Articles tagged with Immunology
Researchers find immunotherapy treatment anti-CTLA-4 leads to greater survival in mice with glioblastoma and discover new way cells kill cancer by triggering microglia, specialized immune cells in the brain. This breakthrough could lead to more effective treatments for human brain cancer.
Researchers unveil a novel signaling pathway that fosters chronic metabolic disorders through aged adipocyte dysfunction. Impaired BCAA catabolism in adipose tissues accelerates aging, while selective inhibition of CRTC2 or PPAR gamma activation may hold potential to inhibit aging and extend health span.
Eosinophilic esophagitis (EoE) is triggered by food allergies or airborne allergens, causing inflammation and damage to the esophagus. A new study found that inhibiting the NLRP3 pathway and releasing Interleukin-18 prevents EoE development.
Researchers have developed an innovative RNA-based strategy to activate dendritic cells, which play a key role in immune response. The approach, called CATCH, eradicated tumors and prevented their recurrence in mouse models of melanoma, suggesting its potential effectiveness against different cancer types.
Researchers found that CD4+ T cells initiate fat wasting, while CD8+ T cells induce muscle wasting, which surprisingly helps the mice fight infection and survive. The study sheds light on the complex relationship between immune cells and wasting responses.
University of Melbourne researchers have discovered that T cells patrol the human eye, protecting it from pathogens and inflammation. The study uses a new imaging technique to capture dynamic behavior of these cells in response to different stimuli.
Researchers at Salk Institute discovered molecular mechanisms of HIV drug-resistance to Dolutegravir, a breakthrough that could lead to the development of new HIV therapeutics. The study revealed how changes in integrase protein structure can lead to resistance and how another compound, 4d, may overcome this resistance.
Researchers from Korea University Medicine have discovered a potential therapeutic target for overcoming cisplatin resistance and neuropathic pain in cervical cancer. By inhibiting TRPV1, they found that resistant tumors became vulnerable to cisplatin, improving the outlook for patients.
A breakthrough mRNA vaccine has been developed to target and stimulate protective immune cell responses against malaria. The vaccine combines an RNA-based approach with a liver-specific adjuvant, generating resident memory cells that halt malaria infection in the liver, providing a broader and more protective immune response.
A new study reveals that breast milk contains a unique set of antibodies passed from mom to baby, which can vary significantly between mothers. This variability may explain why some infants develop life-threatening diseases like NEC, while others do not.
Researchers used a new method to study PFAS's impact on immune cells, finding that they significantly reduced T-cell activity and impaired the function of certain immune cells. This could lead to increased susceptibility to infections and reduced antibody production after vaccinations.
A study by Forsyth Institute researchers reveals a link between periodontal disease and amyloid plaque formation in the brain. Oral bacteria can travel to the brain, causing neuroinflammation and promoting cognitive decline in Alzheimer's patients.
A phase I trial found that combining fecal transplants with immunotherapy is safe and shows promise in improving clinical responses in 65% of patients. The study used healthy donor microbiome to enhance immune system attack on cancer, offering a new paradigm shift in melanoma treatment.
Researchers discovered that Nerofe and Doxorubicin can downregulate KRAS signaling, leading to enhanced apoptosis in colorectal cancer cells. The combination also activates the immune system against tumor cells, increasing immunostimulatory cytokines and recruiting NK cells and M1 macrophages.
Scientists have gained high-res structural insights into a key bacterial enzyme to develop new drugs that target its weaknesses and suppress disease-causing bacteria. The enzyme Lnt is not found in humans and has huge potential as a therapeutic target with fewer side effects for patients.
A new proof-of-concept Randomized Controlled Trial found tofacitinib effective and safe for Polymyalgia Rheumatica treatment, potentially avoiding steroid use. The study's results suggest a promising alternative treatment option for patients with this condition.
A third of under-fives attending Paediatric Emergency Departments have unmet vaccination need, with tetanus and MMR vaccination coverage levels below target. Researchers call for catch-up campaigns to reach this vulnerable group.
Researchers identified four therapeutic monoclonal antibody candidates that neutralized a range of SARS-CoV-2 variants. Prolonged exposure to the virus triggered somatic hypermutations, equipping these antibodies with an extensive binding interface.
Scientists found that CXCL13-mediated recruitment of B cells helps predict response to immunotherapy treatment. This cooperation between T cells and B cells is associated with improved survival in patients treated with immunotherapy.
Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.
The SEB Centenary Conference 2023 features over 800 talks on advances in animal, plant and cell biology. The conference marks the Society's 100th anniversary with special events and projects celebrating historically marginalised scientists.
Researchers identified a rare genetic defect in the DOCK11 gene causing abnormalities in white and red blood cells, leading to inflammation and immune system dysregulation. The defect also affects T cell activation, with potential connections to tumor diseases.
A new study found that pregnancy causes a shift in the types of immune cells present in a woman's blood, with neutrophils increasing dramatically. This discovery provides a 'normal reference' for studying immune changes during pregnancy and may have implications for understanding diseases such as rheumatoid arthritis.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
A study found that patients with atopic dermatitis have a higher proportion of proinflammatory effector T cells and lower suppressive Tregs specific to a particular mite antigen, leading to the development of atopic symptoms.
A new study published in Journal of Leukocyte Biology found that age and sex differences contribute to increased inflammation in older female mice. The research team discovered that immune cells entering areas where they shouldn
Researchers discovered a group of intestinal T cells with α4β7 integrin receptors that can either suppress or enhance anti-PD-1 immunotherapy in cancer patients. Targeting these cells may improve treatment outcomes and reduce resistance to immune checkpoint blockade.
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
Researchers at Karolinska Institutet have identified how memory killer cells are formed and found a correlation between their presence in cancer tissue and improved survival rates in people with melanoma. The study suggests that harnessing the potential of these cells could lead to more effective immunotherapy.
A study has identified a key component of the adaptive immune response to SARS-CoV-2 infection: nucleocapsid-specific T cells. These cells recognize and kill virus-infected cells, controlling viral replication and inflammation in the upper airways. The findings suggest that vaccines targeting this protein could be more effective.
Researchers found that individuals with only one defective allele can suffer from life-threatening diseases, challenging the assumption that defects in one allele are asymptomatic. The study highlights the importance of considering haploinsufficiency, where a single functioning gene is insufficient to prevent disease.
Researchers from Karolinska Institutet in Sweden report that individuals vaccinated against smallpox decades ago retain cross-reactive immunity to mpox. The study found that previous smallpox vaccination provides about 80% protection against mpox.
A recent study published in the Journal of Clinical Immunology suggests that cutaquig infusions at higher infusion rates and volumes are well-tolerated and effective, with reduced infusion time, fewer injection sites, and improved compliance. The study results will be presented at the Clinical Immunology Society 2023 Annual Meeting.
A new study published in Science Advances has found that certain antibodies against the Epstein-Barr virus can mistakenly target the brain and spinal cord, causing damage in multiple sclerosis patients. The research reveals a potential link between EBV infection and MS, with implications for personalized therapies.
A gene-edited calf, named Ginger, has been born with reduced susceptibility to a major viral pathogen, bovine viral diarrhea virus (BVDV). If confirmed by follow-up research, this approach could offer long-term potential to reduce antimicrobial and antibiotic use in the cattle industry.
A study published in Cell Reports Medicine found that pro-inflammatory cell types dominate the intestinal mucosa of children with inflammatory bowel disease, while protective cells are underrepresented. The results provide new insights into the immunology of IBD and may lead to the development of more effective treatments.
Researchers have identified three types of bacteria associated with natural purple photosynthetic bacteria that show strong anticancer efficacy. The bacteria can thrive in hypoxic tumor environments and trigger the immune system to kill tumor cells.
Researchers found that T cells can self-activate by puckering their cell membrane, boosting function and slowing tumor growth in a mouse model. This discovery could inspire new anti-tumor therapeutics and provide insights into treating autoimmune diseases.
A new test has identified several effective antibiotics rejected by standard testing, suggesting the gold-standard test is incorrect ~15% of the time. This study provides a potential solution to address the disparity between recommended antibiotics and actual patient outcomes.
Researchers found a genetic variant of TNFAIP3, which regulates inflammation, can paradoxically protect the kidneys from damage in the short term. The study could lead to simple genetic tests for predicting kidney disease risk and personalized treatment approaches.
A new study has identified a metabolic enzyme called FBP1 that acts as a safety valve to prevent insulin shock. Researchers found that FBP1 inhibits protein kinase AKT, which is the primary conduit of insulin activity, and developed a peptide derived from FBP1 that can reverse insulin resistance and restore normal glycemic control.
A study published in Communications Biology suggests that gut bacteria's digestion of fucose sugar may be behind weaker immune responses to the COVID-19 mRNA vaccine. Individuals with lower T-cell responses had higher expression of genes FOS and ATF3, which are part of a larger group controlling T-cell survival and activity.
Researchers found that extracellular vesicles stimulate killer T cells, promoting their proliferation and activation. The study also reveals that vesicles serve as a 'danger signal' for T cells during infection.
A WVU research team has created an OPTIMAL model to help students overcome fears of learning code and enhance critical thinking skills when using ChatGPT, a popular AI chatbot. The model facilitates chatbot-aided scientific data analysis and aims to improve coding skills and prompting abilities.
A study published in JCI Insight found that pregnant women display robust immune responses to SARS-CoV-2 infection, comparable to those of non-pregnant women. Key differences were observed in the dynamics of innate immune cells at the first line of defense towards viral infections.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
Researchers have discovered that Shigella bacteria can infect humans but not mice due to differences in the shape of a key protein, gasdermin-B. The protein has six different forms, and some isoforms cause cell death while others do not, explaining why Shigella is unable to infect mice.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
An international project aims to discover modifiable cellular and molecular pathways of the developing infant immune system to improve infant vaccine responsiveness and prevent respiratory disease. By analyzing infants' immune systems from birth to five years old, researchers hope to identify biomarkers that predict vaccine responsiven...
A new study published in Cell Reports shows that gut bacteria from the patient's own intestine can cause post-operative infections, which are often fatal. The liver plays a key role in controlling these spreading bacteria through special immune cells called innate lymphoid cells.
A study published in the Journal of Experimental Medicine reveals a unique subset of fibroblastic reticular cells in omental milky spots crucial for immune cell recruitment to prevent sepsis. These cells regulate the display of CXCL12, recruiting lymphocytes to sites of inflammation.
Researchers at Indiana University School of Medicine discovered that bacteria causing vaginal infections can also be present in men and transmitted through heterosexual sex. The study found that only men who reported having vaginal sex carried the bacteria, with detectable presence for at least two months after intercourse.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
Researchers found that hematopoietic stem cells use aggrephagy to collect and destroy misfolded proteins, a process that is critical for maintaining stem cell fitness and longevity. Boosting this pathway could help preserve stem cell health and mitigate blood and immune disorders.
Researchers created a three-dimensional structure that mimics bone and houses osteosarcoma cells beside immune cells, finding increased inflammation reduces chemotherapy effectiveness. The study highlights the importance of the tumor microenvironment in disease progression and treatment.
A new study by researchers at the University of Liège reveals that monocytes, blood immune cells, have the ability to proliferate and generate macrophages to replace damaged or missing immune cells. This discovery challenges current knowledge of cell proliferation and has implications for understanding various diseases, including cancer.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
The study reveals that gasdermin E drives changes in neurons that contribute to disease progression, leading to mitochondrial damage and axon degeneration. Inactivating gasdermin E prevents cellular damage and delays the progression of ALS in mice.
A biological messenger called interleukin-33 (IL-33) plays a crucial role in maintaining cytotoxic T cells' 'marathon runner' state, allowing them to provide sustained immunity against chronic infections. This finding has implications for improving treatment of hepatitis C and cancer immunotherapy.