Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Researchers at University of Toledo have developed a mouse model that spontaneously develops type I diabetes and its complications, allowing for study of disease progression. The breakthrough has the potential to reshape how type I diabetes is studied and may lead to new treatments or a cure.
A study of 959 obese pregnant women found no significant difference in birth outcomes between early and routine gestational diabetes screening. Early screening was associated with increased insulin use, a potential drawback for patients.
A study analyzing electronic health records found that Native Americans experience a higher incidence of ischemic stroke, with common risk factors including high blood pressure, diabetes, and smoking. The study also revealed significant increases in these modifiable risk factors between 2000 and 2016.
A study published in the Journal of Obesity found that losing weight quickly versus slowly does not provide additional health benefits, with improvements in metabolic health being similar regardless of rate. The focus should be on achieving sustained weight loss at a safe pace of one to two pounds per week.
Geriatric frequent users are more likely to have multiple chronic conditions and require more resources and medical interventions. The most common conditions among these patients include diabetes, kidney disease, and congestive heart failure.
The University of Illinois Chicago will continue its role as the Chicago field center for the Hispanic Community Health Study/Study of Latinos, a multi-site study of health issues and risk factors among Hispanic/Latino adults. The new funding will support phase III of the study, which aims to bring back participants for a follow-up exa...
Researchers have pinpointed a mechanism that leads to steroid diabetes in patients undergoing long-term cortisone treatment. The findings suggest that the E47 transcription factor plays a key role in the changes in gene expression, particularly in liver cells.
The interoperable Artificial Pancreas System smartphone app has shown improved time in the target glucose range and a statistically significant reduction in time below 70mg/dL. The study suggests that this system could provide personalized care for patients with diabetes, offering flexibility and convenience.
A recent study found that insulin deprivation in mice resulted in decreased ATP production in brain regions critical for memory, similar to previous findings in skeletal muscle. Intranasal insulin treatment reversed this decline, suggesting insulin's role in maintaining brain mitochondrial function.
A new study finds that people with pre-diabetic blood sugar levels are at a lower risk for developing cardiovascular disease. However, most individuals will go on to develop diabetes unless they take measures to reduce their blood sugar levels.
Researchers at the University of Copenhagen's Niels Bohr Institute have found a new mechanism in bodily cell regulation through chaos. Chaotic swings in a protein's concentration activate genes, optimally tuning the immune system.
A new Ohio State University study found that adhering to heart health guidelines can lower the risk of developing diabetes by 70% over 10 years. Researchers analyzed data from 7,758 participants and discovered that those with normal blood glucose levels who met four or more guideline factors had a significant reduction in diabetes risk.
Researchers have developed a breakthrough technology to grow human blood vessels as organoids in a petri dish, which can be used to study vascular diseases and identify potential treatments. The discovery has the potential to unravel causes of conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.
A recent study by researchers at The Ohio State University Wexner Medical Center found that following heart health guidelines can significantly reduce the risk of developing diabetes. Participants who met the recommended ranges for four or more of the seven factors had a 70% lower risk of developing diabetes over the next 10 years.
A study published by The Endocrine Society found that gastric bypass surgery improves relative muscle strength and physical performance in people with obesity. Despite dramatic weight loss causing a decline in absolute strength, patients experience meaningful improvements in walking speed and other measures of physical function.
Scientists at the University of Bergen found that glucagon-producing cells in the pancreas can change identity and adapt to produce insulin for damaged or missing cells. This discovery may lead to new treatments where the body produces its own insulin with minimal assistance.
Researchers found that participants who completed mindfulness training lost an average of 3 kilograms more than those who did not attend the course. The study suggests that mindfulness techniques can help improve eating behavior and facilitate successful weight loss in individuals with obesity.
Research suggests that a novel protein called Nischarin may be a promising therapeutic target for obesity and diabetes. Studies found that Nischarin expression is suppressed in fat tissue of obese humans and that its disruption leads to insulin resistance in female mice, but not male mice.
Researchers explore protein tyrosine phosphatases in metabolic diseases to understand diabetes development. They focus on inflammation's role in pancreas and liver cells, aiming to identify new therapeutic approaches targeting PTPs.
A Swedish study found that the risk of heart attack peaks at around 10 pm on Christmas Eve, especially for older and sicker individuals due to heightened emotional stress. This risk is also higher during New Year's and Midsummer holidays, as well as Monday mornings.
Researchers found a novel time-keeping mechanism within liver cells that contributes to disease development when its natural rhythm is disrupted. The study suggests that the circadian clock modulates HNF4A's classical functions, providing a potential explanation for diseases such as diabetes and cancers.
A study published in Palgrave Communications found a strong negative correlation between median household income and obesity rates in the US. Since 1990, the rise of obesity has been fastest among the poorest regions, with lower-income households facing a higher likelihood of suffering from obesity and diabetes.
A study published in Nutrition and Diabetes found that four dried fruits - dates, apricots, raisins, and sultanas - have a lower glycemic index than white bread. The results suggest that dried fruits can be used as a low glycemic index food source to replace higher glycemic index foods.
Patients with diabetes are more likely to experience hypoglycemia after fasting, which can lead to faintness, confusion, and loss of consciousness. The study suggests that routine fasting guidelines may not be necessary anymore, and proper education about fasting and diabetes is lacking.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism reveals weight cycling is associated with a higher risk of death. Conversely, weight loss from weight cycling can reduce diabetes risk in people with obesity.
A new study by American Society of Nephrology examined 281,233 patients with diabetes and CKD in 130 VA facilities. The findings point to areas where care might be improved and standardized among facilities.
A recent study found that high blood pressure affects around 19% of Indian adults, with diabetes being a major risk factor. Screening for hypertension should start at age 18-19 and include education on healthy lifestyles to prevent the condition.
A new study suggests that antioxidants can reduce cognitive impairments caused by low blood sugar in diabetic patients. The research found that stimulating antioxidant defenses with sulforaphane improved cognitive ability in mice, indicating potential benefits for humans.
Researchers identified a gene mutation in SGLT1 that helps protect against spikes in glucose levels, resulting in lower incidence of obesity, diabetes, death, and heart failure. The study's findings suggest potential therapeutic targets for metabolic disease.
A new study suggests that regular vitamin B12 screening in metformin-treated type-2 diabetes patients can reduce the risk of irreversible nerve damage. The study found that nearly 70% of patients were not being checked for vitamin B12 levels, despite a link to peripheral nerve damage.
Research found that individuals with diabetes who switched to high-deductible health plans experienced delays in seeking care for symptoms of blood vessel diseases, including cardiac chest pain and transient ischemic attacks. The study suggests that increased out-of-pocket costs lead to changes in healthcare behavior.
Physicians say firearms are within their lane, disagreeing with NRA's stance on gun violence prevention. The American College of Physicians is collaborating with the American Foundation for Firearm Injury Reduction in Medicine to provide funding for research and develop practice recommendations on firearm injury prevention.
Researchers at Purdue University have developed a shoe insole that gradually releases oxygen to aid healing of diabetic foot ulcers. The insole can be customized to fit individual wound sites and is designed to improve mobility for patients with diabetes, who are at risk of losing toes or limbs if left untreated.
A study by OHSU researchers found that patients with diabetes or prediabetes in states with Medicaid expansion programs had better access to healthcare services, including preventive screenings and medication. This increase was particularly notable for patients with lower socioeconomic status.
A study published in Gerontology and Geriatric Medicine found that regular exercise among Japanese expatriates can reduce time spent sitting down and improve mental health. Compared to non-exercisers, those who exercised regularly spent 135 minutes less time sitting and had a higher quality of life score.
Researchers are creating three-dimensional models of blood vessels using pig arteries and human endothelial cells to study fibroblast behavior. This could provide a powerful tool for diabetes basic research and drug screening systems.
Researchers have developed a mouse model that closely replicates human diabetic nephropathy, revealing a key role for immune and inflammatory responses in promoting kidney damage. This finding suggests targeting these pathways may be useful for preventing or slowing the development of diabetic nephropathy.
A study of 472,000 participants found that women with these conditions experience a higher relative risk of heart attack compared to men. The excess risk persists even in older age and could lead to an additional burden on society.
A UK Biobank study found that certain risk factors have a greater impact on women's heart attack risk than men's. High blood pressure, smoking, and diabetes increased the risk of heart attack more in women than in men.
A study of over 600 patients with overweight or obesity found that a hypocaloric Mediterranean diet combined with daily exercise maintained clinically significant weight loss after one year. Patients showed improvements in glucose metabolism and inflammatory markers, while those with diabetes saw particularly high benefits.
Research reveals that diabetics' enzyme can flip blood vessel cells, creating gaps three times more permeable than normal. Controlling this process could ease swelling, nerve pain, and infection risks.
A new study in the American Journal of Preventive Medicine reports that most US adults do not engage in muscle-strengthening exercise (MSE), with nearly 60% doing no MSE at all. The investigation found that low-to-moderate frequency of MSE is linked to fewer reported health conditions such as diabetes, obesity, and cancer.
A Rutgers study suggests that extremely high blood pressure is responsible for severe organ damage due to hypertensive emergencies in African-Americans with diabetes. Better controlling blood pressure can help prevent life-threatening complications and target organ damage associated with hypertensive emergencies.
A Loyola University Chicago study reveals that diabetes causes heart failure through the accumulation of methylglyoxal, which weakens heart muscle cells. The findings suggest new drug treatments to counter the effects of methylglyoxal and prevent heart failure in diabetics.
A study by University of Pittsburgh researchers found that measuring percentage of weight regained after bariatric surgery can help predict serious health problems. The rate of weight regain was highest in the first year following maximum weight loss, indicating early detection and treatment may be crucial.
A new study published in The Lancet found that lorcaserin, an appetite-suppressant drug, decreases the risk of developing diabetes and increases the rates of remission of high blood sugar in obese and overweight patients. Lorcaserin also reduces the risk of kidney complications due to diabetes.
A nationwide study found that people with diabetes from deprived backgrounds are twice as likely to be admitted to hospital for major cardiovascular events. Socioeconomic inequalities persist, despite improvements in overall cardiovascular disease outcomes.
A new study based on SWAN data suggests that women with a history of hypertensive disorders of pregnancy and gestational diabetes may experience a greater burden of hot flashes during the menopause transition. The study identified social factors such as education as influential in shaping pregnancy outcomes and hot flashes.
Researchers found that 79% of insulin temperature logs contained deviations from the recommended range, with fridge storage being the biggest issue. This can lead to reduced potency and variability in dosing for people with diabetes, highlighting the need for proper storage and monitoring practices.
A new study found increasing infection rates for urinary tract infections, sepsis, and skin infections among people with diabetes in the USA. Rates of infection-related hospitalisations increased by 52% between 2010 and 2015 compared to the general population.
A large study in Shanghai, China found that socioeconomic development contributed to lower death rates for most diseases, likely due to lifestyle factors. Death rates from infectious diseases, maternal issues, and injuries decreased between 1974 and 2015.
Researchers found that vitamin B complex supplementation improved blood glucose regulation and kidney function in children with type-1 diabetes. The study suggests that simple supplementation may be a safe and cost-effective strategy for early protection of kidney function.
A team of researchers, led by Professor Davide Calebiro, will investigate the function of G protein coupled receptors (GPCRs) to develop new therapies for diseases like heart failure and diabetes. They will use innovative microscopy methods to directly visualize individual receptors in living cells.
The TGen-UNM consortium has been awarded a $2.8 million grant to investigate the genetic causes of diabetic retinopathy and develop precision medicine-based treatments. The study aims to identify new biomarkers and therapeutic targets to prevent the progression of the disease.
A new analysis published in The Lancet found that more than half of all countries are not on track to meet the UN target to reduce premature deaths from non-communicable diseases by a third by 2030. For women aged 30-70, only 9% of countries are on track, and for men, it's just 3%. The study highlights the need for policy changes to ad...
Researchers analyzed Twitter conversations around OpenAPS, a DIY system combining off-the-shelf CGMs and insulin pumps, to understand its benefits and limitations. The study found that OpenAPS improved self-reported A1C and glucose variability while reducing daily distress and burden, but also raised concerns about safety and regulation.
Dr. Ming-Hui Zou's research focuses on how high glucose affects mitochondria, leading to atherosclerosis and endothelial dysfunction in diabetes. The study aims to understand the cellular mechanisms behind these complications and explore potential self-defense mechanisms.
A new poll suggests that primary care providers could play a crucial role in promoting vision care for adults age 50 and older. The poll found that nearly a quarter of respondents said they hadn't had their eyes checked by an eye doctor in three years or more, citing cost and lack of insurance coverage as major barriers.
A large study found that care coordination strategies significantly reduce symptoms of depression and improve health in seniors with multiple chronic diseases. The review included 25 studies and 12,579 older adults, highlighting the potential benefits of managing co-existing chronic illnesses in a coordinated manner.
Deaths from drug overdose and suicide in the US have surpassed those from diabetes, with rates increasing by 80% between 2000 and 2016. Researchers urge national initiatives to tackle common factors behind 'self-injury', citing trauma, adversity, and mental health issues as key drivers.