Articles tagged with Cardiovascular Disease
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A daily statin medication reduced the risk of major adverse cardiovascular events by 35% among people living with HIV. The NIH study, REPRIEVE, enrolled over 7,700 volunteers and found that pitavastatin calcium lowered cardiovascular risk without increasing adverse drug events.
A new study from Uppsala University found that patients can experience twice as much improvement in blood pressure by changing medication as they would by doubling their current dose. The study, involving 280 patients and testing four different blood pressure-lowering drugs, challenges the conventional strategy of recommending equally ...
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
Researchers from Karolinska Institutet found that people with obesity due to genetic predisposition have a lower risk of cardiovascular disease. The study analyzed data from over 15,000 twins and medical registries, suggesting that genetics may play a role in mitigating the risk of cardiovascular disease.
Researchers found decreased lung injury, coughing up blood, and mortality rates after balloon pulmonary angioplasty between 2013 and 2022. The minimally invasive procedure is now considered a safer option for inoperable CTEPH patients.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
A new proteomic risk model developed by Penn Medicine researchers is more accurate than existing clinical models for predicting cardiovascular risk among chronic kidney disease patients. The model uses nearly 5,000 proteins and identified specific proteins that can help identify individuals at high risk of future cardiovascular events.
Researchers found that statin users can engage in moderate-intensity exercise without exacerbating muscle injury or symptoms. The study's findings are reassuring for people experiencing muscle pain or fatigue from statins and provide important guidance for maintaining physical activity and heart health.
A new study published in The European Heart Journal – Digital Health found that smart watch data can predict a higher risk of developing heart failure and irregular heart rhythms. Researchers used machine learning to analyze ECG recordings from wearable devices and identified extra beats as indicators of increased cardiovascular risk.
Researchers successfully add purified curcumin to probiotic yogurt, preserving its dissolved form and enhancing its health properties. The study shows that the curcumin inhibits yeast, fungi, and bacteria growth while maintaining the recommended levels of beneficial lactic acid bacteria.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
A team of researchers from Ohio University discovered that CIDEC protein improves vascular and metabolic dysfunction, reducing insulin resistance and lipid levels in high-fat diet-induced mice. The study contributes to understanding the role of the vascular endothelium in regulating systemic metabolism.
Researchers compared seven dietary programmes, finding Mediterranean programmes lower risk of mortality, non-fatal heart attacks, and stroke. Low fat programmes also showed benefits for mortality and non-fatal heart attacks, but with less pronounced effects.
Researchers at Sanford Burnham Prebys have identified a group of proteins called AJSZ that help solve a known problem in cellular reprogramming. By blocking the activity of these proteins, they were able to reduce scarring on the heart and induce a 50% improvement in overall heart function in mice that have undergone a heart attack.
A new AI tool analyzed food consumption data from over 600 residents in long-term care homes, revealing a need for improved dietary habits. The study suggests that a diet rich in whole grains, plant-based proteins, and plain fruits and vegetables can help reduce inflammation and improve clinical outcomes.
Three pre-clinical studies published in Journal of Pharmaceutical Analysis explore the molecular mechanisms underlying cardiovascular and neurological diseases, providing new avenues for therapeutic strategies.
Research highlights that intensive behavioral weight loss programs significantly reduce cardiovascular disease and Type 2 diabetes risk factors, which persist for at least five years. Participants who lost weight through such programs had lower risk factors compared to those in less intensive or no weight loss programs.
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
A study published in Lasers in Surgery and Medicine suggests that light therapy, known as photobiomodulation (PBM), can improve heart function and reduce the thickness of the cardiac wall in middle-aged mice. The research also found improved neuromuscular coordination and a significant survival rate among mice with severe heart disease.
A new American Heart Association scientific statement provides guidance on interpreting incidental genetic variants associated with cardiovascular disease risk. The statement aims to determine whether a variant truly carries a health risk and suggests next steps for individuals and healthcare professionals.
A study of global clinical practice guidelines found close alignment in recommending daily intake of fruits, vegetables, legumes, and whole grains for treating and preventing major chronic diseases. The findings aim to increase clinician confidence in providing optimal care.
A new study found that Hispanic, Black, and low-socioeconomic status smokers are less likely to use e-cigarettes as a quit-smoking tool and more likely to believe e-cigarettes pose greater harm than cigarettes. This perception may prevent e-cigarette uptake among these populations, exacerbating racial and health disparities in smoking.
The Lp(a) Discovery Project will develop clinical standards for optimal patient care through a new screening measure and quality improvement interventions. The three-year project aims to fill knowledge gaps around Lp(a) and encourage better treatments to reduce cardiovascular risk.
UConn researchers have developed simple measurements and equations that better predict fat distribution in individuals based on their sex and ethnicity. The tools account for differences in body composition between ethnic populations and women and men, providing a more accurate assessment of obesity-related health risks.
A 29-year study found that being fit reduces the risk of death from cardiovascular disease in men with high blood pressure. High fitness levels attenuate, but do not eliminate, the increased risk of cardiovascular mortality in individuals with elevated blood pressure.
A new study finds that smokeless tobacco products increase the risk of developing peripheral artery disease by two-fold compared to non-users. The study analyzed data from 14,344 participants and found a significant association between smokeless tobacco use and PAD, with a rate of 4.4 cases per 1,000 person years.
The study found that statin use for primary prevention was low among all racial and ethnic groups, despite varying levels of 10-year ASCVD risk. Improving access to care may help increase equitable use of primary prevention statins in Black and Hispanic adults.
A clinical trial found that moderate salt restriction reduced blood pressure and depressive symptoms without adverse effects in patients with primary aldosteronism. The study suggests a feasible approach to improving care for these patients and may also benefit those with essential hypertension.
A real-world analysis found that high-risk Americans who fail to reach guideline-recommended LDL-C levels experience a 44% higher rate of cardiovascular events. The study, presented at the AMCP Conference, used data from over 300 million Americans and compared those who met and maintained recommended targets with those who did not.
The VALOR-QI program will provide a blueprint for quality care improvement, focusing on high-risk patients and addressing health equity gaps. It will offer education, staff training, monitoring, and other steps to achieve better compliance with cholesterol management.
A new study published in the European Heart Journal shows that using waist-to-height ratio instead of BMI provides a clearer picture of patient outcomes in heart failure. The researchers found that greater adiposity is associated with worse outcomes, including high rates of hospitalization and reduced health-related quality of life.
Research found that pregnancy complications such as preterm delivery, hypertensive disorders, and gestational diabetes are associated with increased risk of mortality. Women who experienced these complications had a higher risk of all-cause mortality, with some complications linked to specific causes of death like cardiovascular diseases.
A study by Tokyo Medical and Dental University reveals that chronic kidney disease promotes vascular calcification by altering signaling molecules in blood vessel walls. The researchers identified four microRNAs that target a key pathway driving calcification, providing potential biomarkers and therapeutic targets for both diseases.
A team of UCF researchers is working on a new project to educate the next generation of nurses, nurse practitioners, and social workers to improve heart health in medically underserved communities. They are using high-fidelity simulation scenarios to foster inter- and intradisciplinary care.
Researchers at Medical College of Georgia identified an increased prevalence of disease-causing genetic variants in females with unexplained infertility. The study found that 17% of these women had gene variants known to cause heart problems and cancer.
Children from low-income neighborhoods are more likely to develop preventable heart disease due to high blood pressure, according to a new study. The research highlights the importance of considering neighborhood-related factors when diagnosing hypertension in youth.
A pooled data analysis of available evidence shows that sticking closely to a Mediterranean diet cuts a woman's risks of cardiovascular disease and death by nearly 25%. The study, which included over 700,000 women, found lower risk of coronary heart disease and stroke in those who followed the diet most closely.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
A new study suggests that pregnant women who have dimmed lights and screens for three hours before sleep are less likely to develop gestational diabetes. Dim light exposure before bedtime may help regulate glucose levels, reducing the risk of this common pregnancy complication.
A three-year study found that exceeding ozone limits is associated with substantial increases in hospital admissions for heart attack, heart failure, and stroke. Ozone pollution harms the heart and blood vessels, particularly in older people, who may be vulnerable to its adverse effects.
A large study found that individuals with atrial fibrillation had a modestly elevated risk of developing dementia, particularly in younger adults and those without chronic kidney disease. The risk was higher in younger adults and those without chronic kidney disease, but did not substantially vary across sex, race, or ethnicity.
An international team of researchers analyzed data from 93 studies on cardiovascular diseases and exposure to radiation, finding a modestly increased excess risk of heart disease with low dose radiation. The study suggests that mechanisms for these cardiovascular effects are poorly understood and that further research is needed.
Researchers at Brigham and Boston Medical Center found associations between kidney damage and increased risk of heart disease and death. The study analyzed kidney tissue from 597 adults with chronic kidney disease, linking specific lesions to cardiovascular events.
Researchers at Gladstone Institutes discovered that chronically low oxygen levels, similar to those experienced at high elevation, rewire how mice burn sugars and fats. The study found lasting changes in metabolism, including lower blood glucose levels and body weight, which mirror what has been seen in humans who live at high altitude.
A new study found that poor sleep is associated with compromised cardiovascular health in middle and old age, with men losing nearly 7 years of heart disease-free life compared to healthy sleepers. Women also experienced a significant loss of normal heart health, with up to 2 years lost due to general poor sleep.
A randomized controlled trial of MOXIE shows a significant reduction in clinical outcomes, including hospitalizations and all-cause mortality. The intervention improved patient engagement and behavior change, leading to better health outcomes for seniors at elevated risk of cardiovascular events.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
A University of Chicago study found that older adults living near fracking sites in Pennsylvania had higher rates of cardiovascular disease hospitalizations compared to those in nearby New York state. The study linked exposure to air and water pollution from fracking activity to increased health outcomes.
A 'keto-like' diet, characterized by low carbohydrates and high fat intake, has been linked to higher levels of LDL cholesterol and a twofold increased risk of cardiovascular events. Regular consumption of this diet was associated with an average increase in blood LDL cholesterol levels over 11.8 years.
The study found that transcatheter edge-to-edge repair achieved a successful repair for nearly 9 out of 10 patients and reduced valve leakage from severe to moderate or less in almost 90% of patients. Patients who underwent the procedure were half as likely to die within one year compared with those in whom the procedure was unsuccessful.
A study found that time-restricted feeding improves muscle performance in obese fruit flies by upregulating genes related to glycine production and utilization. This approach may provide a natural alternative therapy for managing obesity-related pathologies.
Two studies found that adults with high cardiovascular health scores tend to live longer lives free of major chronic diseases. The research highlights the importance of maintaining ideal cardiovascular health to delay onset of age-related diseases, allowing individuals to enjoy life in their years as well as their years in life.
A new study found that walking an additional 500 steps per day was associated with a 14% lower risk of heart disease, stroke or heart failure. This benefit is significant for older adults, as most studies have focused on early-to-midlife adults.
A recent study led by Murdoch Children's Research Institute has revealed a new pathway for how genetic mutations impact heart muscle function. The research identifies the gene ALPK3 as a key player in cardiomyopathy, a group of diseases affecting the heart's ability to pump blood, and provides hope for new targeted therapies.
Researchers at University Hospitals Cleveland Medical Center discovered that S-nitrosohemoglobin senses areas with insufficient oxygen and restores blood flow for oxygenation. This breakthrough opens up a new line of drug development to correct poor tissue oxygenation, including peripheral artery disease and sickle cell disease.
Researchers found that self-perceived interpersonal racism in employment, housing, and police interactions was associated with a 26% higher risk of coronary heart disease among Black women. The study analyzed data from the largest follow-up study on the health of Black women in the US.
A new review paper from Mayo Clinic outlines how obesity impacts common tests used to diagnose heart disease, such as ECG, CT scan, MRI, and echocardiogram. The study highlights the need for alternative approaches to prevent weight gain in patients with heart disease.
Applying evolutionary principles to medicine inspires new ways of preventing and treating disease, including overcoming chemotherapy resistance and antibiotic resistance. Evolutionary-inspired strategies like 'anti-evolution' drugs and extinction therapy can tackle these global health threats.
Researchers found that 11 minutes of moderate-intensity physical activity per day, equivalent to a brisk walk, lowers the risk of diseases like heart disease and stroke. This amounts to a 23% lower risk of early death, with benefits also seen in reduced cardiovascular disease and cancer risks.
A new study by Brigham and Women's Hospital found that over 20% of patients at high risk of cardiovascular disease refused statin medications. Women were more likely than men to refuse statin therapy, with a 50% higher rate of never accepting the recommendation.