Articles tagged with Gastroenterology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A Chinese medicine compound, delisheng, has shown satisfactory anti-cancer effects on hepatocellular carcinoma cells in a three-dimensional cell culture model. The compound's ginseng component is believed to be responsible for its anti-tumor activity, which may lead to new treatment options for HCC patients.
Over two decades, a study in the UK found that ultrasound-guided liver biopsy is the preferred method due to its reduced complications. The majority of biopsies were performed on patients with raised liver tests and hepatitis C infection.
Patients with non-cirrhotic and nontumoral extrahepatic portal vein obstruction often present with well-tolerated bleeding. Cirrhosis- and tumor-related portal vein thrombosis generally carries a grim prognosis. A large sample size study found that hypercoagulable states are less common in this population.
A systematic review found that early nasogastric enteral nutrition is effective and safe for treating severe acute pancreatitis. It appears to be a cost-effective alternative to conventional nutritional routes, with no worsening of clinical outcomes.
A retrospective study of 68 postoperative CRC patients found that 18F-DG PET/CT detected more lesions than CT or ultrasonography alone in 30.4% of cases with recurrence and/or metastasis. The imaging technique also helped alter treatment plans in 16.2% of cases.
Researchers found that prolonged antiviral therapy can improve residual liver function and reduce portal hypertension in patients with compensated hepatitis C virus-related cirrhosis. The study, published in the World Journal of Gastroenterology, suggests that this treatment approach may delay complications and prolong survival rates.
A large sample size study found endoscopic resection to be a safe and effective treatment for gastrointestinal smooth muscle tumors (SMTs) with base sizes ≤ 2 cm. No severe complications or recurrences were observed in cases treated using the 'pushing' or 'grasping and pushing' technique.
A study published in the World Journal of Gastroenterology found that electroacupuncture at PC6 can decrease the frequency of transient lower esophageal sphincter relaxation (TLESR) induced by gastric distention in cats. The effect appears to act at the brain stem, mediated through nitric oxide (NO), CCK-A, and mu-opioid receptors.
The study found that transcutaneous cervical esophageal ultrasound (TCEUS) is not a substitute for 24-hour pH monitoring or manometry in diagnosing gastroesophageal reflux disease (GERD) and esophageal motor disorders. TCEUS can aid in estimating GER and motility disorders, but it cannot replace these established diagnostic methods.
Researchers have found that ultra-low-dose aspirin can normalize platelet-endothelial cell alterations and bleeding time in rats with portal hypertension. This effect is mediated by Cyclooxygenase 2 inhibition, a finding that could have implications for treating this debilitating condition.
A team has developed M-POSSUM, a modified scoring system that combines elements of Glasgow Coma Scale (GCS), APACHE and POSSUM to predict postoperative morbidity and mortality in high-risk surgical patients. The study found that M-POSSUM is more accurate than original POSSUM and APACHE II.
Researchers found that patients with large polyps or adenomas may need more frequent follow-up, while those with only a few small polyps can be screened less often. Relatives of patients with large polyps should also be targeted for screening.
Researchers have found promising results with three new non-invasive imaging tests that can diagnose fibrosis and cirrhosis of the liver without a biopsy. Ultrasound-based transient elastography was accurate in identifying patients with cirrhosis, while MR elastography showed nearly 100% accuracy in detecting any degree of liver fibrosis.
A recent study published in World Journal of Gastroenterology found a significant association between GERD and obesity in women, but not men. The researchers suggest that estrogen may play a role in this correlation.
The American Gastroenterological Association has established minimum standards for gastroenterologist performance of CT colonography, requiring at least 75 endoscopically confirmed cases to be interpreted. The guidelines emphasize the importance of training and quality control to ensure accurate screening for colorectal cancer.
The American Gastroenterological Association recommends gastroenterologists use evidence-based sedation protocols for endoscopic procedures to improve quality of practice and reduce adverse events. Proper training and experience are crucial for administering sedation safely.
Biologics may be a valuable treatment option for inflammatory bowel disease (IBD), offering new hope for patients. However, gastroenterologists must carefully weigh the potential benefits against significant side effects and costs. Research is ongoing to better understand the role of biologics in IBD treatment.
The Eli and Edythe Broad Foundation has awarded a three-year grant to the American Gastroenterological Association to support research fellowships for high school students interested in gastroenterology. The program will provide $2,500 each to five students to fund a 10-week research session under the supervision of an approved preceptor.
New studies examine factors that affect colonoscopy quality, including age, location, and technician training. Research suggests that competence in efficient colonoscopy requires more than 150 cases, with success rates improving significantly after this threshold.
The AGA Institute's Obesity Task Force Report highlights the need for a comprehensive approach to addressing obesity, considering its impact on healthcare budgets and societal practices. The report emphasizes the role of gastroenterology in treating obesity, with novel therapies and policies being developed.
A new study found that routine colonoscopic surveillance improves survival for colorectal cancer patients. Patients who underwent regular follow-up colonoscopies had better five-year survival rates compared to those who did not receive screenings.
A study published in Clinical Gastroenterology and Hepatology found that stool DNA testing can detect colorectal cancer with 88% accuracy, regardless of its stage or location. This non-invasive screening test offers a patient-friendly alternative to traditional colonoscopy.
The IDIBAPS project has validated the first prognostic DNA chip, called the IBDchip, which predicts inflammatory bowel disease (IBD) prognosis and treatment response. The chip is a simple device requiring only a small blood sample and can detect 61 genetic mutations.
The AGA Institute's report emphasizes the need for gastroenterologists to adapt to changing practices, technologies, and economic pressures. Key findings include the potential obsolescence of common endoscopic procedures due to technological advancements and increased utilization of nurse practitioners and physician assistants.
Researchers at the Mayo Clinic have developed a novel method to digitally capture and analyze colonoscopy video files, extracting objective quality metrics. The study also found adalimumab effective in inducing remission in patients with moderate to severe Crohn's disease.
The study found that virtual colonoscopy can detect polyps and cancers, but also reveals findings outside the colon that require additional testing, adding significant costs
Healthcare providers must weigh benefits and risks of NSAID use, which are associated with gastrointestinal complications. The AGA Institute recommends lower-risk agents and gastroprotection methods for patients at high risk of GI complications.
The partnership aims to support the training of young investigators in pediatric gastroenterology, hepatology, and nutrition. Hepatology will now be made available without charge to NASPGHAN fellows.
The APPROVe trial shows rofecoxib effective in reducing the recurrence of colorectal adenomas, a precursor to colon cancer. Patients taking rofecoxib had a lower recurrence rate (41% vs 55%) and reduced risk of advanced adenomas compared to those on placebo.
A study found that African Americans with hepatitis C infection experience a lower response rate to peginterferon alfa-2a and ribavirin combination treatment compared to Caucasian Americans. The racial difference in viral responses was seen as early as the fourth week of treatment, with African Americans having a significantly lower su...
A study by researchers at Mount Sinai School of Medicine identified CD23, a protein in the intestinal tract, as a receptor for IgE associated with allergic reactions. CD23 levels were found to correlate strongly with food-specific IgE in stool samples from patients with allergies.
A study of patients over 65 showed that AMITIZA significantly increased spontaneous bowel movements, improving symptoms of chronic idiopathic constipation. The medication was well-tolerated, with fewer adverse events compared to placebo, and is approved for use in adults regardless of age or gender.
A recent study found that AMITIZA improved symptoms of irritable bowel syndrome with constipation (IBS-C), including abdominal pain and bloating. The treatment was associated with significant improvements in patients' quality of life.
Research presented at Digestive Disease Week 2006 highlights current trends and advancements in GI cancers, clinical studies, and lifestyle choices. The meeting showcases more than 5,000 abstracts on the latest advances in GI research, medicine, and technology.
The AGA Institute presented notable clinical and basic science research highlights during the American Gastroenterological Association's (DDW) annual meeting. These findings include studies on the association between flexible sigmoidoscopy and colorectal cancer, as well as the role of Wnt signaling in gut development and repair.
Regular screening significantly reduces cancer deaths in families with hereditary Lynch syndrome, with a 70% decrease in mortality rates. Additionally, research finds that people with IBD-related CRC have similar prognoses as the general population, while a self-propelling colonoscope shows promise in efficient and safe detection.
COX-2 inhibitors and other NSAIDs can provide pain relief for patients with dormant inflammatory bowel disease without increasing the risk of flare-ups. Studies show that these medications are tolerated well by IBD patients, despite minimal risks, and can be a safe option for pain management.
A study found that genetic differences account for approximately 30% of variability in response to COX-2 inhibitors, such as celecoxib and rofecoxib. This suggests a potential target for developing diagnostic methods to identify patients at increased risk of cardiovascular events.
A study published in Gastroenterology found that nearly 2% of the general population has Barrett's esophagus, a condition linked to increased risk of esophageal cancer. The study highlights the need for screening and awareness among patients and physicians.
A recent study published by the American Gastroenterological Association found that consuming more than two cups of coffee or tea per day can reduce the risk of chronic liver disease by half. Researchers discovered that caffeine played a significant role in this protective effect, suggesting potential applications for liver health.
A nationwide survey found that 54% of NSAID users were unaware of potential side effects, and 18% had previously experienced complications. The study emphasizes the need for patient and physician education to prevent unnecessary complications from painkiller misuse.
A recent study found that even healthy people taking high doses of ibuprofen are at risk of internal bleeding, with blood loss ranging from 40mL to 299mL. The research highlights the need for caution when using ibuprofen, particularly in older adults and those with debilitating conditions.
New studies show that young African Americans are at a much higher risk of developing pre-cancerous polyps compared to other racial groups. The American College of Gastroenterology recommends that African Americans begin colonoscopy screening at age 45, as opposed to the current recommended age of 50.
Researchers found that IBS patients often believe it causes cancer, is caused by food allergies or intolerance, or changes in daily routine. Patients also reported significant concerns and effects on daily life, indicating a need for improved education and support.
Researchers found that both lying and truth-telling affected cardiac symptoms, while the act of lying was associated with gastric symptoms. The EGG showed a significant decrease in normal gastric slow waves when the subject was lying, corresponding to an increase in average heart rate.
Researchers found that people with diabetes are 1.4 times more likely to develop colon cancer compared to those without the condition. The study analyzed data from a nationally representative sample of patients and controlled for various factors, including age and obesity.
A study found that treatment with tegaserod significantly improved work attendance among patients with IBS symptoms of abdominal pain/discomfort, bloating and constipation. The study showed a 27% decrease in self-reported absenteeism and improvements in daily activities for approximately 50% and 40% of patients respectively.
A new study found that second and third-born children perceive greater parental protectiveness than only children, especially in mothers with IBS. This increased protectiveness may lead to more school absences and reported symptoms in later-born children of IBS mothers.
Researchers found that obese individuals who engaged in physical activity experienced fewer gastrointestinal (GI) symptoms compared to those with sedentary lifestyles. High body mass index (BMI) was linked to increased symptoms of irritable bowel syndrome (IBS), abdominal pain, and diarrhea.
The NIH has launched a new commission to address digestive diseases, building on the findings of a previous study that highlights the economic burden of these conditions. The commission will guide research into combating digestive diseases and translate advances into clinical practice.
Research confirms that patients with inflammatory bowel disease (IBD) are more likely to develop conditions such as asthma, multiple sclerosis, and other demyelinating disorders. The studies found a nearly two-fold increased risk of multiple sclerosis in IBD patients, highlighting the need for closer monitoring.
A recent study published by the American Gastroenterological Association found that nearly 80% of Asian patients with chronic HCV developed cirrhosis after 60 years of infection. The study's results confirm that fibrosis progression is the same across ethnic groups, leading to cirrhosis and liver disease at a similar rate in everyone.
Researchers found that older patients with newly diagnosed diabetes are considered a high-risk group for developing pancreatic cancer. The study, conducted by the Mayo Clinic College of Medicine, included 2,122 patients aged 50 and older who were diagnosed with diabetes between 1950 and 1995.
Research estimates a lifetime cancer risk of 0.14% and 0.022% from virtual colonoscopy, with the colon, stomach, and bladder being at greatest risk. While low radiation risks are promising, practical issues such as bowel preparation and patient compliance remain to be addressed.
Researchers found that a diet high in vitamin B6 may reduce the risk of colorectal cancer in women, particularly those who consume alcohol. The study suggests that maintaining a normal or high intake of vitamin B6 can help prevent the development of cancerous polyps in the colon.
Researchers found that rifaximin significantly improved disease activity in patients with Crohn's disease. The analysis of 8 patients showed a mean decrease in Harvey Bradshaw index of 7.1, indicating potential effectiveness as a treatment.
A survey of 1908 participants with gastroesophageal reflux disease (GERD) in Europe and the US found that nearly half experience sleep problems, impacting work and personal lives. The study suggests that GERD symptoms can be related to other health conditions like depression and anxiety.
Studies evaluate wireless capsule endoscopy, barium contrast series, and endoscopic gastric plication for small bowel surveillance and GERD treatment. These procedures show varying degrees of success in detecting polyps and reducing symptoms.
Researchers say virtual colonoscopy may be the answer to improving screening rates for colorectal cancer. The non-invasive test is highly sensitive and specific, while also being convenient and cost-effective, with minimal risk of side effects.
Researchers found that adding a fish oil, soluble fiber, and antioxidant supplement to standard medical therapy significantly reduced the dose of corticosteroids needed to control symptoms. The study provides an alternative treatment option for patients with ulcerative colitis.