.
A new modeling study suggests that a single dose of cholera vaccine could be as effective as the traditional two-dose regimen in preventing deaths. The researchers estimate that a one-dose campaign reaching half the population would have averted over 78,000 cases and prevented 738 deaths.
A new minimally invasive vaccine combines cancer cells with immune-enhancing factors, evoking an immune response in a simpler and more economical way. The approach has shown promising results in experimental animal models, shrinking tumors and protecting animals from tumor growth.
A mathematical model shows that using one dose of the oral cholera vaccine can prevent more cases and save more lives than the recommended two doses, especially in crisis situations. The study found that a single dose could protect more people in the long run and improve herd immunity.
Scientists have finally understood the structure of a flexible plant virus that has resisted description for over 75 years, revolutionizing efforts to stop such viruses and potentially leading to new vaccine delivery methods.