Articles tagged with Hypertrophy
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Exposure to triclocarban, a common antibacterial agent, promotes myocardial hypertrophy in human cardiac organoids. The study found that TCC interferes with endothelial cell metabolism, leading to nitrosative stress and inflammation. This new mechanism suggests a potential treatment target for myocardial hypertrophy.
Researchers at Temple University Health System discovered a promising alternative to control hypertension and associated cardiovascular problems. The infused juice concentrate from the Japanese plum was found to attenuate growth-promoting signals induced by angiotensin II, reducing hypertrophy of the aorta and inflammation.
A recent study by researchers at UNICAMP found that low-load with many repetitions and high-load with fewer repetitions both promote similar muscle growth. Muscle activation patterns were different, but metabolic stress was the same in both groups.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
New research from Edith Cowan University found that lowering weights sees the same improvements as lifting, despite only doing half as many reps. This focus on eccentric muscle contractions can allow people to spend their time exercising more efficiently and improve strength and size of muscles without needing to go to the gym.
A study by CNIC scientists has identified a key role for the MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy. Inhibition of p38α promotes an unexpected activation of the other branch of the pathway, consisting of the proteins MKK3, p38γ, and p38δ. This activation induces another key pathway in cardiac hypertrophy, the mTOR pathway.
A new study found that left-ventricular hypertrophy is a stronger predictor of heart failure than coronary artery calcium score. The study analyzed data from 6,814 men and women with no known heart disease and found that LV hypertrophy increased the risk of CHD events by 4.3 times.
Focusing on movement during weightlifting may improve performance by reducing mechanical inefficiency and increasing automatic control processes. This contradicts the traditional mind-muscle connection theory, which suggests focusing on individual muscles enhances activation and development.
Researchers at UNC School of Medicine discovered that Lin28a is needed for the development of pathological hypertrophy, a process where the adult heart enlarges in response to cardiac stress. This discovery could lead to more potent therapeutics for heart disease treatment.
Researchers at Beth Israel Deaconess Medical Center have identified a developmental cause of adult-onset cardiac hypertrophy, a leading cause of heart failure. The study reveals that genetic mutations affecting the Ras/MAPK cell signaling pathway can lead to the development of cardiac hypertrophy in adults.
The European Society of Cardiology recommends redefining cardiac hypertrophy as myocardial remodelling to account for changes in non-myocyte cells and cell division. This change aims to improve communication among researchers and clinicians, leading to better risk stratification and treatment.
A protein long thought secondary to stressors like hypertension is actually a primary regulator according to researchers. Knocking out GSK-3alpha causes significant hypertrophy in mice models. The findings also suggest GSK-3alpha as a positive regulator of the beta-adrenergic system, potentially helping failing hearts pump better.
A new research method using radiofrequency energy shows promise in treating symptoms of tonsillar hypertrophy in children, offering a safer alternative to traditional tonsillectomy surgery. The technique resulted in significant improvements in over 91% of the children who underwent treatment.
A study published in Circulation Research suggests that compounds related to Viagra can counter heart failure by reducing abnormal cardiac growth. PDE1 inhibitors show promise as a new drug target, potentially combined with Viagra or beta blockers for enhanced efficacy.
Researchers have found that Viagra amplifies the effects of a protective protein called RGS2, which shields the heart from damage caused by high blood pressure. The study, published in the Journal of Clinical Investigation, provides insights into the biology of RGS2 and its potential as a therapeutic target for heart failure.
Researchers have provided insight into the signaling mechanisms behind high blood pressure-induced heart muscle thickening. A new study found that mice lacking RGS2 developed hypertrophy more rapidly than normal mice, leading to heart failure and death at a young age.
A new study finds that moderate long-term exercise in male and female mice induces a sex-dependent cardiac adaptation, with females exhibiting greater physiological changes. This research may help improve treatment strategies for women and men with heart disease.
Functional rhinoplasty techniques improve nasal airway function by addressing septal deviation, valve collapse and turbinate hypertrophy. Surgical procedures significantly reduce patient scores indicating improved nasal obstruction severity, with similar rates of improvement seen across different techniques.
Researchers discovered that a 'fickle' enzyme plays both protective and detrimental roles in the heart. When its cofactor is present, it helps regulate blood flow and heart function, but without it, the enzyme produces factors contributing to oxidative stress.
Researchers at Johns Hopkins Medicine found that sildenafil can treat enlarged hearts by blocking the breakdown of cyclic GMP, a key molecule involved in heart stress. The study showed significant improvements in heart function, including increased contractility and cardiac output, even after hypertrophy had developed.
Penn researchers suggest novel genetic causes for cardiac hypertrophy and new therapeutic agents against it. They also demonstrate that anti-HDAC drugs can block the development of hypertrophy in animal models.
The study reveals that female mice develop cardiac hypertrophy when estrogen is blocked, mimicking human conditions. The discovery could lead to a better understanding of the molecular signals causing heart enlargement and potential ways to prevent or reverse it.
A new Cincinnati Children's Hospital Medical Center study found that thickening of the heart can develop as early as adolescence in women, with obesity being the main factor. The study also discovered significant racial disparities in left ventricular hypertrophy prevalence among young African American and Caucasian women.
Research on Fas signaling reveals its involvement in the development of cardiac hypertrophy, a condition characterized by abnormal heart growth. Understanding this mechanism is crucial for developing effective treatments to manage cardiac hypertrophy and associated diseases.