Articles tagged with Respiratory Disorders
Men are more likely to be infected with TB due to increased exposure to the bacteria over their lifetime. Despite this, they were not significantly more likely to develop active TB disease compared to women.
The BEST-BE observational study will track the incidence of pulmonary exacerbations, health-related quality of life changes, and adverse events in adults with non-CF bronchiectasis. The study aims to deepen evidence on brensocatib's long-term efficacy and safety profile.
New research at Aston University shows that mānuka honey's effectiveness against disease-causing bacteria cannot be attributed solely to its sugar content and methylglyoxal levels. The study identified additional bioactive compounds responsible for the antimicrobial activity, which may lead to the development of more effective honey-de...
Researchers found that dexamethasone reduces infection-driven macrophage metabolic activity and lowers inflammatory signals, preserving the immune system's ability to control the infection. This study suggests a new approach for managing nontuberculous mycobacterial disease.
UC San Diego Health has been ranked as the top care facility in California and among the top 20 in the nation for eight medical specialties. The institution achieved this distinction through its patient-dedicated, collaborative spirit and commitment to delivering outstanding care.
Researchers found four immune system genes shaped by ancient infectious diseases, which may influence severe COVID-19. Rare genetic variants in these genes were associated with increased risk of severe illness and organ transplants.
A recent Finnish study found that exposure to dog-associated microbes in early childhood reduces the risk of respiratory tract infections and antibiotic courses. Dog ownership is linked to higher richness and diversity of microbiota, but not directly associated with reduced infection rates.
Researchers have identified a natural protective protein called BMP3 that helps maintain healthy lung blood vessels. Increasing BMP3 levels in preclinical models of pulmonary arterial hypertension reversed key features of the disease, including damaged blood vessels and impaired heart function.
The American College of Chest Physicians has released a new clinical guideline for the management of adult bronchiectasis, providing 13 evidence-based recommendations to standardize care delivery and improve patient outcomes. The guidelines aim to reduce exacerbation frequency, inflammation, and disease progression.
The American College of Chest Physicians' open-access journal CHEST Critical Care has received its first Journal Impact Factor of 2.7, reflecting the dedication of its authors, reviewers, and readers. This recognition highlights the journal's growing impact in critical care medicine.
A cluster randomized clinical trial found that portable high-efficiency particulate air (HEPA) filters reduced winter respiratory infection rates among older adult residents in some care homes. However, the study showed no significant difference in infection rates between homes with HEPA filters and those without them.
The Pulmonary Embolism Reporting and Data Systems (PE-RADS) framework provides a simple, 0-4 grading scale for classifying acute pulmonary embolism using CT and MR angiography. The system aims to improve communication and patient care with standardized terminology and risk stratification.
Researchers have identified a protein called vitronectin that triggers the scarring in lungs leading to idiopathic pulmonary fibrosis. This discovery opens up a new potential treatment pathway using the vitronectin-macrophage pathway to inhibit scar tissue growth.
Researchers propose a new perspective on ARDS pathogenesis, arguing that multiple forms of regulated cell death communicate through extensive molecular crosstalk. This crosstalk collectively drives lung inflammation and respiratory failure, highlighting the need for network-based therapeutic strategies.
A recent study has found that vaping and smoking can lead to reduced blood vessel functionality, breathing efficiency, and exercise capacity in young adults. The research, conducted on 75 people aged 18-30, revealed a 15% reduction in fitness compared to those who have never smoked or vaped.
A new study published in the Annals of the American Thoracic Society found that nearly one-third of COPD patients demonstrate unacceptable inhaler technique, leading to smaller lung function improvements. Instructing patients to hold their breath for 5-10 seconds improves acute bronchodilation.
The Bronchiectasis and NTM Association leveraged registry data for improved research and clinical practice, benefiting patients with bronchiectasis and nontuberculous mycobacterial disease. The Registry supports collaborative research and planning of multi-center trials, aiming to elevate patient outcomes.
A nationwide China study analyzed 695,142 hospitalized patients and identified eight life-stage pathogen profiles, three co-detection networks, and marked male predominance in bacterial and fungal infections. The study found distinct shifts in microbes across infancy to old age, accompanied by sex disparities.
Researchers developed an app to monitor daily voice changes, which can detect early signs of exacerbations in asthma and COPD. By analyzing tone, pitch, pauses, and voice quality, the TACTICAS study found that voice deteriorates as symptoms worsen, allowing for potential treatment.
Research examines air quality and respiratory health among children in communities surrounding the Salton Sea, finding that outdoor dust events significantly affect indoor air quality. Families describe daily challenges of protecting children from dust and pollution, which can impact school attendance and overall quality of life.
Research suggests that inhaled vitamin D can protect against dust, pollution, and pathogens in the lungs, potentially improving outcomes for those with chronic lung disease. Human clinical trials are needed to confirm these findings and explore the therapeutic benefits of direct lung delivery.
A recent study found that people with active TB have a specific inflammatory response in their airways, dominated by neutrophils that can lead to disease progression. In contrast, those who control the infection have a different immune cell balance, suggesting a way to predict and prevent TB through early intervention.
Severe pneumonia has been found to have three distinct biological subtypes, which differ in immune response and lung damage. These subtypes are linked to varying patient outcomes, with some recovering quickly and others remaining critically ill. The discovery could lead to personalized treatments for patients with severe pneumonia.
Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.
NYU Langone Health has performed the world's first HIV-positive-to-HIV-positive lung transplant, expanding options for patients with limited donor availability. The successful surgery marks a significant milestone for the HIV-positive community and represents progress in creating equity in organ transplantation.
Remote monitoring approaches did not increase home time but reduced it for those 65 years and older, supporting tailored care after acute infections. The findings suggest reevaluating remote monitoring to align with patients' needs and desires.
A clinical trial tested four remote monitoring approaches against usual care and found that none outperformed usual care in reducing readmissions. The study highlights the importance of studying real-world care models to optimize outcomes.
A large-scale study on Swedish children with asthma found that living with cats did not worsen asthma outcomes. The study of 30,277 children over 24 months showed similar asthma severity and lung function in cat-exposed and non-exposed groups.
Researchers describe a novel disorder caused by biallelic loss-of-function variants in the TMEM63B gene, resulting in severe lung disease. The disorder presents with early onset respiratory distress, lung abnormalities, and developmental delay but no epilepsy.
Researchers at UTHealth Houston identified hidden systemic inflammation in patients with primary ciliary dyskinesia using a simple oral swab. This approach enables easier monitoring and could lead to more personalized treatment of other chronic lung conditions.
Hospitalized children with acute respiratory tract infections often have underlying chronic conditions that require intensive care. The study found that these patients are at a higher risk of severe disease and death. Understanding the epidemiologic profile of this population can help optimize outcomes for pediatric patients.
A study published in JAMA Network Open found that maternal RSV vaccination reduces hospitalization risk in young infants by nearly 70%. The vaccine also showed effectiveness against severe lung infections caused by the virus.
A study finds that maternal RSV prefusion F vaccination protects against RSV-associated acute respiratory illness and lowers hospitalization rates among infants under 1 year. The findings support the effectiveness of this vaccine in preventing severe respiratory illnesses.
A new study finds herbal cigarettes can be as damaging as tobacco cigarettes, emitting comparable or even more harmful emissions. Fine particles and oxidative potential were measured, revealing a significant risk to cardiovascular and respiratory health.
Researchers at Trinity College Dublin found that cells with latent TB remain metabolically flexible, allowing strong antibacterial responses. In contrast, cells from people with active TB disease show impaired metabolism and weaker responses to infection.
A new study published at ATS 2026 International Conference found that many patients who initially struggle to meet CPAP usage thresholds continue to use and benefit from the therapy. The research challenges long-held assumptions about CPAP adherence, suggesting that early struggles don't predict treatment failure.
A new study found that switching to a nicotine e-cigarette reduces toxicant exposure and improves quitting rates, with the nicotine group having a higher chance of quitting entirely. The study's results suggest that nicotine e-cigarettes could serve as an effective off-ramp for smokers seeking to reduce their tobacco use.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
A study led by University of Arizona researchers found that azithromycin did not improve symptoms in preschool children with severe wheezing. The trial results challenge the idea that certain types of bacteria contribute to wheezing and asthma, suggesting that viral infections play a more significant role.
A new study presents dual immunization against respiratory syncytial virus (RSV) using RSVpreF and nirsevimab, showing reduced hospitalizations among infants in France. The study found that this combined approach demonstrates potential for enhanced RSV prevention and protection
A new study shows that New York City's public housing mold intervention program significantly reduces asthma-related emergency department visits. The program, Mold Busters, improved ventilation and trained staff in evidence-based mold removal, leading to a 9 fewer asthma-related ED visits per thousand people.
A new study quantifies the economic burden of tuberculosis, revealing that it costs the world an estimated $1.35 trillion annually. The disease disproportionately affects economically productive years, trapping families in poverty and impacting workforce participation and national development.
A new study finds that pediatric pulmonary rehabilitation significantly improves exercise capacity, strength, and quality of life in children with chronic respiratory diseases. Spirometry, a key measure of lung function, remains stable but doesn't improve. The program is also associated with high patient and caregiver satisfaction.
A new study suggests that a visual measure of illness perception can effectively convey symptom-related quality of life for patients with chronic lung illnesses. The study found that patients' visual perceptions of their lung disease were equally effective as standard questionnaires and test results in predicting quality of life.
The Bronchiectasis and NTM Care Center Network now spans 62 centers across the US, offering specialized care and support for individuals with bronchiectasis and nontuberculous mycobacterial (NTM) lung disease. The network aims to improve quality of life for those affected by these conditions.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
A systematic review found that structured exercise programs can modestly improve quit success, while a single bout of exercise can rapidly reduce nicotine cravings. Exercise type and intensity may also play a role in reducing cravings.
The RURAL Cohort Study aims to understand why residents of rural communities experience higher rates of heart, lung, and blood-related diseases, as well as shorter life expectancy and less-than-optimal overall health outcomes. The study uses a custom-built mobile examination unit to bring research directly to the community doorstep.
The American Thoracic Society has launched a quality improvement initiative to tackle the underdiagnosis of bronchiectasis in the US. The study aims to investigate the scope of the problem and drive meaningful change in how the disease is identified and managed.
A national survey of Australian tunnel construction workers found significant silica dust exposure risks, with many reporting barriers to effective dust control measures. The study calls for stronger regulatory enforcement and oversight to prevent preventable disease in the high-risk industry.
Johns Hopkins researchers have identified a club cell-specific role for the protein RhoA in asthma airway inflammation. The study demonstrates how RhoA can be selectively targeted to prevent asthma-related complications, and offers new details on a potential cell-specific therapeutic target.
Researchers identified blocking ID1 and ID3 as a promising therapeutic strategy to halt and reverse lung scarring in idiopathic pulmonary fibrosis. The approach showed significant reduction in lung scarring and improvement in lung function across multiple experimental systems.
The number of pediatric lung transplants is expected to decline as highly effective therapies for cystic fibrosis reduce the need for transplantation. Complex cases with multi-system disease and severe cardiopulmonary compromise are on the rise, requiring highly specialized teams and close collaboration.
A landmark trial presented at ESCMID Global 2026 finds that improving oral hygiene for hospital patients reduces the risk of non-ventilator-associated hospital-acquired pneumonia (NV-HAP) by 60%. The study, involving over 8,000 patients, shows a substantial improvement in oral care practices among hospital patients.
Researchers developed an inhaled treatment to reduce lung inflammation and fluid build-up after severe infections. The therapy targets Angiopoietin-like protein 4 (ANGPTL4) and showed promise in preclinical studies.
A recent study published in Respiratory Physiology & Neurobiology found that breathing therapy devices don't affect all parts of the airway equally, with some areas experiencing stronger pressure and friction. The research provides valuable insights into how to improve device settings for patients with respiratory disorders.
A study estimates that quitting tobacco could give a major economic uplift to over 20 million households in India, with the greatest impact felt in rural areas and among the poorest households. The analysis suggests that these households would receive a significant boost in income, potentially moving up one or two economic classes.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Inuit communities in Nunavik, Quebec, are facing a devastating tuberculosis epidemic, with rates 1000 times higher than non-Inuit populations. The study's findings highlight the need for increased healthcare resourcing and community-led initiatives to address this crisis.
A meta-analysis of GLP-1 receptor agonist studies found potential safety signals for gastrointestinal side effects, while some evidence suggested a link to reduced respiratory disease risk. Further research is needed to confirm the latter association.