Articles tagged with Respiratory Disorders
A new diagnostic method using AI and genetic information can accurately identify pneumonia in critically ill patients, distinguishing between infectious and non-infectious causes. The model has been shown to reduce inappropriate antibiotic use by over 80% and could lead to faster diagnosis and improved patient outcomes.
The study demonstrates a significant association between the overall asynchrony index (OAI) and patient outcomes in COVID-19-associated severe pneumonia. Patients with a high asynchrony burden had significantly higher intensive care unit mortality and fewer ventilator-free days, highlighting the importance of PVA monitoring.
The emergence of A(H3N2) subclade K viruses in Australia and New Zealand extended their influenza seasons, with Australia experiencing a record-breaking season. The viruses were likely imported from the US and accounted for half of Australian viruses and over two-thirds of New Zealand viruses.
A study found that lung microbiomes play a significant role in pneumonia, with patients having oral-like pneumotypes more likely to recover. The researchers identified four distinct microbial patterns, or 'pneumotypes,' associated with different types of pneumonia.
A cohort study of adults aged 45 or older with RSV infection found a significant excess risk of cardiovascular events over 1 year, comparable in magnitude to influenza infection. This highlights the importance of RSV as a potential risk factor for cardiovascular morbidity and underscores the need for vaccination to mitigate this burden.
A new study links rising temperatures to reduced sleep quality and length in US adults, particularly those living on the West Coast. The research estimates that by 2099, people could lose up to 24 hours of sleep each year due to heat, highlighting the potential impact of climate change on sleep health.
Researchers create a simple, automated way of making lung organoids, which could help test early-stage experimental drugs more effectively. The bioreactor produces larger numbers of organoids with fewer manual labor requirements, offering promise for personalized patient treatments.
Researchers have found that early-infancy RSV infection significantly increases the risk of developing childhood asthma, especially in those with family history of allergy or asthma. Protecting newborns against RSV could substantially reduce asthma cases later in life.
A monthly injection has helped 90% of severe asthma patients reduce their reliance on daily steroid tablets. Treatment with tezepelumab improved asthma symptoms, lung function, and overall quality of life, with two-thirds of patients experiencing no asthma attacks.
The new system can reveal early cancers, lung disease, hidden material defects and changes in porosity without multiple exposures or complex mechanical movement. This method produces low-dose and faster images, lowering patients' radiation dose and making clinical translation feasible.
A cross-sectional survey of 29,268 participants found a significant association between dysfunctional breathing and respiratory conditions, as well as non-respiratory diseases like epilepsy. Tobacco use was also linked to increased prevalence of DB, particularly among those with comorbidities.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
Researchers at UBC Okanagan develop an innovative airflow system that captures and removes exhaled aerosols, significantly reducing the probability of infection. The new device outperforms conventional ventilation systems, offering a comfortable and effective solution for indoor spaces.
A large analysis found that even low-intensity smokers have a significantly higher risk of heart disease and death compared to non-smokers. Quitting smoking at a younger age is the best way to decrease this risk.
In response to rising RSV cases, ECDC advises policymakers and public health authorities on effective ways to mitigate the impact of RSV disease in infants. Immunisation interventions, including long-acting monoclonal antibodies and maternal vaccines, can prevent severe illness and hospitalization.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
A new nasally-delivered vaccine has been shown to prevent severe disease and curb bacterial transmission, addressing a global need for next-generation immunisation technologies. The vaccine targets the respiratory mucosa, providing stronger protection against respiratory infections.
Research published in ERJ Open Research suggests that assessing hospital patients' reported shortness of breath could help doctors prioritize care for those at high risk of death. Patients who developed shortness of breath were six times more likely to die than those who did not, with a higher rating indicating greater risk.
The study demonstrated that nebulized HL231 at 261 µg/141 µg dose achieved comparable bronchodilation efficacy, pharmacokinetic profiles, and safety outcomes to Ultibro. HL231 showed a clear dose-response relationship with predominantly mild-to-moderate adverse events.
A new study published in the American College of Allergy, Asthma and Immunology's annual meeting reveals a significant association between military deployment and an increased risk of developing chronic respiratory conditions. Deployed veterans were found to have a 55% higher risk of asthma compared to non-deployed peers.
A new study found that thunderstorms trigger sharp increases in asthma-related emergency department visits. Researchers analyzed 4,439 asthma-related ED visits and identified 38 thunderstorm days, with a mean of 17.91 admissions on storm days compared to 3.09 on non-storm days.
Researchers at MIT have identified possible antigens for a new TB vaccine, stimulating a strong immune response in T cells. The study reveals 27 TB peptides that appear most often on infected cell surfaces and elicit a T cell response in at least some samples.
Two landmark international studies published in The Lancet and Nature Medicine expose the need for faster recognition, better diagnostics, and personalized treatment pathways to combat pneumonia and sepsis. Irish ICUs face a shortage of beds, with implications for delayed care and increased mortality.
Acute lung injury is characterized by diffuse inflammation and intractable hypoxemia, with N6-methyladenosine methylation playing a crucial role in its pathogenesis. The review synthesizes findings from multiple studies, highlighting the dynamic nature of m6A methylation and its associated proteins.
The study highlights the frequent use of aerosol therapy in critically ill patients with acute respiratory distress syndrome (ARDS), with bronchodilators being the most commonly prescribed drugs. However, the lack of sound scientific evidence and randomized controlled trials suggests that standardized protocols are needed to align clin...
A major study published in the European Respiratory Journal found that heatwaves increase the risk of moderate-to-severe obstructive sleep apnoea (OSA) by 13% during peak heatwave periods. The risk is higher when humidity is also high, with a 1.1% increase for every 1°C rise in nighttime temperature.
Two abstracts using Bronchiectasis and NTM Research Registry data were presented at CHEST 2025, focusing on advancing excellence in pulmonary medicine. The registry provides a national database for collaborative research and multi-center clinical trials.
The American Thoracic Society's new Clinical Practice Guideline provides evidence-based recommendations for tracheostomy care in children. The guideline emphasizes the importance of applying ethical principles and involving caregivers in decision-making, with a focus on ensuring high-quality, family-centered care.
Scientists found that breathing dusty air from the Salton Sea can alter the lung microbiome and trigger immune responses in mice. The study suggests that chronic exposure to such dust could have significant health effects, including asthma.
The Bronchiectasis and NTM Care Center Network has accepted 25 new sites, expanding access to high-quality, specialized patient care for bronchiectasis and NTM lung disease. The network aims to enhance care and improve quality of life for patients living with these conditions.
A new study projects that US funding cuts will result in a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia experiencing a significant spike in preventable cases and deaths over the next decade. The loss of US bilateral health aid is projected to result in an additional 2.5 million pediatric T...
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
The American College of Chest Physicians has designated October 19, 2025, as 'Love Your Lungs Day' in recognition of respiratory health. This initiative aims to raise awareness about lung diseases such as asthma and COPD, promoting equity and supporting healthcare providers.
Researchers discovered reduced concentrations of key lipids in patients with NSAID-exacerbated respiratory disease (N-ERD), whereas healthy controls showed increased levels with low-dose aspirin. Elevated lipid mediators linked to inflammation were also observed, suggesting potential new diagnostic and treatment options.
Researchers developed a more accurate cough-detection model using wearable health monitors' audio and movement data. The new model can distinguish between coughs and nonverbal sounds, improving the accuracy of respiratory disease tracking.
A study of 200 classrooms found that HEPA purifiers did not significantly reduce respiratory viral exposures, suggesting additional interventions are needed. Maintaining classroom humidity between 40% and 60% may help lower viral exposures and improve comfort for students and teachers.
Researchers aim to determine if biomarkers can identify adults at risk of developing interstitial lung disease (ILD), a chronic condition that causes inflammation and scarring in the lung tissue. The approach could lead to the development of new, better treatments with more tolerable side effects.
A new study from Trinity College Dublin finds that dexamethasone can reduce inflammation in TB patients while enhancing the function of their macrophages to kill Mycobacterium tuberculosis. The research suggests using steroids as an adjunct therapy in conjunction with existing treatments, particularly in cases with excessive inflammation.
Denis Evseenko and Toby Maher are developing a regenerative drug to block cells that promote fibrosis in the lungs, aiming to slow or reverse IPF damage. The team plans to test the safety and therapeutic potential of their drug-like molecules in animals and human cells.
Researchers found tiny air pollution particles sticking to red blood cells after exposure to roadside pollution, which can travel to organs like brain and heart. Wearing an FFP2 face mask reduces the amount of particles stuck to red blood cells.
Two abstracts using Bronchiectasis and NTM Research Registry data were presented at the European Respiratory Society Congress, highlighting advances in respiratory medicine and science. The Registry collects clinical data from individuals with non-cystic fibrosis bronchiectasis and nontuberculous mycobacterial pulmonary disease.
The American Thoracic Society has partnered with Oxford University Press to manage production and dissemination of its four peer-reviewed journals. The collaboration aims to expand the reach of ATS publications and maintain their high impact in respiratory research.
A new study found that children who prefer pickled, smoked, and fried foods are more likely to have asthma. In contrast, seafood preference appears to reduce asthma risk among normal-weight children. The findings highlight the importance of early-life dietary habits in shaping respiratory health.
A new study found that exercise-based rehabilitation programs can improve immune cell function in individuals with post-COVID syndrome. This leads to reduced inflammation and symptoms such as fatigue and joint pain. The research suggests that exercise may help restore a more normal, well-regulated immune system.
A global study found that children under 14 years old lose nearly 8.45 million years of healthy life due to second-hand smoke exposure. The study, presented at the European Respiratory Society Congress, highlights the disproportionate burden on low-socio-economic regions.
Research presented at the European Respiratory Society Congress found a link between indoor wood burning and decline in lung function. The study used data from the English Longitudinal Study of Aging and found that people using solid fuel stoves had lower FEV₁ values, indicating increased risk of respiratory complications.
A multi-national study found that higher levels of air pollution are linked to worse symptoms of obstructive sleep apnea (OSA) in European patients. The study revealed a modest but measurable increase in the apnoea hypopnea index (AHI) for every one unit increase in PM10 concentration.
Research shows that remote monitoring of children's asthma can prevent hospitalizations by around 57%. The system helps keep symptoms under control, leading to better outcomes and lasting self-management skills. This innovative approach could revolutionize healthcare services for patients with asthma.
A pilot study found that hypnosis significantly improved patients' tolerance of masks, allowing them to breathe more comfortably. The study showed a substantial improvement in non-invasive ventilation (NIV) tolerance, reduced agitation, and lower requirements for sedation and anti-anxiety medication.
A gold-standard randomised-controlled trial found that specialised singing programmes can improve the symptoms and quality of life of people with lung disease, particularly those with chronic breathlessness. The SINFONIA study showed a significant improvement in quality of life for patients with COPD and ILD.
A low-cost drug, heparin, has been shown to be effective in treating seriously ill COVID-19 patients by reducing the risk of ventilation and death. The study found that inhaling heparin targeted directly to the lungs improved breathing and oxygen levels in patients.
Research presented at the European Respiratory Society Congress found that a healthy diet rich in fruits and vegetables can partially mitigate the adverse effects of air pollution on lung function. Women who consumed four portions of fruit per day or more appeared to have smaller reductions in lung function associated with air pollution.
Researchers found that universal screening for asthma symptoms and environmental triggers can identify more patients with asthma in specific communities. The study also highlights the importance of addressing environmental triggers in homes, particularly among children with asthma.
A new robot-assisted bronchoscope has been shown to diagnose tiny lung tumors in hard-to-reach areas with over 84% success rate, more than three times higher than traditional methods. The technology enables accurate diagnosis in patients where conventional bronchoscopy offers no viable option.
Research suggests that exposure to dog allergens in the home may reduce the risk of developing childhood asthma by five years old. Babies with higher levels of Can f1, a dog skin protein, had around a 48% lower risk of developing asthma and better lung function.
A new study found that inhaling marijuana daily is associated with a 44% increased chance of developing asthma. Experts say people should avoid inhaling cannabis to reduce the risk of chronic lung disease. The study's authors emphasize the need for clearer messages about the risks of cannabis use.
Researchers from UMD found that cats can survive bird flu if treated promptly with oseltamivir, a common influenza treatment. Early intervention significantly increases the chances of survival and strong protection against reinfection for several months.
Researchers at Tulane University have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, detecting TB in samples with very low levels of bacteria. The new test shows high sensitivity and accuracy, offering a significant step forward toward effective diagnoses via a variety of samples.
The American College of Chest Physicians has achieved a critical milestone in its advocacy efforts, leading to changes in federal coverage guidelines for noninvasive ventilation devices used in the home. These revised guidelines reflect major recommendations submitted by CHEST and aim to enhance patient care.
Researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy. The study found that IPF is not simply accelerated aging, but a unique biological condition shaped by age-related dysfunction.