Articles tagged with Immunology
A new model suggests that antibodies select antigens based on their surface characteristics, similar to a child playing on stepping stones. The researchers used DNA origami to simulate the behavior of antibodies and found that they tend to favor closer antigen distances.
A team led by Professor Charles Gauthier is developing a glycoconjugate vaccine using sugars expressed on the surface of Burkholderia pseudomallei. The vaccine aims to stimulate an immune response and increase its efficacy.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
A recent Cornell University study reveals that white-tailed deer can shed and transmit the COVID-19 virus for up to five days following infection. The virus replicates in the deer's respiratory tract, lymphoid tissues, and central nervous system, making them a potential reservoir for the virus in nature.
Genetic testing of saliva samples has been shown to be more quick and sensitive than nasal swab testing for detecting SARS-CoV-2 virus, with implications for improving public acceptance of COVID-19 testing and reducing healthcare worker risks
Researchers have discovered an essential role of LCOR in enabling cancer cells to present tumour antigens, making them visible to the immune system. This approach increases the success of immunotherapy in triple-negative breast cancer, a subtype with low treatment response rates.
A new study published in Frontiers in Oncology has shown that mRNA-based Covid-19 vaccines are well-tolerated by high-risk patients with impaired immunity. The trial enrolled 566 patients and found no evidence of increased adverse events or interference with treatment, reassuring vaccine-hesitant immunocompromised individuals.
Researchers at Harvard's Wyss Institute create functional lymphoid follicles on a chip, replicating human immune responses and predicting vaccine efficacy. The discovery offers a new tool to model the complex choreography of human immune responses to infection and vaccination.
A study published in eLife found that measuring changes in immune cell populations may help predict the prognosis of patients with ALS. Certain immune cells were associated with better or worse survival rates, providing new insights into the disease's progression.
Scientists at LMU found that mild disease courses are characterized by strong antiviral upregulation of interferon-stimulated genes, preventing viral spread and lung infection. This 'specific immunological signature' is initially independent of antibodies and holds promise for modulating the immune system to activate these mechanisms.
A new study suggests that persistent breathlessness after COVID-19 is linked to altered immune cell landscapes in the airways and signs of ongoing lung damage. While preliminary results indicate a possible improvement over time, further research is needed to confirm these findings and explore potential treatments.
A new human CD8+ T cell subset has been identified that suppresses pathogenic CD4+ T cells in autoimmune and infectious diseases. This subset, known as KIR+CD8+ T cells, is increased in the blood and inflamed tissues of patients with autoimmune conditions and COVID-19.
The Vilcek Foundation will award three prizes of $50,000 each to early-career immigrant researchers in biomedical science. Past recipients include notable scientists such as Ibrahim Cissé and Viviana Gradinaru.
A study suggests that targeting necroptosis in muscle fibers using an inhibitor can lessen myositis-induced muscle weakness and cell death, promoting muscle regeneration. This approach shows promise for treating polymyositis with potentially fewer infectious complications than current immunosuppressive therapies.
Researchers have identified a link between autoantibodies against type I interferon and increased risk of severe COVID-19. The study's findings suggest that screening for these autoantibodies could help identify patients at high risk of life-threatening complications, enabling early intervention and treatment.
Dixit's work on programmed cell death and inflammation has led to therapies for autoimmune disorders and rheumatoid arthritis. The Vilcek Foundation recognizes his contributions as an immigrant scientist in the US.
A new study by Karolinska Institutet reveals that natural killer cells respond to a specific peptide on the surface of infected cells. This peptide triggers an activation response in NK cells carrying the NKG2A receptor, allowing them to kill virus-infected cells.
Researchers used identical twins to exclude genetic influences and track immune system changes responsible for triggering multiple sclerosis. The study found that an error in the communication of immune cells leads to greater activation of T cells, causing damage in the central nervous system.
Researchers found that infusing bone-marrow stem cells into mice with sepsis increased their survival by 50-60% and decreased inflammation. This treatment could offer an alternative to current granulocyte transfusions, which have limited benefits.
Researchers found that deleting the PLA2G7 gene in mice partially mimics the anti-aging effects of caloric restriction. The study suggests that reducing PLA2G7 may lower inflammation and improve health span without reducing calorie intake.
Scientists have developed a genetically encoded biosensor called OxLight1, which enables them to study the action and release mechanisms of neuropeptides like orexin in living mice. The researchers found that the level of orexin release correlates with neuronal activity, revealing previously invisible aspects of healthy brain function.
A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood, potentially allowing for individualized prediction of outcomes in immunotherapy patients. This approach offers the opportunity to ask and answer questions about the immune system in health and disease.
Scientists analyzed over 100,000 cells from 15 human brain metastases and identified two functional archetypes of metastatic cells, each containing both immune and non-immune cell types. These archetypes work together within single cells to shape inflammatory and proliferative processes co-existent in each metastatic tumor.
Researchers at Gladstone Institutes and UC San Francisco have developed a CRISPR activation method that allows them to activate genes in human immune cells, revealing key regulators of cytokine production. This breakthrough accelerates immunotherapy research and may lead to more powerful cancer treatments.
Researchers detect four cryptic variants of SARS-CoV-2 in NYC wastewater samples, suggesting possible animal origins. The variants' mutations could help identify the next variant of concern for COVID-19.
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
A meta-analysis of 87 surveys from 35 African countries found that nearly one in ten sexually active men have paid for sex and are 50% more likely to be living with HIV. Men who pay for sex should be recognized as a priority population for HIV prevention efforts.
Researchers at UC Riverside have identified a new host protein interaction in chickens that triggers a strong immune response against viral infections. The discovery sheds light on the differences between bird and human immune responses to zoonotic viruses.
Immunosequencing of T cells combined with machine learning techniques reveals that participants with higher numbers of pre-existing memory CD4 T cells develop immunity more quickly and produce more antibodies following vaccination. This study has significant implications for immunity and vaccine development efforts.
The four-year programme will investigate the chemical signatures that trigger immunity in fungal infections, which kill an estimated 1.6 million people worldwide annually. By understanding these signatures and how fungi disguise them, researchers hope to uncover the origins of antifungal immunity.
Acute COVID-19 infection can lead to various neurological symptoms, including confusion, stroke, and depression, which persist months after infection. The authors propose possible mechanisms, such as vascular and immune dysfunction, that may give rise to these symptoms and trigger future neurodegenerative diseases.
Researchers at Karolinska Institutet found that memory T cells formed after previous infection or mRNA vaccination can still recognize the omicron variant, suggesting protection against severe disease. The study also suggests booster immunization may provide benefits beyond neutralizing antibodies.
Researchers found that magnesium is essential for the functioning of T cells, which can eliminate abnormal or infected cells. Increasing local magnesium concentration in tumors strengthened the immune response against cancer cells.
Researchers found that smart windows with dynamic tinting can completely disinfect surfaces within 24 hours, reducing bacterial growth rates and viability. In contrast, traditional windows with blinds blocked almost all daylight, promoting contamination on glass, plastic, and fabric surfaces.
Researchers found elevated protein levels and unexpected antibodies in cerebrospinal fluid of patients with post-COVID cognitive symptoms, suggesting inflammation and a systemic response. The study suggests an activated immune system may be the cause of brain fog, a common after-effect of COVID-19.
A new study found that a third dose of the BNT162b2 vaccine increases protection against the Omicron variant by 23-fold. The data suggest that a third dose augments antibody-based immunity against Omicron.
New research highlights key differences between COVID-19 variants alpha and omicron, including the impact on virulence and disease severity. The study suggests that omicron's genetic makeup is less conducive to causing severe illness compared to its older variant sibling, alpha.
A new study by the University of California - San Francisco found an association between increased drinking and hospital visits for atrial fibrillation in a large population. The study linked acute alcohol consumption with a higher risk of new-onset AF in previously undiagnosed individuals.
A new graft strategy has reduced chronic graft-versus-host disease in leukemia patients by depleting naïve T cells from donor blood. The approach has shown promising results, with only 7% of patients developing chronic GVHD compared to 30-60% with standard treatment.
Researchers discovered that in familial Alzheimer's disease caused by mutations in presenilin 1, Aβ43 generation is stable and unaffected by lower levels of other Aβ proteins. The study provides strong evidence for alternative mechanisms of amyloid beta processing in familial AD compared to sporadic AD.
Researchers developed an immunotherapy strategy using in vivo generated transient engineered CAR T cells to reduce fibrosis and restore cardiac function. The approach showed promise as a personalized therapeutic platform for treating various other fibrotic diseases.
Researchers create new method to genetically analyze resting CD4+ T cells, allowing targeted modifications and insights into HIV interaction. This enables the investigation of cellular factors playing a role in infection and the development of new therapeutic approaches for eliminating HIV from the body.
Researchers found that fibrin buildup triggers an overactive immune response, damaging gums and underlying bone. Suppressing abnormal fibrin activity could hold promise for preventing or treating periodontal disease.
Scientists at the University of Basel have discovered a new signaling pathway that enables T cells to survive for decades. Coronin 1 regulates this pathway, which suppresses T cell death by maintaining PI3Kdelta activity. This finding has significant implications for understanding and controlling immune function.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
A study published in Allergy reveals the importance of PU.1 transcription factor in regulating CCL17 gene expression, which contributes to allergic diseases. The research found that suppressing PU.1 can reduce inflammation in asthmatic mice, paving the way for novel treatments.
Researchers have discovered an ancient category of MHC molecules, MHC-W, which represent a missing link for explaining how class I molecules evolved from a class II-like origin. This finding resolves a long-standing puzzle in immunogenetics.
A December 2020 survey found that about two-thirds of adults in Jordan, the West Bank, and Syria were unwilling or hesitant to get vaccinated against COVID-19. Concerns over vaccine rigor and long-term health risks were primary reasons for hesitation.
Researchers at Hokkaido University and Texas A¼M University identified a key mechanism used by SARS-CoV-2 to evade host immune systems, targeting the MHC class I pathway. The study found that the virus suppresses the activation of this pathway using the ORF6 protein, allowing it to persist in the body and infect others.
Researchers report that combining infection and vaccination produces high-quality antibodies effective against COVID-19 variants. The study found that prior-infected individuals who received a vaccine had potent antibodies against new variants, contrary to previous findings suggesting reduced potency.
Studies in mouse models found that maternal immune activation can alter brain development and lead to autism-like behavioral symptoms. The research also revealed a link between maternal microbiome changes and offspring's susceptibility to intestinal inflammation, with increased IL-17a production by T cells.
Researchers at LMU have found a new marker in the blood of Covid-19 patients that correlates with disease severity. Phosphatidylserine levels can potentially trigger inflammatory processes and coagulation disorders, enabling better diagnostics and predicting severe cases.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
A new particulate saponin/TLR agonist vaccine adjuvant has been shown to alter lymph flow and modulate adaptive immunity. This study demonstrates the potential of this ingredient as a more effective vaccine booster.
A new study found that vaccinated UK healthcare workers who were previously infected with different COVID-19 variants show varying levels of protection against new variants. The results suggest that the sequence of variant exposure influences immunogenicity profiles, highlighting the need for tailored vaccine development.
A new approach for identifying shared patterns in immune cell receptor sequences may help determine if a person has previously been infected or vaccinated against a given pathogen. Researchers have developed software called tcrdist3 to facilitate this process.
Researchers discovered Roquin's role in controlling immune cell activation and autoimmunity. Mutations can improve anti-tumor responses.
A study published in the American Journal of Respiratory and Critical Care Medicine found that prostacyclin treatment reduced damage to vital organs and halved mortality rates among critically ill Covid-19 patients. The research team hopes to investigate larger patient populations in future studies.