About The Study: The results of this cohort study suggest that semaglutide use was associated with an increased risk of nonarteritic anterior ischemic optic neuropathy in patients with diabetes. However, the study’s retrospective design presents limitations, as it can only infer associations rather than establish causality; further studies are needed.
Corresponding Authors: To contact the corresponding authors, email Chun-Ju Lin, MD ( doctoraga@gmail.com ) and James Cheng-Chung Wei, MD, PhD ( jccwei@gmail.com ).
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(doi:10.1001/jamaophthalmol.2025.0349)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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JAMA Ophthalmology