Articles tagged with Cancer Patients
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Scientists at the University of Utah Health have discovered an enzyme called DGK iota that appears to reduce the incidence of Ras-induced tumors in mice. The researchers found that mice with a deleted DGK iota gene developed fewer tumors, while those with an intact gene and activated Ras exhibited significantly more tumors.
Researchers found that advanced NSCLC patients with high EGFR gene copy number, protein expression, or mutations respond better to gefitinib. High EGFR gene copy number is associated with prolonged survival and disease control.
Metal stents have been shown to be a safe and effective treatment for bile duct obstructions caused by pancreatic cancer. The study found that 90% of patients had open stents after three months and 80% after one year, with minimal complications.
A Northwestern Memorial HealthCare study identified a gene variant TGFBR1*6A associated with a high risk of colorectal cancer. The variant was found to be more prevalent among patients without a mutation in other genes, suggesting its potent contribution to familial cases.
Georgetown University is helping create a national cancer biomedical informatics grid to link research centers in real time, sharing data and results more rapidly. The $20 million grant aims to improve cancer research and treatment through the adoption of common research tools.
Researchers have identified a new tumor suppressor gene, ARLTS1, that increases the risk of cancer in some individuals. The findings suggest that ARLTS1 may play an important role in the development of certain types of cancer, particularly familial cancers.
Researchers have discovered gene portfolios that can define a patient's likelihood of developing cancers, responding to treatment, and fending off malignancies. These 'Death from Cancer Signature' portfolios provide opportunities for early identification and targeted therapies, potentially improving five-year survival rates.
A clinical trial found that systematic aortic and pelvic lymphadenectomy improved progression-free survival, but not overall survival, in patients with advanced ovarian cancer. The procedure did not significantly increase median overall survival duration.
The Lance Armstrong Foundation is supporting a University Hospitals of Cleveland research project exploring the impact of exercise and dietary counseling on obese endometrial cancer patients. Dr. von Gruenigen's study aims to improve quality of life for this high-risk group, which accounts for over 40,000 cases annually in the US.
A new study suggests that mammography is catching breast cancer earlier, but the increasing number of in situ cancers poses a challenge to healthcare professionals. The researchers found a sixfold increase in noncomedo DCIS and a nearly fourfold increase in LCIS among postmenopausal women.
A multicenter trial found that alpha-tocopherol supplementation increased the rate of developing a second primary cancer during treatment but reduced the risk after treatment ended. After 8 years, the proportion of participants free of a second primary cancer was similar in both groups.
A new study found that altering food schedules and light/dark exposure in mice modified the expression of circadian clock genes and genes involved in carcinogenesis and tumor progression. The authors conclude that the altered light/dark or feeding schedules may slow tumor growth in chronic jet-lagged mice.
Randy 'Duke' Cunningham, a prostate cancer survivor, receives funding for cancer research through his committee work. Deidre Downs, Miss America 2005, continues her childhood cancer research efforts through CureSearch and her medical student program.
A meta-analysis of 27 clinical trials found that erythropoietin treatment lowers the likelihood of needing a blood transfusion and improves hematologic response in cancer patients. However, results on overall survival are inconclusive, suggesting erythropoietin should not be used to increase survival outside clinical trials.
Participation in cancer clinical trials improves survival, with significant benefits for Kaposi Sarcoma patients. Young adults with sarcomas face limited treatment options and low clinical trial participation rates, contributing to poor survival rates.
A retrospective study found that African-American women with advanced endometrial cancer have more aggressive tumors, leading to poor survival rates compared to Caucasian patients. The study suggests biologic differences in gene expression may underlie this racial disparity.
Researchers found that a specific viral protein EBNA3C triggers uncontrolled growth of B cells, initiating cancer. The study provides new insights into how Epstein-Barr virus drives cancer and paves the way for developing targeted therapeutics.
A national study of cancer patients who underwent bone marrow transplantation reveals long-term quality of life issues persist for decades. Cancer survivors report lingering sleep, sexual problems, pain, cognitive decline, and poor physical well-being compared to healthy peers.
A study found that long-term vitamin E supplementation had no clear impact on fatal and nonfatal cancers, major cardiovascular events, or deaths. However, the daily administration of natural source vitamin E increased the risk of heart failure.
A recent study found that Medicaid patients diagnosed with late-stage cancer have significantly poorer survival rates than those diagnosed earlier. The median survival was 18 months for late enrollers compared to 38 months for early enrollers and non-Medicaid patients.
A study found that most patients would be interested in learning aggregate results of trials they participated in, regardless of future care impact. Participants who received results by mail were generally comfortable with this method, and 90% were glad to have been offered the results.
A new chemotherapy combination has shown significant improvement in survival rates for brain tumour patients, with almost half of those with an inactivated MGMT gene surviving after 2 years. The treatment also did not negatively impact patients' quality of life, offering a promising breakthrough in glioblastoma treatment.
Researchers have found that a combination of surgery and intraperitoneal hyperthermic chemotherapy (IPHC) improves overall survival and quality of life in patients with tumors of the appendix, small bowel, ovarian cancer, colon, rectum, stomach, and mesothelioma. The treatment has been shown to be effective for high-grade and low-grade...
A study by American College of Radiology found MRI to be useful in assessing suspected breast cancer patients, detecting additional cancers not visible on mammography or sonography. The use of computer-assisted diagnosis improved accuracy and led to recommended mastectomies for some patients.
A pilot study found cryoablation to be an effective treatment for cancer patients' severe pain, providing relief until the end of life. The procedure involves freezing tumor tissue and surrounding areas to kill cancer cells and ease pain, with most patients tolerating it well despite some nerve damage in one patient.
Researchers have identified a novel marker, AP-2y, for detecting testicular cancer in semen samples. The test showed a sensitivity of 46% and was highly specific, with no false-positives.
A new study reveals that referrals to palliative care come too late to improve quality of life for cancer patients. Researchers surveyed 318 family members and found that only 48% thought referral timing was appropriate, while most believed care was given too late.
A study published in the Journal of the National Cancer Institute found that increases in managed care market share were not associated with improved quality of care for cancer patients, except for a specific blood test. The authors conclude that expansion of managed care may not improve quality of care for all patients.
A new test, NMP22 tumor marker assay, has been shown to be three times more effective than a traditional laboratory test in detecting bladder cancer. The test can detect the disease in patients with blood in their urine and certain risk factors, such as smoking and exposure to chemicals.
A new, point-of-care urine-based test for the protein NMP22 proteomic marker shows promise in detecting bladder cancer, particularly in patients at elevated risk. The test identified several malignancies missed by initial cystoscopy and detected muscle invasive cancers with high sensitivity.
A UCLA study found that green tea extract may help fight bladder cancer by interrupting the development of invasive cells. The extract affects actin remodeling, a process crucial for cell movement and invasion.
A new leukemia drug treatment has shown promise for MDS patients with 5q minus syndrome, becoming transfusion independent in 91% of cases. The defective chromosome abnormality may be linked to other serious cancers, including leukemias and small cell lung cancer.
Patients with cancer have a significantly increased risk of developing venous thrombosis, with the risk highest in the first few months after diagnosis. The study found that patients with hematological, lung, or gastrointestinal cancers had a higher risk compared to those without cancer.
A third of European cancer patients use CAM, with women, younger patients, and those with poor prognosis using it more often. The most commonly used CAM therapies were herbs, homeopathy, and spiritual therapies.
A large study of Swedish twins found no association between neuroticism, extraversion, and increased cancer risk. Despite previous hypotheses linking these traits to cancer, the research suggests that certain personality traits do not influence cancer risk.
The study identified specific characteristics of tissues removed during surgery as risk factors for endometrial cancer recurrence. Approximately one-third of patients with endometrial cancer in the US may benefit from enrollment in clinical trials addressing new treatment approaches.
A study of 90 patients reveals 50% experienced delirium, with distinct clusters of symptoms including psychotic problems, cognitive impairment, and mood disturbance. Early recognition is crucial to prevent poor outcomes, as delirium can lead to increased risk of falls, infections, and mortality.
Fewer than half of patients had received at least one screening test more than six months prior to diagnosis. Patients with a history of screening had earlier stage and presumably more treatable disease, highlighting the underuse of colorectal procedures in clinical practice.
Researchers found that 39% of healthy patients with mesenteric lymph nodes had no evidence of disease one year after their initial examination. Follow-up imaging is not necessary for patients with multiple small nodes scattered throughout the abdomen.
Scientists have discovered a new gene, Bnip3L, that helps p53 eliminate cancer cells under low-oxygen conditions. Silencing this gene allows tumors to grow more aggressively in hypoxic environments.
Researchers analyzed data from Iceland's National Cancer Registry and deCODE genetics database to investigate cancer risk in families. The study found that for 16 out of 27 cancers studied, relatives of patients were at a significantly higher risk of developing the same type of cancer. Lifestyle factors like smoking and diet also contr...
A recent study investigated whether NCI cancer centers have better outcomes due to their designation. The research found that perioperative mortality was lower at these centers for four out of six procedures, but five-year survival rates did not differ significantly between the two types of institutions.
Women diagnosed with breast cancer through physical examination are more likely to undergo chemotherapy and mastectomy compared to those detected by screening mammography. The study found that cancers detected by mammography were smaller and had lower rates of lymph node spread, allowing for less-toxic treatment options.
Researchers analyzed death certificate data from Ohio between 1989-2000 and found no significant dip or peak in cancer deaths around Christmas, Thanksgiving, or birthdays. Women dying of cancer were more likely to die during the week before their birthday compared to men.
A study analyzing cancer death records from 1989-2000 found no correlation between cancer mortality and holiday events like Christmas or birthdays. However, it did reveal a slight increase in cancer deaths among certain populations, such as black Americans before Thanksgiving and white women on their birthdays.
A Northwestern University study reveals potentially fatal blood clots in up to 20% of cancer patients treated with thalidomide. The drug's exclusive off-label use hinders information sharing about side effects.
The guidelines provide recommendations for screening and management of late effects in pediatric cancer survivors, aiming to improve adult quality of life. The report authors anticipate that widespread use will help researchers determine the efficacy of screening survivors to reduce medical complications and death.
The study found that PET/CT imaging was effective in detecting new malignancy and precisely localizing disease extent in patients with suspected occult recurrent cancer. The imaging modality provided valuable information for treatment planning, potentially avoiding further invasive procedures.
The patientINFORM consortium, led by commercial giants Elsevier, Springer, and Wiley, has sparked controversy among advocates for enhanced public access to research. While the proposal aims to make taxpayer-funded research available, critics argue it discriminates among illnesses without justification and fails to respect all patients'...
The Advexin therapy, which delivers normal p53 genes to cancer cells, resulted in significantly smaller tumors and increased infiltration of T-lymphocytes, a key component of the immune system. After surgery, researchers found higher levels of normal p53 mRNA and an increase in the p53 protein, suggesting improved cancer response.
A study of 226 elderly adults with advanced cancer, congestive heart failure, or COPD found that virtually all participants experienced moderate to severe symptoms, including limited activity, fatigue, and physical discomfort. The study highlights the importance of addressing these symptoms in this vulnerable population.
A study published in JAMA found that MRI can accurately detect breast cancer with a high sensitivity rate of 88.1%, but its effectiveness decreases when ruling out malignancies. The technology is most beneficial for patients with difficult-to-interpret mammograms.
Researchers have successfully demonstrated that half-matched donor (haploidentical) natural killer cells can survive and persist to actively attack cancer cells, potentially leading to remission and eligibility for bone marrow transplant. This breakthrough treatment option shows promise for some patients with AML.
A new oral therapy, Zarnestra, has shown benefit in improving blood counts and preventing leukemia development in patients with myelodysplastic syndrome (MDS). The drug, a farnesyl transferase inhibitor, produces responses in about one-third of patients, offering hope for those at high-risk for developing acute myelogenous leukemia (AML).
A team of researchers from the University of Pennsylvania School of Medicine has developed a host of imaging techniques to develop better ways to look noninvasively at the molecular characteristics of tumors. They aim to forecast early response to chemotherapy so that treatment choices can be adjusted.
Researchers at the Mayo Clinic have identified a potential biomarker for aggressive kidney cancer, which can help improve treatment outcomes by identifying patients at high risk of disease progression. The study found that high levels of B7-H1 molecule are associated with increased risk of cancer spread and mortality.
Urinary incontinence and abdominal pain are key symptoms of ovarian cancer, with crampy abdominal pain being the most common symptom. The study found that women often ignore or downplay these symptoms, leading to delayed diagnosis.
Research reveals elderly patients are significantly under-represented in cancer clinical trials, with only 36% of trial participants aged 65 and older compared to 60% of the U.S. cancer population. This underrepresentation may be due to concerns about treatment effectiveness and side effects.
The NYU team's algorithm detects genetic differences between normal and cancer cells, revealing excess or missing DNA segments associated with various cancers. The software will be made available online in mid-December.
Researchers found that patients with a family history of pancreatic cancer are more likely to be diagnosed at an earlier age and have a smoking history. The study suggests that strong counseling against smoking is necessary for these patients, as well as smoking cessation programs.