Articles tagged with Oral Cancer
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
A study by researchers from Okayama University found that Japanese university students' willingness to undergo regular dental check-ups is associated with their thoughts regarding the health-belief model and oral health behaviors. The study suggests that the perceived benefit of undergoing regular check-ups drives young students toward...
A cost-effectiveness analysis of direct oral anticoagulants (DOACs) versus low-molecular-weight heparin (LMWH) for cancer-associated thrombosis found that DOACs are more medically effective and cost-effective. The most cost-effective DOAC, apixaban, was also shown to be the least costly anticoagulant.
Researchers found that oral cancer cells releasing EVs under TGF-β induce EndoMT in endothelial cells, leading to vascular destabilization. This process may facilitate cancer cell entry into the bloodstream, promoting metastasis.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
A study from Tokyo Medical and Dental University reveals that the TGF-β signaling molecule can induce EMT in oral cancer cells, leading to high motility and metastatic potential. KRTAP2-3 expression is associated with poorer overall survival, suggesting its role as a prognostic biomarker.
Researchers conducted a study on administering immunotherapy drug pembrolizumab before surgery for oral cavity cancer and found no increased rates of complications during and after surgery. The findings are encouraging for patients who have not previously received treatment for their oral cavity cancer, suggesting that complication rat...
A new study by University of Cambridge researchers found that male dogs are four to five times more likely than female dogs to be infected with the oro-nasal form of Canine Transmissible Venereal Tumour. This unusual cancer is infectious and can spread between dogs through contact, commonly affecting genitals but also the nose and mouth.
MD Anderson research highlights new treatments for skin cancers, including novel therapies. The institution also showcased improved goals of care programs, which demonstrated significant reductions in ICU mortality and improved patient outcomes during the COVID-19 pandemic.
A study by researchers at UCSF found that e-cigarette use costs the US $15 billion annually in healthcare expenditures, with each user paying around $2,000 extra per year compared to non-users. The study, published in Tobacco Control, highlights the growing concern over health care costs associated with e-cigarette use.
A new study from University of Gothenburg found that men with high childhood BMI are at an elevated risk of obesity-related cancer, even if their weight is normal in young adulthood. The study analyzed data from 6,565 men born between 1945 and 1961 and found a persistently increased risk of adult obesity-related cancer.
Deleting or inhibiting a protein called lysine-specific demethylase 1 (LSD1) may curb the growth of oral squamous cell carcinoma tumors. The study found that disrupting LSD1 promotes anti-tumor immunity, which can help fight cancer. The discovery could lead to new and potentially more effective therapies for oral cancer patients.
A new study found that e-cigarette vapers and hookah smokers are more likely to exhale particles through their nose compared to cigarette smokers. This unique breathing pattern may expose the nose and sinuses to higher levels of emissions, increasing the risk of upper respiratory diseases.
A new poll shows that most teens and young adults know it's possible to catch or spread a sexually transmitted infection by having unprotected oral sex, but over half underestimate the level of that risk. Young people also call for more education about the risks of oral sex and normalization of protection through popular culture.
The European Research Council has awarded Kai Kretzschmar a Starting Grant to systematically characterise oral epithelial stem cells. This will help decipher the mechanisms underlying the diversity of the oral epithelium and its contribution to oral squamous cell carcinomas.
A new national study found that oropharyngeal cancer incidence is increasing rapidly across the US, particularly among men and in the Midwest and Southeast. The study also reported a significant increase in large tumor diagnoses and mortality rates over the last decade.
A recent study has identified a new mechanism by which oral cancer cells acquire radioresistance through the transfer of microRNA, specifically miR-503-3p. This discovery brings hope for the development of new treatments for radiation-resistant oral cancer.
Researchers have identified a significant association between periodontal disease, oral pathogens, and the development of gastric cancer. The study suggests that individuals with gastric cancer have a higher prevalence of oral pathogens, which may contribute to the risk of developing the disease.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
Researchers identified a key mechanism in which tumor microenvironment induces an anti-inflammatory phenotype, promoting tumor growth. The vitamin D signaling pathway plays a crucial role in this process.
Exposure to secondhand smoke increases oral cancer risk by 51%, according to a review of existing research. Long-term exposure is associated with significantly higher risk, highlighting the need for effective prevention programmes.
Scientists have discovered a potential new therapy target for canine cancer, specifically oral malignant melanoma in dogs. The treatment targets the PD-L1 molecule, which has shown promise in human cancer treatments, and significantly increased survival time for dogs with pulmonary metastatic OMM.
The University at Buffalo has received a $1.5 million grant to develop new therapies for oral cancer by targeting macrophage genes that regulate inflammation, aiming to increase survival rates and sensitivity to chemotherapies.
Researchers will investigate how oral cancer releases mediators that sensitize and activate pain-sensing nerves, promoting cancer growth and pain. The goal is to develop novel approaches for treating oral cancer and pain.
Researchers Seiichi Yamano and Brian Schmidt aim to develop a new class of medicines using gene therapy to effectively treat oral cancer pain. They will test whether co-delivery of DNA and RNA can safely alleviate oral cancer pain, offering an alternative to opioids.
A new study finds that alcohol accounts for a considerable portion of cancer cases (4.8%) and deaths (3.2%) in the US, with higher rates in New England and Western states. The study calls for implementation of policies and cancer control efforts to reduce alcohol consumption and its burden on cancer-related mortality.
A new study by Johns Hopkins Medicine found that various oral sex behaviors may increase the risk of oral HPV infection and head and neck cancer. Behaviors such as having multiple partners, early age of sexual initiation, and higher 'intensity' of oral sex were associated with a higher risk of the disease.
A recent study published in Cancer reveals that having multiple oral sex partners and engaging in high-intensity sex at a younger age significantly increase the likelihood of developing HPV-related oropharyngeal cancer. The research also found that older sexual partners and extramarital relationships are associated with higher risk.
Researchers are using AI to improve treatment outcomes for patients with oral squamous cell carcinomas by predicting which patients need chemotherapy, radiation, or surgery. The project aims to develop a more precise and personalized approach to cancer care.
Researchers at Tokyo Medical and Dental University have discovered that stimulating β-ARs can halt the progression of oral cancer. The study found that specific compounds, such as isoxsuprine, effectively interfered with epithelial-mesenchymal transition (EMT), a process that enables cancer cells to spread and form secondary tumors.
Research at NYU College of Dentistry identifies genes highly expressed in painful, metastatic oral cancers, revealing a mechanism for cancer pain. The study's findings may lead to the development of biomarkers and objective molecular tests to diagnose risk of metastasis.
Research finds that oral cancer is promoted by periodontal pathogens and can be inhibited by a bacteriocin, a naturally occurring antimicrobial peptide. The study offers new insights into the development of oral cancer and suggests potential therapeutic applications for nisin, a commonly used food preservative.
Researchers from Case Western Reserve University are developing a hand-held device that can non-invasively detect oral cancer by analyzing the ratios of two key proteins. The device aims to reduce the need for painful biopsies and provide an accurate diagnostic alternative, especially in resource-poor settings.
A study published in The Lancet Public Health found that nearly 60% of US parents of unvaccinated adolescents have no intention to initiate the HPV vaccine series. Healthcare providers play a crucial role in addressing parental misconceptions and ensuring series completion.
A study published in the journal Gut found that people with periodontal disease may be at a higher risk of developing oesophageal and gastric cancer. The research examined data from over 98,000 women and men and found a 43-52% increased risk associated with periodontal disease.
NYU Dentistry researcher Yi Ye has received a $2.2 million NIH grant to investigate how oral cancer cells invade nerves and cause pain. Her study aims to understand the role of Schwann cells in this process and identify potential targets for treating oral cancer-related pain.
The Caravaggio study found that oral apixaban is at least as effective as dalteparin in preventing recurrent venous thromboembolism and major bleeding events in patients with cancer. The trial showed no significant difference in the risk of major bleeding, including gastrointestinal cancers, between the two treatments.
APG-157, a plant-based drug containing curcumin, was shown to reduce inflammation and attract immune cells to tumor tissues in patients with oral and oropharyngeal cancers. The treatment also decreased Bacteroides species and had no adverse effects.
A recent study found that over 70% of US adults are unaware that human papillomavirus (HPV) causes anal, penile, and oral cancers. The study, led by researchers at the University of Texas Health Science Center at Houston, also showed low HPV vaccination rates among eligible individuals.
Javier Jo's research aims to detect oral cancer at an early stage using a hand-held endoscope that can recognize patterns and signatures of precancerous and cancerous lesions. The technology has the potential to increase the number of patients diagnosed with oral cancer at an earlier stage, improving survival rates and quality of life.
The study found a decline in vaccine-type oral HPV infections among unvaccinated men, suggesting herd protection. However, the prevalence of oral HPV infections remained unchanged in unvaccinated women, possibly due to low statistical power.
A recent study by Brigham researchers found that sociodemographic factors, such as income and race, predict differences in oral cancer screening (OCS) rates. The results show that minority and low-income individuals are less likely to receive recommended OCS exams at dental visits, highlighting disparities in access to quality care.
A large UK cohort study found poor oral health is strongly associated with a higher risk of hepatocellular carcinoma (HCC), the most common form of liver cancer. Poor oral health, including painful gums and loose teeth, was linked to an increased risk of HCC in patients.
Researchers found that repeated detection of HPV DNA in oral rinses after cancer treatment was associated with a higher risk of cancer recurrence and death. The study suggests HPV DNA may be a promising biomarker for understanding cancer treatment response and future risk of progression.
A significant rise in oral cancer and pre-cancerous lesion detection by dentists in Ontario is reported, with a nearly doubling of cancers detected between 2005 and 2015. The study suggests that comprehensive training and continuing education programs for oral health professionals may be behind the dramatic increase in detection rates.
Researchers at the University of Otago and Indian Statistical Institute have discovered distinct epigenetic markers in oral cancer tissues that are associated with patient survival. The findings, published in the journal Epigenomics, could help save thousands of lives by identifying cancer cells early.
A Rutgers study found that smokers perceive snus as less harmful for lung cancer and heart disease but more harmful for oral cancer. The researchers suggest that quitting tobacco is the best course of action, while switching to snus may reduce risks for non-quitters.
A USC study found that e-cig users develop abnormal gene expression linked to cancer development in oral tissue, similar to those seen in cigarette smokers. The research suggests that e-cigs may not be as benign as previously believed.
Oral mucositis affects nearly 40% of patients receiving chemotherapy and 80% of those receiving radiation therapy. A new study tests photobiomodulation as a non-invasive replacement for opioids to alleviate pain, promote healing, and improve quality of life for cancer patients.
A Rutgers study found a 40% increase in head and neck cancer diagnoses among WTC first responders between 2009 and 2012. The research highlights the need for ongoing monitoring and treatment of those exposed during the initial response.
A new study found that an ultrarestrictive opioid prescribing strategy was associated with fewer pills dispensed after surgery, without changes in postoperative pain scores or complications. The protocol reduced opioid pill dispensing by 72-85% for patients undergoing different types of surgery.
High levels of air pollutants, especially PM2.5, may be associated with an increased risk of developing mouth cancer, according to the first study of its kind. The study found that exposure to high levels of PM2.5 was linked to a 43% heightened risk of a mouth cancer diagnosis.
The study, conducted by the University of Sheffield, found that 2.2% of participants were infected with high-risk human papillomavirus (HR-HPV) oral infection, lower than previous US studies. Smoking and sexual behavior were identified as significant risk factors for oral HPV infection.
A new study found that preoperative oral care by a dentist can decrease postoperative pneumonia and death within 30 days of surgery. The practice improved patient outcomes, suggesting potential improvements for preventing postoperative complications.
A systematic review of 33 studies found that more processed starches increase the risk of cavities due to their breakdown into sugars in the mouth. Whole grain carbohydrates, on the other hand, may offer protection against gum disease and a lower risk of oral cancer.
A global review of almost 20 million people found that diabetes significantly raises the risk of developing cancer, with women at even greater likelihood. The study highlights the need for more research into the role diabetes plays in cancer development and the importance of sex-specific research.
This review discusses immune-suppressive mechanisms in oral cancer, including regulatory T cells, myeloid-derived suppressor cells, and cancer-associated fibroblasts. The complexity of these mechanisms is explored, with a focus on identifying potential therapeutic targets for oral squamous cell carcinoma development.
A recent study published in the journal Microbiome has found that drinking alcohol can disrupt the balance of oral bacteria, leading to an overabundance of harmful germs. Researchers discovered that moderate drinkers had fewer beneficial bacteria than non-drinkers, while heavy drinkers had more potentially harmful bacteria species.
New research from the University of British Columbia has found that non-smokers with oral precancerous lesions are more than twice as likely to progress to cancer compared to smokers. Oral precancerous lesions in non-smokers progressed faster to cancer than smoking-associated lesions.
Researchers link oral health to cancer prevention via bacteria associated with periodontitis. Periodontitis may facilitate the spread of oral bacteria and their virulence factors to other parts of the body, contributing to cancer development.