Articles tagged with Diabetes
A single blood test measuring glycated CD59 at week 24-28 of gestation identified women with GDM with high sensitivity and specificity. The study found that median levels of plasma GCD59 were 8.5-fold higher in women who failed the GCT and 10-fold higher in women diagnosed with GDM.
A new study finds a single measurement of plasma glycated CD59 (GCD59) can identify women at risk for gestational diabetes with high accuracy. Higher GCD59 levels are associated with an increased risk of large-for-gestational-age newborns, highlighting the potential of this biomarker to improve pregnancy outcomes.
Researchers from Georgia State University are investigating the role of mitochondrial dysfunction in developing diabetic cardiomyopathy, a leading cause of heart failure and death in diabetic patients. They aim to understand how increased FUNDC1 expression impairs mitochondrial function, leading to cardiac damage and dysfunction.
A Finnish study found that central obesity, insulin resistance, diabetes, lipid abnormalities, and high alcohol consumption are the strongest predictors of severe liver disease. Among individuals who consume excessive amounts of alcohol, only diabetes is a significant predictor.
A new study found that Medicaid expansion resulted in a 19% increase in prescription fills for adults, with the largest growth in medications for diabetes and birth control. The study also showed that increases in prescription drug utilization were greater in areas with higher uninsured rates and larger Hispanic and black populations.
A study published in JAMA finds that adhering to the 2016 USPSTF recommendations for statin therapy could lead to a lower number of individuals recommended for primary prevention statin therapy. This is due to a higher estimated ASCVD risk threshold and required presence of at least one cardiovascular risk factor.
A new study from the Icahn School of Medicine at Mount Sinai suggests that the sympathetic nervous system, not macrophages, is the main driver of thermogenesis. The research team found that catecholamines released by the sympathetic nervous system can convert white fat tissue into a tissue resembling brown fat.
Researchers have synthesized and evaluated three novel aldose reductase inhibitors, showcasing a spirobenzopyran scaffold that inhibits the target enzyme without affecting ARL1. These results suggest a promising tool for developing effective ARIs to treat diabetic complications.
A new study published in PLOS One found a significant correlation between the consumption of n-6 polyunsaturated fatty acids (PUFAs) and sedentary behavior in pre-teen girls. The research also suggests a weak association between PUFA intake and diabetes risk among adult women in Europe. Researchers recommend further studies to confirm ...
A study of 500,000 Chinese adults found that higher fresh fruit consumption was associated with a lower incidence of diabetes and reduced occurrence of complications in people with diabetes. Fresh fruit consumption was linked to an estimated 0.2% reduction in the absolute risk of diabetes over 5 years.
A new study found a link between neurological birth defects in infants and several neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. Researchers also identified a medicine that could treat these diseases by reducing misfolded proteins.
Research found that bigger women have a significantly higher risk of atrial fibrillation due to their larger body size, with those in the highest body surface area quartile having nearly three times the risk as those in the lowest. The study's findings suggest that avoiding excess weight may be beneficial for tall individuals.
Research tracked over 3,000 women and found that small weight gains within the healthy BMI range doubled their risk of gestational diabetes compared to those with stable weights. Women who gained more than 2.5% of their body weight each year had almost triple the risk of developing gestational diabetes.
Researchers at the University of California, Davis have discovered a possible new route to regenerating beta cells, giving insight into healthy metabolism and diabetes. This discovery could lead to better treatment or cures for diabetes by understanding how these cells mature into functioning beta cells.
A new simple tool can help identify individuals with a higher risk of developing prediabetes. The tool is based on the time it takes to reach a maximal sugar level during an oral glucose tolerance test, indicating poorer pancreatic function and increased risk for diabetes.
A study led by the University of California - San Francisco found that South Asians and Hispanics of normal weight are more likely to have high glucose and hypertension compared to whites. The researchers found that non-whites need lower BMI levels to match the cardio-metabolic risks of whites with a higher BMI.
Researchers developed a decision-tree tool to screen women with gestational diabetes for obstructive sleep apnea. The study found that neck circumference was significantly larger in the OSA group, and having a neck circumference greater than 35.5 cm was associated with higher risk for sleep apnea.
A study at Kanazawa University found that individuals with higher selenoprotein P levels exhibit reduced responses to physical exercise. The research team demonstrated that mice deficient in selenoprotein P showed improved exercise capacity and reduced blood glucose levels after exercise training. Furthermore, women with high selenopro...
The patent analysis highlights the importance of saffron bioactives in treating multiple disorders, including neurological and metabolic conditions. Novel derivatives of safranal show promise in treating infectious diseases.
The American College of Physicians recommends treating substance use disorders as chronic medical conditions with evidence-based public and individual health initiatives. The guidelines aim to improve access to care and reduce the societal burden of these disorders.
Research at Technical University of Munich found that diabetes causes loss of small blood vessels around the heart, affecting cardiac muscle. Genetic therapy promoting pericyte growth may offer a remedy, providing new perspectives for treating patients.
Researchers found that fat cells produce uridine during fasting, helping to maintain energy balance. This discovery may lead to a better understanding of metabolic disorders and new treatments.
Researchers found whole-body vibration (WBV) to be as effective as regular exercise in improving bone formation and insulin sensitivity in obese mice. WBV was shown to mimic the metabolic effects of exercise, with benefits seen in both genetically normal and obese mice.
A University of Queensland study found that older Australian women taking cholesterol-lowering statins face a significantly increased risk of developing diabetes. The risk was highest for those taking higher doses of statins, with a 50% increase in the likelihood of new-onset diabetes.
Researchers at the University of Alberta found that feeding obese mice with resveratrol altered their gut microbiome, improving glucose tolerance. Fecal transplants from healthy mice also showed rapid and dramatic effects on blood sugar levels in obese mice.
Researchers at Case Western Reserve University School of Medicine have identified the CD40 receptor on Mueller cells as the primary driver of diabetic retinopathy. The study reveals that this receptor initiates inflammation in the retina, leading to vision impairment.
Researchers analyzed data from over 4700 women to find a significant association between early puberty and later development of gestational diabetes. Women who started their periods before age 11 were 50% more likely to develop gestational diabetes.
A new study by the University of Warwick found that workers with desk-bound jobs have bigger waists and increased risk of heart disease. To avoid these risks, researchers suggest spending at least seven hours a day on your feet or walking seven miles.
The study focuses on combining SPRA technology with polypseudorotaxane (PPRX) technology to create a sustained and controllable insulin release system. Four types of PPRXs were developed, showing improved blood glucose reduction times and safety profiles.
A recent survey found that more than two-thirds of non-foot-specialist clinicians are unaware of Charcot neuroarthropathy, a rare form of foot damage. The condition can lead to significant disability and morbidity if not diagnosed early. Improving education on this topic is crucial for better patient outcomes.
Researchers found that patients who experienced food insecurity had a higher incidence of stroke risk factors, such as hypertension and diabetes. In contrast, patients not labeled food insecure had lower rates of these conditions.
Research presented at American Stroke Association's International Stroke Conference 2017 found that people with middle age heart disease risks, such as diabetes, high blood pressure or smoking, are at higher risk for dementia later in life. The study, which enrolled 15,744 participants, revealed that the risk of dementia was significan...
A new study by UNC School of Medicine researchers found that the IRS-1 protein plays a crucial role in maintaining vascular smooth muscle cell differentiation, which helps prevent atherosclerosis. In people with diabetes, low IRS-1 levels contribute to abnormal cellular proliferation and increased risk of heart disease.
A study published in Cell Reports found that genetic variation in mice shapes their gut microbiome, which regulates insulin secretion and contributes to the onset of metabolic disease. The researchers observed a correlation between specific bacteria in the microbiome and metabolic traits such as body weight and glucose levels.
The Helmholtz Zentrum München will receive 1.5 million euros to develop stem cell culture models on a chip for investigating pancreatic diseases and testing therapy options. The goal is to explore biology, identify points of attack, and potentially develop beta cell replacement therapy.
A new study found that hemoglobin A1c readings are lower among individuals with sickle cell trait, suggesting a potential systemic underestimation of blood sugar control. This could lead to false sense of security for patients with diabetes.
A study found that standard hemoglobin A1c criteria underestimates long-term glucose levels in African Americans with sickle cell trait, resulting in fewer cases of prediabetes and diabetes. This could lead to missed opportunities for intervention and higher diabetic complications rates
In patients with diabetes, an immune system receptor called Toll-like receptor 4 is activated by dying cells and bacteria, leading to inflammation and bladder dysfunction. Preventing this activation enables the bladder wall to remain strong and elastic.
A long-term study of 4811 London-based office workers found no association between sitting and developing type 2 diabetes. The researchers suggest that the risks are linked to TV time and poor diet, rather than sitting itself.
A five-year clinical trial aims to test whether losing weight before pregnancy can reduce the risk of developing gestational diabetes again, with over 250 overweight or obese women participating. The study will also examine perinatal outcomes for mothers and children.
Researchers at Joslin Diabetes Center have discovered a potential way to reduce complications from blood clot removal during stroke treatment. By targeting the plasma kallikrein protein, they aim to increase the efficacy of tissue plasminogen activator (tPA) therapy while minimizing bleeding and swelling.
A new analysis published in PLOS ONE found that the proportion of US deaths attributable to diabetes is as high as 12%, three times higher than estimates based on death certificates. Diabetes was estimated to be the third leading cause of death in the US in 2010, after heart disease and malignant neoplasms.
A recent study published in PLOS ONE found that diabetes accounts for 12% of deaths in the United States, significantly higher than previously thought. This increase is attributed to the growing prevalence of diabetes, which has risen by nearly 300% since 1980, affecting over 21 million Americans.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
A single episode of high fat intake caused immediate increases in fat accumulation and alterations in liver metabolism. Insulin resistance, elevated triglycerides, and increased glucagon levels were also observed.
Researchers found statins reduce venous thromboembolism (VTE) risk by 15-25%, providing evidence for its potential protective effect. A comprehensive review of 36 studies involving over 3.2 million people supported this finding.
Research suggests that exposure to insecticides like carbamates can disrupt melatonin receptor signaling, leading to a higher risk of metabolic diseases such as diabetes. The study highlights the need to assess environmental chemicals for their ability to disrupt circadian activity.
A large study published in Depression and Anxiety found that gestational diabetes increases the risk of postpartum depression (PPD) in first-time mothers. Women with a history of depression are more than 20 times more likely to experience PPD, highlighting the importance of considering these conditions together.
Research published in JAMA Network found that diabetes in middle-aged Chinese adults leads to a nine-year loss of life on average. The study discovered higher mortality risks from ischemic heart disease, stroke, and cancer, particularly in rural areas.
A new study by University of Utah Health found that commercial truck drivers with three or more medical conditions are quadruple their chance of being in a crash compared to healthier drivers. The research suggests that a driver's poor health can increase the risk not only for themselves but also for others around them.
Researchers found that the serum stearic acid/palmitic acid (S/P) ratio was a reliable marker in predicting diabetes remission after bariatric surgery. Patients with higher S/P levels before surgery had greater possibilities for diabetes remission after surgery.
A Baylor College of Medicine team discovered that disrupting the natural cycle of muscle fuel usage can lead to diabetes but also enhances exercise endurance. Mice with disrupted HDAC3 showed superior endurance by burning more lipids and less glucose.
A population-based cohort study found that primary care physicians with higher ambulatory volumes deliver lower-quality diabetes care, while those with higher diabetes-specific volumes provide better care. The study's results suggest a clear association between physician volume and quality of diabetes management.
A study presented at EuroEcho-Imaging 2016 found that chemotherapy caused heart damage in cancer patients with diabetes, leading to a higher risk of heart failure. The researchers also discovered that patients with diabetes experienced a significant decrease in global longitudinal strain, an early predictor of heart failure.
A new test can identify obese women at high risk of developing diabetes in pregnancy, allowing for timely and targeted interventions. The study developed prediction tools using various clinical factors and biomarkers, including blood pressure and anthropometric measures, to accurately define risk in this group.
Researchers found that a SNAP23 inhibitor increases insulin secretion in mice, suggesting a novel therapy for diabetes. The study also showed that SNAP23 promotes vesicle fusion in nonneuronal cells, including pancreatic cells.
A new regional center for diabetes translation research has been established at Albert Einstein College of Medicine, supported by a $2.9-million NIH grant. The center aims to improve diabetes prevention and control in low-income communities and racial/ethnic groups disproportionately affected by the disease.
A MU study found that Hispanic adults with diabetes experienced significant improvements in blood sugar levels through peer support interventions. The meta-analysis of 17 randomized control trials suggests that these interventions can be an effective way to improve glycemic control and health education for minority patients.
A study found that genetic variants in PCSK9 and HMGCR genes associated with lower LDL cholesterol lowered the risk of cardiovascular events and diabetes, suggesting a protective effect. The risk of diabetes was increased, but only in individuals with impaired glucose metabolism, called pre-diabetes.
Researchers found that diabetes causes a specific inflammation leading to heart arrhythmias. Two promising drugs inhibit this inflammatory process, reversing cardiac alterations in diabetic mice.