Articles tagged with Oral Cancer
A new study found significantly reduced bacterial diversity and richness, and fungal richness in tumor tissue compared to non-tumor tissues, suggesting potential markers for earlier diagnosis. The findings may lead to precautionary testing in high-risk patients and improved patient outcomes.
Scientists at Trinity College Dublin have identified Fusobacteria and Campylobacter species in oral leukoplakia, a pre-cancerous growth that can precede oral cancer. The study suggests these bacteria may also contribute to colon cancer progression.
A recent study published in Cancer Research found that certain oral microbiota are associated with an increased risk of esophageal cancer. Bacteria such as Tannerella forsythia and Porphyromonas gingivalis were linked to higher risks of esophageal adenocarcinoma and squamous cell carcinoma, respectively.
A study of over 120,000 patients found that certain bacteria in the mouth are associated with an increased or decreased risk of developing esophageal cancer. The presence of Tannerella forsythia was linked to a 21% increased cancer risk, while Streptococcus and Neisseria were associated with a 24% decrease in risk.
A study in Myanmar found that all mouth cancer patients use smokeless tobacco, with betel quid chewing being a common habit among the population. The study highlights the importance of increasing awareness about the risks of betel quid chewing to prevent head and neck cancer.
A new study suggests that the risk of developing HPV-related throat cancer remains generally low, making mass screening for oral HPV infection unnecessary. The study found that current tests for oral HPV infections are not very predictive of oropharyngeal cancer risk.
A study published in Annals of Oncology found that men who smoke and have multiple oral sex partners are at higher risk of developing oropharyngeal cancer. Despite the risk, the likelihood is still relatively low, making screening a challenge.
A study led by the University at Buffalo found a significant association between periodontal disease and increased cancer risk in postmenopausal women. The study revealed that women with a history of gum disease had a 14% higher risk of overall cancer, as well as higher risks for gallbladder and esophageal cancers.
Researchers at NYU Dentistry aim to understand how immune cells contribute to sex differences in oral cancer pain. The study will determine if neutrophil infiltration affects pain levels in patients and explore a potential mechanism for improving pain management.
A phase III trial of 447 patients with biliary tract cancers showed that giving capecitabine after surgery extended survival by a median of 15 months compared to surgery alone. The treatment was associated with a 20% lower chance of death, but the difference was not statistically significant for the overall population.
A recent study found that HPV vaccination can prevent oral HPV infections by 88%, but low uptake rates among males limit its impact. The study used data from the National Health and Nutrition Examination Survey and found that only 6.9% of men had received at least one dose of the vaccine, compared to 29.2% of women.
Researchers at Kumamoto University find that interleukin-6 (IL-6) helps cancer cells survive radiation therapy by suppressing oxidative stress through the Nrf2-antioxidant pathway. This discovery offers new potential therapies targeting IL-6 to combat radioresistant cancers.
A specific group of genetic variants in the human leukocyte antigen genomic region is linked to enhanced protection against HPV-positive oropharyngeal cancer. The study found eight loci associated with susceptibility to oral cavity and pharyngeal cancer, including seven that had not been previously linked to mouth or throat cancer.
The University of Warwick is conducting a breakthrough research project to improve the diagnosis and treatment of oral cancers in Pakistan, using digital pathology. The project will generate a repository of information about different types of cancer cells found in oral cancers, enabling pathologists to analyze samples more accurately.
A new study found that working memory dysfunctions and depression are predictors of non-adherence to oral cancer therapies. The research highlights the importance of assessing cognitive functions before initiating treatment to identify patient profiles at risk of non-adherence.
A $5,000 grant will support a school-wide program to educate patients about self-oral cancer screening. The program, led by Dr. Kitrina Cordell, aims to improve early detection and survival rates for oral cancers.
Scholars propose five guidelines to prevent disputes over frozen embryos, including clear contract language, requiring a binding agreement, and anticipating potential tragedies. These recommendations aim to provide clarity for the estimated million frozen embryos in the US, reducing uncertainty and shifting terrain of varying state laws.
Researchers at New York University are investigating a novel, non-viral gene delivery method for treating oral cancer pain. The method has shown promise in preclinical studies, with a significant reduction in cancer pain and minimal cytotoxicity.
A trial by the University of Pittsburgh Cancer Institute found that broccoli sprout extract activates a detoxification gene, protecting against oral cancer recurrence. The results were confirmed through human, animal, and laboratory tests.
Researchers at Boston University School of Medicine have discovered a reliable marker (PDGFRβ) to detect carcinoma-associated fibroblasts in oral cancer tissues. This finding could lead to the development of more effective cancer therapies by combining anti-PDGFRβ treatment with existing tumor treatments.
Researchers will test peripherally-restricted cannabinoids (PRCBs) to alleviate oral cancer and chemotherapy-induced neuropathic pain symptoms. The five-year study aims to determine the antitumor potential of PRCBs, their effectiveness against cancer pain, and potential tolerance development.
Researchers discovered a strong link between HPV-16 presence in the mouth and increased risk of oropharyngeal cancer. Detecting oral HPVs may help predict people's risk for developing head and neck cancers.
A new study reveals a strong association between human papillomavirus (HPV) types and the risk of head and neck squamous cell carcinoma (HNSCC). Detection of HPV-16 in the oral cavity significantly increases the risk of oropharyngeal squamous cell carcinoma, highlighting the role of HPV in HNSCC.
A genetic biomarker called loss of heterozygosity (LOH) predicts which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The study found that LOH-positive patients had a three-year cancer-free survival rate of 74% compared to 87% for LOH-negative patients.
A genetic biomarker called loss of heterozygosity (LOH) predicts which patients with premalignant mouth lesions are at highest risk of developing oral cancer. The study found that LOH-positive patients had a lower three-year cancer-free survival rate, but no benefit from erlotinib treatment.
Researchers have developed a groundbreaking method to identify and separate human tonsil cancer stem cells, providing new insights into the disease. The study shows that these stem cells are key players in the development of tonsil cancer, with HPV infection being a major risk factor.
The University of Hawai'i Cancer Center has been awarded a five-year $5.5 million grant to support research on cervical cancer, oral cancer, and other cancers affecting Pacific Islanders in the region. The partnership aims to reduce the disproportionate cancer burden in Pacific Island populations.
A large US study found that light to moderate drinking is associated with an increased risk of certain alcohol-related cancers in women, mainly breast cancer, and men who have ever smoked. Overall, the study suggests that women should not exceed one standard drink a day and men should not exceed two standard drinks a day.
Researchers at the University of Toronto found that an abnormal immune response between neutrophils and cancer cells drives oral cancer metastasis. This connection may lead to targeted immunotherapies to shut down the abnormal response.
Researchers discovered that patients with detectable HPV16 DNA in their saliva after cancer treatment are more likely to develop cancer recurrence. The finding could lead to earlier detection and better prognosis for these patients, enabling them to receive timely treatment options.
The study found that persistent HPV16 DNA detection after treatment was associated with worse disease-free survival and overall survival. This could be a useful tool for long-term tumor surveillance, potentially reducing the need for costly imaging and intensifying visits.
Researchers at NYU's Bluestone Center are working on a novel non-viral gene delivery method to treat oral cancer pain, which is consistently ranked as one of the most painful cancers. The method aims to reverse epigenetic changes using gene therapy and selectively disrupt nociceptive signaling with limited off-target effects.
A new study published in ecancermedicalscience suggests that turmeric's curcumin can quell the activity of human papillomavirus (HPV) in oral cancer cells, potentially providing a means of future control for the virus-related cancers.
Researchers have found that broccoli sprout extract can protect against oral cancer in mice and has shown protective changes in the lining of the mouths of healthy human volunteers. A human clinical trial is underway to explore its potential in preventing head and neck cancer recurrence.
A new study suggests that vaccinating 12-year-old boys against HPV can save $8 million to $28 million over their lifetimes due to reduced incidence of HPV-related oropharyngeal cancer. The study's findings have significant implications for public health policy in countries where HPV vaccination is not currently funded.
A green tea compound may trigger a process in the mitochondria that leads to cell death, reducing cancer cell defenses. Researchers found EGCG selectively targets sirtuin 3 in cancer cells, causing oxidative stress and programmed cell death.
A McGill University study found that men who had female partners with oral and/or genital HPV infections were more likely to have oral HPV themselves. The prevalence of oral HPV was higher among male smokers, non-monogamous individuals, and those with a partner having oral or genital HPV infection.
A study by Johns Hopkins Medicine found that tobacco use is associated with an increased risk of oral human papillomavirus type 16 (HPV16) infection. The researchers discovered that people who recently used or were exposed to tobacco had a higher likelihood of having oral HPV16 DNA, independent of their sexual behavior.
A study published in Nicotine & Tobacco Research suggests that a mix of gain- and loss-framed messages may work best to help convince smokers to quit. The research found that
Researchers found that personal biases and communication styles of providers played a significant role in decreasing HPV vaccination rates among teens. Providers who believed their patients were at low risk for sexual activity delayed vaccine administration, often without readdressing the decision.
The human papillomavirus (HPV) infection affects both men and women, leading to genital warts and various types of cancer. Vaccinating boys against HPV can prevent these health issues and reduce the burden on healthcare systems.
Researchers at Scripps Florida have identified a link between genetic mutations and mucoepidermoid carcinoma, an oral cancer affecting the salivary glands. The discovery could lead to targeted therapies that target the underlying genetic causes of the cancer.
Researchers at the University of Texas Health Science Center at San Antonio have discovered that capsazepine can shrink oral cancers while leaving healthy tissues intact. The study's findings suggest that capsazepine may reduce oral cancer pain by blocking tumor-secreted factors from stimulating pain-sensing neurons.
A pilot study at CWRU Dental School and UH Case Medical Center investigates the use of human beta-defensin-3 (hBD-3) to detect oral cancers. High levels of hBD-3 have been found in precancerous tissues and some oral cancers, suggesting its potential as an early diagnosis tool.
Researchers have identified changes in the oral microbiome that may be associated with oral cancer development. The study found significant decreases in abundance of certain bacterial groups, such as Firmicutes and Actinobacteria, in cancer samples compared to normal tissue.
A study published in Journal of Clinical Oncology found low transmission rates among long-term partners of patients with oral HPV infection. The prevalence of oral HPV among partners was comparable to the general population, confirming that couples do not need to change their intimacy due to cancer diagnosis.
People with late-stage cancer at the back of the mouth or throat that recurs after chemotherapy and radiation treatment are twice as likely to be alive two years later if their cancer is caused by HPV. The longer survival pattern holds even if the cancer returns.
A new study reveals a significant increase in oropharyngeal cancers among young adults, with human papillomavirus (HPV) identified as a possible cause. The five-year survival rate for this age group is 54%, with African Americans facing poorer outcomes compared to other races.
The US Preventive Services Task Force found no evidence that screening for oral cancer by primary care physicians reduces morbidity or mortality. Oral cancer is often diagnosed at advanced stages, highlighting the importance of earlier diagnosis.
The study aims to investigate the effectiveness of treating precancerous lesions in reducing the incidence of anal cancer in HIV-infected men and women. The project will enroll 5,058 participants and follow them for up to five years to determine the incidence of cancer.
A recent study found a significant increase in young adults with oropharyngeal cancer, attributed to the human papillomavirus (HPV), particularly among Caucasians. In contrast, African Americans face poorer survival rates despite lower incidence rates. The study's findings highlight the need for increased awareness and screening for HP...
A new study found that poor oral health is associated with an increased risk of oral human papillomavirus (HPV) infection, which can cause oropharyngeal cancers. Good oral hygiene practices can help prevent HPV infection and its related cancers.
Researchers at Queen Mary University of London discovered that omega-3 fatty acids selectively inhibit the growth of malignant and pre-malignant cells without affecting normal cells, suggesting potential use in cancer treatment and prevention. Further research is needed to define therapeutic doses.
Researchers found that single men and smokers are more likely to acquire cancer-causing oral human papillomavirus (HPV), while healthy men with newly acquired HPV infections rarely persist beyond one year. The study suggests a potential link between persistent oral HPV16 infection and oropharyngeal cancer.
A study led by Johns Hopkins investigators found that long-term couples need not change their sexual practices due to low oral HPV infections among spouses/partners. Persistent oral HPV infections are a risk for developing oropharyngeal cancers, but the study suggests these risks remain low.
Research from Boston University School of Medicine found that alcohol consumption is a major contributor to cancer deaths and years of potential life lost in the US. The study showed that reducing alcohol consumption can be an effective cancer prevention strategy.
A new study by the American Cancer Society finds a strong inverse association between caffeinated coffee intake and oral/pharyngeal cancer mortality. Consuming more than four cups per day was associated with a 49% lower risk of death from these cancers.
Researchers found that nisin slows or stops tumor growth by interrupting the cell cycle in cancer cells but not healthy ones. The study's findings suggest that nisin triggers cell death through the activation of protein CHAC1, which is a new role for this protein.
A new study found that compounds in the arcea nut can directly cause DNA damage and increase the risk of oral cancer in betel quid users. The substances, present in amounts sufficient to cause harm, were discovered through research published in Chemical Research in Toxicology.
A new gene test has been developed to detect pre-cancerous cells in patients with benign-looking mouth lesions. The test shows a cancer detection rate of 91-94% and could potentially allow at-risk patients to receive earlier treatment, significantly improving their chance of survival.