Articles tagged with Vaccination
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A new study reveals that laboratory mice infected with common human viruses develop an immune system similar to newborn humans, but unlike adult humans. This finding suggests that the lack of infection may be a reason why research mice differ from humans.
A new mouse model developed by researchers at the University of Wisconsin-Madison School of Veterinary Medicine enables the study of Zika virus infection and its effects on the brain. The model, which lacks key immune system components, allows for the testing of vaccines and antivirals against the virus.
A phase 1 trial evaluated two candidate Ebola vaccines, Ad26.ZEBOV and MVA-BN-Filo, in healthy volunteers. The study found that immunization with Ad26.ZEBOV generated an initial immune response and sustained elevation of specific immunity, suggesting partial protection against Ebola.
An immunization regimen using two Ebola vaccine candidates was found to be safe and well-tolerated, inducing an immune response in healthy adult volunteers. The study's results suggest that the vaccines could provide durable protection against Ebola, which is essential for areas with intermittent outbreaks.
Scientists at the University of Wisconsin-Madison have created a mouse model to study Zika virus, allowing researchers to test vaccines and antivirals while understanding the virus's effects on human brains. The model, lacking key immune system defenses, shows the virus causes severe pathology in brain tissue.
A new HPV vaccine could significantly reduce cervical cancer incidence by 73% and healthcare costs if states coordinate policies to improve coverage. Increased funding can lead to improved vaccine coverage and public health.
Scientists at Oxford University have identified biomarkers that could indicate TB risk and provide clues to assess the effectiveness of potential new vaccines. The discovery was made using immune correlates, also known as biomarkers, which can be measured in the blood.
A mobile-phone-based system is demonstrating huge potential for improving public health service delivery in resource-poor settings. The system has facilitated ongoing data collection, greatly improving data quality, timeliness, and cost-effectiveness.
A recent study found that HPV vaccination stimulates robust immune responses in girls and young women with chronic kidney disease and dialysis, but less optimal responses among those with a kidney transplant. This highlights the need for additional research to protect kidney transplant recipients from HPV infections.
A vaccine developed for smallpox improved lung function in a mouse model of idiopathic pulmonary fibrosis by inducing resident memory CD4+ T cells. This immune response was associated with reduced fibrosis and increased survival rates.
The NIH has awarded six grants to study the molecular mechanisms behind combination vaccine adjuvants, which improve vaccine effectiveness and could lead to new treatments for diseases like HIV and tuberculosis. Researchers will explore how individual adjuvants work in combination and how synergies between them can be optimized.
Researchers at McMaster University have identified a critical step in the immune system's recognition of DNA viruses, which could lead to vaccinations for herpes, the common cold, and even cancer. The discovery involves an interaction between proteins S6K1 and STING that triggers antiviral responses.
A novel vaccine strategy has been developed to provide both short-term and long-term protection against the Chikungunya virus. The strategy combines a non-viral, vector-based monoclonal antibody delivery method with a DNA-based vaccine approach.
A team of UCI scientists led by Philip Felgner has received $8 million to develop a new vaccine for Q fever, a highly infectious agent considered a potential bioterrorism weapon. The vaccine aims to mitigate severe side effects of the current vaccine and is expected to be safer and more effective.
Researchers at UTMB have developed a new mouse model for Zika infection, removing a bottleneck in preclinical testing. The model is available for immediate screening of antivirals and vaccine candidates.
Researchers at Oregon Health & Science University recommend revisiting current adult vaccination schedule due to long-lasting immunity against tetanus and diphtheria. A revised 30-year schedule could reduce healthcare costs by two-thirds, saving approximately $280 million annually.
Researchers analyzed numerous studies and reports to find that unvaccinated individuals comprised a substantial proportion of cases in measles and pertussis outbreaks. Vaccine refusal was associated with an elevated risk for measles and pertussis, even among fully vaccinated individuals.
A new study found that conflicting expectations between parents and medical providers about scheduling follow-up appointments is the most common reason for patients not completing the HPV vaccine series. Researchers suggest improving education and dialogue between providers and parents to increase vaccination completion rates.
Researchers from Penn Medicine warn that labelling public health initiatives as 'natural' could lead to harmful decision-making by some parents. They argue that this messaging undermines important health practices, such as childhood vaccination.
Researchers developed a nanoparticle technology called Salipro to stabilize membrane proteins in a lipid environment, allowing for high-resolution studies of their structure and function. This enables the discovery of new drugs, therapeutic antibodies, and vaccines targeting these proteins.
Researchers found that carbohydrate polymers control the physical behavior of vaccines and provide a protective cloud against protein denaturation. The conjugates were over 50 times larger than the protein, with flexible properties that retained the highly flexible nature of the carbohydrates.
Two investigational vaccines against Ebola virus disease induced an immune response among 1,000 participants in the Phase 2 PREVAIL I trial. The cAd3-EBOZ and rVSV-ZEBOV vaccines were well-tolerated and elicited measurable and demonstrable antibodies, respectively.
A new Penn study reveals that fish induce production of a specific antibody, IgT, in response to pathogen exposure on their gills. The researchers found that IgT coats the microbiota in the gills, helping control the community of friendly microbes.
A new vaccination scheme is projected to reduce the frequency of Hand, Foot, and Mouth Disease (HFMD) in China. The study suggests that serotype replacement will not significantly impact the benefits of a HFMD vaccination campaign, with cross-protection lasting an average of 6.77 weeks.
Researchers present an experimental Ebola vaccine with 100% efficacy against the virus in West Africa and propose a novel vaccination strategy using ring vaccination. This innovative approach could be adapted to combat other emerging threats like Zika virus.
University of Leeds researchers will run computer software to identify compounds that could be the basis of antivirals for Ebola. The project focuses on finding effective anti-viral drugs, as vaccines are not yet available to treat infected patients.
Development assistance for vaccines in low- and middle-income countries increased from $822m in 2000 to $3.6bn in 2014, driven by the creation of Gavi and US/UK contributions.
Researchers at Columbia University's Mailman School of Public Health review vaccination policies, finding that states like Mississippi and West Virginia have high immunization rates with strict exemption laws. The authors suggest alternatives to eliminating nonmedical exemptions entirely, including making them more difficult to obtain.
A Kaiser Permanente study found moderate protection against whooping cough during the first year after vaccination, but effectiveness dwindles to less than 9% after four years among teenagers vaccinated with newer acellular pertussis vaccine as infants and children. Targeted rounds of vaccination may be necessary for adolescents.
A study by the University of Pennsylvania School of Nursing found that voucher promotions and celebrity PSAs did not increase Tdap vaccination among caregivers. The researchers discovered that financial barriers were a significant factor, but so were perceptions about the risk and severity of whooping cough.
UC Davis researchers have created virus-like particles based on Hepatitis E proteins to target breast cancer. These particles can carry vaccines or drugs, potentially delivered through food or drink.
A new study found that 75% of vaccine-related posts on Pinterest are negative towards vaccination, highlighting the need for better communication about vaccination. The researchers argue that institutions need to value public engagement and advocacy to effectively promote vaccines.
Researchers at Colorado State University are developing a multiplayer game to plan for disease outbreaks. The game uses powerful software to predict and analyze the severity of an outbreak, providing real-time visualizations such as heat maps of potential danger zones.
A follow-up study found most vaccinated children maintained anti-hepatitis A antibodies until age 15-16 years, suggesting protection for at least 30 years. The findings support current US vaccine recommendations and do not require booster doses.
Researchers show that large groups of people sharing in a conspiracy will very quickly give themselves away, using equation to estimate time before exposure. For instance, moon landing hoax would be revealed in just 3 years and 8 months.
Human monoclonal antibodies isolated from Ebola survivors can neutralize multiple species of the virus, including Bundibugyo, Sudan, and Zaire viruses. These findings suggest a common therapeutic or vaccine strategy could solve all Ebola viruses.
Researchers have found a link between the chickenpox and shingles vaccine and corneal inflammation in rare instances. Primary care physicians should discuss this potential side effect with susceptible patients before vaccination.
A new study published in Nature Communications has identified predictors and response mechanisms to the hepatitis B vaccine. Researchers found that elevated levels of inflammatory response transcripts correlate with weaker responses, while augmented B-cell responses are linked to stronger reactions.
BioMARC, a high-containment biopharmaceutical unit at CSU, has been awarded $4.6 million to develop and manufacture vaccines for three additional viruses causing severe long-term disease. The facility will produce vaccines using VRP technology, which works to better immunize individuals.
A large-scale clinical trial has been launched in Brazil to evaluate a candidate vaccine for dengue fever, which affects half the world's population and causes 500,000 hospitalizations annually. The vaccine, TV003, aims to prevent the mosquito-borne illness with a robust antibody and cellular immune response.
A $3.82 million NIH grant will prepare the Schistosomiasis Vaccine (SchistoShield) for human clinical trials, aiming to reduce infections in millions worldwide. The vaccine has potential impact on up to one billion people and is part of a broader research effort with over $11.5 million in total funding.
Researchers developed a vaccine effective in protecting dromedaries against MERS-CoV, reducing nasal excretion and transmission. Vaccination may also protect humans at high risk of infection, but further studies are needed to determine duration of protection.
Recent studies identified five distinct lineages of MERS-CoV in camels, with low barrier for interspecies transmission. A vaccine was found to be effective in preventing clinical symptoms and reducing virus levels in vaccinated camels.
Researchers have developed a new vaccine candidate that significantly reduces the virus load in infected camels, offering a promising method to prevent human infections. The vaccine also provides dual activity, protecting camels from another disease similar to smallpox.
A US$200,000 grant from the Bill & Melinda Gates Foundation will support the development of a one-shot vaccine for tapeworms, reducing deaths from neurocysticercosis in developing countries. The vaccine aims to break the lifecycle of the parasite, causing brain cysts and seizures.
The La Jolla Institute will characterize immune responses to dengue virus and Mycobacterium tuberculosis with the HIPC grant. The research aims to identify effective gene signatures for vaccines against these diseases, which are major global health challenges.
A study found a transient increased risk of ischemic stroke and myocardial infarction after herpes zoster diagnosis, peaking within the first week. The risk gradually decreased over six months.
A Kaiser Permanente study found that elderly patients with end-stage renal disease who received the shingles vaccine were half as likely to develop shingles. The vaccine was most effective when given shortly after beginning dialysis, reducing the risk by nearly 70%.
A £5.7 million grant from the Biotechnology and Biological Sciences Research Council (BBSRC) will support the development of cheap and effective vaccines for poultry. The project aims to reduce infections in humans and minimize antibiotics in the food chain, with potential applications for cattle, sheep, and goats.
Researchers have found novel mechanisms to inhibit chikungunya virus at multiple stages of infection, including entry and release from cells. The discovery could lead to the development of a single vaccine that protects against multiple alphaviruses.
The article provides recommendations for primary care physicians to screen for mental health issues in Syrian refugees, such as anxiety and post-traumatic stress disorder. It also highlights the importance of vaccinations, including measles, mumps, and rubella, as well as screening for chronic Hepatitis B and tuberculosis.
A study in Tanzania found that using incentives increased dog vaccination turnout by 34 dogs per village, while a household questionnaire underestimated coverage by 6.6%. The researchers recommend using incentives and the questionnaire as a reliable method to assess post-vaccination coverage.
A Phase 2 clinical trial is underway to test a chikungunya vaccine in 400 healthy adult volunteers. The trial aims to assess the safety and immune response of the vaccine, which has shown promising results in previous studies.
A recent study by the CDC and University of Georgia found that 75% of first-time expectant mothers planned to follow the recommended childhood immunization schedule. Most undecided mothers had low levels of confidence in vaccines, suggesting targeted outreach may be needed.
A content analysis of nearly 500 anti-vaccination websites found that over two-thirds used misinformation and pseudoscience to claim vaccines are dangerous. The sites also promoted positive behaviors like eating healthy and breastfeeding, often using these tactics to sway vaccine-hesitant parents.
Research by University of Colorado School of Medicine faculty found that one in five pediatricians dismiss families who refuse vaccines. The study suggests that states with philosophical exemption laws and easier exemption processes have lower vaccination rates and higher rates of vaccine-preventable diseases.
A Cancer Research UK survey found that around 20% of unvaccinated ethnic school girls believe they don't need the HPV vaccine. Reasons cited include lack of sexual activity and perceived side effects, highlighting barriers to vaccination uptake.
Saint Louis University's Vaccine and Treatment Evaluation Unit will study the safety and effectiveness of vaccines using omics technologies, including transcriptomics, proteomics, lipidomics, and metabolomics. The research aims to understand the immune system's response to infectious diseases.
Researchers have developed a new way to enhance the effectiveness of antigen-based vaccines by mimicking the natural arrangement of multiple TLR agonists. This triply-linked activator more effectively triggers an immune response than mixing individual components, paving the way for improved vaccine design.
A new study by the American Academy of Pediatrics found that nearly three-quarters of mothers and fathers start developing vaccine preferences for their newborns before they know they are having a baby. Parents who were more educated and had previously discussed vaccines with their partner were more likely to form these early preferences.