Articles tagged with Cancer Patients
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Researchers have found a biomarker that can distinguish between HG-PIN lesions destined to become cancerous and those that will remain benign. The PTOV1 gene marker is linked to prostate cancer development and can help determine which men with HG-PIN are at substantial risk of developing prostate cancer.
Researchers measured breast cancer patients' upper limb volume before and after surgery to establish a baseline and monitor for lymphedema. The study found that early detection using compression garments effectively treated subclinical lymphedema.
A new study published in the Journal of the National Cancer Institute estimates that Medicare costs for elderly cancer patients will top $21.1 billion over a 5-year period. The estimated cost varies widely depending on tumor type, stage at diagnosis, and phase of care.
Cancer rates are on the rise in Albania, driven by changing lifestyles and limited healthcare resources. The country is seeking international support to tackle the crisis, with organizations like IAEA working to improve cancer control and palliative care.
A study published in JAMA found that cisplatin is not an effective alternative to standard treatment for anal cancer, with a lower disease-free survival rate and more colostomies. The research suggests that fluorouracil plus mitomycin and radiotherapy remains the best treatment option for patients with anal canal cancer.
A randomized controlled trial found that chemotherapy with cisplatin before concurrent chemoradiation did not improve disease-free survival for patients with anal canal cancer. The therapy resulted in a higher rate of colostomy procedures and was associated with severe hematologic toxicity.
Stored ovarian tissue from cancer patients may contain residual cancer cells that can re-infect the body if not checked. Research suggests that few fertility centers have the skills and technology to detect these cells, highlighting the need for improved testing methods.
A recent study published in the journal Cancer found that nearly half of Canadian cancer survivors were overweight or obese, comparable to the general population. The research highlights the importance of promoting physical activity and healthy eating habits among cancer patients to prevent recurrence and improve overall health.
Researchers detail chemotherapy's damage to the brain, finding that healthy cells die off long after treatment ends. The study identifies 5-fluorouracil as a contributor to chemo brain, with damaged oligodendrocytes leading to cognitive decline and demyelination.
A new study reveals that cancer survivors in Canada have low levels of physical activity and high prevalence of obesity. The findings suggest that lifestyle interventions to promote physical activity and healthy weight management are necessary among cancer survivors to control their disease.
A study found that follow-up care for breast cancer patients costs less when led by nurses rather than physicians, with significant savings potential for healthcare budgets. Specialist nurse-led follow-up resulted in €866 per patient over a five-year period, making it a cost-effective alternative.
Researchers found that common versions of FGFR2 and TNRC9 genes increase breast cancer risk in women carrying damaged BRCA2 gene. The study suggests that knowledge of a BRCA mutation is necessary but not sufficient to fully understand cancer risk.
OHSU Cancer Institute researchers discovered the gene ASPP2 is necessary in eliminating cancer cells. This protein activates pathways that tell cancer cells to die, protecting them from one of the steps leading to cancer. The study may lead to better therapies and cancer care for patients.
Researchers have developed tests that diagnose, predict or monitor cancer risks without invasive tissue sampling. Oral epithelium can be used as a surrogate tissue to assess molecular damage to the lungs, allowing for convenient biomonitoring methods.
Researchers found that lung cancer patients over 80 fare equally well after surgery as their younger counterparts, while elevated interleukin-12 levels are associated with poorer survival rates in melanoma patients. DNA methylation decreases with age, potentially contributing to cancer development.
Researchers are using cellular strategies and new vaccines to direct the body's immune system against cancer. A phase I/II trial of a live Listeria cancer vaccine has shown that it is safe for humans and can reduce tumor size in some patients, with three women experiencing approximately 20 percent tumor reductions.
Researchers present promising results for new therapies targeting VEGF receptors and blood vessel formation in various types of cancer. These treatments have shown potential to shrink tumors and prolong survival for patients with glioblastoma and rectal cancer.
A study from Georgetown University Medical Center suggests that high-energy space radiation can lead to premature aging and prolonged oxidative stress in cells, potentially causing colon cancer. The researchers found that exposure to high-LET radiation induced a highly oxidative environment in cells, conducive to cancer development.
Researchers found that sunitinib treatment slowed tumor growth and reduced the risk of metastasis in patients with advanced hepatocellular carcinoma. The median progression-free survival was four months, and the median overall survival was 10 months.
Researchers found that combining low-dose DFMO with sulindac reduced recurrent colorectal adenoma risk by up to 95% without significant toxicity. The combination therapy also showed significant reductions in advanced adenoma recurrence rates, including a 92% reduction for larger adenomas.
Researchers at Penn School of Medicine have developed a targeted therapy combination that overcomes treatment resistance in liver cancer by combining sorafenib with the TRAIL pathway. This combination restores sensitivity to cell death and kills cancer cells, offering new hope for patients.
A study found that MRI examinations before surgical treatment changed the treatment plan in 28% of cases, with 15 patients opting for mastectomy. The delay caused by MRI screenings also increased treatment time by 14 days on average.
Researchers at the University of Pennsylvania School of Medicine have discovered that Notch signaling is not universally essential for maintaining stem cells in bone marrow. This finding opens up new possibilities for developing effective leukemia therapies without harming normal bone marrow.
A recent study suggests that depression care management can improve survival rates in older cancer patients. The research found that comorbid depression shortens survival time with cancer, but intervention with medication and psychotherapy can extend life among cancer patients.
The Lombardi Comprehensive Cancer Center has published a new manual for childhood cancer survivors, providing information on late effects and promoting shared care. The manual aims to ease the transition from active treatment to follow-up care and address psychosocial needs.
Patients with breast cancer who developed anemia during chemotherapy had a significantly higher risk of local recurrence compared to those without anemia. Anemia was defined as a serum hemoglobin level below 12 g/dL during chemotherapy, and occurred in 18.2% of patients receiving CMF chemotherapy.
Biotech companies are developing novel biomarkers to improve cancer diagnostic tests, potentially reducing treatment costs. Researchers at various institutions, including the Ludwig Institute for Cancer Research and Wayne State University School of Medicine, are working on early detection tools for malignancies.
A new breed of targeted cancer drugs is attacking specific proteins in cancer cells, but also causes devastating dermatologic side effects. The Cancer Skin Care Program at Northwestern University provides specially formulated lotions and drugs to help patients preserve their dignity and quality of life.
Recent data from the National Oncologic PET Registry (NOPR) shows that PET scans can dramatically change treatment plans for cancer patients, with a 36.5% change in treatment or no-treatment decisions reported.
Recruitment of pediatric cancer patients into clinical trials is challenging due to age-specific barriers. The article emphasizes the need for more research and international cooperation to improve trial participation, particularly among young people.
The use of sentinel lymph node biopsy (SLNB) increased substantially from 1998 to 2005, but disparities persist in access to the procedure. Non-white women, older women, and those living in poorer areas were less likely to receive SLNB than their counterparts, highlighting uneven access to this less-invasive breast cancer staging test.
A multi-center study found that prostate size and urinary symptoms influence patient satisfaction with cancer treatment. Men with larger prostates may experience improved urination after surgery, while African-American men tend to be less satisfied despite receiving similar care.
Researchers found that only about 45% of cases used tumor markers AFP and HCG, with all three markers measured in just 16% of the time. This suggests low usage rates despite the importance of tumor markers in showing patient response to treatment and disease recurrence.
Zur Hausen demonstrated the role of human papillomavirus in cervical cancer, providing key findings that led to the recognition of HPV as a primary cause. His research also linked HPV to other cancers, including laryngeal carcinoma and penile carcinoma.
Researchers found that surgery combined with heated Intraperitoneal Hyperthermic Chemotherapy (IPHC) improves survival rates for patients with peritoneal carcinoma originating from colorectal or appendix cancer. The study also showed that IPHC may have some benefit in select patients with peritoneal carcinoma and hepatic metastases.
Routine diagnostic approaches for bile duct cancer are only moderately sensitive, with a combination of brush cytology and forceps biopsy yielding only a minor increase in sensitivity. The study highlights the need for additional diagnostic techniques to improve detection rates.
Scientists have discovered specific methylation patterns in tumors and tissue that can predict which lung cancers are more likely to recur. These patterns could lead to reclassifying small lung cancers as advanced disease, allowing for more aggressive treatment options.
A randomized clinical trial found that postoperative chemotherapy does not improve survival in patients with localized gastric cancer. Despite promising results in advanced gastric cancer, the combination of cisplatin, epirubicin, and other chemotherapies did not show significant benefits.
A new study reveals that patients with kidney cancer often receive less optimal surgical care based on the surgeon's practice style rather than medical factors. The study found significant variation in surgeons' preferences for partial nephrectomy and laparoscopic surgery, despite their benefits.
Jeffrey A. Toretsky, a pediatric oncology physician and researcher at Georgetown University's Lombardi Comprehensive Cancer Center, has received a prestigious Clinical Scientist Award in Translational Research from the Burroughs Wellcome Fund. The award will support his research to identify molecular mechanisms of EWS-FLI1 and develop ...
Researchers at Memorial Sloan-Kettering Cancer Center have discovered a new genetic marker that increases breast cancer risk by 1.4 times in women with the DNA variation. The study used genome-wide association mapping to identify a gene locus on chromosome 6 associated with breast cancer risk.
Researchers at Memorial Sloan-Kettering Cancer Center discovered a novel mechanism that can enhance the function of AML1, a protein frequently impaired in acute leukemia. The study identified the methyltransferase enzyme controlling normal AML1 activity and demonstrated its ability to regulate transcription factors.
A recent study published in the Psychological Bulletin found that when couples face a cancer diagnosis, women are consistently and severely distressed. The researchers analyzed data from 43 studies worldwide and concluded that gender plays a greater role than who the patient is in coping with cancer.
The initiative aims to bring team-based science to bear on major cancer research questions, integrating expertise and resources to solve the most challenging problems. Twelve proposals were reviewed by an external scientific advisory panel, and four Keystone Programs were awarded $5 million in funding over five years.
Researchers developed artificial cell-like particles made of biodegradable material that can target specific diseases or infections. The new method enhances T cell activation by up to 45 times, addressing limitations of previous immunotherapy procedures.
Treating anemia with ESAs increases risk of VTE and death among cancer patients, according to a review of phase 3 trials. There was a significantly increased risk (57") of VTE among patients treated with ESA, while the risk of death was higher for ESA-treated patients compared to the control group.
A Northwestern University study found that cancer patients taking erythropoiesis-stimulating agents (ESAs) have a 10% increased risk of death compared to those who did not take the drugs. The study's findings suggest that ESAs may stimulate the growth of cancer cells, leading to shorter survival rates.
A study found that a single 20-minute expressive writing session can positively impact cancer patients' thoughts and feelings about their disease. Patients who reported changes in their thoughts and feelings after writing also experienced better physical quality of life three weeks later.
Optimal band imaging improves depression-type early gastric cancer diagnosis by clearly identifying contrasting demarcation lines between cancerous and noncancerous areas. This technology enhances capillary pattern and pit patterns in endoscopic images, leading to improved detection rates.
A new study found that uninsured patients are more likely to be diagnosed with advanced stage cancer compared to those with private insurance. The study, which analyzed over 3.5 million cancer patients, also showed that Medicaid-insured patients face similar risks, particularly for cancers with early detection methods.
A Dutch study found that only 17% of individuals who survive pediatric cancer receive follow-up care at age 35, highlighting the need for family doctors to be involved. The study suggests that shared care between dedicated clinics and family practitioners can increase surveillance for adverse effects.
Uninsured and Medicaid-insured US patients are more likely to present with advanced cancer at diagnosis than privately insured patients. The authors found that these disparities affect ethnic minorities and cancers with early detection potential, underscoring the need for adequate healthcare coverage.
Researchers found a biomarker that identifies men with a five-fold increased risk of prostate cancer recurrence if their tumors show silencing of the CDH13 gene. The study, which examined DNA methylation changes in 151 research subjects, suggests a potential tool to improve prediction accuracy and inform clinical practice.
A study published in the Journal of the National Cancer Institute found that HPV-positive head and neck cancer patients have higher response rates to chemoradiation therapy and better two-year overall survival rates compared to HPV-negative patients.
A study found that breast cancer survivors, especially older women, are at a greater risk of dying from non-cancer causes than from breast cancer. Factors such as pre-existing diseases like heart disease and osteoporosis are associated with this increased risk. The researchers also found that women with cancer cells in the lymph nodes ...
Researchers found 41 inaccurate statements on 18 websites, 5.2% of total analyzed web pages. Despite quality criteria, no combination could differentiate accurate from inaccurate content.
A study found that healthcare providers play a significant role in patients' likelihood of being screened for colorectal cancer. Patient barriers such as concerns about payment and fears of detection also impact screening rates. Interventions targeting both providers and patients are necessary to boost screening rates.
A new study found that 41 false statements appeared on 18 web pages (5.2%) and that websites with complementary or alternative medicine were 15.6 times more likely to have inaccuracies. The authors advise patients to be skeptical of online health information and consult a clinician before taking action.
The Simons Foundation's $10 million grant will support preclinical studies of new therapies for gliomas, a type of brain cancer. The goal is to develop treatments that target cancer cells and abnormal signaling pathways while sparing nearby sensitive tissues.
A comprehensive review of scientific literature found that cancer survivors use nutritional supplements at a higher rate than the general population, with breast cancer survivors reporting the highest use. However, research suggests that certain supplements may interfere with treatment or even accelerate cancer growth.