Articles tagged with Cancer Patients
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A study analyzing phase 1 cancer trials from 1991-2002 found a significant decrease in treatment-related deaths and serious toxicity, with adjusted odds of death being less than one-tenth those of patients participating in earlier trials. Targeted therapies and improved supportive care are likely contributing factors.
A comprehensive analysis of Phase 1 cancer trials found a significant drop in drug-related deaths and an improvement in the risk/benefit ratio. The study suggests that increased attention to patient safety, less-toxic targeted therapies, and improved supportive care have contributed to these improvements.
Increased investment in radiotherapy can significantly improve cure rates for European cancer patients. In the UK and Netherlands, calls for increased funding led to substantial improvements. However, under- utilization of radiotherapy is common in many EU countries due to inadequate infrastructure and staffing.
The GENEPI project aims to predict radiotherapy efficacy and side effects based on genetic, physical, and patient-related factors. It will establish a pan-European database on radiation-related morbidity, enabling researchers to investigate factors influencing individual responses to radiotherapy.
A multi-center, double-blind study found that patients taking toremifene 20 mg had a lower cumulative incidence of cancer after 12 months, with a 48% reduction compared to placebo. High-grade prostatic intraepithelial neoplasia (PIN) is a precursor to prostate cancer.
A study of 47,949 participants found that moderate to high levels of alcohol consumption were associated with an increased risk of atrial fibrillation in men. However, no association was found between alcohol consumption and the risk of atrial fibrillation in women.
Experts call on EU politicians to improve cancer treatment access, modernize healthcare through increased funding and reduced bureaucracy. The European CanCer Organisation highlights the need for political will to translate scientific discovery into practical treatments.
A new partnership aims to develop nanotechnology tools for linking molecular signatures to cancer behavior and clinical outcome. Researchers will create nanoparticles for molecular profiling of cancer, as well as imaging microscopes and software integrated with nanotechnology discoveries.
A case-control study of 300 bladder cancer patients and 300 control subjects found higher levels of arylamine-hemoglobin adducts in cancer patients than in control subjects. The findings suggest exposure to arylamines is a causal factor for most cases of bladder cancer in humans, with potential non-smoking-related sources identified.
Dr. David S. Alberts, a renowned cancer researcher, has been honored with the 2004 American Association for Cancer Research (AACR) – Cancer Research and Prevention Foundation Award for Excellence in Cancer Prevention Research. He is recognized for his groundbreaking work on chemoprevention and treatment of various types of cancer.
A study found that even healthy subjects experience declines in sexual function over five years, but patients treated for prostate cancer show much greater decline with significant impact on urinary function. Men undergoing radical prostatectomy are particularly affected.
A population-based case-control study found no association between SV40 exposure and increased risk of NHL. SV40 seropositivity was detected in 7-10% of patients and less than 2% of controls, indicating a possible cross-reactivity with related human polyomaviruses.
Researchers have discovered that a mutant gene's failure to convert vitamin A into retinoic acid leads to colon cancer. Introducing retinoids may prevent or control the growth of colon cells, offering new avenues for therapy development.
Researchers developed a novel gene-based therapy that substantially decreased tumor size and eliminated cancer cells in experimental mice. The treatment, which uses recombinant adenoviruses encoding interferon-alpha, showed promise in responding to even resistant bladder cancer cell lines.
A study surveyed 900 physicians from the Society of Gynecologic Oncologists, revealing that a physician's comfort level discussing death and their medical ethics training significantly affect end-of-life choices for terminally ill patients. Key aspects of effective conversations include 'straight talk' and compassion.
Researchers analyzed data from over 400,000 breast cancer patients to estimate the probability of death after diagnosis. The study found that breast cancer patients with ER-negative tumors were more likely to die from their cancer than those with ER-positive tumors.
Researchers analyzed data from over 400,000 breast cancer patients to calculate probabilities of death from breast cancer vs. all other causes combined. They found that patients with ER-negative tumors and larger tumors were more likely to die from their cancer than those with ER-positive tumors and smaller tumors.
Physicians often recommend more frequent surveillance colonoscopies than recommended guidelines, citing clinical evidence and personal factors as influential. This may lead to unnecessary procedures, affecting quality of care and resource utilization.
A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibility genes. The study found evidence of a gene on the long arm of chromosome 17 and four other regions that might hold susceptibility genes. Additionally, researchers have discovered that men who carry a specific mutation in the MIC-...
Researchers recruiting patients from high-risk clinics for cancer intervention studies risk introducing bias, as controls are more likely to receive interventions than some case patients. This can lead to a false impression of intervention efficacy or underestimate its harm.
A recent study published in Cancer revealed that African-American women are four times more likely than white women to show significant alterations in the tumor suppressor gene p53. This finding suggests a greater burden of poor prognostic factors among African-American women, highlighting a potential link between genetic mutation and ...
Researchers found that black patients are more likely to receive care from physicians who report inadequate access to high-quality diagnostic imaging, sub-specialists, and other essential resources. This disparity in care may be driven by differences in the physicians' access to local services and specialists.
A study found that low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of postmenopausal breast cancer in overweight and obese women. The association was strongest in women who gained weight over the years of follow-up.
A new study found that Akt pathway activation is associated with better response rates and reduced disease progression in lung cancer patients treated with gefitinib. The researchers identified P-Akt positivity as a key marker for predicting patient response, but not P-MAPK positivity.
The UC Davis Cancer Center has a vigorous clinical trials program, with about 16% of new cancer patients participating in trials. This rate is significantly higher than the national average of less than 3%.
In Harare, Zimbabwe, cancer survival rates are disturbingly low, with black patients facing significantly lower survival rates than white patients. The study's findings highlight the need for better access to early detection and treatment methods.
A study found that physical symptoms, such as shortness of breath and weakness, predict cancer prognosis. Physical health-related quality of life (hrQoL) factors were stronger predictors of survival than psychosocial factors.
Researchers used gemcitabine and low doses of radiation to treat muscle-invasive bladder cancer in 24 patients. Most were able to keep their bladders intact and were cancer-free after four years, with 65% still cancer-free.
A randomized trial of 605 patients with four or more positive lymph nodes found no difference in 5-year relapse-free survival and overall survival between conventional and high-dose chemotherapy. High-dose chemotherapy was shown to confer extra cost and toxicity without added anticancer benefit.
New research suggests that cancer-related fatigue is more closely tied to depression and impaired physical performance than previously thought. A study of 70 patients in remission found no correlation between fatigue and various physiological markers, but significant associations with depression and physical performance.
Cancer patients anticipate an average of 8.7 symptoms, with fatigue, nausea, and hair loss being the most common expected side effects. The study identifies characteristics of patients who expect more side effects, including age, gender, educational background, and type of cancer.
A study published in Critical Care found that severe sepsis affects around 5% of cancer patients hospitalized in the US, resulting in a mortality rate nearly five times higher than non-cancer patients. Early antibiotic treatment could significantly improve cancer survival rates.
Researchers have discovered a potential immunotherapy strategy for cancer treatment by reactivating specific memory T cell subsets from cancer patients. These activated cells effectively recognize and reject xenotransplanted autologous tumors, reducing tumor size in mice.
Researchers found that 35% of patients with non-metastatic breast cancer exhibited impairments in verbal learning and memory functions before treatment. After treatment, 61% demonstrated 'chemobrain' declines in memory and learning, with improvements seen in 50% one year later.
A new technique for preserving fertility in young women with cancer has been successfully used on eight female patients. The method involves removing immature eggs from the ovaries, maturing them through in-vitro maturation (IVM), and freezing them for later use.
A new study shows that VELCADE (bortezomib) can significantly extend survival and induce important responses in relapsed and refractory multiple myeloma patients. The median overall survival was 17.2 months, with a 14.1-month duration of response and 15.3-month time to disease progression.
Researchers have identified a possible connection between the IRF1 gene and tamoxifen resistance in breast cancer. By adding interferon to antiestrogen therapy, tumors may become sensitive to treatment, potentially inhibiting new cancers or disease reoccurrences.
The study found that 85% of cancer patients use prayer as a common non-medical therapy for healing, while 25% change their diets or use mega-vitamins to improve their health. Patients often don't discuss these therapies with their doctors due to communication gaps.
Researchers found that approximately 50% of gemcitabine dose was converted to an active form, while the remaining 50% remained inactive. This discovery highlights the need for alternative treatment schedules for cancer patients undergoing gemcitabine infusions.
The study found that minority groups are underrepresented in cancer clinical trials, with Hispanic patients representing only 3.1% of trial participants. Additionally, elderly patients, both minorities and whites, were strikingly underrepresented compared to their younger counterparts.
A retrospective study of 110 elderly leukemia patients found similar complete remission and two-year survival rates as younger patients when treated with anthracyclin-based induction chemotherapy. The study's findings suggest that age is not a predictor of survival, but rather the treatment protocol received.
Researchers found that clinicians missed about half of symptoms reported by patients, and patients also missed about half of the symptoms recorded by physicians. The study suggests that new patient reporting tools should be developed for use in chemotherapy clinical trials to improve accuracy.
A prospective study of 89 caregivers found that as breast cancer patients progressed to the last stages of their illness, caregivers experienced increased depression and burden. The authors emphasize the need to address family caregiver needs during patient care, given hospital bed shortages for palliative and hospice care.
A Phase II trial has shown SU11248 benefits more than half of patients with gastrointestinal stromal tumors (GIST) that have developed resistance to Gleevec, a widely used drug in treating the disease. The drug was found to be effective in shrinking tumors and stabilizing disease for extended periods.
A new study demonstrates that Xeloda reduces the risk of colon cancer recurrence (relapse-free survival) by 14% compared to i.v. 5-FU/LV after surgery. The global trial, X-ACT, met its primary endpoint and offers new hope for patients with early stage colon cancer.
The CAMPTOSAR plus cisplatin regimen demonstrated improved one-year survival rates (59.2%) and response rates (31%) compared to current standard treatments. Patient toxicities were also significantly reduced, with fewer grade 3-4 neutropenia and thrombocytopenia cases.
A study of 494 cancer patients found that specific genetic variants are associated with increased fatigue and distress, suggesting a possible link between genetics and quality of life in cancer patients. The research aims to develop personalized treatments tailored to an individual's genetic profile to improve their quality of life.
Researchers found that women with breast tumors retaining the Stat5 protein biomarker have a highly favorable prognosis and may be cured by surgery alone. The study suggests that detection of this marker could lead to improved individualized therapy, including more careful follow-up and aggressive treatment for high-risk patients.
Researchers found that collecting comorbidity information from cancer registrars improves prognostic accuracy for various cancer types. Comorbidity data complements tumor stage in predicting patient outcomes.
Fox Chase Cancer Center and Wilex partner to accelerate development of anti-cancer drug for breast cancer treatment. The open-label Phase I study will evaluate safety and biological activity of WX-UK1 in combination with chemotherapy agent capecitabine.
Researchers found that comorbidities are strongly correlated with cancer survival rates, with severe comorbidities reducing overall survival by 33% after five years. Comorbidity data is most useful in treatable types of tumors, like prostate and breast cancer.
The European Society for Medical Oncology (ESMO) has launched a new charitable foundation with the goal of making the best treatment available to every cancer patient. The ESMO Foundation will provide much-needed funds for education, research, and patient care.
Researchers from Michigan Medicine have discovered a protein biomarker and cell-signaling pathway that may aid in the detection and treatment of pancreatic cancer. The study found that a specific protein called CEACAM 1 is elevated in the blood of pancreatic cancer patients, allowing for better differentiation from normal tissue.
Researchers found a synergistic effect between Herceptin and chemotherapy agents, increasing tumor shrinkage in 79% of patients. The combination also showed unusually long times to progression, providing hope for improved breast cancer treatment options.
A nationwide study found that patients undergoing kidney cancer surgery at high-volume hospitals have a 32% lower risk of dying compared to those at medium- and low-volume hospitals. High-volume hospitals also performed more partial nephrectomies, a procedure with equally effective cancer control.
A seven-year international study involving 872 patients with colon cancer has resolved concerns about laparoscopic surgery, finding it to be as safe and effective as standard surgery. The study found similar rates of complications, cancer recurrence, and overall survival between the two groups.
A recent study has found that minimally invasive laparoscopically assisted colectomy is an acceptable alternative for treating colon cancer when performed by experienced surgeons. The procedure's success depends on stringent surgical standards being followed.
A multicentre, randomized, double-blind and placebo-controlled study is underway to evaluate the efficacy and safety of Tectin in moderate to severe inadequately controlled cancer-related pain. The trial has shown promising results, with almost three-quarters of patients experiencing a clinically meaningful analgesic response.
Researchers found that taxanes significantly improved immune function in breast cancer patients, with a 37% increase in T cell growth and a 39% boost in NK cell activity. The study's findings suggest that taxanes may improve patient outcomes or quality of life by enhancing the body's ability to respond to infection or cancer recurrence.
The study found that combination PET/CT correctly identified 94% of malignant lesions, but only 36% of benign nodules. It also showed that the technique accurately determined the stage of cancer in 61 patients, but may overstage or understage tumors.