Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Research identifies common molecular mechanism underlying diabetes-induced nerve damage, paving way for potential drug candidates. The study found that reactive oxygen species play a key role in the process and that pharmacological inhibition of ROS can prevent nerve damage.
Researchers have identified a specific gene, ADCY3, that predisposes Greenlanders to obesity and diabetes when it is inactive. The study, published in Nature Genetics, found that 4.4% of test subjects had the gene inactive, leading to significant weight gain and increased risk of diabetes.
A University of Iowa study reveals how excess fat in the heart's mitochondria leads to impaired energy production and cardiac damage. Researchers found that lipid overload causes small, misshapen mitochondria that don't produce energy efficiently.
A new Northwestern Medicine study finds that blacks have the same risk of developing diabetes as whites when all biological factors are considered over time. Obesity is identified as the primary cause of early onset diabetes in blacks, with black women developing diabetes at triple the rate of white women.
A study published in British Journal of Clinical Pharmacology found that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for major birth defects and pregnancy loss compared to the general population. The increased risk is not due to metformin, but rather the underlying diabetes.
New research suggests that a diet low in branched-chain amino acids (BCAAs) may improve metabolic health and promote leanness. The study found that obese mice on a specialized diet experienced improved glucose metabolism and energy expenditure despite not reducing overall calorie intake.
A study led by Stanford University School of Medicine found that higher blood sugar levels in early pregnancy are associated with a greater risk of congenital heart defects in babies. The researchers analyzed data from over 19,000 pregnancies and found a significant link between blood glucose levels and the risk of heart defects.
Researchers at UCLA discovered that high glucose levels in pregnant women can lead to premature heart cell maturation, increasing the risk of congenital heart disease. The study found that targeting the pentose phosphate pathway could help generate more mature cells for regenerating heart tissue.
A centralized chronic disease management program produced significant improvements in patient outcomes for those with diabetes, hypertension, or cardiovascular disease. Practices with central population health coordinators showed greater improvements in testing and clinical targets compared to those without coordinators.
A new study from Washington University School of Medicine in St. Louis suggests that kidney dysfunction increases the risk of diabetes. Elevated urea levels, which can be lowered through medication and diet, are a likely cause of this relationship.
A Stanford University School of Medicine study found that men with varicoceles, enlarged veins in the scrotum, are more likely to develop heart disease, diabetes, and hyperlipidemia. However, asymptomatic varicoceles do not increase the risk of these diseases.
A study published in The Lancet Diabetes & Endocrinology found that diabetes and high BMI were responsible for 544,300 new cancer cases globally in 2012. The authors project a significant increase in the proportion of cancers attributable to these risk factors, particularly in low- and middle-income countries.
A new study published in The Lancet Diabetes & Endocrinology found that diabetes and being overweight or obese are responsible for nearly 800,000 new cancer cases globally. High BMI was linked to twice as many cancers as diabetes, with liver cancer and endometrial cancer being the most common types.
A study comparing diabetes foot care regions in England found that areas with comprehensive services had significantly lower rates of major amputations. The introduction of key services, including podiatry staffing and orthotist availability, led to improved outcomes.
Rutgers New Jersey Medical School immunologist Luis Ulloa believes the body has an electrical network that can be used to manipulate and help control its functions. He suggests phone-based bioelectronic medicine could treat inflammatory disorders like arthritis, colitis, diabetes, obesity, and life-threatening infections.
Scientists at University of Basel find feedback mechanism to maintain insulin production in overweight patients, using ILC2 immune cells and retinoic acid. The study highlights the complex interactions between endocrine and immune cells in regulating insulin release.
A new study found that child snoring is associated with worsening obesity and increased metabolic risk, creating a vicious cycle. Children who snored were more likely to develop higher body fat mass and obesity later in childhood or adolescence.
Researchers have identified a new blood-sugar marker, fructosamine, that can predict patients at highest risk of complications after joint surgery. The test detects changes in glucose control faster than current markers, which could help prevent life-threatening post-surgery complications.
A new study reveals that unequal exposure to environmental pollutants may drive higher diabetes rates among minority and low-income populations. Endocrine-disrupting chemicals can hinder insulin production, increasing the risk of diabetes.
A study of 2,908 participants found no change in glycemic control among people with diabetes in the US between 1998-2010 and 2007-2014. Despite an increase in awareness and testing for HbA1c levels, there was no significant improvement in glycemic control during this period.
The Endocrine Society examines how diabetes damages microvascular system, causing complications such as diabetic retinopathy and kidney disease. Maintaining tight control over blood sugar levels may help reduce risk of complications, but also poses risk of hypoglycemia and cardiovascular issues.
Research found that eating fat at night leads to higher blood fat levels, a risk factor for heart disease and diabetes. The study's findings suggest ignoring the body's natural 24-hour cycle can harm health.
A new study published in Nature Cell Biology shows that human stem cells can be used to produce insulin-producing cells that can be transplanted into diabetes patients. The development of these cells depends on their sense of direction and polarity, which can be controlled using a specific signal pathway.
A history of kidney stones may increase the risk of metabolic and hypertensive complications during pregnancy. Research found that women with pre-existing kidney stones were more likely to experience gestational diabetes and hypertension.
A UC Riverside study highlights significant health problems affecting historically ignored racial groups, including multiracial, Native Hawaiian, and American Indian populations. The research reveals high rates of obesity and diabetes among these groups, with disparities exceeding those experienced by non-Hispanic white adults.
A massive database of mobile app designs has been created to help designers find cost-effective solutions, allowing for the automated exploration of less common screens and machine-learning models that can go beyond simple search interactions.
A new study suggests that increased screening by primary health care providers is yielding a bigger proportion of diagnoses, leading to more opportunities for treatment. The study found that the proportion of missed cases of diabetes dropped significantly over time, from 16.3% to 10.9%, and targeted screening in high-risk populations c...
Scientists identify protein disulfide isomerase (PDI) as a key therapeutic target to improve blood vessel health in diabetes. PDI regulates angiogenesis, wound healing and mitochondrial function, offering new potential treatments.
Older patients with diabetes are at an 84% higher risk of developing postoperative cognitive dysfunction (POCD) than those without diabetes. POCD affects 10-13% of patients after major surgery, particularly seniors, and can result in increased complications and impaired quality of life.
The Marshall University Joan C. Edwards School of Medicine has launched a new program to improve access to diabetes care in West Virginia, thanks to a $1.5 million grant from the Merck Foundation. The program aims to address healthcare disparities among vulnerable populations and promote health equity.
Researchers at Nationwide Children's Hospital describe a gene-environment interaction that increases the risk of congenital heart defects in infants born to diabetic mothers. Maternal hyperglycemia disrupts normal heart development by reducing nitric oxide production and increasing expression of Jarid2, a repressor of Notch1.
A study comparing diabetes foot care services across England found that areas with 10 key services had lower rates of major lower limb amputations. These services include administrative support, standardized screening, and effective care pathways.
A study published in JAMA Internal Medicine found that women with a history of gestational diabetes were at a modestly higher risk of cardiovascular disease. However, adhering to a healthy lifestyle appeared to help mitigate this risk in younger women, particularly those who were predominantly white and followed healthy habits over time.
A new type of diabetes has been identified caused by a mutation in the RFX6 gene, leading to reduced insulin secretion and increased risk before age 20. GIP analogs may provide a novel treatment option for patients with this condition.
A study published in Neurology found a significant increase over 10 years in the percentage of people with stroke who have high blood pressure, diabetes, and other risk factors. The prevalence of these risk factors increased from 88% to 93%, with high cholesterol and drug abuse rates doubling.
Scientists have discovered a new molecule that stimulates blood vessel formation, which could help treat non-healing wounds and injuries associated with diabetes. The discovery has the potential to reduce the number of limbs amputated due to diabetes, offering a cost-effective treatment option.
The Joslin Diabetes Center has been awarded $8.2 million from the National Institutes of Health (NIH) in continued support for its Diabetes Research Center program. The funding will enable researchers to advance treatments and potentially find a cure for diabetes.
A new study published in PLOS ONE found that a significant proportion of South Africans with diabetes do not receive adequate care, with nearly twice the proportion of cases being undiagnosed. The research highlights gaps in screening, diagnosis, treatment, and control of the disease, particularly among adults aged 40-plus.
This thematic issue explores customized diabetes management in medically complex patients, including those with mental illness, post-bariatric surgery, older adults, and disparity populations. Key findings highlight the importance of psychosocial assessment and medication adjustments to improve patient outcomes.
A new study found that both restrictive spirometry pattern and reduced forced vital capacity were associated with increased arterial stiffness in men and women. Arterial stiffness increased fourfold when FVC decreased, highlighting the importance of assessing and following up on individuals with restrictive spirometry patterns.
Researchers at WashU Medicine have identified a way to convert white fat into beige fat, a type of fat that burns calories and protects against obesity. By blocking a specific protein in white fat cells, scientists can induce the production of beige fat, leading to weight loss and improved metabolic health.
A new study reveals that endoplasmic reticulum-associated degradation plays a crucial role in controlling hormone levels and systemic water balance. The research found that misfolded proteins can lead to hormone imbalance and diseases such as diabetes insipidus, highlighting the importance of protein folding and quality control.
A new study suggests that nearly 11% of Medicare participants with diabetes have very low blood sugar levels indicating over-treatment. However, only 14% of these patients had a reduction in blood sugar medication refills in the next six months.
Chronic kidney disease is characterized by gradual loss of kidney function over time. Poor sleep duration and quality are associated with steeper declines in kidney function and increased risk of developing kidney failure.
A new study reveals that up to 11% of older Americans with well-controlled diabetes are being overtreated, while around 7% are undertreated. The research emphasizes the need for personalized care in treating diabetes in older patients.
Researchers found that a weight loss of more than 10% can lead to a significant reduction in disease risk for individuals with metabolically unhealthy obesity. This intermediate goal can serve as a low-hanging fruit, providing documented protection against obesity-related metabolic diseases, and improving patient motivation through doc...
A recent study published in Diabetologia found that weight loss after obesity surgery can reverse early eye damage caused by obesity, high blood pressure, and diabetes. The research team discovered improvements in the retinal microvasculature of obese subjects following bariatric surgery.
Women with diabetes who regularly drink caffeinated coffee or tea may live longer than those who don't consume caffeine at all. The study found that higher levels of caffeine consumption from coffee were associated with a reduced risk of death from any cause, particularly from cardiovascular disease.
Michael N. Hall's discovery of the TOR protein has led to a fundamental change in how cell growth is understood, providing critical information for developing anti-cancer drugs. The Lasker Award recognizes his pioneering research on cell growth regulation and its role in diseases such as cancer and diabetes.
Martha Sajatovic, MD, receives international grants to develop and test adherence enhancement programs for chronic psychiatric disorders. The projects also explore patient-centered approaches to diabetes management, including Shared Medical Appointments (SMAs) and targeted training for illness management.
A Singapore-based health study found that consuming red meat and poultry increases the risk of developing diabetes. The study suggests replacing these meats with fish, tofu, or legumes may help reduce the risk.
A new study shows that untreated sleep apnea increases blood sugar, fat levels, stress hormones, and blood pressure while participants slept. Continuous positive airway pressure (CPAP) therapy is recommended to prevent these consequences.
Researchers at LSU Health New Orleans have discovered the potential of a protein called Nischarin to treat or prevent metabolic diseases such as obesity and diabetes. The findings showed that Nischarin interacts with and controls the activity of a gene called AMPK, leading to improved glucose and insulin tolerance.
A study by researchers from the German Center for Diabetes Research found that nearly 22% of hospitalized patients in Tübingen had diabetes or prediabetes. Patients with diabetes required longer hospital stays and were at a higher risk of complications, highlighting the need for early detection and treatment.
A new paradigm for microbiome research suggests that each person's microbiome responds differently to stress, rather than following a predictable pattern. This concept, called the Anna Karenina principle, has key implications for antibiotic therapy, chronic disease management and other medical approaches.
A new method using molecular spectroscopy enables researchers to extract biochemical profiles containing information about disease progression. The method facilitates improved understanding of the mechanistic processes on molecular and cellular levels that are key to developing diabetes.
Researchers at Beth Israel Deaconess Medical Center found that consuming walnuts activates the right insula, a brain area linked to cognitive control and salience. This activation is associated with reduced hunger and increased feelings of fullness.
Researchers at the University of Wisconsin-Madison have developed a new measurement for the volume and activity of beta cells, which are responsible for producing insulin. The new test uses PET scanning to detect minute levels of a radioactive chemical in the mouse pancreas, providing a more accurate assessment of insulin production.
A recent review suggests that frailty can be prevented with proper exercise, weight management and socialization. By adopting these measures, the elderly may be able to live healthier lives and avoid symptoms like fatigue and isolation.
Researchers at the University of Bergen have successfully transformed skin puncture cells from diabetes patients into insulin-producing cells. The goal is to transplant these cells under the skin, potentially replacing insulin shots and blood sugar measurements.