Articles tagged with Immunology
A study found that naldemedine reduces constipation in cancer patients taking opioids, improving quality of life and reducing nausea. After 14 days, 64.6% of naldemedine-treated patients showed no signs of constipation compared to 17.0% in the placebo group.
Researchers found that macrophages produce lipid mediators that promote and suppress inflammation in AKI. The study suggests that MAFB regulates the production of pro-resolving LMs, shifting from a pro-inflammatory to a pro-resolving state.
A large study found that women with premature ovarian insufficiency are 2.6 times more likely to have an autoimmune disorder, with some conditions increasing the risk by 26 times. The study suggests a strong link between POI and severe autoimmune diseases, highlighting the need for medical professionals to be aware of this increased risk.
A recent study by Dr. Esteban Ballestar's group identifies an immune cell population that is more effective in responding against cancer cells under hypoxia. Macrophages undergo changes that enhance their ability to trigger an immune response, leading to better patient outcomes in bladder and ovarian cancers.
A large-scale study will enroll 1,000 patients with acute Lyme disease to identify causes of prolonged symptoms. The research team aims to shed light on why some return to good health and others develop debilitating symptoms.
Researchers found that neoself-antigens, presented on MHC-II, induce an immune response and lead to autoimmunity in lupus patients. EBV reactivation increases the presentation of these antigens, triggering T cell activation and autoimmune disease development.
Researchers have developed user-friendly tools to analyze spatial proteomics data, enabling biologists to understand how cells communicate with each other. The study sheds light on cellular mechanisms behind synaptic partner matching and immune system coordination, paving the way for new discoveries in biology.
A new study found that vaccination against respiratory syncytial virus (RSV) for adults over 60 can prevent illness, hospitalizations, lost quality of life, and deaths. The vaccines, Arexvy and Abrysvo, have been shown to be cost-effective in reducing healthcare utilization and societal costs.
Heidelberg researchers describe a new bottom-up approach to engineer precise immune responses using nanotechnology and synthetic biology. This innovative field holds promise for groundbreaking approaches in disease treatment and prevention.
Researchers from Osaka University discovered that Ikaros binds to Foxp3 to inhibit the expression of target genes, including Ifng, in regulatory T cells. This interaction is crucial for maintaining immune homeostasis and preventing autoimmune disorders.
Researchers at UC Santa Barbara discovered that macrophages can be programmed to respond to light, triggering an increase in their appetite and improving the effectiveness of cancer immunotherapies. The findings offer a new way to enhance trained immunity, a type of memory exhibited in the innate immune system.
A study by Aarhus University researchers reveals that the TMEFF1 gene produces a protein blocking herpesvirus entry into nerve cells, explaining why brain infections are rare. This discovery has great perspectives for understanding viral infections and potentially developing new treatments.
A new DNA-powered signal amplification technology called ACE significantly enhances the sensitivity of mass cytometry, enabling the detection of multiple proteins in single cells. This breakthrough allows researchers to investigate complex biological processes and study immune cell functions with unprecedented depth.
A study published in the Journal of Clinical Immunology found alemtuzumab to be safe and effective in treating Asian patients with inborn errors of immunity after allogeneic hematopoietic cell transplantation. The drug was shown to improve overall survival rates, with 94.7% of patients surviving post-transplantation.
Researchers at Stowers Institute for Medical Research have identified the dengue virus genome's use of less efficient codons in its host's machinery to replicate and spread. This discovery has implications for developing novel antiviral treatments and vaccines, as well as understanding the relationship between viruses and their hosts.
Researchers found that the recent SARS-CoV-2 variants BA.2.86 and JN.1 have only minor changes in immune evasion compared to their predecessor Omicron, contradicting initial public health concerns.
A nested case-control study found that completing fecal immunochemical tests lowers overall death risk from colorectal cancer, particularly in the left colon. The association was observed across racial and ethnic groups, supporting its use in population-based screening strategies.
A novel strategy using venetoclax and azacitidine demonstrates significant anti-cancer effect with mild toxicity for relapsed/refractory AML patients. The treatment showed markedly better survival rates after one year compared to a control group, with improved 'graft-versus-leukemia effects' via alterations of immune cells.
A new study reveals that about two percent of the population develop autoantibodies against type 1 interferons, making them more susceptible to severe viral infections. The autoantibodies remain detectable in the blood for life and are associated with a compromised type 1 interferon system.
Researchers at Memorial Sloan Kettering Cancer Center found that the spatial arrangement of three immune cells - dendritic cell, cytotoxic T cell, and helper T cell - is crucial for effective killing of cancer cells. This discovery has immediate therapeutic implications for immunotherapy treatments.
A new cellular immunotherapy approach shrank tumors in several patients with metastatic colon cancer, showing promise for treating other solid cancers. The treatment involved genetically engineered lymphocytes that recognized and attacked specific cancer cells.
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Researchers at Lund University developed a hybrid antibody that significantly improves immune function despite weaker binding to antigens. The new antibody's longer stem enhances mobility and signaling capacity, leading to better protection against SARS-CoV-2 and streptococcal bacteria.
Researchers found that adding JAK inhibitors to cancer checkpoint inhibitor immunotherapies improves patients' responses in two separate clinical studies. The combination therapy resulted in better clinical responses in patients with metastatic non-small cell lung cancer and those with relapsed or refractory Hodgkin lymphoma.
Researchers used single-cell sequencing technology to study immune responses in healthy adult volunteers exposed to SARS-CoV-2. They discovered unique immune responses associated with resisting sustained viral infection and disease, including activation of specialized mucosal immune cells and a reduction in inflammatory white blood cells.
Researchers at University of Cambridge uncover unified healer army of regulatory T cells that constantly move and repair damaged tissue. This discovery has implications for treating various diseases, including autoimmune disorders and infectious diseases.
Lopatkin's lab will investigate how bacterial metabolism contributes to antibiotic resistance using sophisticated tools and techniques. The research aims to identify drug-resistance mutations that arise in bacteria adapting to different antibiotics and metabolism-altering chemicals.
A new study finds that periods of fasting can reprogram the immune system's natural killer cells to better fight cancer. The research suggests that fasting may help improve immune responses and make immunotherapy more effective by training NK cells to survive in the tumor environment and produce more cytokines.
Researchers develop fully human antibodies that can neutralize the alpha-latrotoxin of the European black widow, a neurotoxin causing severe pain and hypertension. The study uses in vitro methods to create recombinant human antibodies, offering a safer treatment alternative with potential cross-reactive properties.
Scientists studied how microgravity impacts human peripheral blood mononuclear cells and identified potential compounds to counter its effects, including the antioxidant quercetin. The findings have implications for immune aging on Earth and provide a resource for developing countermeasures.
Scientists at Salk Institute discover a molecular mechanism that helps macrophages mount a coordinated response tailored to a specific immune challenge. The discovery reveals new immune system mechanisms that could be targeted with therapeutics to regulate inflammation.
The NADINA trial found that 59% of patients responded well to neoadjuvant immunotherapy before surgery, allowing them to forgo adjuvant treatment. This treatment approach also showed rapid effects, with 95% of patients remaining tumor-free after just six weeks.
This study found that lowering the fecal immunochemical test positivity threshold can achieve comparable sensitivity and specificity to the multitarget stool RNA test without additional testing. The findings are similar to previous observations with multitarget stool DNA testing, suggesting a potentially simpler screening method.
Researchers at University of Turku have discovered a novel RNA that controls the development and function of regulatory T cells. This finding may enable the development of precision medicine treatments for autoimmune diseases and cancer.
Researchers have identified genetic changes that can leave children born with little to no immune defense against infection. The study links mutations in the NUDCD3 gene to Severe Combined Immunodeficiency and Omenn syndrome, rare and life-threatening immunodeficiency disorders.
A new approach to fighting Epstein-Barr virus-related diseases has been discovered by University of Basel researchers. By inhibiting a specific metabolic pathway in infected cells, the risk of downstream disease can be diminished.
A new type of immune cell, MR1T cells, has been found to detect cancer cells through metabolic traces. This discovery opens up new avenues for targeted therapies against various types of cancer. The cells recognize altered metabolism in cancer cells, which produces specific molecules on the surface.
A team of POSTECH and ImmunoBiome has discovered a dietary-derived bacterial strain, IMB001, that induces nutritional immunity and boosts anti-tumor responses. The strain works by skewing tumor-infiltrating macrophages toward an inflammatory phenotype, leading to increased cell death of rapidly multiplying tumor cells.
A Cleveland Clinic-led team of scientists discovered that protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment. The interaction between VISTA and a newly discovered inhibitory receptor LRIG1 suppresses T cell replication, survival, and function.
Four new research papers demonstrate progress in germline-targeting HIV vaccines, which could offer broad protection. The approach involves priming young B cells to produce broadly neutralizing antibodies against HIV, a crucial step towards developing an effective vaccine.
A research team led by Gloria Choi and Jun Huh will investigate how fever improves autism symptoms in an effort to develop therapies that replicate this effect. They plan to explore the molecular mechanisms behind the 'fever effect' and its potential applications for individuals with autism spectrum disorders.
Researchers found that inflammatory proteins peak at different times of day based on whether new mothers breastfeed or formula-feed their babies. The study's findings suggest a unique immune profile for lactating mothers and highlight the need for further research into postpartum breastfeeding.
Researchers from Wyss Institute and Harvard University developed a biomaterial vaccine that enhances and sustains lymph node expansion, leading to more effective anti-tumor responses. The vaccine formulation, based on microscale mesoporous silica rods, reprograms antigen-presenting cells to orchestrate complex immune responses.
LMU researchers identified key enzymes involved in recognizing foreign RNA for TLR7 activation, including RNase T2 and PLD exonucleases. These findings provide important insights into the complex activation mechanism of TLR7, which plays a crucial role in defending against viruses.
A machine learning tool called PheNet can identify patients with rare, undiagnosed diseases years earlier, improving outcomes and reducing cost and morbidity. By analyzing patterns in electronic health records, the tool ranks patients by likelihood of having a disorder like common variable immunodeficiency.
The Human Frontier Science Program has awarded 2024 research grants to 108 top life scientists from 23 countries. The program supports interdisciplinary research and international collaboration, with grants averaging $400,000 per year.
Researchers discovered that Acanthophora spicifera extracts inhibit Vibrio coralliilyticus growth and improve survival rates in Ostrea edulis larvae. The study highlights the potential of natural compounds from seaweeds as an alternative to antibiotics for aquaculture disease control.
Increased vitamin D bioavailability leads to changes in the microbiome favoring Bacteroides fragilis, enhancing immune-mediated resistance to cancer. Fecal transplantation transfers this anti-cancer immunity to other mice.
A team of researchers found that immune cells maintain their alertness through the JAK-STAT signalling pathway when there is no immediate threat. This discovery could lead to new approaches for enhancing the immune system's attention and preventing autoimmune diseases.
Researchers at TUM have uncovered a mechanism by which tumor cells prevent the formation of immune responses, including cytotoxic T cells. This discovery provides rationales for new cancer immunotherapies and could enhance existing treatments.
The Vilcek Foundation will award three prizes of $50,000 each to young immigrant scientists in the US whose early career work has a significant impact on their field. Applications close June 10, 2024, and prizewinners will be selected by a jury of biomedical science experts.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
Researchers have demonstrated that attaching 'empty' backpacks to neutrophils activates them against cancer. The treated neutrophils infused into mice with cancer activated other immune cells and reduced tumor size. This technique is attractive as a 'drug-free' cell therapy for cancer.
Researchers identified a case of chronic inflammatory bowel disease after a blood stem cell transplant, linked to a genetic mutation in the recipient's body. Genetic analysis revealed that the donor carried a similar mutation, which triggered an autoimmune response.
Researchers have discovered a way to enhance the functionality of CD34-negative hematopoietic stem cells, which could lead to better treatments for blood-related diseases. The treated cells showed improved homing abilities and increased gene activity, suggesting they could be more effective as a treatment option.
Researchers found that Kupffer cells in liver respond to high cholesterol by removing excess, revealing the liver's role in regulating cholesterol levels. This discovery suggests atherosclerosis is a systemic disease affecting multiple organs.
New research reveals that lockdowns had a significant impact on the gut microbiome development of babies born during these periods. Babies born during lockdown periods showed lower rates of allergic conditions compared to pre-pandemic babies, likely due to reduced infection and increased breastfeeding.
A new study from EPFL reveals how the CRL5–SPSB3 ubiquitin ligase targets and degrades nuclear cGAS, preventing it from mistakenly attacking the body's own tissues. This regulation ensures a sophisticated balance between immune readiness and protecting the integrity of the cell's genome.
Researchers at City of Hope have developed a new approach to target and destroy hard-to-kill leukemia stem cells. The therapy method uses Type II interferon to disrupt the cancer cells' ability to divide, and a T cell engager antibody to create a bridge between the immune system and the leukemia stem cells.