Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
The study focuses on combining SPRA technology with polypseudorotaxane (PPRX) technology to create a sustained and controllable insulin release system. Four types of PPRXs were developed, showing improved blood glucose reduction times and safety profiles.
Researchers found that patients who experienced food insecurity had a higher incidence of stroke risk factors, such as hypertension and diabetes. In contrast, patients not labeled food insecure had lower rates of these conditions.
A recent survey found that more than two-thirds of non-foot-specialist clinicians are unaware of Charcot neuroarthropathy, a rare form of foot damage. The condition can lead to significant disability and morbidity if not diagnosed early. Improving education on this topic is crucial for better patient outcomes.
Research presented at American Stroke Association's International Stroke Conference 2017 found that people with middle age heart disease risks, such as diabetes, high blood pressure or smoking, are at higher risk for dementia later in life. The study, which enrolled 15,744 participants, revealed that the risk of dementia was significan...
A new study by UNC School of Medicine researchers found that the IRS-1 protein plays a crucial role in maintaining vascular smooth muscle cell differentiation, which helps prevent atherosclerosis. In people with diabetes, low IRS-1 levels contribute to abnormal cellular proliferation and increased risk of heart disease.
A study published in Cell Reports found that genetic variation in mice shapes their gut microbiome, which regulates insulin secretion and contributes to the onset of metabolic disease. The researchers observed a correlation between specific bacteria in the microbiome and metabolic traits such as body weight and glucose levels.
The Helmholtz Zentrum München will receive 1.5 million euros to develop stem cell culture models on a chip for investigating pancreatic diseases and testing therapy options. The goal is to explore biology, identify points of attack, and potentially develop beta cell replacement therapy.
A study found that standard hemoglobin A1c criteria underestimates long-term glucose levels in African Americans with sickle cell trait, resulting in fewer cases of prediabetes and diabetes. This could lead to missed opportunities for intervention and higher diabetic complications rates
A new study found that hemoglobin A1c readings are lower among individuals with sickle cell trait, suggesting a potential systemic underestimation of blood sugar control. This could lead to false sense of security for patients with diabetes.
In patients with diabetes, an immune system receptor called Toll-like receptor 4 is activated by dying cells and bacteria, leading to inflammation and bladder dysfunction. Preventing this activation enables the bladder wall to remain strong and elastic.
A long-term study of 4811 London-based office workers found no association between sitting and developing type 2 diabetes. The researchers suggest that the risks are linked to TV time and poor diet, rather than sitting itself.
A five-year clinical trial aims to test whether losing weight before pregnancy can reduce the risk of developing gestational diabetes again, with over 250 overweight or obese women participating. The study will also examine perinatal outcomes for mothers and children.
Researchers at Joslin Diabetes Center have discovered a potential way to reduce complications from blood clot removal during stroke treatment. By targeting the plasma kallikrein protein, they aim to increase the efficacy of tissue plasminogen activator (tPA) therapy while minimizing bleeding and swelling.
A new analysis published in PLOS ONE found that the proportion of US deaths attributable to diabetes is as high as 12%, three times higher than estimates based on death certificates. Diabetes was estimated to be the third leading cause of death in the US in 2010, after heart disease and malignant neoplasms.
A recent study published in PLOS ONE found that diabetes accounts for 12% of deaths in the United States, significantly higher than previously thought. This increase is attributed to the growing prevalence of diabetes, which has risen by nearly 300% since 1980, affecting over 21 million Americans.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
A single episode of high fat intake caused immediate increases in fat accumulation and alterations in liver metabolism. Insulin resistance, elevated triglycerides, and increased glucagon levels were also observed.
Researchers found statins reduce venous thromboembolism (VTE) risk by 15-25%, providing evidence for its potential protective effect. A comprehensive review of 36 studies involving over 3.2 million people supported this finding.
Research suggests that exposure to insecticides like carbamates can disrupt melatonin receptor signaling, leading to a higher risk of metabolic diseases such as diabetes. The study highlights the need to assess environmental chemicals for their ability to disrupt circadian activity.
A large study published in Depression and Anxiety found that gestational diabetes increases the risk of postpartum depression (PPD) in first-time mothers. Women with a history of depression are more than 20 times more likely to experience PPD, highlighting the importance of considering these conditions together.
Research published in JAMA Network found that diabetes in middle-aged Chinese adults leads to a nine-year loss of life on average. The study discovered higher mortality risks from ischemic heart disease, stroke, and cancer, particularly in rural areas.
A new study by University of Utah Health found that commercial truck drivers with three or more medical conditions are quadruple their chance of being in a crash compared to healthier drivers. The research suggests that a driver's poor health can increase the risk not only for themselves but also for others around them.
Researchers found that the serum stearic acid/palmitic acid (S/P) ratio was a reliable marker in predicting diabetes remission after bariatric surgery. Patients with higher S/P levels before surgery had greater possibilities for diabetes remission after surgery.
A Baylor College of Medicine team discovered that disrupting the natural cycle of muscle fuel usage can lead to diabetes but also enhances exercise endurance. Mice with disrupted HDAC3 showed superior endurance by burning more lipids and less glucose.
A population-based cohort study found that primary care physicians with higher ambulatory volumes deliver lower-quality diabetes care, while those with higher diabetes-specific volumes provide better care. The study's results suggest a clear association between physician volume and quality of diabetes management.
A study presented at EuroEcho-Imaging 2016 found that chemotherapy caused heart damage in cancer patients with diabetes, leading to a higher risk of heart failure. The researchers also discovered that patients with diabetes experienced a significant decrease in global longitudinal strain, an early predictor of heart failure.
A new test can identify obese women at high risk of developing diabetes in pregnancy, allowing for timely and targeted interventions. The study developed prediction tools using various clinical factors and biomarkers, including blood pressure and anthropometric measures, to accurately define risk in this group.
Researchers found that a SNAP23 inhibitor increases insulin secretion in mice, suggesting a novel therapy for diabetes. The study also showed that SNAP23 promotes vesicle fusion in nonneuronal cells, including pancreatic cells.
A new regional center for diabetes translation research has been established at Albert Einstein College of Medicine, supported by a $2.9-million NIH grant. The center aims to improve diabetes prevention and control in low-income communities and racial/ethnic groups disproportionately affected by the disease.
A MU study found that Hispanic adults with diabetes experienced significant improvements in blood sugar levels through peer support interventions. The meta-analysis of 17 randomized control trials suggests that these interventions can be an effective way to improve glycemic control and health education for minority patients.
A study found that genetic variants in PCSK9 and HMGCR genes associated with lower LDL cholesterol lowered the risk of cardiovascular events and diabetes, suggesting a protective effect. The risk of diabetes was increased, but only in individuals with impaired glucose metabolism, called pre-diabetes.
Researchers found that diabetes causes a specific inflammation leading to heart arrhythmias. Two promising drugs inhibit this inflammatory process, reversing cardiac alterations in diabetic mice.
Heavy smokers with diabetes are at increased risk of death from causes other than lung cancer, according to a study published in the Radiological Society of North America. The study found that participants with diabetes had a doubled risk of all-cause mortality and non-lung cancer mortality compared to those without diabetes.
A new study finds that dementia rates are decreasing in the US, particularly among those with more years of education. However, three risk factors – diabetes, high blood pressure, and obesity – are on the rise and could offset these gains.
A new study found that low blood sugar in hospitalized patients is associated with increased short- and long-term mortality risk. The study's authors recommend increasing awareness of hypoglycemia and improving quality of care for patients who experience it.
Scientists at the University of Michigan are studying protein degradation in pancreatic beta cells to better understand diabetes at the molecular level. They found that proinsulin misfolding can lead to diabetic disease and identified a way to stimulate the degradative pathway to restore normal insulin secretion.
A new study published in Developmental Cell demonstrates that a nerve growth protein plays a crucial role in regulating blood sugar levels by prompting pancreatic cells to release insulin. The research, led by Johns Hopkins University biologist Rejji Kuruvilla, has potential implications for the treatment of type-2 diabetes.
A QUT study reveals foot disease affects 10% of hospital patients, with half hospitalized due to the condition. The study estimates $4.7 billion annual cost and fills nearly 5,000 hospital beds each night.
Researchers studied nearly 3,000 black participants in the Jackson Heart study, who reported their smoking status. The study found that those smoking over a pack a day had a 62% higher risk of developing diabetes compared to others.
A recent study found that the incidence of coronary heart disease in the US declined by nearly 20% between 1983 and 2011. The decline was attributed to improvements in diabetes treatment and control, as well as changes in awareness and prevention efforts.
Researchers found that people with RA have double the risk of CV events as those in the general population, rates similar to those with type-2 diabetes. Chronic inflammation in RA contributes independently to cardiovascular risks for these patients.
A portable breathalyzer has been developed to diagnose diabetes noninvasively in offices. The device traps and analyzes acetone levels in exhaled breath, with accuracy matching mass spectrometry readings.
A new study published in The Diabetes Educator found that nearly 1 in 5 women with diabetes also suffer from depression. Younger age, poor health, not completing high school, and inactivity due to pain or poor health were identified as key predictors of comorbid depression among adult women.
A five-year study in Tanzania aims to determine whether combining diabetes and hypertension screening with HIV screening will increase HIV testing and care. The integrated approach is expected to improve health outcomes and reduce costs, addressing growing global epidemics of HIV, diabetes, and hypertension.
A study by Washington University School of Medicine researchers found that blocking the production of fat inside immune cells may prevent chronic inflammation in people with diabetes. This could have a profound impact on health and potentially lead to new treatments for cancer and other conditions.
Researchers at Cedars-Sinai discovered that cutting nerves to the kidneys dramatically improves liver sensitivity to insulin, effectively curing insulin resistance in laboratory animals. The study reveals a previously unknown communication pathway between the kidneys and liver to regulate blood sugar levels.
A study published in CMAJ found that telemedicine, including text messaging and web portals, can effectively manage diabetes by monitoring blood sugar levels and motivating patients. The use of interactive formats such as web portals or text messaging was most effective in controlling HbA1C levels.
A new study found that resveratrol supplements can lower total testosterone levels by 23.1% in women with polycystic ovary syndrome (PCOS), while also improving diabetes risk factors such as fasting insulin levels. The results suggest resveratrol may be a promising treatment for PCOS and related metabolic problems.
People with epilepsy are seven-fold more likely to experience discrimination due to health problems than the general population. Adverse life events such as discrimination may be an important factor in the development of depression and anxiety disorders among individuals with epilepsy.
A new BU study reveals that the nation's two largest soda companies sponsored at least 96 national health organizations from 2011 to 2015, dampening efforts to combat obesity and reduce soda consumption. The companies' tactics include using relationships with health groups to develop positive associations for their brands.
Researchers at Oregon State University have identified how xanthohumol works and why it has promise in addressing high cholesterol, blood sugar, obesity, and other issues of metabolic syndrome. Xanthohumol may be used as a supplement or prescription drug to address these disorders.
The Global Burden of Disease study 2015 found that life expectancy has risen globally, but 70% of deaths are now due to non-communicable diseases. The study analyzed 249 causes of death, 315 diseases and injuries, and 79 risk factors in 195 countries and territories between 1990 and 2015.
Fruit fly research sheds light on human diabetes, revealing insulin signaling mechanisms and potential new treatments for the disease. The study's findings have implications for understanding and addressing type 2 diabetes.
A new study found an association between exposure to endocrine-disrupting chemicals (EDCs) and lower vitamin D levels in U.S. adults, with the link strongest in women. The study suggests that EDCs may alter the active form of vitamin D in the body.
A study analyzing the American College of Cardiology's PINNACLE registry reveals that nearly 2 out of 5 people with diabetes are not prescribed statin therapy to lower their risk of heart attack, stroke, and related death. The study found a wide variation in statin use across cardiology practices.
A newly developed compound inhibits high blood sugar's deleterious effects on kidney cells and slows kidney disease progression in diabetic mice. It protects kidneys in early and advanced phases of diabetes, improves function, and reduces inflammation.
Eating red meat increases significant risks for diabetes, heart disease, stroke, and certain cancers. The production of red meat also creates an environmental burden with impacts on greenhouse gas emissions and water use.
A new study found that carefully administering small doses of hydrogen sulfide can restore mitochondrial efficiency and prevent hyperglycaemia-induced damage to blood vessels. This could lead to new treatments for common heart and blood vessel complications associated with diabetes.
Researchers found that transplantation of human placental stem cells into diabetic rats improved blood flow and reduced critical limb ischemia, a condition leading to diabetic foot and amputation. The study suggests that mesenchymal stem cells have the potential to treat diabetes-related complications.
Researchers found that patients are willing to participate in telemedicine for diabetic retinopathy screening if it is convenient and tailored to their needs. The study suggests that telemedicine could ease the burden on patients who face high costs, lack of access, or difficulty with transportation.