Articles tagged with Cardiovascular Disease
Researchers successfully treated atherosclerosis and fatty liver disease using DT-109 in nonhuman primates, which has potential as a dual therapy for two common conditions. The compound reduced the formation of atherosclerotic plaques and stopped critical processes that lead to vascular calcification.
A study analyzing 17,500 individuals found that immune resilience counters factors of aging and mortality through TCF7 gene regulation, reducing mortality risk by 69% in midlife. This promotes salutogenesis, actively fostering health and well-being.
Researchers discover a link between gut health and blood cancer risk, finding that age-related gut changes can accelerate the growth of pre-leukemic blood cells. A specific bacterial sugar, ADP-heptose, plays a key role in this process, and a new blood test detects its activity.
A new analysis found that oral hormone therapy can lower levels of lipoprotein(a), a genetic risk factor associated with higher risk of heart attack and stroke. Hormone therapy also improved biomarkers of cardiovascular health, including cholesterol levels.
Long COVID can result in significant health risks for young people, including chronic kidney disease, gastrointestinal symptoms, and cardiovascular conditions. Studies found that children with COVID-19 face elevated risks of developing these conditions, even years after the initial infection.
Researchers at Tulane University identified a potential new way to treat idiopathic pulmonary fibrosis (IPF) using an FDA-approved cancer drug. The treatment works by blocking the CTLA4 protein, which blocks overactive T cells, allowing the immune system to clear out damaged cells that cause lung scarring.
A new study from Columbia University Mailman School of Public Health found significant associations between cognition and established risk factors for Alzheimer's disease in individuals aged 24-44. The researchers used biomarkers related to cognitive impairment and cardiovascular health to predict long-term trajectories of cognitive de...
Researchers highlight microRNAs' role in regulating adipose tissue function and potentially reversing fibrosis. Engineered stem cells with targeted miRNAs offer a precise molecular intervention strategy to combat fibrosis in various organs.
Researchers found an association between urinary incontinence and cardiovascular disease risk factors or events, such as dyslipidemia and stroke. The study suggests that screening for urinary incontinence may be necessary to prevent CVD risk in affected women.
A recent study of 249,190 individuals found a significant link between exclusive e-cigarette use and chronic obstructive pulmonary disease (COPD) and hypertension in adults aged 30-70. In contrast, traditional combustible cigarette smoking was associated with increased risks for various cardiometabolic diseases.
Researchers discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective treatment. Restoring this mechanism prevents progression of HFpEF and alleviates lipid overload in heart cells, providing molecular evidence for a promising therapeutic...
Early application of ezetimibe in combination with statins reduces risk of new cardiovascular events and death in cardiac patients. The study analyzed data from 36,000 patients who had a myocardial infarction between 2015 and 2022.
Adverse pregnancy outcomes like gestational diabetes and high blood pressure contribute significantly to cardiovascular disease risk factors in midlife. Prioritizing weight management among those considering pregnancy may promote both maternal and future cardiovascular health.
A new American Heart Association scientific statement emphasizes the importance of multidimensional sleep health in reducing cardiometabolic risks. The statement reviews evidence on the relationship between sleep and various health factors, including body fat, blood sugar, cholesterol, and blood pressure.
Stephan Windecker, a world-renowned cardiologist, will be honored with the TCT 2025 Career Achievement Award for his extraordinary contributions to interventional cardiology. His extensive research has shaped clinical practice worldwide and influenced the future of cardiovascular medicine.
The American Heart Association will strengthen and expand Hawaii's stroke system of care, reducing death and disability rates from stroke in rural populations. The initiative aims to enhance coordination among emergency responders, hospitals, and healthcare providers.
Novel biomarkers like miRNA-34a link anthracyclines to cardiotoxicity, while stem cell therapy and nanotechnology offer potential for prevention and treatment. Traditional strategies have limitations, but new approaches hold hope for improved patient outcomes.
A new study found that both employed people with obesity and employer representatives acknowledge the impact of obesity on future health problems and perceive lifestyle change alongside anti-obesity medications as the most effective approach for maintaining weight-loss reduction. Cost of medication coverage remains a significant barrie...
The WNFC's player ambassadors will amplify public service announcements, social media content, and local community education events to raise awareness about cardiovascular disease and CPR education in women. The league has also implemented a requirement for all coaches to be certified in CPR, AED, and first aid.
A recent study published in the International Journal of Cardiology analyzed data from multiple clinical trials to assess the therapeutic impact of pulmonary artery denervation (PADN) on pulmonary hypertension patients. PADN showed significant reductions in mean right atrial pressure, mean pulmonary artery pressure, and pulmonary vascu...
Researchers at Weill Cornell Medicine found that decreased ceramide levels in blood vessels can cause chronic illnesses. Ceramides regulate blood vessel tone and prevent blood clots, but low levels increase inflammation, high blood pressure, and glucose levels, leading to cardiometabolic conditions.
A new study found that genetic predisposition to sedentary behavior is associated with a higher risk of developing the most common cardiovascular diseases. Individuals with the highest genetic predisposition accumulated more daily sedentary time and had a 20% higher risk of cardiovascular diseases.
A team of researchers has developed a gene-therapy strategy to treat arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5), a rare and deadly hereditary disease. The treatment, using adeno-associated viruses, improved cardiac function and prolonged survival in mice with ARVC5-like disease.
Scientists have discovered a novel regulator of the mitochondrial sodium-calcium exchanger (NCLX), which helps maintain calcium balance in mitochondria. The discovery of TMEM65 could lead to new therapeutic agents to combat calcium overload associated with heart failure and Alzheimer's disease.
A new scientific statement highlights the potential of technology-based health solutions to promote heart-healthy behaviors and increase equitable access to resources. The statement emphasizes the need to address barriers faced by populations most impacted by adverse social drivers of health, particularly those with lower socioeconomic...
A study found that migrants experience a 'clear change' in their gut microbiome composition after migration, leading to increased rates of cardiovascular disease. The Amsterdam UMC-led research showed that specific groups of microbes disappear or emerge along the migration axis.
The Ralph L. Sacco Scholarships in Brain Health support research into vascular disease's impact on cognitive decline, dementia, and brain health. Researchers Hortense Triniac and Katy Walsh will study protein interactions to reduce stroke risk and investigate cerebral amyloid angiopathy.
A study found that pedometers capture a remarkable 88% of the health information provided by more advanced accelerometer measurements. Walking at a brisk pace is essential for cardiovascular health optimization, with a minimum cadence of 80 steps per minute strongly associated with good aerobic fitness.
A study from Tanzania found that a Western diet can cause inflammation and reduce immune response, while an African diet rich in vegetables and fermented foods has positive effects on the immune system. The study suggests that short-term dietary changes can have long-lasting effects on health.
Scientists have discovered that early-life cardiac injury in parents can alter heart development and function in offspring, leading to improved cardiac remodeling and increased blood ejection volume. This finding suggests a potential long-term impact on cardiovascular health.
New research published in the Journal of the American Heart Association suggests that even sporadic physical activity can have lasting health benefits, making it easier for people to prioritize their well-being amid busy schedules. The study found that completing 150 minutes of moderate to vigorous physical activity per week, regardles...
Researchers from Florida Atlantic University challenge the current aspirin guidelines based on a flawed trial, advocating for healthcare providers to make individual clinical judgments about prescribing aspirin. They stress that patients should consult their primary care provider to balance the benefits of clot prevention against bleed...
The American Heart Association invites communities nationwide to walk together on National Walking Day to break the cycle of sedentary behavior. Regular walking can improve both physical and mental well-being, even in small steps.
Researchers Schmidt and Selvin will explore the connections between cardiovascular disease and diabetes, with a focus on large white blood cells and wearable continuous glucose monitors. Their work aims to develop new treatment therapies and improve health outcomes for people with diabetes.
A new study found that compound heatwaves significantly increase cardiac mortality and are more impactful than traditional binary definitions of heatwaves.
Research shows that highly reactive components in particulate matter disappear within hours, leading to inaccurate estimates of their presence and potential health risks. This discovery highlights the need for more accurate measurements and better protective measures.
Swedish researchers have identified 20 genetic variants associated with an increased risk of atherosclerosis, a leading cause of cardiovascular disease. The study used advanced imaging techniques to examine millions of genetic variants, providing new insights into the disease process and potential ways to prevent it.
A new method combines ECGI with digital twins to locate the origin of premature ventricular contractions, improving accuracy by an average of 7.8 mm. The method has been applied in a real clinical case and is expected to facilitate planning interventions and reduce treatment costs.
Dr. David Winchester will lead the American College of Cardiology's Board of Governors, guiding chapters representing all 50 states and promoting heart health improvement in communities. His term aims to address practice challenges through advocacy and chapter support.
A recent study found substantial rural-urban disparities in cardiometabolic risk factors and cardiovascular diseases among US adults. Social risk factors are identified as the primary driver of these disparities, with efforts to address socioeconomic conditions in rural communities critical to reducing the gap.
A minimally invasive procedure using a clip to repair the tricuspid valve significantly reduced symptom severity and decreased recurrent hospitalization for heart failure. The study found a 28% reduction in hospitalizations at two years, with improved safety and effectiveness compared to medical therapy alone.
Patients with severe triple-vessel heart disease showed no significant difference in outcomes between CABG and PCI at five years. The FAME-3 trial enrolled 1,500 patients with triple-vessel disease and found that both procedures performed similarly well, considering recent advances in surgical and minimally invasive techniques.
A new study has found that clopidogrel outperforms aspirin monotherapy in reducing heart attack rates without increasing bleeding risk in high-risk patients following percutaneous coronary intervention (PCI). Researchers observed a significant reduction in ischemic endpoints, primarily driven by a decrease in heart attacks.
A new transcatheter valve has shown high survival rates and improved quality of life in patients with aortic regurgitation. The trial found an overall mortality rate of 8.1% at one year, meeting non-inferiority to open heart surgery outcomes.
A new study by Intermountain Health finds that peripheral artery disease is often underdiagnosed and undertreated, particularly in women. The condition affects nearly 10% of the US population and has a high mortality rate, with patients having a 50% chance of dying from it.
The BHF PROTECT-TAVI trial found no reduction in stroke rate for patients undergoing TAVR with an embolic protection device. Despite its large sample size, the study showed that cerebral embolic protection devices do not improve outcomes for TAVR patients.
Patients who received nurse-led follow-up care had a 30% lower rate of cardiovascular death, non-fatal heart attacks, or strokes at five years compared to those receiving standard care. This was achieved through improved lifestyle habits and medication adherence.
A new mobile integrated health program delivered in-home visits from paramedic teams to people with heart failure did not significantly reduce hospital readmissions or improve health status compared to standard follow-up phone calls. However, the study found that women and younger patients may benefit more from this intervention.
A study published in JAMA Cardiology found that legislation to reduce sodium in processed food in South Africa is linked to significant declines in blood pressure levels. The reduction in sodium intake has been associated with lower rates of cardiovascular disease mortality and stroke, potentially saving millions of lives globally.
A four-year study presented at the American College of Cardiology's Annual Scientific Session found that oral semaglutide reduced cardiovascular death, heart attack, and stroke by 14% compared to a placebo. The drug's benefits are comparable to injectable forms and offer an alternative for patients who prefer not to take injections.
A Phase 2b trial found lorundrostat significantly reduced blood pressure in patients with uncontrolled hypertension by 7.9 mm Hg and 6.5 mm Hg compared to placebo at 12 weeks. The drug showed an acceptable side effect profile, with consistent patterns across secondary endpoints.
A study found that semaglutide significantly improved maximal walking distance in people with symptomatic peripheral artery disease (PAD) and Type 2 diabetes. Patients taking semaglutide also experienced improvements in symptoms and quality of life compared to those on a placebo.
A study presented at the American College of Cardiology's Annual Scientific Session found that dapagliflozin significantly reduced the rate of worsening heart failure in elderly patients with heart failure undergoing transcatheter aortic valve replacement. The trial, called DapaTAVI, enrolled 1,257 patients and showed a 28% lower rate ...
An AI model has been developed to detect blocked coronary arteries based on ECG readings, achieving high accuracy and outperforming expert clinicians. The model could help physicians quickly identify patients who require urgent treatment for a heart attack.
In an open-label study, patients hospitalized for a serious heart attack who received rivaroxaban or warfarin had similar efficacy and safety outcomes. Rivaroxaban showed comparable results in dissolving left ventricular blood clots at three months follow-up.
A new clinical trial found that oral semaglutide can significantly reduce cardiovascular events in people with type 2 diabetes and pre-existing cardiovascular disease. The medication decreased the risk of major cardiac events by 14% compared to placebo, with nonfatal myocardial infarction seeing the greatest reductions in risk.
The American College of Cardiology has recognized 10 young researchers with the Young Author Achievement Award, showcasing their groundbreaking work published in JACC journals. The awardees will be recognized during ACC.25 in Chicago, March 29-31, 2025.
The American College of Cardiology recognizes Jennifer Mateo Soto and Opeyemi Olalekan Oni for their innovative cardiovascular research projects in low- and middle-income countries. The awardees will receive $25,000 to support their research, which aims to improve the care of people at risk or living with cardiovascular disease.
The American College of Cardiology will honor three early career cardiologists with the Hani Najm Global Scholar Award Observership Program at ACC.25, taking place in Chicago. The program encourages international cardiology professionals to share knowledge and enhance their training by shadowing a practicing cardiologist in the US.
The American College of Cardiology has recognized 21 distinguished award recipients for their outstanding contributions to the field of cardiovascular medicine. The awardees will be honored during Convocation at ACC.25 in Chicago, showcasing their remarkable work in transforming cardiovascular care and improving heart health.