Articles tagged with Cancer Patients
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Researchers found a high correlation between EGFR mutations and sensitivity to gefitinib therapy in lung cancer patients, particularly in women and non-smokers. The study also revealed significant differences in response rates between Japanese and American patients, suggesting genetic variation plays a crucial role in drug effectiveness.
A study of 32 patients with suspected paraneoplastic neurological disorders found that PET imaging successfully identified relevant lesions undetectable by alternative methods. The results suggest that PET is an appropriate and promising tool for patients with undiagnosed paraneoplastic neurological disorders.
The article highlights the complexities of managing cancer pain in patients with a history of addiction, emphasizing the need for multidisciplinary care teams. The Pain Management Center at Fox Chase Cancer Center offers innovative strategies, including patient contracts and collaboration between nurses and physicians.
A new analysis from Duke University Medical Center uses breast cancer data to develop personalized risk predictions and prognoses for individual patients. The study integrated traditional clinical variables with genomic information, including genetic fingerprints of a patient's tumor, to improve accuracy.
The study found that CellCept significantly reduced the risk of malignancy in patients following heart transplantation, with a 27% lower relative risk compared to azathioprine (AZA). The use of CellCept was also associated with a reduced risk of certain rare cancers, particularly skin cancer.
A randomized, controlled trial among 2163 adult smokers at eight primary care clinics found that clinicians following the AHRQ Guideline offered more assistance to those who wished to quit. This led to improved rates of smoking cessation, with test site patients reporting abstinence from smoking at higher rates than control site patients.
Researchers identified 24 genes that can be used to single out patients for alternate therapies or lower radiation doses. The test could make treatment decisions easier and allow for personalized treatment plans tailored to individual patients' needs.
Researchers used SELDI-TOF mass spectrometry to analyze proteins in CSF of patients with known malignancies and non-cancerous conditions. They identified specific protein fingerprints that reliably distinguished between cancerous and non-cancerous disease, offering a promising diagnostic tool.
A study at the University of Texas M. D. Anderson Cancer Center found that Tibetan yoga improved sleep quality and reduced need for sleep medication in lymphoma patients. Despite no differences in other quality of life measures, the brief 7-week study suggests potential benefits of Tibetan yoga as a stress-reducer in cancer patients.
Researchers have identified two distinct patterns of gene activity that correlate with patient outcomes in intermediate-risk AML. The findings could lead to more personalized treatment approaches for patients with this type of cancer.
A survey of 32 popular English-language websites found that many promoted unproven therapies and some were even dangerous, while others provided valuable and reliable information. The researchers recommend a seal of approval scheme for complementary and alternative websites to minimize harm.
Researchers develop a method to identify biologically significant cancer subtypes using gene expression data and patient clinical history, showing it's a powerful predictor of patient survival. The approach reduces the chances of including unrelated genes, increasing the probability of identifying clinically relevant subsets of genes.
Women are more likely to develop lung cancer, with longer survival rates compared to men. Estrogen signaling and hormonal factors may play a role in these differences.
A study published in Journal of Clinical Oncology found that extended lymph node dissection does not increase long-term survival among gastric cancer patients, potentially increasing morbidity and hospital mortality. The procedure may only be beneficial if safe and effective alternatives can be developed.
Two new studies found no association between aspirin use and mortality from pancreatic cancer, while elevated insulin production was linked to an increased risk of colorectal cancer. Hyperinsulinemia, a condition associated with type 2 diabetes, also appears to be linked to an increased risk of colorectal cancer.
Researchers developed a biomarker to detect HBV mutations that speed up liver cancer development. Studies found HBV mutations predicted major liver disease, including liver cancer, up to eight years before diagnosis.
Breast cancer patients in Europe increasingly use complementary and alternative therapies (CAMs) to improve quality of life. CAMs may complement conventional treatments but can also interact dangerously with drug regimes, requiring careful consideration by doctors and patients.
A new study found that women with ductal carcinoma in situ (DCIS) who undergo conservation treatment have a similar rate of survival compared to those who undergo mastectomy. Close monitoring and regular screenings are crucial for successful treatment and early detection of recurrence.
A new tumor classification system combines molecular biology and classic pathology to provide a comprehensive and consistent way of typing tumors. The system uses both the type of cells that form a tumor and its molecular characteristics to determine its behavior, offering improved accuracy and insight into treatment options.
The Journal of Clinical Oncology (JCO) will provide free online access to its archived research, including articles published from January 1999 to the present. This move aims to improve cancer care worldwide by increasing access to essential information.
A study found that gefitinib is effective for patients with non-small cell lung cancer who are female, never smoked, and have a specific type of cancer. The researchers identified two key factors associated with sensitivity to the drug: having adenocarcinoma with bronchioloalveolar features and never having smoked.
A large international study found that patients switched from tamoxifen to AROMASIN after 2-3 years experienced a significant reduction in breast cancer recurrence and longer disease-free survival. The study suggests a potential new treatment option for post-menopausal women with estrogen-receptor positive breast cancer.
The UK Teenage Cancer Trust is calling for government action to address the poor survival rates and lack of support for young cancer patients. The charity argues that current systems often lead to late diagnosis, inadequate clinical trials, and a lack of specialized care, resulting in poor outcomes.
Cancer specialist Professor Bleyer warns that teenagers and young adults are 'orphaned in the world of cancer care delivery,' citing a 25-year stagnation in survival rates compared to children and older adults. The main reasons include delayed diagnosis due to psychological factors, lack of routine medical care, and underinsured status.
A study found that 71% of Japanese outpatients would like to make treatment decisions in collaboration with their physician. Patients prefer to involve their families in decision-making, but only allow them to support the patient's decision, not provide a third opinion.
New guidelines have been revised to improve the detection of hereditary nonpolyposis colorectal cancer (HNPCC) by prioritizing MSI testing in patients under 50 and those with family history, reducing risk for cancers associated with specific mutations.
Researchers at the University of Pennsylvania are conducting a clinical trial to evaluate the safety and efficacy of a telomerase peptide-based vaccine against breast cancer. The study aims to stimulate an immune response that can target and kill cancer cells, with the goal of improving patient health.
Researchers found that a combination of surgery and intraperitoneal hyperthermic chemotherapy (IPHC) can increase survival rates for patients with peritoneal carcinomatosis. The procedure, which delivers heated chemotherapy directly to the tumor site, has shown promise in improving quality of life and extending survival.
A recent study found racial disparities in the delivery of care to black and white rectal cancer patients. Black patients were diagnosed at a younger age and had more advanced disease, leading to differences in treatment outcomes. The study suggests that improved access to state-of-the-art surgical care for minority patients with recta...
African-Americans are more likely to have advanced stage cancer by the time it's diagnosed, and less likely to receive radiation therapy after surgery. Rectal cancer patients of any race still don't always receive optimal post-surgery care, highlighting a need for further studies to improve treatment guidelines.
A recent study found a significant link between increased levels of C-reactive protein and colon cancer risk. However, the study's findings do not suggest that C-reactive protein is a definitive marker for colon cancer risk.
Researchers discuss the need for additional research and standardization in partial-breast irradiation and accelerated partial-breast irradiation. A new study also finds that preoperative chemoradiation may benefit some patients with rectal cancer, while a diet high in glycemic load is linked to an increased risk of colorectal cancer.
A study found that PET scans revealed significant abnormalities in 53 patients, including 30 cases with malignant or premalignant tumors unrelated to primary cancer. Follow-up was crucial to diagnose incidental findings, which were often asymptomatic.
A review of 26 studies found that cancer patients enrolled in clinical trials did not have significantly better health outcomes compared to those not participating. The studies highlighted the importance of clinical trials in advancing treatment and improving options for patients with cancer.
A review of 26 studies found some evidence that cancer trial participants had better outcomes, with three studies suggesting improved outcomes. However, the limitations of the data made it difficult to establish a definitive link between trial participation and improved outcome.
A meta-analysis of genetic counseling for breast, ovarian, and colorectal cancer found improved knowledge of cancer genetics, but no impact on perceived risk. A gene mutation affecting folate metabolism alters the sensitivity of colon and breast cancer cells to chemotherapy drugs.
Researchers have discovered several protein profiles that are present more commonly in patients with HNSCC than in healthy smokers or control patients, enabling accurate diagnosis. The newly developed technology could potentially lead to the development of a reliable screening test for early detection and diagnosis of HNSCC.
Researchers found that digital photographs improved detection of new or changed moles, increasing accuracy by over 10% compared to skin self-examinations alone. Baseline photography may effectively improve diagnostic accuracy in patients performing skin self-examinations.
A study of Medicare-eligible patients with lung, breast, colorectal, and gastrointestinal tumors found a rise in chemotherapy use and emergency room admissions near death. However, an increase in hospice care usage suggests that improved palliative services may reduce aggressive end-of-life treatment.
Researchers found no association between BRCA1/2 mutations and colorectal cancer risk in two studies. No increased risk was observed among Ashkenazi Jewish mutation carriers or those with a family history of breast cancer.
A study found that nearly one-third of online bladder cancer information is outdated and inaccurate, with limited information on treatment options and follow-up care. The researchers recommend using reliable sources such as the National Cancer Institute and MEDLINEplus for accurate information.
Researchers analyzed data on 553 patients treated with imatinib, finding that complete cytogenetic response significantly impacted long-term outcome. Patients with low Philadelphia chromosome positivity had higher chances of achieving a complete response.
Researchers at Moffitt will evaluate vaccine therapy INGN 225 in a phase I/II study for patients with advanced breast cancer. The treatment has shown promising results in preclinical trials, with 100% protection against tumors achieved when dendritic cells were activated.
A study by Michigan Medicine found that seeking a second opinion for breast cancer may significantly alter diagnosis and treatment plans. The research, led by Dr. Amy Rochester Guest, suggests that patients with complex cases or those who are diagnosed with both breasts affected benefit most from consulting specialized teams.
A new cryoablation technique has shown promising results in killing most small malignant breast cancers, with seven out of nine patients experiencing complete tumor necrosis. The technique also showed no cosmetic changes to the breast's appearance and may be a viable option for women with early-stage disease.
Researchers found that calcium supplements reduced the risk of colorectal cancer recurrence only among individuals with baseline vitamin D levels above the median. Serum vitamin D levels were also associated with reduced adenoma recurrence among individuals taking calcium supplements.
A new CT scan technique called multi-detector CT urography (MDCTU) has been shown to detect various urinary system problems, including bladder cancer, kidney stones, and cysts. The technique is more accurate than traditional methods and may be beneficial for high-risk patients.
The partnership aims to address unequal burden of cancer on minority communities by providing access to clinical trials and strengthening cancer research programs. The collaboration will enhance cancer treatment capability and produce healthier outcomes for patients in South Central Los Angeles.
A clinical study found that molecular markers can predict which head and neck cancer patients will respond better to radiotherapy. The study identified two tumor profiles with different clinical outcomes, one with a high response rate of 67% and another with a poor response rate of 37%.
Researchers develop protein profiles to classify gliomas and predict aggressiveness with high accuracy. The 'molecular fingerprint' can help tailor treatment decisions for patients, distinguishing between aggressive and less aggressive tumors.
Researchers found that black patients undergoing surgery had a median survival time 1.8 years less than white patients, with disparities smaller among radiation therapy and non-aggressive therapy groups. The study suggests genetic and environmental factors may contribute to these racial disparities in prostate cancer treatment outcomes.
Black patients with locally advanced prostate cancer may have had less access to specialized radiation therapy, which is preferred over surgery. Postmenopausal women who consume moderate amounts of alcohol may be at an increased risk for cancer due to increased blood serum levels of the fat hormone leptin.
A Phase I study for non-small cell lung cancer used stereotactic radioablation, increasing radiation doses without prohibitive toxicity. 87% of patients showed positive tumor response, with no local recurrence at the highest dose levels.
The University of Pittsburgh will focus on clinical trials to test treatment efficacy and tolerance in older cancer patients, while also addressing behavioral and social issues faced by the elderly. The project aims to better understand the needs and concerns of older adults with cancer.
The UCI Cancer Center is one of six institutions nationwide chosen to conduct early-phase clinical trials testing cancer prevention agents. The center will receive over $2.2 million initially, with a focus on assessing the potential of various substances in preventing cancer recurrence.
Scientists at Memorial Sloan-Kettering Cancer Center discovered that the amount of PTEN protein produced affects prostate cancer progression. Mouse models showed varying levels of PTEN protein led to aggressive or benign tumors, suggesting novel clinical strategies for diagnosis, treatment, and prevention.
Brain cancer patients undergoing radiation therapy are at risk of life-threatening infections due to suppressed immune systems. Researchers found that monitoring immune cell counts and administering prophylactic antibiotics can prevent these side effects, with no patient developing pneumonia or other serious infections in the study.
A multicentre trial involving 351 patients found that anaemia treatment with epoetin beta did not improve cancer control or survival rates. Instead, patients receiving epoetin beta had a 60% better chance of progression-free survival compared to those given placebo.
A multi-center study led by Fox Chase Cancer Center oncologist aims to develop an interactive internet-based tool to assess patient values and information needs, providing education on cancer treatment and communication skills training. The goal is to improve doctor-patient communication and patient satisfaction.
A study published in the American Journal of Managed Care found that guideline-based cancer pain management offers effective pain relief in 80% of patients compared to 30% effectiveness for non-specialty providers. The targeted approach ensures a pre-determined treatment plan, reducing variability and increasing patient outcomes.