Ischemia

AI model predicts 10-year stroke risk based on routine cardiology test

Intravenous tirofiban after tenecteplase in acute ischemic stroke

Chinese Medical Journal article explores the mechanism of GADD45B in intestinalischemia/reperfusion

Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.

Severe strokes linked to 5 times higher dementia risk

A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.

USC study identifies brain rewiring mechanism that may aid stroke recovery

Researchers discovered that stroke survivors with severe motor impairment show signs of brain 'youthfulness' in undamaged regions, suggesting the brain's ability to adapt and compensate. This finding provides new insights into neuroplasticity and may guide personalized rehabilitation strategies.

AI assisted tool linked to improved stroke care and outcomes

A clinical decision support system using AI-assisted imaging analysis and evidence-based treatment recommendations showed better quality care and long-term outcomes for patients with acute ischemic stroke. The tool reduced new vascular events by 26% at three months and maintained the reduction at 12 months.

Wegovy may have highest ‘eye stroke’ and sight loss risk of semaglutide GLP-1 agonists

Analysis of unintended side effect reports reveals that Wegovy carries the highest risk of 'eye stroke' and sudden sight loss among semaglutide drugs, with odds nearly 5 times higher than Ozempic. The risk is particularly pronounced in men, with a signal nearly 3 times higher than in women.

Low-intensity treadmill exercise preconditioning mitigates post-stroke injury in mouse models

A study published in Translational Exercise Biomedicine found that low-intensity treadmill exercise preconditioning significantly reduced brain injury and improved neurological outcomes after ischemic stroke in mouse models. The exercise group showed lower infarct size, increased microvessel density, and reduced inflammation.

GLP-1 drugs like Ozempic could cut risk of major heart complications after heart attack, study finds

GLP-1 weight-loss drugs may prevent further tissue damage following a heart attack, significantly reducing the risk of further life-threatening complications. Researchers found that these drugs improve blood flow to the heart by activating potassium channels, relaxing constricted blood vessels and reducing heart damage risk.

Study reveals new cellular mechanisms that allow the most common chronic cardiac arrhythmia to persist in the heart

Researchers identify non-contractile cell populations and their role in sustaining atrial fibrillation, a persistent and challenging-to-treat cardiac arrhythmia. The study provides insight into the cellular mechanisms involved and suggests new therapeutic strategies targeting these components.

New-onset nonarteritic anterior ischemic optic neuropathy and initiators of semaglutide in US veterans with type 2 diabetes

A nationwide cohort study found that semaglutide initiators had a significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy compared to sodium-glucose cotransporter-2 inhibitor initiators. The absolute risk was low, but clinicians and patients should be aware of this rare but evident increased risk.

Smoke from wildfires linked to 17,000 strokes in the US alone

Research links long-term exposure to wildfire smoke with increased risk of stroke in US adults, estimating around 17,000 annual cases. The study suggests wildfire smoke may be more harmful than pollution from other sources, and highlights the need for preventative measures.

Stroke survivors miss critical treatment, face greater disability due to systemic transfer delays

A new study suggests that gaps in the nation's stroke transfer system reduce survivors' chances of receiving critical treatment and increase disability. Patients with longer delays in hospital transfer experienced worse disability after their stroke, highlighting missed opportunities for many stroke patients.

‘Revoice’ device gives stroke patients their voice back

Researchers developed a wearable Revoice device that decodes speech signals and emotional cues to enable seamless real-time communication in people with post-stroke dysarthria. The device achieved a word error rate of 4.2% and sentence error rate of 2.9%, showing promising results for stroke rehabilitation.

SwRI, Trinity University to synthesize novel compound to mitigate effects of stroke, heart attack

Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.

Intense light therapy may lower risk of myocardial injuries after non-cardiac surgery

A study published in Annals of Translational Medicine found that intense light therapy can lower troponin levels and increase ANGPTL4 protein, protecting heart tissue. The treatment may reduce the risk of myocardial injuries after non-cardiac surgery, which affects 20% of patients and increases one-year mortality rates.

New monoclonal antibody targets deadly sepsis

Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.

Centuries after discovery, red blood cells still hold surprises

Researchers at University of Pennsylvania discover red blood cells contribute to clot contraction, shrinking and stabilizing blood clots. The finding opens door to new strategies for studying and treating clotting disorders, such as excessive bleeding or dangerous clots like those seen in strokes.

Brain Network Disorders review highlights role of JAK2 pathway in worsening ischemic stroke outcomes

The JAK2-STAT3 pathway contributes to inflammation and injury after ischemic stroke. Targeting this pathway shows promise for reducing brain swelling, neuronal death, and improving recovery. Several inhibitors have been found effective in preclinical models, including Tyrphostin AG490, Ruxolitinib, and natural compounds like genistein.

GLP-1 RAs and risk of nonarteritic anterior ischemic optic neuropathy in older patients with diabetes

A study found that semaglutide and liraglutide use are associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in older patients with type 2 diabetes. The GLP-1 receptor agonists showed varying levels of risk, with liraglutide posing the greatest threat.

Gene therapy improves blood flow in the brain in patients with sickle cell disease

Gene therapy has been shown to significantly improve blood flow in the brains of patients with sickle cell disease, decreasing the risk of stroke. The treatment has a more substantial and long-lasting protective effect than other treatments like hydroxyurea or blood transfusions.

Researchers advocate for stronger blood clot prevention measures after leg artery procedures in high-risk patients

Patients with chronic limb-threatening ischaemia (CLTI) are at risk of serious complications, including major amputations and heart attacks. A new statement from the European Society of Cardiology recommends using dual pathway inhibition (DPI) to prevent blood clots in CLTI patients after leg artery procedures.

Marfan syndrome increases risk of brain alterations

Researchers found that Marfan syndrome increases vulnerability to brain damage from reduced oxygen supply and raises the risk of subsequent neurological disorders. The study highlights the importance of recognizing and managing neurological risks in Marfan patients to prevent complications.

Family Heart Foundation announces results of real-world study in 273,770 individuals with cardiovascular disease demonstrating that risk of subsequent cardiovascular event increases with rising lipoprotein(a) levels

A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.

Shingles vaccine lowers the risk of heart disease for up to eight years

A study of over a million people found that shingles vaccination lowers the risk of cardiovascular events, including stroke and coronary heart disease, by up to 26%. The vaccine's protective effect lasts for up to eight years, with strongest benefits in younger people and men.

Rethinking stroke risk in patients with atherosclerotic carotid stenosis

A multicenter study found that radiologically unstable plaque, particularly intraplaque hemorrhage, significantly increases the risk of ischemic stroke and ocular symptoms in patients with symptomatic mild carotid stenosis. Surgical intervention, such as carotid endarterectomy, may be a protective factor for these patients.

Nontraditional risk factors shed light on unexplained strokes in adults younger than 50

Researchers found that adults under 50 with migraine headaches and certain heart defects are at increased risk of stroke. The study highlights the importance of assessing both traditional and nontraditional risk factors in younger people to prevent strokes.

Stroke deaths and their racial disparities increased over last 20 years

A recent study found that ischemic stroke mortality rates have increased in the US over the past two decades, particularly among racial minorities and rural residents. The majority of these deaths now occur at home, rather than in hospitals or medical facilities.

Global study led by UCalgary researchers establishes long-term risk of stroke

A global study led by UCalgary researchers found that one in five people who experience a minor stroke or TIA will have another stroke within 10 years. The study analyzed data from over 171,000 patients across four continents and shows a persistently high risk of future strokes for at least a decade.

University of Minnesota Medical School study identifies key heart marker predicting ischemic stroke and dementia

A University of Minnesota Medical School study identified a key heart marker predicting ischemic stroke and dementia, which could lead to improved patient outcomes. The left atrium's ability to stretch was found to be the most accurate predictor.

Rivaroxaban comparable to warfarin in left ventricular blood clots

In an open-label study, patients hospitalized for a serious heart attack who received rivaroxaban or warfarin had similar efficacy and safety outcomes. Rivaroxaban showed comparable results in dissolving left ventricular blood clots at three months follow-up.

Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy Risk Among Patients With Diabetes

A cohort study found semaglutide use is associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in people with diabetes. However, the retrospective design limits the study's ability to establish causality, necessitating further research.

Long-term risk of stroke after transient ischemic attack or minor stroke.

A study published in JAMA found that patients who have experienced a transient ischemic attack (TIA) or minor stroke are at a persistently high risk of subsequent stroke. The findings highlight the need for improved long-term stroke prevention measures in this patient group.

Impaired gastric myoelectrical rhythms associated with altered autonomic functions in patients with severe ischemic stroke

Patients with severe ischemic stroke show impaired gastric motility and autonomic dysfunction, with reduced normal gastric slow waves and increased sympathetic activity. These findings suggest a link between gastric myoelectrical rhythms and autonomic function in ischemic stroke.

Researchers to showcase research into neonatal brain repair at the PREMSTEM Conference

The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.

Real time monitoring of stroke using light and sound

A POSTECH research team developed a photoacoustic computed tomography (PACT) system that non-invasively monitors cerebrovascular changes in small animals with early stages of an ischemic stroke. The technology also measures oxygen saturation in blood vessels, allowing precise tracking of vascular recovery after stroke.

Semaglutide and nonarteritic anterior ischemic optic neuropathy

A study published in JAMA Ophthalmology found a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy among individuals with type 2 diabetes associated with semaglutide use. The findings suggest that further investigation is needed into the clinical implications of this association.

UCalgary stroke researchers find silver linings in neuroprotection studies

Researchers analyzed data from three trials and found nerinetide provided a clinically significant benefit to patients. The findings suggest that treating early, fast, and administering the drug can lead to improved patient outcomes.

Emboa Medical creates, validates novel catheter to improve stroke patients’ outcomes

Emboa Medical creates a microstructured catheter called TRAP, which mimics a boa constrictor's teeth arrangement to grab onto blood clots without tearing them. The TRAP design has shown significant benefits in removing clots on the first attempt and improving outcomes for stroke patients.

Clot-busting meds may be effective up to 24 hours after initial stroke symptoms

Researchers found that clot-dissolving medication alteplase improved stroke patients' recovery by more than 50% when given up to 24 hours after the beginning of an ischemic stroke. This breakthrough may provide hope for stroke patients worldwide who may not have access to clot-dissolving medications within the approved time window.

UCalgary researchers confirm best approach for stroke in medium-sized blood vessels

UCalgary researchers confirm that endovascular thrombectomy (EVT) is not effective for patients with blockages in medium-sized blood vessels. The ESCAPE-MeVO clinical trial found no improvement in outcomes for these patients compared to standard care. EVT was previously shown to improve patient outcomes after large-vessel strokes.

University of Cincinnati experts present research at International Stroke Conference 2025

Researchers at the University of Cincinnati presented studies on intracerebral hemorrhage treatment eligibility, finding only 3% of patients are eligible for a minimally invasive procedure. Additionally, a study found racial disparities in stroke recovery, with Black individuals experiencing worse functional outcomes after ischemic str...

Clot-buster meds & mechanical retrieval equally reduce disability from some strokes

The DISTAL trial found that endovascular therapy in addition to best medical therapy did not reduce disability more than clot-busting treatment alone for patients with medium distal vessel blockages. The study showed that mechanical clot removal was a safe option, but its benefits were uncertain.

New York Valves: The Structural Heart Summit is back!

The summit features live case demonstrations, interactive debates, hands-on training, and the latest evidence-based practices in structural heart care. Attendees will witness innovation in action, exploring breakthroughs in surgical techniques, transcatheter interventions, and personalized treatment strategies.

Ozone exposure linked to hypoxia and arterial stiffness

Researchers found that brief ozone exposure reduces blood oxygen saturation, triggers hypoxia-related biomarkers, and increases arterial stiffness. Ozone pollution is a worldwide health issue, linked to increased risk of cardiovascular diseases.

Microvascular over-dilation may lead to muscle hypoxia

Persistent microvascular over-dilation may cause muscle hypoxia, worsening chronic limb-threatening ischemia outcomes. Research suggests this phenomenon could be used to screen and treat patients with the disease.

Stem cell therapy jumpstarts brain recovery after stroke

Researchers at Gladstone Institutes have shown that modified stem cells can improve brain activity after a stroke, even when administered one month later. The treatment reversed brain hyperexcitability and restored balance in neural networks, leading to long-lasting effects on brain function and repair.

Chinese Medical Journal article reveals the potential of efferocytosis in mitigating stroke-induced brain damage

Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.

Robot rehabilitation can offer optimal post-stroke treatment

Researchers at Osaka Metropolitan University developed a world-first system to automatically recommend optimal rehabilitation programs for stroke patients based on their motor paralysis degree. This system uses data from Teijin Pharma Ltd.'s ReoGo-J robot, providing tailored care even for staff without robotic experience.

Study likely to change standard of care for deadly strokes

A meta-analysis of four randomized clinical trials found that endovascular therapy significantly reduces patient mortality and overall post-stroke disability for vertebrobasilar stroke patients. EVT is nearly 2½ times more likely to achieve a positive outcome compared to standard medical management.

Smoking tobacco from childhood can cause premature heart damage

A study published in JACC found that children who started tobacco smoking at age 10 were significantly more likely to experience premature cardiac injury and increase their risk of cardiovascular mortality. Researchers also discovered that continued smoking from childhood can cause lasting damage to heart muscle and function.

Mexican American women less likely to take stroke prevention medications as prescribed

A new study published in the Journal of the American Heart Association found that Mexican American women are more likely to miss prescribed doses of stroke prevention medications. The study highlights sex-associated disparities in stroke care, particularly among racial and ethnic minorities.

Energy crisis in kidney cells

A new study published in Nature Communications reveals that energy imbalances in podocytes contribute to kidney damage and proteinuria after ischemia-reperfusion injury. The researchers found that interventions targeting mitochondrial dynamics held promise in alleviating foot process effacement and improving podocyte outcomes.

Mapping of atherosclerotic plaque cells may predict future risk of stroke or heart attack

A new study maps genetic traits to cellular composition of atherosclerotic plaques, predicting future stroke or heart attack risk. The research improves risk assessment and treatment for patients with atherosclerosis.

In-situ engineering of native extracellular matrix to improve vascularization and tissue regeneration at the ischemic injury site

Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.

Blood thinners didn’t reduce cognitive decline in adults 65 and younger with AFib

A recent study published at the American Heart Association's Scientific Sessions 2024 found that blood thinners did not reduce cognitive decline in adults younger than age 65 who have atrial fibrillation (AFib) but no other risk factors for stroke. The trial included over 1,200 participants and followed them for an average of 3.7 years...

Exploring the efficacious subfractions and underlying mechanisms of Herba Siegesbeckiae against myocardial ischemia/reperfusion injury via the UCHL5/NLRP3 pathway

This study explores the efficacy of Herba Siegesbeckiae subfractions in protecting against myocardial ischemia/reperfusion injury. The HS-C subfraction exhibited significant protective effects, attributed to its ability to inhibit the UCHL5/NLRP3 pathway.

What’s chubby enough for lower disability after stroke?

A recent study published in Topics in Stroke Rehabilitation found that slightly overweight stroke survivors (BMI 22.1-27.5 kg/m²) have a lower risk of sustaining disabilities compared to those with normal weight. The research suggests that a higher-than-normal BMI may be beneficial for recovering from a stroke with less disability.

Smarter clot busting: WPI researcher to develop real-time imaging technology for stroke treatment

Yihao Zheng and his team are developing a fiber-optic probe that analyzes artery blockages in the brain and guides procedures for blockage removal. The technology uses light and advanced calculations to determine the properties of blood clots, enabling doctors to make informed decisions about how to remove them.

Groundbreaking surgical technique makes combined face and whole-eye transplantation a reality

The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.