Articles tagged with Antibody Dependent Cell Mediated Cytotoxicity
Researchers from Chiba University found that antibody therapeutics with stronger Fcγ receptor binding are more likely to be recognized as foreign and associated with higher anaphylaxis risk. High affinities for Fcγ receptors critical determinants of anaphylaxis, study suggests.
New research suggests that ADCC responses and strain susceptibility influence HIV-1 mother-to-child transmission during breastfeeding. Enhancing ADCC through a vaccine may not be sufficient to prevent transmission due to chronically infected individuals' ADCC-resistant strains.
A new study found that infants with high levels of antibody-dependent cellular cytotoxicity (ADCC) against their mother's strain of HIV are less likely to get infected through breastfeeding. The study also showed that ADCC is more effective than neutralizing antibodies in protecting infants against HIV transmission and improving outcomes.
Researchers at Cardiff University have discovered a unique way to target human cytomegalovirus (HCMV), a master at hiding from the immune system. A new type of antibody marks infected cells, allowing the immune system to see and kill them.
Researchers are developing fucosylation inhibitors to enhance the targeting and killing of cancer cells by making cancer therapies more selective. Dr. Robert Britton's project aims to create molecules that do not attach to themselves, allowing for improved stability and cytotoxicity.
The Michigan Alzheimer's Disease Core Center will support researchers and clinicians from three major universities in developing new treatments and understanding the causes of dementia. The center aims to provide training opportunities across many areas of research and facilitate collaboration among experts.
The University of Pennsylvania's Alzheimer's Disease Core Center has been awarded $8.8 million over five years from the National Institute on Aging to investigate Alzheimer's disease and related dementias. The center will focus on recruiting, studying subjects with early-stage AD, and expanding its bioinformatics infrastructure.
Researchers found that HIV evolves to evade ADCC antibodies, but these antibodies can force the virus to become weaker. This study suggests that inducing ADCC responses through a vaccine could help prevent HIV infection.