Articles tagged with Immunohistochemical Analysis
Researchers at Salk Institute uncover an unexpected role for HDAC enzymes in controlling critical genes involved in DNA repair, making pancreatic cells more vulnerable to therapies that induce DNA damage. This finding paves the way for new treatment strategies combining entinostat with DNA-damaging therapies.
Researchers from The University of Osaka identified a unique genetic pattern in carcinoma cuniculatum, a rare type of oral cancer with slower growth and lower risk of spread. This discovery may lead to improved diagnosis and targeted treatment for this challenging-to-diagnose condition.
A new study from the University of Southern Denmark reveals that the brain's self-healing abilities are hindered by inflammation after a stroke. The researchers mapped specific cells that play a central role in rebuilding myelin, but found gender differences in how men and women respond to injuries.
Researchers found cyclin D1 expression in patients with penile cancer (PC) is associated with clinical and histopathological features. Patients with cyclin D1 expression had lower disease-free survival compared to the cyclin D1-negative group.
A novel reporter cell experimental system enables the visualization of sequential changes during endothelial-mesenchymal transition (EndoMT) induced by transforming growth factor-β. Researchers identified CD40 as a potential partial EndoMT marker, which suppresses the transition from partial to full EndoMT.
Researchers found that Matcha tea powder reduces depression in mice by activating dopaminergic neural circuits and improving mood. The study's results suggest that Matcha's antidepressant-like effects depend on the animal's prior mental state, with stress-susceptible mice showing a significant response.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
Researchers have discovered that reduced TGFBR2 abundance is significantly associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. An AI-based process accurately identified HCC tissue, confirming the biomarker's potential for early detection.
A recent study has found a correlation between paternal age and the development of neurodevelopmental disorders in children. The research, published in PLOS ONE, suggests that older fathers may pass on epigenetic markers that increase the risk of conditions such as autism and ADHD.
A peer-reviewed study published in Oncotarget found that OncoDNA's comprehensive testing and analysis services, combining multiple biomarkers, increased oncologists' ability to make informed treatment decisions. The study showed a significant improvement in overall survival for late-stage patients, from six months to over 12 months.
Researchers identified LNγ2, LNβ3, and active MMP7 as molecular markers for tumor aggressiveness in biliary tract cancer. The study found that these markers were associated with tumor progression, depth of invasion, and advanced stage. Down-regulation of MMP7 expression resulted in a significant decrease in cancer cell invasion.