Articles tagged with Diabetes
Researchers at Joslin Diabetes Center have identified two molecular pathways that activate brown fat, a type of fat that burns energy rather than storing it. The study provides new opportunities to stimulate brown fat growth, which could lead to the development of treatments for obesity and diabetes.
A recent study published in Neurology found that people with diabetes are twice as likely to develop dementia as those with normal blood sugar levels. The study, which monitored over 1,000 participants for an average of 11 years, also found that controlling diabetes is crucial to prevent cognitive decline.
A survey of federally funded programs in 57 US states and territories found a need for specific, adapted diabetes treatment guidelines. Current national guidelines may not be optimal within each state's resources, and officials lack scientific evidence to adapt them.
The tip sheet highlights common barriers to depression disclosure among patients, including concerns about antidepressant prescriptions and confidentiality. It also explores the widespread use of NSAIDs by patients with chronic kidney disease, despite warnings against their use. Additionally, the article critiques long-established coro...
Multiple lifestyle improvements can reduce the risk of developing diabetes by up to 80%, according to a study of over 100,000 men and women. Additionally, researchers warn that Babesia, a parasitic disease, poses a threat to the nation's blood supply, highlighting the need for donor-screening strategies.
Researchers at the University of Alberta found that resveratrol prevents a metabolic syndrome in offspring born growth-restricted, characterized by glucose intolerance and insulin resistance. The study suggests resveratrol may be a potential pharmacological treatment to prevent future metabolic problems.
Researchers found an inverse relationship between blue light transmission and risk of sleep disturbances in the elderly. The study suggests that natural yellowing of the eye lens, which absorbs blue light, may be responsible for insomnia in older adults.
A review of seven studies involving over 100,000 participants found that higher levels of chocolate consumption were associated with a 37% reduction in cardiovascular disease and a 29% reduction in stroke. However, the authors caution that further studies are needed to confirm these findings.
The Homburg Cream and Sugar study reveals a correlation between triglyceride and glucose tolerance with cardiovascular outcomes in patients with stable coronary artery disease. Postprandial triglyceride levels were found to be strongly correlated with glucose metabolism, particularly in those with normal glucose tolerance.
The study predicts a significant increase in obesity rates in the US and UK, with an estimated 65 million additional obese adults in the US and 11 million more in the UK by 2030. This would lead to increased healthcare costs and a higher risk of chronic diseases such as diabetes, coronary heart disease, and cancer.
A new web-based bodyweight simulation model simulates physiological differences between people based on sex, age, height, and weight. It provides a rough dieting rule for typical overweight adults: every 10 calories per day reduction in energy intake results in about 1 pound of weight loss over 3 years.
A study by UC Davis researchers found biological indicators of toxic fat cells in those with metabolic syndrome, which may lead to diabetes and cardiovascular disease. The discovery supports a new high-risk obesity category for these conditions.
Researchers found people with diabetes alone had a 35% higher risk and those with hypertension alone had a 17% higher risk. The study also showed hyperlipidemia reduced the risk by 5%. Regular eye exams are recommended for those at increased risk of glaucoma.
A study at Joslin Diabetes Center and Children's Hospital Boston found that 'good' brown fat is prevalent in leaner children, increasing until puberty and then declining. Boosting brown fat activity may be an effective approach to combating childhood obesity.
A new study reveals that hydrogen sulfide helps protect blood vessels from the complications of diabetes by controlling an early checkpoint in related processes. The researchers found that diabetic rats have lower levels of 'swamp gas' and improved blood vessel function after treatment.
Stephanie Lewis, a graduate student at Virginia Tech, is using computational modeling and experimental methods to identify molecules that can activate PPAR\u00b71, a therapeutic target for suppressing inflammation in chronic diseases. Her research aims to find novel compounds with insulin-sensitizing and anti-inflammatory actions.
A study found that high blood pressure, diabetes, smoking, and obesity in middle age can lead to brain shrinkage and decreased cognitive function over time. The study involved 1,352 participants without dementia and found associations between these risk factors and white matter hyperintensities and executive function decline.
A study found that measuring hemoglobin A1c levels in patients with diabetes can improve models for predicting cardiovascular disease risk. The level of risk varies among patients, and the test reflects average blood glucose levels over two to three months.
Researchers identify gaps in care for underserved older adults with diabetes and propose treatment models incorporating telehealth, geo-mapping, and community-based education. Better data are needed to evaluate access to care by minority groups.
A new patient-centered medical home (PCMH) model has shown significant improvement in diabetes management, increasing adherence to evidence-based care guidelines and clinical outcomes. The study found a notable increase in patients receiving essential services such as yearly exams and vaccinations, leading to better health outcomes.
Scientists at WashU Medicine identified three unexpected players, small RNA molecules, that help a cell initiated its own demise when overloaded with fat. The research links these molecules to the cellular damage characteristic of common metabolic diseases like diabetes.
A new study found that patients with diabetes who took higher doses of Aspirin (up to 325mg/day) had a 23% lower risk of death from heart attack. Pharmacists can play a significant role in administering this treatment, working proactively with physicians and patients.
A study found that poor pre-pregnancy diet can lead to reduced birth weights, catch-up growth after weaning, and increased insulin sensitivity in offspring. These effects combined increase the risk of developing type II diabetes and obesity later in life.
Two studies suggest diet soft drink consumption may lead to increased risk of diabetes, cardiovascular disease, and other chronic conditions. Diet soda users experienced a 70% greater increase in waist circumference compared to non-users.
A major international study reveals that the number of adults with diabetes has reached 347 million, more than double the number in 1980. The prevalence of diabetes has risen or remained unchanged in virtually every part of the world over the last three decades.
A new study found that diabetes prevalence has increased globally over the past three decades, with 350 million adults affected. The study also showed that high-income countries such as the USA and Western Europe have higher rates of diabetes than other regions.
Barbara E. Corkey, PhD, is being honored by the American Diabetes Association for her 35-year contributions to understanding diabetes and its treatment. Her work has shown that oscillations in beta cell Ca2+ fluxes influence insulin secretion and that elevated glucose and lipids cause tissue malfunction in diabetes.
Researchers found that patients with RA or psoriasis who were treated with TNF inhibitors or hydroxychloroquine had a lower risk of developing diabetes. The study suggests an association between these medications and reduced diabetes risk, but the cause is not yet known.
The prevalence of diabetic kidney disease (DKD) in the US has increased significantly over the past two decades, with a 34% rise from 1988-1994 to 2005-2008. The estimated numbers of persons with DKD have also increased, from 3.9 million in 1988-1994 to 6.9 million in 2005-2008.
A meta-analysis of 32,752 participants found that intensive-dose statin therapy was associated with a higher incidence of new-onset diabetes compared to moderate-dose therapy. In contrast, intensive statin therapy reduced the number of major cardiovascular events.
Researchers at Case Western Reserve University discovered a genetic factor that regulates obesity-induced inflammation contributing to chronic health problems. By controlling levels of Kruppel-like factor 4 (KLF4) in macrophages, they may develop a novel treatment for obesity and its complications such as diabetes and heart disease.
The ABCD2 score, used to identify people at risk of stroke after transient ischemic attack, has low sensitivity and limited clinical application. The study found that patients with an ABCD2 score above five had only a low rate of subsequent strokes.
A low-cost healthy lifestyle program, including self-weighing weekly or monthly, has been shown to prevent excessive weight gain in pregnant women with pre-existing overweight. Regular monitoring of weight gain and simple health messages can reduce pregnancy complications, such as gestational diabetes and birth complications.
Researchers found that HbA1C test is not predictive of outcomes in diabetes patients with kidney disease on dialysis. In contrast, the glycated albumin or GA assay was a strong predictor of patient survival and hospitalizations.
Researchers have made significant breakthroughs in detecting diabetes and cardiovascular disease through advanced lipid genetics. Dr. Joanne Curran discovered that dihydroceramide (dhCer) is a reliable early indicator of diabetes risk, while Dr. Sara Willems found a link between genetic variants and atherosclerosis.
A new University of Illinois study published in the Journal of Physiology found that a high-fat diet during pregnancy programs a woman's baby for future diabetes. Exposure to such a diet modifies gene expression in the livers of offspring, increasing the likelihood of early insulin resistance and diabetes.
A Johns Hopkins team has identified a newly discovered protein called Iduna that protects the brain against stroke and neurologic disorders. The protein works by interrupting a cascade of molecular events that result in cell death, and its presence increases three- to four-fold in preconditioned mouse brain tissue.
Women who gained 2-3 BMI units between the first and second pregnancy were more likely to develop GDM in the second pregnancy. Conversely, women who lost over 6 pounds between pregnancies reduced their risk of developing GDM by approximately 50%. The association was strongest in women who were overweight or obese in their first pregnancy.
A common CT scan test could help identify individuals with diabetes at high risk of early death, who may benefit from targeted medical care and interventions. Researchers found that those with higher levels of calcified plaque buildup in their blood vessels were more than six times more likely to die prematurely.
A clinical trial found that Metagenics' UltraMeal PLUS 360° is effective in lowering cardiovascular risk factors and resolving metabolic syndrome. The study showed a 40% increase in resolving metabolic syndrome compared to a Mediterranean-style diet alone.
A cluster randomized trial found that lifestyle interventions, including physical activity and dietary counselling, reduced the risk of large for gestational age newborns by 44% in pregnant women at high risk. However, the study did not show a significant reduction in the risk of gestational diabetes.
A four-year school intervention in Michigan improved middle school students' cholesterol levels and resting heart rates, reducing obesity-related health risks. The program goals included eating more fruits and vegetables, getting at least 150 minutes of physical activity, and spending less time in front of screens.
A recent study published in the Canadian Medical Association Journal found that Canadian Inuit have similar diabetes levels to the general population, contrary to previous assumptions. Researchers analyzed data from over 2,500 participants and found that obesity rates were high among Inuit, with 28% being overweight and 35% obese.
TZDs act on PPARγ, enhancing sodium transport and water reabsorption, but also have direct effects on kidney channels, explains a recent Cell Metabolism study. The findings may lead to combination therapy and selective PPARγ modulators to prevent massive fluid retention.
The Ohio University College of Osteopathic Medicine will establish an extension campus in Columbus to address the shortage of primary care physicians and the growing diabetes epidemic. The new campus will enroll 50 new students annually, with plans to graduate 200 students by 2019.
A UBC study found that a strong relationship with a primary healthcare provider is key to managing chronic conditions. Patients who felt connected to their provider reported better health outcomes and self-management skills.
A collaborative effort aims to tackle health disparities in Appalachia through research collaborations, community engagement, and translational science. The Appalachian Translational Research Network (ATRN) will focus on addressing obesity, smoking, and diabetes to improve health outcomes in the region.
The University of Louisville School of Nursing has established a Kentucky Racing Health Services Center (KRHSC) to provide comprehensive health care services to track workers. KRHSC, led by Whitney Nash, serves about 2,500 patients annually, offering acute and chronic care as well as preventive services.
Researchers at TGen found that PVT1 expression levels increased up to 5-fold in response to hyperglycemia, leading to excessive accumulation of extracellular matrix in glomeruli. Knocking down PVT1 reduced ECM protein levels, suggesting a potential molecular mechanism for diabetic nephropathy.
Researchers found obese patients with metabolic syndrome and high blood pressure are at substantial risk for cardiac, pulmonary, and neurologic complications. The study provides a simple way to identify patients who may face higher risks following surgery.
A Loma Linda University study found that vegetarians experience a 36 percent lower prevalence of metabolic syndrome than non-vegetarians. The condition is associated with an increased risk of heart disease, diabetes, and stroke.
The American Academy of Neurology has issued a new guideline on the most effective treatments for diabetic nerve pain. Pregabalin was found to be an effective treatment in improving quality of life, while several other treatments including gabapentin, valproate, antidepressants and opioids should also be considered.
A study of 26,643 U.S. adults found that combining creatinine, cystatin C, and urine albumin-to-creatinine ratio improved prediction of end-stage renal disease and all-cause death. The researchers identified a 3-fold risk of death and 4-fold risk of end-stage renal disease associated with the combined markers.
Scientists will present their work on reversing the obesity epidemic by understanding its molecular underpinnings. The conference will feature talks on emerging research, treatment options, and the impact of obesity on various bodily systems.
A study found that diabetes is associated with a lower risk of prostate cancer in men, but a higher risk of other cancers and mortality in both men and women. Diabetes was linked to increased risks for colon, rectal, and liver cancers in men and women.
Middle-aged adults with diabetes are more likely to develop age-related conditions like cognitive impairment, incontinence, and vision problems. The study found that those with diabetes developed these conditions nearly double the rate of those without diabetes.
Research suggests that nearly half of atrial fibrillation cases can be avoided by maintaining a normal blood pressure and healthy body weight, without smoking. The study found that high blood pressure was the strongest predictor of atrial fibrillation, accounting for over one-fifth of all cases.
Scientists have established a strong link between nicotine and diabetes complications, finding that concentrations of nicotine similar to those found in smoker's blood raise levels of HbA1c by up to 34%. This discovery may encourage patients with diabetes to quit smoking and has implications for the use of nicotine-replacement therapy.
Researchers found that mice with short telomeres developed higher blood sugar levels and secreted less insulin, mimicking early stages of human diabetes. The study suggests that shorter telomeres may predispose people to age-related diabetes, paving the way for potential biomarkers.
A University of Missouri researcher has discovered a plant oil called sterculic oil that may help reduce belly fat and insulin resistance in humans. The oil contains unique fatty acids that suppress an enzyme associated with insulin resistance, improving metabolic profiles and reducing the risk of chronic diseases.