Articles tagged with Oral Cancer
A new method has been developed to rapidly identify genes that drive tumor growth in various types of cancers. Organoids were used to test candidate genes, revealing promising targets for precision oncology. The study's findings may lead to the development of targeted therapies for patients with esophageal squamous cancer.
A new study found that consuming ultra-processed foods is associated with a higher risk of developing upper aerodigestive tract cancers. The study analysed data from 450,111 adults and found that eating more UPFs was linked to a 23% higher risk of head and neck cancer and a 24% higher risk of oesophageal adenocarcinoma.
Researchers used spatial transcriptomics to analyze cancer cells at the edge and center of tumors, finding distinct gene expression patterns that can predict clinical outcomes and response to therapy. These findings hold promise for improving treatment strategies across various cancer types.
Cancer researchers at University of Cincinnati Cancer Center are exploring a new method called lattice therapy, which delivers higher doses to tumors and lower doses to surrounding tissues. The approach has shown promise in reducing treatment time and improving patient outcomes for head and neck, lung, and brain tumors.
Research reveals strong associations between oral health and survival among people diagnosed with head and neck cancer, with better oral health linked to increased survival. Frequent dental visits were found to be associated with earlier cancer diagnosis and less deadly disease stages.
A new study finds that targeting the ORAI1 calcium channel may provide a promising approach to treating oral cancer. The study reveals that activating this channel causes an influx of calcium into cancer cells, leading to increased pain sensitivity.
A recent study from Leipzig University found no significant link between oropharyngeal cancer and high-risk sexual behavior. The research, which analyzed data from over 300 patients with head and neck cancer, suggests that HPV infection is a key risk factor for the disease.
A study published in Cancers found that a combination of radiotherapy followed by immunotherapy is effective against oral malignant melanomas in dogs. The treatment strategy increased overall survival time compared to immunotherapy alone. Researchers are now exploring the optimal protocol for this therapy to increase its effectiveness.
Researchers developed a new metric to analyze the relationship between nerve density and oral cancer progression. Normalized nerve density was found to be associated with poor survival rates for patients with tongue cancer, highlighting its potential as a tool for identifying aggressive tumors.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
Researchers developed a non-invasive diagnostic test called PANDORA that accurately identified patients with oral squamous cell carcinoma and pre-cancerous conditions. The test, which measures dielectrophoresis in cells, shows over 92% accuracy in detecting oral cancer.
A new study of over 200 people with premature aging syndromes caused by abnormally short telomeres suggests that chromosomal instability may not be the reason for increased cancer risk. Instead, immune system cells that age and die prematurely may play a role in cancer predisposition.
Researchers identify the minimum contribution of TACC3 for FGFR3-TACC3 fusion protein activation, revealing a novel target for treating FGFR translocation-driven cancers. The study shows that clinically identified FGFR3-TACC3 fusion proteins differ in biological activity depending on specific breakpoints.
Researchers have developed a hand-held device that can rapidly and accurately identify lesions in the mouth that will develop into cancer. The Liverpool Diagnostic Infrared (LDIR) Wand employs infrared lasers to predict future cancer risk based on machine learning analysis.
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
A study by researchers from Okayama University found that Japanese university students' willingness to undergo regular dental check-ups is associated with their thoughts regarding the health-belief model and oral health behaviors. The study suggests that the perceived benefit of undergoing regular check-ups drives young students toward...
A cost-effectiveness analysis of direct oral anticoagulants (DOACs) versus low-molecular-weight heparin (LMWH) for cancer-associated thrombosis found that DOACs are more medically effective and cost-effective. The most cost-effective DOAC, apixaban, was also shown to be the least costly anticoagulant.
Researchers found that oral cancer cells releasing EVs under TGF-β induce EndoMT in endothelial cells, leading to vascular destabilization. This process may facilitate cancer cell entry into the bloodstream, promoting metastasis.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
A study from Tokyo Medical and Dental University reveals that the TGF-β signaling molecule can induce EMT in oral cancer cells, leading to high motility and metastatic potential. KRTAP2-3 expression is associated with poorer overall survival, suggesting its role as a prognostic biomarker.
Researchers conducted a study on administering immunotherapy drug pembrolizumab before surgery for oral cavity cancer and found no increased rates of complications during and after surgery. The findings are encouraging for patients who have not previously received treatment for their oral cavity cancer, suggesting that complication rat...
A new study by University of Cambridge researchers found that male dogs are four to five times more likely than female dogs to be infected with the oro-nasal form of Canine Transmissible Venereal Tumour. This unusual cancer is infectious and can spread between dogs through contact, commonly affecting genitals but also the nose and mouth.
MD Anderson research highlights new treatments for skin cancers, including novel therapies. The institution also showcased improved goals of care programs, which demonstrated significant reductions in ICU mortality and improved patient outcomes during the COVID-19 pandemic.
A study by researchers at UCSF found that e-cigarette use costs the US $15 billion annually in healthcare expenditures, with each user paying around $2,000 extra per year compared to non-users. The study, published in Tobacco Control, highlights the growing concern over health care costs associated with e-cigarette use.
A new study from University of Gothenburg found that men with high childhood BMI are at an elevated risk of obesity-related cancer, even if their weight is normal in young adulthood. The study analyzed data from 6,565 men born between 1945 and 1961 and found a persistently increased risk of adult obesity-related cancer.
Deleting or inhibiting a protein called lysine-specific demethylase 1 (LSD1) may curb the growth of oral squamous cell carcinoma tumors. The study found that disrupting LSD1 promotes anti-tumor immunity, which can help fight cancer. The discovery could lead to new and potentially more effective therapies for oral cancer patients.
A new study found that e-cigarette vapers and hookah smokers are more likely to exhale particles through their nose compared to cigarette smokers. This unique breathing pattern may expose the nose and sinuses to higher levels of emissions, increasing the risk of upper respiratory diseases.
A new poll shows that most teens and young adults know it's possible to catch or spread a sexually transmitted infection by having unprotected oral sex, but over half underestimate the level of that risk. Young people also call for more education about the risks of oral sex and normalization of protection through popular culture.
The European Research Council has awarded Kai Kretzschmar a Starting Grant to systematically characterise oral epithelial stem cells. This will help decipher the mechanisms underlying the diversity of the oral epithelium and its contribution to oral squamous cell carcinomas.
A new national study found that oropharyngeal cancer incidence is increasing rapidly across the US, particularly among men and in the Midwest and Southeast. The study also reported a significant increase in large tumor diagnoses and mortality rates over the last decade.
A recent study has identified a new mechanism by which oral cancer cells acquire radioresistance through the transfer of microRNA, specifically miR-503-3p. This discovery brings hope for the development of new treatments for radiation-resistant oral cancer.
Researchers have identified a significant association between periodontal disease, oral pathogens, and the development of gastric cancer. The study suggests that individuals with gastric cancer have a higher prevalence of oral pathogens, which may contribute to the risk of developing the disease.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
Researchers identified a key mechanism in which tumor microenvironment induces an anti-inflammatory phenotype, promoting tumor growth. The vitamin D signaling pathway plays a crucial role in this process.
Exposure to secondhand smoke increases oral cancer risk by 51%, according to a review of existing research. Long-term exposure is associated with significantly higher risk, highlighting the need for effective prevention programmes.
Scientists have discovered a potential new therapy target for canine cancer, specifically oral malignant melanoma in dogs. The treatment targets the PD-L1 molecule, which has shown promise in human cancer treatments, and significantly increased survival time for dogs with pulmonary metastatic OMM.
The University at Buffalo has received a $1.5 million grant to develop new therapies for oral cancer by targeting macrophage genes that regulate inflammation, aiming to increase survival rates and sensitivity to chemotherapies.
Researchers will investigate how oral cancer releases mediators that sensitize and activate pain-sensing nerves, promoting cancer growth and pain. The goal is to develop novel approaches for treating oral cancer and pain.
Researchers Seiichi Yamano and Brian Schmidt aim to develop a new class of medicines using gene therapy to effectively treat oral cancer pain. They will test whether co-delivery of DNA and RNA can safely alleviate oral cancer pain, offering an alternative to opioids.
A new study finds that alcohol accounts for a considerable portion of cancer cases (4.8%) and deaths (3.2%) in the US, with higher rates in New England and Western states. The study calls for implementation of policies and cancer control efforts to reduce alcohol consumption and its burden on cancer-related mortality.
A new study by Johns Hopkins Medicine found that various oral sex behaviors may increase the risk of oral HPV infection and head and neck cancer. Behaviors such as having multiple partners, early age of sexual initiation, and higher 'intensity' of oral sex were associated with a higher risk of the disease.
A recent study published in Cancer reveals that having multiple oral sex partners and engaging in high-intensity sex at a younger age significantly increase the likelihood of developing HPV-related oropharyngeal cancer. The research also found that older sexual partners and extramarital relationships are associated with higher risk.
Researchers are using AI to improve treatment outcomes for patients with oral squamous cell carcinomas by predicting which patients need chemotherapy, radiation, or surgery. The project aims to develop a more precise and personalized approach to cancer care.
Researchers at Tokyo Medical and Dental University have discovered that stimulating β-ARs can halt the progression of oral cancer. The study found that specific compounds, such as isoxsuprine, effectively interfered with epithelial-mesenchymal transition (EMT), a process that enables cancer cells to spread and form secondary tumors.
Research at NYU College of Dentistry identifies genes highly expressed in painful, metastatic oral cancers, revealing a mechanism for cancer pain. The study's findings may lead to the development of biomarkers and objective molecular tests to diagnose risk of metastasis.
Research finds that oral cancer is promoted by periodontal pathogens and can be inhibited by a bacteriocin, a naturally occurring antimicrobial peptide. The study offers new insights into the development of oral cancer and suggests potential therapeutic applications for nisin, a commonly used food preservative.
Researchers from Case Western Reserve University are developing a hand-held device that can non-invasively detect oral cancer by analyzing the ratios of two key proteins. The device aims to reduce the need for painful biopsies and provide an accurate diagnostic alternative, especially in resource-poor settings.
A study published in The Lancet Public Health found that nearly 60% of US parents of unvaccinated adolescents have no intention to initiate the HPV vaccine series. Healthcare providers play a crucial role in addressing parental misconceptions and ensuring series completion.
A study published in the journal Gut found that people with periodontal disease may be at a higher risk of developing oesophageal and gastric cancer. The research examined data from over 98,000 women and men and found a 43-52% increased risk associated with periodontal disease.
NYU Dentistry researcher Yi Ye has received a $2.2 million NIH grant to investigate how oral cancer cells invade nerves and cause pain. Her study aims to understand the role of Schwann cells in this process and identify potential targets for treating oral cancer-related pain.
The Caravaggio study found that oral apixaban is at least as effective as dalteparin in preventing recurrent venous thromboembolism and major bleeding events in patients with cancer. The trial showed no significant difference in the risk of major bleeding, including gastrointestinal cancers, between the two treatments.
APG-157, a plant-based drug containing curcumin, was shown to reduce inflammation and attract immune cells to tumor tissues in patients with oral and oropharyngeal cancers. The treatment also decreased Bacteroides species and had no adverse effects.
A recent study found that over 70% of US adults are unaware that human papillomavirus (HPV) causes anal, penile, and oral cancers. The study, led by researchers at the University of Texas Health Science Center at Houston, also showed low HPV vaccination rates among eligible individuals.
Javier Jo's research aims to detect oral cancer at an early stage using a hand-held endoscope that can recognize patterns and signatures of precancerous and cancerous lesions. The technology has the potential to increase the number of patients diagnosed with oral cancer at an earlier stage, improving survival rates and quality of life.
The study found a decline in vaccine-type oral HPV infections among unvaccinated men, suggesting herd protection. However, the prevalence of oral HPV infections remained unchanged in unvaccinated women, possibly due to low statistical power.
A recent study by Brigham researchers found that sociodemographic factors, such as income and race, predict differences in oral cancer screening (OCS) rates. The results show that minority and low-income individuals are less likely to receive recommended OCS exams at dental visits, highlighting disparities in access to quality care.
A large UK cohort study found poor oral health is strongly associated with a higher risk of hepatocellular carcinoma (HCC), the most common form of liver cancer. Poor oral health, including painful gums and loose teeth, was linked to an increased risk of HCC in patients.
Researchers found that repeated detection of HPV DNA in oral rinses after cancer treatment was associated with a higher risk of cancer recurrence and death. The study suggests HPV DNA may be a promising biomarker for understanding cancer treatment response and future risk of progression.
A significant rise in oral cancer and pre-cancerous lesion detection by dentists in Ontario is reported, with a nearly doubling of cancers detected between 2005 and 2015. The study suggests that comprehensive training and continuing education programs for oral health professionals may be behind the dramatic increase in detection rates.
Researchers at the University of Otago and Indian Statistical Institute have discovered distinct epigenetic markers in oral cancer tissues that are associated with patient survival. The findings, published in the journal Epigenomics, could help save thousands of lives by identifying cancer cells early.