Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A computer-software program, LOGIC-Insulin, effectively controlled blood-sugar levels in critically ill patients compared to nurse-directed care. The study showed improved blood-glucose control and reduced risk of hypoglycemia in the LOGIC-Insulin group.
A comprehensive review of 142 clinical trials found that strategies targeting patients and the healthcare system are effective in improving diabetes outcomes. Programs aimed at physicians were only successful for diabetics with poor health control, while patient-targeted interventions showed promise regardless of HbA1c levels.
A study by a CCNY-led team found correlations between the spread of obesity and food marketing and distribution patterns. The researchers suggest that collective behavior plays a significant role in the spread of the epidemic, not individual factors such as genetics or lifestyle choices.
Researchers combined data from 11 integrated health systems to form the SUPREME-DM DataLink, a unique resource for population-based diabetes research and clinical trials. The database contains over 1.1 million people with diabetes, mirroring the general population, allowing for more effective prevention and treatment strategies.
Researchers at Columbia University Medical Center have identified a brain receptor called Gpr17 that appears to play a central role in regulating appetite. Blocking the action of this protein, which is also found in humans, could lead to new drugs for preventing or treating obesity.
A Wayne State University researcher is investigating the role of Nrf2-KEAP1 in diabetic retinopathy. The study aims to understand how diabetes causes oxidative stress and damage to mitochondria, ultimately accelerating cell death and developing retinopathy.
A study of nearly 200,000 individuals found daily low-dose aspirin use associated with increased risk of major gastrointestinal or cerebral bleeding. Patients with diabetes had high rates of major bleeding, irrespective of aspirin use.
Researchers at Joslin Diabetes Center found that cold exposure stimulates brown fat energy expenditure with fewer other systemic effects, suggesting a promising approach to treating obesity. The study disproves the use of ephedrine as a weight loss drug, which has side effects.
Scientists at EMBL have created a first complete atlas of RNA-binding proteins, revealing over 300 previously unknown proteins. This discovery opens new avenues for studying diseases such as diabetes and glaucoma, suggesting that gene mutations may affect RNA control rather than protein function.
A new study published in Obesity found a correlation between PCB exposure and increased distribution of body fat to the abdomen. Researchers analyzed data from over 1,000 70-year-olds and found that high levels of PCB189 were related to a high proportion of visceral fat.
A study found that over 8% of VA patients with diabetes may be over-treated, while 6% are under-treated. An individualized approach could help identify the right treatment plan for each patient.
Women referred to the telephone-based nurse management program had a lower risk of high baby birth weight and were more likely to have postpartum glucose testing, leading to earlier identification and management of postpartum glucose intolerance or diabetes. The study suggests that this program can improve outcomes for women with gesta...
A 34-year study found that Japanese-American men who did not eat foods rich in vitamin D had a higher risk of stroke later in life. Men with the lowest dietary vitamin D intake had a 22% increased risk of stroke, while those with the highest intake had a 27% lower risk.
The study found that kidney stone prevalence nearly doubled from 8.8% in 2007-2010 to 17.6% in 1994, with obesity and diabetes being key risk factors. Maintaining a healthy lifestyle and body weight can reduce the risk of kidney stones.
A study published in CMAJ found that excess maternal weight before and during pregnancy is a significant predictor of larger-than-average babies. Researchers analyzed data from 472 women and found that maternal glucose levels and lipid levels also play a role, but to a lesser extent.
Researchers at the University of Cincinnati have identified apolipoprotein A-IV (apoA-IV) as a promising target for a new diabetes treatment. The study found that apoA-IV improves insulin secretion and reduces blood sugar levels in mice with impaired glucose tolerance.
Researchers have identified methylglyoxal as the culprit behind increased pain sensitivity in diabetics. The team proposes using small peptides to target and reduce MG activity, leading to a reduction in pain.
A study found that ACE2 is protective against diabetic complications in both lab models and human patients. High levels of ACE2 in vascular reparative cells prevent heart function decline and renal failure in diabetics.
A collaborative care intervention improved depression-free days and quality-adjusted life-years among adults with depression and poorly controlled diabetes. The intervention, which included team-centered care and nurse management, resulted in significant improvements in depression scores and quality of life.
The TEAMcare program, a collaborative approach to managing chronic diseases like depression and diabetes, appears to pay for itself. After accounting for the program's $1,224 per patient cost, it may save as much as $594 per patient in outpatient costs.
A new study challenges traditional risk factors for contrast-induced nephrotoxicity, finding that patients with history of renal disease, hypertension, and heart disease are at greater risk. In contrast, diabetes is not a significant predictor of reduced renal function.
A study found that high-fat diets cause differences in gut flora between thin and diabetic mice, with certain bacteria linked to diabetes development. The research suggests that modifying the gut microbiota through dietary fibers may prevent metabolic diseases like diabetes.
A study published in Diabetes Care found that high levels of phthalate metabolites are associated with an increased risk of developing diabetes. The research, conducted among over 1,000 elderly individuals, suggests a connection between environmental chemicals and the development of type-2 diabetes.
A new study reveals that overweight pregnant women with mildly elevated blood sugar levels are at a higher risk of adverse pregnancy outcomes than previously thought. These women, who do not have gestational diabetes or obesity, carry significant risks for their health and the health of their babies.
Researchers at Brigham and Women's Hospital found that prolonged sleep restriction with simultaneous circadian disruption increases the risk of developing diabetes and obesity. This is because disrupted internal clocks can lead to poor insulin secretion and increased glucose concentrations in the blood.
A new study from Queen Mary University of London reveals that people with diabetes face numerous challenges in self-managing their condition, including social and environmental factors. The research highlights the need for healthcare professionals to better support patients in managing their disease.
Researchers have made a breakthrough in treating autoimmune diabetes using genetically modified gut bacteria, increasing the frequency of cured mice compared to traditional methods. The new approach has no adverse side effects and allows the immune system to function normally.
A new study found that 84% of female dialysis patients experienced sexual problems, which are often overlooked by clinicians. The study also highlighted the impact of various factors such as age, education level, and presence of depression on sexual dysfunction in these patients.
A study published in the Journal of Nutrition found that genetically-determined differences in salivary amylase activity influence blood glucose levels after starch consumption. Individuals with high salivary amylase activity tend to have lower blood glucose levels and may be better adapted to eat starch-rich foods.
A phase II study found metformin reduced fasting glucose, insulin levels and body mass index in men with prostate cancer. The medication also appeared to slow the growth rate of prostate cancer in a proportion of men.
Researchers found that inhibiting only mTORC1, a protein complex regulating growth and differentiation, prolongs life in mice without adverse effects on glucose tolerance or insulin sensitivity. This discovery may lead to the development of a drug specifically targeting mTORC1 to promote longevity while preventing diabetes.
Researchers found metformin increases heart-pumping capacity, reduces fat accumulation, and limits cell death in rats. Long-term effects suggest the medicine's benefits persist for a year or more.
A study by Penn researchers found that peer mentoring significantly improved glucose control in African American veterans with diabetes. The intervention, which included financial incentives, showed a statistically significant effect on improving HbA1c levels. The authors suggest that social support and camaraderie among veteran partic...
Researchers analyzed 100,000 molecular components from a patient's genome, revealing genetic risks and biomarkers for diseases. The study provides insights into the correlation between individual genetic profiles and environmental interactions in disease development.
A Stanford researcher used an integrative 'omics' profile to discover and track his own type-2 diabetes onset, demonstrating the potential of personalized medicine. By analyzing his DNA, RNA, proteins, metabolites, and immune system responses, he was able to identify the disease early and make lifestyle changes to prevent further damage.
A new research survey found that the Bangladeshi community in NYC experiences significant barriers to diabetes care, including low English proficiency and limited awareness. The study also showed a high willingness among respondents to participate in community health programs for prevention and care.
A study by Columbia researchers suggests that intestinal progenitor cells can be coaxed into producing insulin, offering a potential new treatment for type I diabetes. The technique involves knocking out the Foxo1 gene in these cells, which then produce functional insulin-producing cells.
The study demonstrated that XMetA markedly reduced elevated fasting blood glucose levels and normalized glucose tolerance in mice experimentally rendered diabetic. After six weeks of treatment, there was a statistically significant reduction in hemoglobin A1c levels in animals treated with XMetA compared to controls.
Scientists at the Diabetes Research Institute developed an oxygen-generating biomaterial to enhance insulin-producing cell survival. The material, PDMS-CaO2, generates critical oxygen for up to six weeks, mimicking the native pancreas environment.
Researchers found elevated levels of Toll-like receptors (TLRs) in individuals at risk for heart disease and diabetes, indicating a key role in the inflammatory response. The study suggests that suppressing TLR activity may be effective in treating these conditions, providing new insights into the development of metabolic syndrome.
Researchers found that women with pregnancy-related hypertensive disorders or diabetes may be at increased risk of cardiovascular disease later in life. Complications such as preeclampsia and gestational diabetes were linked to higher CVD risk factors, including fasting glucose and insulin levels.
A new UCLA study found that a widely used assessment tool for community health centers may not accurately measure the quality of diabetes care. The study examined 30 Los Angeles County health centers and found no correlation between the tool's scores and the actual quality of care.
Scientists discovered that problems controlling blood sugar in the intestines can lead to chronic inflammation and insulin resistance. Researchers found a link between fatty acid synthase enzyme defects and diabetes, suggesting potential new targets for therapy.
A NYU nursing-dental research team discovered that oral blood samples drawn from deep pockets of periodontal inflammation can measure hemoglobin A1c, a key indicator of diabetes status. The study found minimal false positive and negative results, making it a promising alternative to finger-stick samples.
Researchers at Baylor College of Medicine discover that ROCK1 protein activates mitochondrial fission, leading to diabetic kidney disease. The study reveals a key metabolic pathway involved in the progression of kidney disease in diabetes.
A new study finds that total knee replacement (TKR) in elderly osteoarthritis patients can reduce mortality rates by half and lower the risk of heart failure. Additionally, TKR may result in reduced healthcare costs due to lower Medicare payments over a seven-year period.
A new metabolic 'breathalyzer' technology can detect early signs of disease by analyzing changes in glucose metabolism, offering a potential breakthrough in disease diagnosis. The method uses isotopic signatures of carbon-containing metabolic byproducts to distinguish between healthy and diseased states.
The Stichting af Jochnick Foundation is funding research into the fundamental causes of diabetes at Karolinska Institutet, aiming to develop more effective treatments for the disease. The project will use unique methods to study insulin regulation in living organisms and identify new targets for drugs.
A recent study found that diabetes prevalence varies greatly across developing countries, with some areas having as low as 0.27% and others up to 15.54%. The study also highlights the importance of addressing treatment gaps, which can lead to increased health complications and costs.
Researchers found a significant association between chronically elevated glucose levels and minute levels of troponin T, a blood marker for heart damage. The high-sensitivity test detected low levels of cTnT in 66% of the study population, suggesting potential pathways for diabetes-related heart disease.
Researchers found that elderly individuals with high insulin sensitivity had larger brains and better verbal fluency skills compared to those with low insulin sensitivity. Higher insulin sensitivity was also associated with more grey matter in regions important for language skills.
A new study from Henry Ford Hospital found that diabetes affects hearing loss in women, with poorly controlled diabetes leading to significantly worse hearing. The study also showed that men have worse hearing loss across the board, regardless of age or diabetes control.
A high animal fat diet before conception may increase the risk of gestational diabetes during pregnancy, according to researchers. Women who consumed a diet high in animal fat and cholesterol had a higher risk for developing the condition compared to those with lower intakes.
A large-scale study found that lifestyle counseling significantly reduces time to reach treatment goals for people with diabetes, with those receiving regular counseling achieving lower blood glucose, blood pressure, and cholesterol levels. The study suggests that incorporating counseling into routine care can be an effective strategy ...
Dr. Philipp Scherer's groundbreaking research on adiponectin, a protein that declines with weight gain, has potential as a good predictor of diabetes, heart disease, and cancer risk. His work also highlights the importance of understanding fat cells' role in body energy homeostasis.
A recent study published by JAMA Network found that statin use in postmenopausal women is associated with an increased risk of developing diabetes. The study, which analyzed data from the Women's Health Initiative, included over 153,000 women and found that statin use was linked to a higher risk of new-onset diabetes.
A study published in Cell Stem Cell found that defects in myelin sheath regeneration surrounding nerves can be at least partially corrected following exposure to young immune cells. This suggests that regenerative therapies may work throughout the duration of MS, regardless of age. The findings provide new hope for treating this disease.
A Kaiser Permanente study found that patients with interrupted health coverage receive significantly fewer preventive tests and vaccines. Continuous health insurance coverage is essential to ensure timely care, even at reduced-cost safety net clinics.
Studies found that p53 activation in fat tissue accelerates insulin resistance in heart failure patients. Researchers hope to develop an anti-aging therapy targeting inflammation without compromising tumor-fighting abilities.
A study found that maternal gestational diabetes and low socioeconomic status significantly increase the risk of attention deficit hyperactivity disorder (ADHD) in six year olds. The risk doubles with either factor alone, but increases exponentially when both are present.