Articles tagged with Cardiovascular Disease
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UC Riverside discovered that female mice secrete more RELMalpha, an immune protein, which protects them against obesity and inflammation. In contrast, male mice have lower levels of RELMalpha, leading to increased inflammation and obesity.
A vegetarian diet has been shown to modestly but significantly improve cardiometabolic outcomes in people at high risk of cardiovascular disease. This finding suggests that vegetarian diets could be a useful addition to standard pharmacological therapy for primary prevention.
A new study published in Radiology found that AI can use data from low-dose CT scans of the lungs to improve risk prediction for death from various causes. The study used data from over 20,000 individuals and found that body composition measurements derived from lung screening LDCT were strong predictors of mortality.
The American College of Physicians recommends a federal pandemic preparedness plan, prioritizing health equity and real-time data sharing. ACP also calls for bolstering healthcare supply chains and supporting medical practices during emergencies.
Researchers at EMBL Heidelberg discovered that mutations in the RBM20 gene cause familial DCM by disrupting normal RNA splicing, leading to detrimental cytoplasmic granules. Targeted gene editing via CRISPR-Cas9 and restoring nuclear localisation of RBM20 could improve therapy options for patients.
The July issue of CHEST journal features 49 articles on clinically relevant topics, including disability rights and life-sustaining treatment. The journal offers complementary web resources, such as visual abstracts, to expand the reach of its research.
Dr. Eric Lazartigues has been recognized for his groundbreaking research on salt-sensitive hypertension and the role of the brain renin-angiotensin system in regulating blood pressure. His work has led to a deeper understanding of hypertension's impact on cardiovascular diseases and mortality.
The American Heart Association and the American College of Cardiology recommend a heart-healthy diet and lifestyle to prevent worsening health in people with chronic coronary disease. Clinicians should coordinate care between cardiovascular and primary care professionals, emphasizing team-based approach and social determinants of health.
Researchers at the Medical University of South Carolina have identified a novel class of compounds that effectively lower cholesterol, triglycerides and apoB in human liver-like cells. These molecules work independently of the LDLR pathway and offer a new treatment regimen for patients with familial hypercholesterolemia.
A study published in Science reveals that ganglia in the neck region are responsible for disrupting melatonin production and causing sleep disturbances in people with heart conditions. Researchers found that macrophages accumulate in the ganglion, leading to inflammation and scarring, which can be treated with drugs.
A Michigan Medicine study finds that patients who participate in cardiac rehabilitation have a decreased risk of death years after surgery. The greatest reduction in mortality was found in patients who completed 36 or more sessions, highlighting the need for targeted efforts to improve participation and adherence.
A recent study found that PCSK9 inhibitors may impair lung function in some patients, while statins have a protective effect on the brain, increasing hippocampus volume which may reduce dementia and depression risk. The study used genetic data from 340,000 UK Biobank participants.
Massachusetts General Hospital researchers discovered that concentrating moderate-to-vigorous physical activity into one to two days per week, or the
Researchers created a digital replica of patients' hearts to inform arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis and treatment. The 'genotype-specific digital-twin' strategy could tailor therapies based on individual genetics, improving precision healthcare in other diseases.
A study analyzing 89,000 individuals found that engaging in intense physical activity over a short period (weekend warrior pattern) lowers the risk of atrial fibrillation, heart attack, heart failure, and stroke. This type of activity was associated with similar lower risks compared to evenly distributed physical activity.
A new study reveals that Black patients with ICDs have a significantly higher rate of post-implant cardiac events and risk of death compared to white patients. The study also shows that Black patients are more likely to discontinue medications after one year, but the reasons for this are unknown.
Researchers from Edith Cowan University developed software to analyze bone density scans, detecting abdominal aortic calcification (AAC) at high accuracy. The AI can predict cardiovascular disease events and late-life dementia, allowing for early interventions.
A new study published in the American Journal of Preventive Medicine finds that home blood pressure monitoring can reduce cardiovascular events by 4.9% and stroke cases by 3.8% over 20 years, leading to cost savings and improved health outcomes for underserved populations.
A team of UVA Health experts warns that surgeon-scientists are struggling to obtain research funding, which could lead to a decline in innovations for patients. The researchers found that internal medicine trainees are six times more likely to secure R01 grants and career development awards.
A cohort study found that U.S. veterans with atherosclerotic cardiovascular disease residing in historically redlined neighborhoods still experience higher prevalence of traditional cardiovascular risk factors and adverse cardiovascular events. Redlining's adverse association persists even decades after its discontinuation.
The American Heart Association policy statement outlines strategies to shift towards value-based healthcare and payment models, prioritizing equity, patient and clinician experience, and individual and population health. The recommendations include person-centered, equitable, coordinated care that improves outcomes and controls costs.
Smoke-free legislation associated with significant reductions in morbidity and mortality related to cardiovascular disease and respiratory system disease. Accelerating the implementation of smoke-free laws is crucial for protecting populations against smoking-related harm.
A large-scale global study found that consuming six key foods in combination is associated with a lower risk of cardiovascular disease. The study recommends an average daily intake of two to three servings of fruits, vegetables, and nuts, as well as moderate amounts of fish and whole-fat dairy.
A recent study published in JAMA Network Open has discovered a significant association between high population well-being and reduced cardiovascular disease mortality. The research, led by Erica S. Spatz, found that improved well-being can serve as a focus for advancing cardiovascular health.
A team of researchers from the University of South Australia used a contact-free technique to extract cardiac signals from chimpanzees by filming subtle movements in their face or thorax. The study found that chimpanzees show similar responses to human babies when experiencing fear, excitement, or joy, and that nature scenes can calm t...
Patients with diabetes are at increased risk of cardiovascular disease and loneliness, which can lead to a higher likelihood of developing heart disease. A recent study found that loneliness was associated with a 11% higher risk of cardiovascular disease compared to those with lower loneliness scores.
A large clinical trial found that monthly vitamin D supplements reduced the risk of major cardiovascular events such as heart attacks by 9% in older adults. The study involved over 21,000 Australians aged 60-84 and showed a significant reduction in heart attack rates, but no difference in stroke rates.
A new proposal suggests adopting an 'adolescent cholesterol passport' to prevent atherosclerosis, a leading cause of death worldwide. The tool would involve regular cholesterol screenings starting at age two, with the goal of detecting familial hypercholesterolemia and other genetic conditions early on.
The new institute will integrate vascular biomedicine, systems biology, and heart research to investigate mechanisms of interorgan communication and detect pathologies earlier. It aims to accelerate translation of findings into clinical applications.
A new study published in JAMA found that bempedoic acid can reduce major adverse cardiovascular events in high-risk primary prevention patients who cannot tolerate recommended doses of statins. The treatment has the potential to improve outcomes for these patients, providing a new option for primary prevention.
Head and neck squamous cell carcinoma patients face substantial burden of uncontrolled cardiovascular risk factors, leading to increased risk of stroke and heart attack. Modifiable CV risk factor control is crucial in reducing the risk of adverse cardiovascular events and death among these patients.
A study of 200 people aged 50-70 found that higher carotene levels in the blood were associated with lower atherosclerosis and reduced cardiovascular disease risk. A diet rich in fruits and vegetables, particularly those high in carotenes, may help lower the risk of heart disease.
The study mapped out metabolite by-products of bacteria processing amino acids linked to cardiovascular disease, comparing patient data to assess disease risk. Researchers developed a method for assessing absolute metabolite levels in the bloodstream, allowing identification of cutoff values for low versus high risk.
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
A new study by CNIC researchers reveals that low-grade systemic inflammation triggered by subclinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals. The study found a strong association between atherosclerosis progression and accelerated biological age, with potential reversibility through lifestyl...
The study analyzed data from 15 hospitals nationwide and found that nearly half of patients with symptomatic severe AS received transcatheter aortic valve replacement, while about 36% did not receive any treatment. The program aims to address healthcare disparities in AS care by identifying best practices for treating the disease.
Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.
Peripheral artery disease (PAD) disproportionately affects Black adults, with higher rates of diagnosis and poor outcomes. Low-cost, routine testing can help reduce disparities and health care costs by identifying individuals at risk and providing preventive measures.
Researchers used a new transgenic mouse model to study the impact of oxidative stress on neurons and blood vessels, revealing that high levels of stress can cause sensory neuron degeneration and cardiac hypertrophy. This combination is associated with Friedreich's ataxia, a progressive neurodegenerative disease.
A new study found that elevated Lipoprotein(a) levels are a significant predictor of recurrent coronary heart disease (CHD) in people over 60. The study suggests current cholesterol-lowering medications may not be effective in reducing the risk of recurrent CHD, highlighting the need for novel therapeutics to target elevated Lp(a).
Researchers at Temple University Health System discovered a promising alternative to control hypertension and associated cardiovascular problems. The infused juice concentrate from the Japanese plum was found to attenuate growth-promoting signals induced by angiotensin II, reducing hypertrophy of the aorta and inflammation.
A new study from Keck Medicine of USC reveals significant racial disparities in the diagnosis and treatment of peripheral artery disease (PAD) among Black and white patients. Black patients are nearly 50% less likely to receive vascular interventions, leading to a higher risk of stroke, heart attack, or amputation.
Researchers found that light to moderate drinking reduces stress signaling in the brain, accounting for lower cardiovascular events. The study's findings suggest a potential new approach to reducing heart disease risk without the negative health effects of alcohol.
A new study published in Journal of Leukocyte Biology found that age and sex differences contribute to increased inflammation in older female mice. The research team discovered that immune cells entering areas where they shouldn
Chronic exposure to low levels of contaminant metals through household items, air, water, soil, and food increases the risk of cardiovascular disease. Monitoring environmental metal levels and testing for exposure are key steps to implement public health initiatives.
Research highlights chronic exposure to contaminant metals as a modifiable risk factor for cardiovascular disease. Monitoring environmental metal levels and testing individuals can help implement public health initiatives.
A new study published in JMIR Cardio reveals the potential of AI-QCA in analyzing coronary angiography, providing accurate measurements of coronary stenotic lesions similar to IVUS. This technology has the potential to improve patient outcomes and support clinical decision-making.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
A new metric, space syntax walkability index, is proposed to address limitations in linking cardio-metabolic risk factors to the built environment. The study found that walkability in urban areas is linked to cardio-metabolic risk factors, including blood pressure and obesity.
A new study shows that saracatinib reduces inflammation in patients with atherosclerotic cardiovascular disease by more than 90% and boosts genes that help clean up plaque deposits. The experimental cancer drug may offer an effective therapy for cases where standard treatment fails to help.
Researchers found increased levels of TMAO in abdominal aortic aneurysm (AAA) patients, which led to disease progression. Inhibiting TMAO production reduced aneurysm severity, suggesting a potential therapeutic target.
A study of US adults found that fewer than 1 in 4 use wearable devices to prevent or manage cardiovascular disease, with inconsistent daily use among those who do. This disparity may worsen health inequalities unless strategies are implemented to promote equitable adoption of these tools.
A randomized clinical trial found that peer health coaching improved mental health-related quality of life in veterans with cardiovascular disease risks. The study suggests a peer-support model integrated into primary care can lead to well-being improvements beyond blood pressure control.
Researchers at Lund University have mapped the location where atherosclerotic plaques rupture, identifying an enzyme marker that could predict patients at risk of myocardial infarction or stroke. The study's findings may lead to preventive treatments and new therapies.
Researchers found that women with higher-quality cardiovascular fat during midlife had stronger long-term memory and lower inflammation, while those with lower-quality fat had worsening working memory. The study suggests that taking care of heart health during menopause may protect brain health and reduce dementia risk.
A new study published in Hypertension found that oral estrogen hormone therapy may increase the risk of high blood pressure in women, while transdermal and vaginal formulations appeared to have a lower impact. The research involved over 112,000 women aged 45 years and older who took estrogen-only hormone therapy.
A new study by the University of Utah Health reveals that people with higher cardiovascular disease risk are more likely to develop musculoskeletal disorders. The study suggests prioritizing cardiovascular health can help prevent these conditions and improve quality of life.
Researchers at the University of Arizona studied the impact of grief on heart function and found a significant association between grief severity and elevated systolic blood pressure response. Grief can cause a marked rise in blood pressure, increasing the risk of cardiac events.
A new American Heart Association scientific statement highlights the disproportionate burden of cardiovascular disease on AI/AN women. The study reveals that more than 60% of these women have suboptimal heart health when pregnant, increasing their risk of heart disease later in life.
Researchers developed an AI system, Geneformer, to predict how disruptions in human gene connections cause disease. The model, trained on data from thousands of genes, can identify potential drug targets for diseases like heart disease and cancer.