Articles tagged with Oral Cancer
Researchers found that nisin slows or stops tumor growth by interrupting the cell cycle in cancer cells but not healthy ones. The study's findings suggest that nisin triggers cell death through the activation of protein CHAC1, which is a new role for this protein.
A new study found that compounds in the arcea nut can directly cause DNA damage and increase the risk of oral cancer in betel quid users. The substances, present in amounts sufficient to cause harm, were discovered through research published in Chemical Research in Toxicology.
A new gene test has been developed to detect pre-cancerous cells in patients with benign-looking mouth lesions. The test shows a cancer detection rate of 91-94% and could potentially allow at-risk patients to receive earlier treatment, significantly improving their chance of survival.
Researchers have identified molecular markers that can predict the progression of low-grade oral premalignant lesions to cancer. These markers, including loss of heterozygosity, help clinicians determine which patients are at high risk for progression and need closer follow-up.
A study found that patients with oral cavity tumors positive for human papillomavirus (HPV) had significantly higher levels of chronic inflammation in the mouth compared to those without HPV. The authors suggest that preventing or treating sources of oral inflammation may be a simple way to reduce the risk of oral HPV infection.
A Swedish study found that dental plaque is associated with a significantly increased risk of premature death from cancer. The research tracked the health of almost 1,400 adults for 24 years and found that those with high levels of plaque had a 79% higher risk of dying early from cancer.
Researchers at NYU College of Dentistry and UCSF will use genomic markers to identify oral cancer patients who don't need neck dissection. This study aims to improve quality of life and reduce recovery time for patients, potentially saving lives.
A portable, miniature microscope has been developed to detect oral cancer in real-time, offering a significant improvement over traditional biopsy methods. The handheld probe uses a laser and micromirror technology to create full 3D images of tissue samples, providing high accuracy and potentially reducing treatment costs.
A new clinical trial aims to develop a simple saliva test that can detect oral cancer in its early stages. The test has the potential to reduce the number of unnecessary biopsies and improve survival rates for patients with this common cancer, which affects over 60,000 people worldwide.
Researchers found (S)-NNN to be a strong oral carcinogen, inducing oral cancer in rats. The chemical is present in smokeless tobacco products and has been linked to an increased risk of oral cavity cancers.
A new study published in The Lancet analyzed cancer death rates across India and found that oral, stomach, and lung cancers are major causes of death in men, while cervical, stomach, and breast cancers cause the most deaths among women. The study also highlighted significant geographical and social variations in cancer mortality rates.
Researchers at Queen Mary University of London have identified a mechanism by which normal cells can become cancerous. By understanding how the FOXM1 gene influences cell behavior, scientists may be able to develop new diagnostic tests to detect cancer at an early stage.
African Americans in Georgia have poorer survival rates from cancer compared to national averages, with racial disparities widening rural areas. The study found that MIRs were higher for African Americans than whites across all cancer sites, particularly prostate, cervical, and oral cancers.
A case-control study found that injectable and oral contraceptives are associated with a transiently increased risk of breast and cervical cancer. Extended use, however, is linked to a reduced risk of ovarian and endometrial cancer in black South African women.
Researchers developed a new radiotherapy technique that targets cancerous tissue while reducing irradiation of healthy tissue. This approach resulted in lower toxicity and higher completion rates among patients compared to traditional techniques.
According to UofL research, substituting smokeless tobacco can save lives by reducing the risk of disease and death among smokers. Decades of epidemiologic research support this finding, with smokeless products being 98% safer than cigarettes.
Malnourished cancer patients who received oral nutritional support showed improvements in aspects of quality of life, including emotional functioning and loss of appetite. However, the interventions had no impact on mortality rates or consistent effects on weight gain.
The study found that oral HPV infection was predominantly sexually transmitted and had peaks in different age ranges, with men having a significantly higher prevalence than women. Oral HPV prevalence was associated with several measures of sexual behavior, including the number of partners and current smoking habits.
A recent study found that 7% of the US population between ages 14 and 69 has an oral HPV infection, with men being three times more likely to have it than women. The study also revealed that patients infected with oral HPV type 16 have a 14 times greater risk of developing head and neck cancer.
Researchers created three-dimensional lab-made tissue models to study oral cancer, revealing the importance of epigenetic mechanisms in cancer development and progression. The findings support the need for more complex tissue-like systems in cancer drug screening, replacing conventional petri dish cultures.
Mortality rates for patients with oral cavity and pharynx cancer have decreased significantly between 1993 and 2007. The largest declines were observed among black men and women with at least 12 years of education, suggesting that improvements in detection, treatment, and risk factors contribute to these decreases.
Researchers have identified a four-gene signature that accurately predicts which patients are at higher risk of oral cancer recurrence. The signature contains genes related to cell invasion and is indicative of an increased risk of recurrence even in patients with no visible signs of cancer.
A new study found that graphic cigarette package warning labels, including images of lung and mouth cancer, can significantly reduce demand for cigarettes. The experimental auction involved 404 adult smokers from four states, who bid on packs with different kinds of warning labels.
The World Health Organization has stated that alcohol is carcinogenic in both animals and humans. Several studies have linked alcohol consumption to an increased risk of cancers in the mouth, throat, esophagus, liver, colon-rectum, and breast cancers. New international guidelines are needed to address this issue.
A pan-Canadian clinical trial led by UBC researchers aims to revolutionize oral cancer surgery with a new fluorescence visualization technique, potentially reducing recurrence rates and improving patient outcomes.
A study by University of Pennsylvania School of Medicine investigators shows that mice lacking a key protein develop squamous cell cancers resembling human disease, supporting novel therapies and early detection strategies. The findings settle a 20-year debate and prove the protein's role as a tumor-suppressor.
A UNC study found a significant increase in oral tongue squamous cell carcinoma among young white females, with incidence rates rising by 111% between 1975 and 2007. The researchers suggest that the epidemiology of this cancer may be unique and not associated with human papillomavirus or tobacco/alcohol use.
Scientists have discovered how the human papilloma virus (HPV) triggers cancer in the cervix and mouth, potentially leading to new treatments. The study found that HPV activates a protein called Cdc42, which is already implicated in various cancers, including tumour spread.
A study led by Ohio State University found that a drug currently approved for osteoporosis treatment can reduce bone loss and tumor size in mice with oral cancer. The drug, zoledronic acid, was associated with smaller tumors and an increase in new bone formation.
ASTRO recognizes Brian Hill as a cancer survivor who has given back to the community through his nonprofit, The Oral Cancer Foundation. He was diagnosed with Stage 4 metastatic tonsil cancer in 1997 but went on to donate $1,000 prize money to benefit the foundation.
Studies have found that patients with cancer who experience pain or depression also report a high rate of physical symptoms such as fatigue, dry mouth, and nausea. These somatic symptoms are associated with substantial functional impairment, disability, and healthcare use, even after controlling for medical and psychiatric comorbidity.
A new test for oral cancer, developed by researchers at the University of Sheffield, uses a brush to collect cells from a patient's mouth and analyzes them in under 20 minutes. This technology has the potential to significantly increase early detection rates and improve patient outcomes.
A new study published in the International Journal of Cancer has identified microRNA-138 as a gene that regulates cancer cell migration and may hold the key to reducing the spread of oral cancers. The research found that a reduced level of microRNA-138 is associated with enhanced ability of tongue squamous cell carcinoma cells to spread.
Researchers at CWRU School of Dental Medicine discovered a biomarker called human beta defensin-3 (hBD-3), which is associated with the early stages of oral cancer and can serve as an early warning system. hBD-3 attracts molecules that help cancerous tumors grow and spread.
Rice University researchers, led by John McDevitt, have been awarded $3.7 million to develop a cost-effective Bio-Nano-Chip that can detect early warning signs of disease. The technology has the potential to cut treatment time and costs, enabling emergency medical technicians to perform tests at home or in an ambulance.
Researchers have developed a new model to investigate the link between tobacco use and oral cancer, using carcinogens found in tobacco smoke. The study shows that this approach can lead to better understanding of oral cancer initiation, progression, and prevention.
A new Lancet editorial promotes the 'eat 5 fruit and veg a day' message despite recent findings suggesting a lower protective effect against cancer. Four key benefits remain: heart disease prevention, strong protection against specific cancers, weight management, and bowel cancer prevention.
Researchers have identified five SIBLING proteins that can predict oral cancer development in premalignant lesions. The study found that certain SIBLINGs, such as dentin sialophosphoprotein, increase the risk of oral cancer fourfold, while others, like bone sialoprotein, significantly decrease it.
Mayo Clinic researchers have developed a novel approach for sequencing RNA to study cancer tumors, revealing alterations in gene expression driven by chromosomal regions of gain and loss. This technology allows for detailed analysis of the transcriptome, enabling better understanding of individualized medicine and potential therapeutic...
European cancer mortality has declined steadily, but large variations exist among countries and sex. The decline is largely driven by a decrease in tobacco-related cancers, gastric cancer, and colorectal cancer.
A new study suggests that green tea extract can reduce the risk of oral cancer, with patients who presented with mild to moderate dysplasia having a longer time to develop oral cancer if they took green tea extract. However, more research is needed to confirm its long-term prevention effects.
Researchers at Rice University are developing a rapid saliva test for oral cancer that can be performed by a dentist in under 30 minutes. The test uses a novel microchip, known as a lab-on-a-chip, to detect specific biomarkers in cells, allowing for early diagnosis and improved patient outcomes.
A Phase II dose-finding study found that green tea extract improved histology and trended towards a reduction in biomarkers associated with cancer development in patients with oral leukoplakia. The extract was well-tolerated, with minimal side effects.
The University of Guam has received a five-year, $8M grant to support cancer research and education, with a focus on addressing health disparities among minority populations. The grant aims to increase research capabilities, provide training opportunities, and promote awareness of cancer prevention.
The UCLA School of Dentistry is building a state-of-the-art cancer research facility to consolidate and expand its oral cancer research. The Yip Center for Oral/Head & Neck Oncology Research will include cutting-edge laboratories for genomics, proteomics, and salivary diagnostics research.
Researchers identified 50 microRNAs in saliva that could help detect oral cancer, including miR-125a and miR-200a. The findings suggest a major step forward in early oral cancer detection.
Alpesh Patel, a senior at MCG School of Dentistry, has identified proteins responsible for inhibiting oral cancer cell growth when exposed to blue curing light. He found that this phenomenon reduces tumor growth in mice, offering a promising alternative treatment.
A study published in General Dentistry has found that the VELscope device can detect oral HPV lesions, allowing for early detection and treatment of oral cancer. Regular dental check-ups and screenings are crucial in preventing and detecting oral cancer.
A new study published in the Journal of Prosthodontics found that the absence of Human calmodulin-like protein (CLP) in oral epithelial cells may indicate oral cancer. The researchers used staining to compare CLP expression in normal and cancerous tissues, revealing a significant decrease or complete lack of CLP in malignant regions.
The majority of oral cancers are found late, causing high mortality rates, but early diagnosis improves survivability to 95% and reduces morbidity. Prosthodontists must change their practice paradigm by performing regular oral cancer screening examinations on all patients.
A new Cornell study found a strong relationship between allergies and cancer in tissues exposed to environmental factors, such as eczema, hives, and hay fever. Allergies linked to these conditions were most strongly associated with lower rates of cancers in exposed tissues.
A comprehensive assessment of HPV-associated cancers found significant racial disparities, with higher rates among African American women and Hispanic men. The study also identified the most common types of HPV-related cancers, including cervical, anal, and oral cancers.
A recent study found that HPV vaccination can reduce the incidence of HPV-caused cancers, particularly oral and anal cancers, which are rising in incidence. Researchers propose a simple oral screening test using 'swish and spit' rinses to detect high-risk infections.
A large population study found a significant association between incense use and an increased risk of upper respiratory tract cancers, including squamous cell carcinomas. The study also suggested that incense smoke may add to the cancer risk in smokers, but not in non-smokers.
Research finds that smokeless tobacco products carry a lower cancer risk compared to smoking, particularly for oral and oesophageal cancers. However, users are still at increased risk of other types of cancer, such as lung cancer, especially in countries with high STP use.
A phase II study found that adding cetuximab to chemotherapy improves response rates in head and neck cancer patients, with 86% of patients responding to induction treatment. The addition also led to significant tumor reduction and improved cancer-free survival rates over two years.
Researchers have developed novel approaches to analyze proteins in human saliva and diseased heart tissue, potentially leading to earlier diagnoses of heart disease and oral cancer. By tracking changes in protein profiles over time, scientists may identify key biomarkers for therapeutic intervention.
A new robotic surgery technique called transoral robotic surgery (TORS) has been shown to be effective in removing tonsil cancer with minimal complications and improved patient outcomes. In a study of 27 patients, surgeons successfully removed all cancerous tissues in 93% of cases, with an average surgery time of one hour and 43 minutes.
Research presents findings on plant-derived cancer medicines, highlighting the potential of black raspberry gel in preventing or slowing the growth of oral premalignant tumors. The study demonstrates that the gel slows or reduces lesion progression in about two-thirds of study participants, with no reported side effects.
Researchers discovered that different ethnic groups living in California manifest the disease very differently, with African Americans and Caucasians developing tongue cancer at higher rates. Cultural habits such as cigarette smoking and areca nut chewing contribute to the prevalence of oral cancer in certain groups.