Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A study of over 900,000 VA patients found that routine blood tests with random plasma glucose levels below 200 mg/dL can accurately predict the development of diabetes. Patients with high glucose levels are more likely to be diagnosed with diabetes in the future, making this test a valuable tool for early intervention and prevention.
Research by UMass Amherst epidemiologist Youssef Oulhote found that women with gestational diabetes have a significantly higher rate of transferring synthetic chemicals to their fetus. The study examined blood and umbilical cord samples from 151 mother-newborn pairs in the Faroe Islands.
Researchers identified a molecular mechanism that may be contributing to the global obesity epidemic. The study found that a protein called RAGE on the surface of fat cells can block fat burning when stressed, leading to weight gain. Removing RAGE from fat cells reduced weight gain in mice fed a high-fat diet.
A recent analysis found that US patients with chronic kidney disease (CKD) have a high prevalence of uncontrolled hypertension and diabetes, highlighting the need for improved care. The study also reveals low use of statins in CKD patients, which is not concordant with guidelines.
Researchers found that nearly 50% of chronic kidney disease patients had uncontrolled hypertension and 40% had uncontrolled diabetes between 2006-2014. Statin use was also low, averaging only 3% over the study period.
Researchers found that a 12% calorie reduction over two years improved cholesterol, blood pressure, blood sugar levels and reduced biomarkers of chronic inflammation. Participants who maintained a 25% calorie reduction showed significant weight loss, primarily fat, and reductions in metabolic risk markers.
Researchers at the Feinstein Institutes have discovered how the vagus nerve relays signals from the periphery to the brain to regulate glucose levels. This finding could lead to new ways of measuring blood glucose levels and may uncover a new approach to managing diabetes.
A large-scale study found elevated levels of a biomarker for uranium toxicity in Kuwaiti children who developed obesity and metabolic syndrome. The study suggests that uranium exposure may contribute to the country's high rates of obesity and diabetes.
Scientists at University of Utah Health and Merck Research Laboratories found that altering the production of ceramides can reverse insulin resistance and fatty liver disease in obese mice. By deactivating an enzyme called DES1, they lowered total ceramide levels, improving metabolic health.
Researchers at Joslin Diabetes Center have identified a protein found in the eye that protects against and potentially treats diabetic eye disease. Retinol Binding Protein 3 (RBP3) prevents the development of diabetic retinopathy, and introducing it early can reverse the effects of the complication in rodent models.
A large population-based study found that antidepressants significantly reduced mortality by 35% in patients with diabetes and depression. This significant reduction highlights the importance of addressing depression in individuals with diabetes, a condition where two to three times more people are at risk of depression.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
A recent study highlights the need to screen older individuals with HIV for diabetes mellitus, which shows a significant correlation with age and race. The study also suggests that traditional glycated haemoglobin tests may underestimate diabetes diagnosis in HIV-positive patients, emphasizing the importance of considering alternative ...
Joslin researchers will contribute to mapping specific tissues in the healthy human body using chemical imaging and single-cell sequencing. The goal is to understand how disease affects cells and develop new treatments for metabolic diseases.
Researchers found that levels of neurofilament light chain (NfL) in the blood contribute to stroke risk in diabetic patients. The study discovered a strong association between NfL levels and stroke occurrence, suggesting that adding this protein to existing stroke risk scores can increase accuracy.
Researchers at the University of Nottingham discovered that drinking coffee can stimulate 'brown fat', increasing body heat and burning calories. This could be a key to tackling obesity and diabetes. The study used thermal imaging to trace brown fat reserves and found that caffeine had a direct effect on its functions.
Researchers discovered that Veillonella bacteria in elite athletes' gut microbiomes can enhance exercise performance in mice by breaking down lactate and producing propionate, a short-chain fatty acid. This breakthrough paves the way for highly-validated performance-enhancing probiotics.
Patients managing their health via electronic patient portals had fewer emergency room visits and hospitalizations. Access to the portal was associated with more outpatient office visits, fewer emergency department visits, and fewer preventable hospital stays in patients with multiple complex chronic conditions.
A study from Penn Medicine and Stony Brook University found that language in Facebook posts can identify conditions such as diabetes, anxiety, depression, and psychosis. The researchers analyzed nearly 1,000 patient profiles and built models to predict disease using post language alone or combined with demographic data.
A study at EULAR 2019 found that RA patients with IBD and type I diabetes have higher rates of venous thromboembolism, epilepsy, and heart attacks compared to controls. These findings suggest that these conditions may be novel comorbidities for patients with RA.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.
A VA study examined over 600,000 veterans with diabetes and found that health outcomes were similar regardless of whether primary providers were physicians, nurse practitioners, or physician assistants. The results suggest using these providers in primary care may improve healthcare efficiency.
Researchers have created a novel mouse model of psoriatic arthritis (PsA) by infecting non-obese diabetic mice with an adenoviral vector expressing single-chain IL-23, resulting in symptoms similar to human disease. This breakthrough model can be used to test and optimize PsA therapies.
Researchers from University of Warwick modelled effects of high blood glucose on human endothelial cells, revealing a key mechanism in blood vessel damage. The study identifies increased hexokinase-2 activity and methylglyoxal formation as drivers of metabolic dysfunction and inflammation.
A 12-year study of older adults with prediabetes found that most reverted to normal blood sugar levels, while obesity accelerated its progression to diabetes. Effective weight management and blood pressure control can help reverse prediabetes in older age.
Researchers at WVU discovered that higher exposure to perfluoroalkyl substances was associated with lower rates of coronary heart disease in adults with diabetes. The study, led by Kim Innes, used data from the C8 Health Project and found an inverse association between PFAS levels and heart disease risk.
A new study has identified several potential approaches for improving medication adherence among Latinos with diabetes, including simple measures like pillboxes and family member education. The study also highlights specific challenges faced by underserved Latino communities, such as difficulty understanding medications and managing mu...
A small-scale trial found that participants eating ultra-processed foods consumed more calories and gained weight than those on a minimally processed diet, despite similar calorie counts. The study suggests that ultra-processed foods may be a significant contributor to overeating and weight gain.
Death rates due to heart failure are increasing among younger adults under 65, with black men under age 65 facing the largest increase in premature death. The study found that an estimated 6 million adults in the US have heart failure, which is the number one reason older adults are admitted to hospital.
A new study found that closely monitoring patients with diabetic macular edema who have good vision can be an acceptable initial strategy, with prompt treatment starting if vision worsens. The two-year study showed similar visual acuity outcomes among groups receiving aflibercept injections, laser photocoagulation, or observation.
A nationwide study found patients with diabetes discharged with low glucose values have a higher risk of death and rehospitalization; physicians should avoid discharging patients until glucose levels are above 100 mg/dl
A study found that over 80% of Chinese diagnosed with hypertension and/or diabetes in 2011 were unaware of their conditions years later. Despite increased screening, disease awareness remained limited, highlighting the need for improved communication and follow-up care.
A new study led by Harvard T.H. Chan School of Public Health found that consuming propionate may trigger a cascade of metabolic events leading to insulin resistance and hyperinsulinemia. The research also showed that mice exposed to chronic propionate resulted in weight gain and insulin resistance.
A multinational study led by Vanderbilt University researchers has found that diabetes has reached epidemic proportions in Asia, dramatically increasing the risk of premature death, especially among women and middle-aged people. The study highlights the urgent need for tailored diabetes management programs for Asian populations.
The project aims to integrate diabetes and hypertension services with HIV-infection services to test their efficacy and applicability. Chronic conditions are expected to overtake infectious diseases in sub-Saharan Africa within the next decade.
A study published in Experimental Physiology found that shift work can have a long-term effect on the risk of heart disease and diabetes. Shift work was shown to negatively impact the breakdown of triglycerides and sugar utilization in the body, increasing the risk of these diseases.
A meta-analysis found that liquid meal replacements led to an average of five pounds more weight loss compared to conventional low-calorie diets. Additionally, these liquid meal replacements contributed to better reductions in body mass index and systolic blood pressure.
Researchers have shown that gene transfer therapy can improve left ventricle function and glucose disposal in mice with diabetes. A single injection of a hormone called urocortin 2 increased heart function and reduced blood sugar levels, offering a potential new treatment for cardiovascular disease.
Research presented at ENDO 2019 found that walking downhill after eating reduces bone resorption in postmenopausal women with diabetes. The study suggests combining exercise after meals with downhill walking may help reduce the need for osteoporosis medication.
A nationwide survey of Brazilian teens found that excessive screen time and unhealthy snacking are associated with an increased risk of metabolic syndrome, a cluster of risk factors for heart disease and diabetes. The study suggests that limiting screen time and avoiding snacks in front of screens may help reduce this risk.
A study found that people with diabetes are at a higher risk of fractures, particularly among Caucasians and Hispanics. However, African Americans with diabetes showed little to no increased fracture risk compared to those without diabetes.
The Endocrine Society's Clinical Practice Guideline recommends simplifying medication regimens and tailoring glycemic targets to improve compliance and prevent complications in older adults with diabetes. The guideline prioritizes blood glucose targets over hemoglobin A1c tests, aiming to reduce cardiovascular disease outcomes.
Women with undiagnosed gestational diabetes are at a significantly increased risk of stillbirth, according to new research. The study found that the risk of stillbirth was over four times higher in women who developed signs of gestational diabetes but were not diagnosed, highlighting the importance of proper screening and diagnosis.
A pilot study reveals that over a third of middle school kids had abnormal blood sugar or cholesterol levels. Two students were found to have diabetes, highlighting the need for routine screening in this age group.
Patients with insulin-dependent diabetes are more than five times as likely to experience post-operative hyperglycemia compared to those without the condition. The risk is linked to higher blood glucose levels over the previous three months, regardless of insulin dependency.
Elevated soothability in infants was associated with increased likelihood of early childhood obesity and shorter breastfeeding duration. Infant temperaments of elevated soothability and activity also linked to early introduction of sugary drinks, contributing to obesity risk.
A study has revealed that young adults under 40 are experiencing an alarming increase in heart attacks, despite having the same mortality rates as older survivors. Substance abuse and diabetes may be contributing to this trend, emphasizing the need for prevention and early detection of cardiovascular disease.
A new study suggests that glucagon can help regulate insulin action and prevent blood sugar levels from becoming too high. By activating a protein called PGC1A, glucagon can prepare the liver to respond quickly to insulin signals after meals.
A pilot study found that remote blood pressure monitoring via smartphone app, accompanied by education and health coaching, can significantly improve blood pressure control. Participants who had the highest blood pressure at baseline showed the most reductions in both systolic and diastolic pressure.
Preliminary research found that adding high-quality plant-based foods to a diet decreases the risk of deaths from heart disease. A 10-point increase in score on a healthy plant-based diet scale was associated with a 10% lower risk of cardiovascular disease death.
Researchers found quitting smoking significantly outweighs the risk of gaining weight for people with diabetes, despite potential weight gain being a risk factor for cardiovascular disease. The benefits of quitting smoking are substantial, with cardiovascular disease risk reduced by up to 41% among long-term quitters.
UC San Diego Health, Ochsner Health System, Sutter Health and Stanford Health Care developed diverse models of care incorporating patient-centered technologies with measurable outcomes. Technology improved medication adherence for hypertension and diabetes, reduced distress in cancer patients, and enhanced patient engagement.
A new study reveals that diabetes impairs the antibacterial activity of multipotent stromal cells (MSCs), leading to diminished capacity to fight off bacterial infections. This finding has significant implications for the use of MSCs as a therapeutic strategy in treating diabetes and other autoimmune disorders.
Children's Hospital Los Angeles has been awarded a grant to adapt a patient-driven model of care that increases treatment compliance among difficult-to-reach populations, particularly adolescents with diabetes. The goal is to improve the quality of life and manage diabetes effectively in young adults.
A new study from UC Berkeley finds that a soda tax led to a significant decrease in sugary drink consumption, with water consumption also increasing. The results suggest that taxes may be an effective tool in reducing sugar-linked diseases like diabetes and cardiovascular disease.
A new study from Kanazawa University found that dietary n-6 fatty acid intake influences hypertension risk differently in healthy individuals and those with diabetes. In healthy subjects, high n-6 fatty acid intake is associated with increased hypertension risk, while in patients with diabetes, it may lower blood pressure.
A study of over 30,000 Americans reveals significant differences in managing heart disease risk between women and men. Women have better control of high blood pressure, while both sexes struggle with obesity and cholesterol management.
Diabetes mellitus increases risk of stable ischemic heart disease, with trial data showing no benefit from nuclear stress tests or cardiac computed tomography. Revascularization for SIHD also does not reduce mortality or myocardial infarction rates in diabetic patients without symptoms.
This special issue of Cardiovascular Innovations and Applications Journal covers key aspects of stable ischemic heart disease, including contemporary management strategies and epidemiology. The collection of reviews and commentary provides insights into the latest research and clinical practices for this condition.
Researchers from Mount Sinai will investigate the role of follicle-stimulating hormone (FSH) in regulating bone mass, body composition, and fat deposits during aging and menopause. The program aims to develop an FSH-blocking antibody for preventing and treating osteoporosis and obesity.