Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Researchers identified three genetic variants associated with abnormal insulin production, increasing the risk of developing diabetes. The study's exome array genotyping analysis revealed the involvement of genes TBC1D30, KANK1, and PAM in insulin processing and secretion.
Researchers develop method to reprogram T-cells involved in autoimmune diseases by attaching pancreatic protein to red blood cells, eliminating symptoms of type I diabetes in mice. The approach aims to minimize risks and side effects while targeting specific immune cells involved in the disease.
Researchers found that combining insulin and an EGF inhibitor preserved vascular integrity in diabetic mice, limiting vision damage from diabetic macular edema. The study suggests a potential therapeutic combination to prevent DME in people with diabetes.
Researchers discovered that paroxetine protects endothelial cells from damage caused by high sugar levels in diabetes, preventing hyperglycemia-initiated reactive oxygen species damage. The drug also restores blood vessel function in animals with diabetes, suggesting potential as a new therapy for diabetic complications.
University of Notre Dame biochemist Anthony S. Serianni's research provides new perspectives on sugar breakdown in the human body, particularly for diabetic patients. The study discovered an unexpected reaction pathway involving a novel rearrangement of the carbon backbone, undermining prevailing assumptions about sugar degradation.
A large study finds that post-menopausal breast cancer survivors are more likely to develop diabetes, with a significant association observed after chemotherapy. The risk increases over time, suggesting the need for closer monitoring and screening of these patients.
Researchers found that primary care physicians provide higher quality care to diabetes patients by altering medications and offering lifestyle counseling more frequently. This study highlights the importance of a consistent primary care physician in managing chronic conditions like diabetes.
Researchers performed brown fat transplants in mice to treat obesity, finding significant reductions in body weight and improvements in glucose metabolism. The transplanted brown fat secreted hormones that mediated metabolic effects throughout the body.
A new clinical study from Stanford University School of Medicine and Palo Alto Medical Foundation Research Institute found that pre-diabetic patients respond to self-directed lifestyle interventions, such as a take-home DVD, with similar effectiveness to coach-led programs. The study offers a practical way for primary care physicians t...
Researchers at Karolinska Institutet have discovered that glucagon stimulates its own synthesis, activating a self-reinforcing cycle of hormone production. This finding has significant implications for understanding the regulation of hormone secretion and may hold the key to studying defects in diabetes.
A new study by RAND Corporation reveals that recent Mexican immigrants to the US have a significant amount of undiagnosed disease, including diabetes and high blood pressure. Despite this, they are still generally healthier than native-born residents after accounting for undiagnosed disease.
The Decker School of Nursing at Binghamton University has received a $757,000 grant from the US Department of Health and Human Services to provide financial support for graduate students. Funded students receive tuition waivers and stipends, enabling them to focus on their studies without financial burden.
A new study published in The American Journal of Pathology found that topical application of simvastatin significantly accelerates wound healing in diabetic mice by increasing angiogenesis and lymphangiogenesis. This is attributed to the increased number of infiltrating macrophages producing VEGF-C, suggesting a simple strategy with po...
A new process of creating islet cell clusters has been successfully developed to improve pancreatic transplantation. The clusters were engineered to overcome challenges such as hypoxic conditions and immune reactions, resulting in higher viability rates and potential cure for type I diabetes.
A study of 292 Brazilian women aged 45-72 found that daily step count is a strong predictor of health outcomes, with active women less likely to be obese or develop metabolic syndrome. The study supports the importance of incorporating physical activity into daily life for midlife women's overall health.
Researchers created a culturally relevant guidebook to improve Hispanic health and behaviors, focusing on physical activity and nutrition. The guidebook was well-received by community residents and addressed the Latino Paradox, highlighting the shift in healthy eating habits when immigrants arrive in the US.
A new study found that baby boomers' interest in health issues peaks in the early 50s and again near age 65. Health professionals are encouraged to target this generation with health messages at these times, as they are most receptive to hearing them.
A new study found that diabetic patients have a higher risk of hearing impairment, which is independent of aging or environmental factors. The study's findings suggest that diabetic patients should be screened for hearing impairment at an earlier age to prevent related health problems.
A new set of policy considerations was released by the Alliance to Reduce Disparities in Diabetes to address systemic barriers and structural barriers that hinder effective diabetes care. The document proposes concepts to realign financial incentives, enhance patient self-management, and optimize healthcare systems.
Researchers found that limiting carbohydrates to dinner reduced hunger scores, improved anthropometric outcomes, and lowered inflammatory markers in obese individuals. The innovative dietary pattern led to changes in hormonal secretion patterns favoring satiety and reducing metabolic risks.
Researchers found that children need at least seven minutes a day of intense physical activity to prevent weight gain and obesity. The study tracked over 600 kids aged 9-17 and showed that vigorous activity reduced the risk of unhealthy weight, while sedentary behavior was common.
A recent study published in The New England Journal of Medicine found that cardiac bypass surgery is superior to percutaneous coronary intervention (PCI) for adults with diabetes and multi-vessel coronary heart disease. After five years, the CABG group had fewer adverse events and better survival rates than the PCI group.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
The UMSOM dean and co-author argue that changes to diagnostic criteria could dramatically increase the number of women identified with gestational diabetes, placing a burden on healthcare systems. They advise caution before revising guidelines due to potential risks and costs.
A Mayo Clinic study found that a gene linked to Alzheimer's, heart disease, and diabetes becomes less important to quality of life once people reach their 90s. Researchers discovered that good friends, a positive attitude, and social connectedness have a bigger impact on well-being than the gene in question.
Research highlights the potential impact of airport security scanners on diabetes devices, including insulin pumps and continuous glucose monitoring systems. The Editorial calls for more research to understand and potentially repair this issue affecting hundreds of thousands of people worldwide who use insulin pump therapy.
Diabetic patients with gastroparesis can benefit from chronic electrical stimulation at specific acupuncture points, improving symptoms such as nausea and vomiting. The treatment is home-based, non-invasive, and has low side effects.
A University of Illinois study found that consuming foods with advanced glycation end products (AGEs) can increase cardiovascular complications in people with diabetes. Foods like grilled meats and crispy fried foods contain AGEs, which are associated with plaque formation and heart disease.
Bariatric surgery radically reduces risk factors for heart disease and stroke, with an average reduction of excess weight by 54%. Cardiovascular risks such as high blood pressure, diabetes, and unfavourable blood fats improve or resolve completely after the procedure.
A Johns Hopkins analysis found that three in 10 kidney transplant recipients require hospital readmission within 30 days. The study highlights the need for better outpatient management systems to prevent costly and potentially preventable return visits.
A systematic review and meta-analysis of 27 studies found a strong correlation between psoriasis and an increased risk of developing diabetes. Patients with severe psoriasis are nearly twice as likely to have diabetes compared to the general population.
A study combining 18 research studies found that sitting for extended periods doubles the risk of developing diabetes, heart disease and mortality. Even those meeting physical activity guidelines may still be compromised if they spend too much time sitting.
A study published in JAMA found that high plasma levels of proneurotensin are associated with an increased risk of developing diabetes, cardiovascular disease, and breast cancer in women. The study also found a significant interaction between sex and proneurotensin on the risk of cardiovascular disease.
Researchers found that VEGF-modified bone marrow stem cells sustain pancreatic recovery in a laboratory mouse model of insulin-dependent diabetes. The study provides new insights into mechanisms involved in regeneration of insulin-producing cells and offers evidence for using diabetic patients' own bone marrow as a source of treatment.
Researchers found that inviting patients to read their doctors' notes boosts patient engagement, adherence, and control in healthcare plans with minimal impact on doctor workload. Additionally, the use of electronic health records improves diabetes care by enhancing monitoring, treatment, and glucose control. New equations for estimati...
A large study found that moderate alcohol consumption increases the risk of atrial fibrillation in older people with heart disease or advanced diabetes. The study involved over 30,000 individuals from 40 countries and found a significant increase in atrial fibrillation cases linked to higher alcohol consumption.
A Kaiser Permanente study found that using electronic health records improved drug-treatment intensification, monitoring, and risk-factor control among patients with diabetes. The study also noted greater improvements among patients with poorer diabetes control.
A new study published in The FASEB Journal suggests that being born with a low birth weight may increase the risk of developing cardiovascular disease, kidney disease, and diabetes later in life. Researchers found that older female rats had a reduced ability to become pregnant and carried babies that were smaller or lighter in weight.
A new study finds that women experiencing early menopause are more likely to have a heart attack or stroke due to cardiovascular disease. Women with early menopause were found to be at higher risk for cardiovascular disease, including smoking, diabetes, and excess weight.
Researchers studied mouse offspring to investigate the effects of high-fat diet during pregnancy on microcirculation networks. The study, funded by the British Heart Foundation, aims to understand how maternal diet influences adult diseases like obesity and diabetes.
A new study from the University of Copenhagen suggests that an increased activity of a particular iron-transport protein destroys insulin-producing beta cells, leading to type-2 diabetes. Mice without this iron transporter are protected against developing diabetes, providing potential insights into preventing the disease.
Research from the University of Copenhagen suggests that dividing campaigns into combating non-communicable or communicable diseases is ineffective and expensive. Integrated health programmes focusing on common risk factors like poor nutrition can effectively combat diseases such as diabetes and tuberculosis.
Researchers identified miR-34a's role in fatty liver disease and Type II diabetes. Blocking miR-34a improved metabolic outcomes, including decreased liver fat and improved blood glucose levels.
Dr. James Sowers, a renowned endocrinologist, has received the American Heart Association's Lifetime Achievement Award for his pioneering work on the deadly link between cardiovascular disease and diabetes. His research has significantly advanced our understanding of insulin action, vascular biology, and metabolic disorders.
Researchers at St. Michael's Hospital found that living in less walkable neighborhoods increases the risk of developing diabetes by 50% compared to those living in more walkable areas. The study highlights the importance of neighborhood design on health outcomes, particularly for new immigrants.
A study using cardiac magnetic resonance imaging in Iceland found that unrecognized heart attacks (UMI) were associated with an increased risk of death. The prevalence of UMI was higher than previously suspected, especially among individuals with diabetes.
A steady job is associated with improved medication adherence and reduced risk of non-adherence among working-age diabetics. Lack of employment increases stress, financial strain, and access barriers, leading to lower adherence rates.
Patients with psoriasis are at higher risk of new-onset diabetes mellitus due to chronic inflammation. The study found that the risk increases with severity of psoriasis, with patients having severe psoriasis being more than twice as likely to develop diabetes.
Researchers found a significant link between radiotherapy and an increased risk of developing diabetes in childhood cancer survivors. The study, which analyzed over 2500 patient questionnaires and medical records, suggests that radiation exposure to the tail of the pancreas may be particularly damaging.
A study published in The Lancet found that statin therapy can reduce cardiovascular disease risk, even among patients at high risk of developing diabetes. Patients with diabetes risk factors were 28% more likely to develop diabetes, but still saw a 39% reduced risk of cardiovascular illness and 17% lower mortality.
A new MIT study suggests that the protein SIRT1 plays a crucial role in protecting against metabolic disorders linked to high-fat diets, including diabetes. When given a high-fat diet, mice lacking SIRT1 developed metabolic disorders much sooner than normal mice, highlighting its potential as a safeguard against obesity-linked diseases.
Researchers have identified thioredoxin-interacting protein (TXNIP) as a target for therapies in diabetes and Wolfram syndrome. The molecule is involved in the initiation of local inflammation that can lead to systemic inflammation.
Researchers analyzed data to determine if a higher diagnostic cutoff of A1C level should be used to diagnose diabetes in blacks than in whites. The study found that black people may be more vulnerable to high A1C status, and could benefit from earlier monitoring for early diabetic complications.
A study led by the Brigham and Woman's Hospital found an association between phthalate exposure and an increased risk of diabetes in American women. High levels of phthalates were linked to a higher likelihood of developing diabetes, with possible explanations including medical devices and medication used to treat diabetes.
A new glucose monitor made from inexpensive materials measures sugar levels in urine, helping people with diabetes monitor their blood sugar levels in rural areas of developing countries. The device was developed to address the challenges of providing affordable diabetes testing in regions where poverty limits healthcare access.
A new UC Davis study found that being overweight or obese alone is not linked to an increased risk of death in the short-term. However, severely obese individuals with diabetes or hypertension do face a higher risk of mortality, emphasizing the importance of weight loss and managing co-occurring health conditions.
A new equation that combines creatinine and cystatin C levels provides a more accurate measurement of kidney function, reducing over-diagnosis of chronic kidney disease (CKD). The study suggests that this approach could be used as a confirmatory test for CKD in patients with estimated GFR near 60.
A new study by UNC Chapel Hill researchers reveals Chinese teenagers have a significantly higher rate of diabetes (1.9%) compared to their US counterparts (0.5%). The study also found high levels of inflammation and cardiometabolic risk factors in Chinese children, with over one-third having at least one risk factor.
Researchers at the University of Warwick discovered that strawberry extracts positively activate the Nrf2 protein, decreasing blood lipids and cholesterol levels. This activation reduces the risk of developing heart disease and diabetes by counteracting post-meal blood glucose and low-density lipoprotein.
A Swedish study suggests that antipsychotic drugs during pregnancy are associated with a higher risk of developing gestational diabetes. Women treated with these medications had a fourfold higher risk of gestational diabetes compared to those not taking any medication, according to the study published in Archives of General Psychiatry.