Articles tagged with Insulin
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A new study reveals that insulin is essential for preserving pluripotent stem cells' ability to become any cell type. Insufficient insulin leads to a specialized endoderm cell type, similar to early embryonic cells, suggesting potential importance in human development and pregnancy.
The new model predicts how glucose-responsive insulin (GRI) will affect patients' blood sugar levels based on chemical traits. The MIT team identified several strong GRI candidates and plans to test them in animals.
A Chinese study found very low rates of blood glucose monitoring among nearly 19,000 patients with type 2 diabetes before and after initiating basal insulin treatment. The data showed an increase in mean SMBG frequency after 6 months, but the percentage of patients who never monitored their blood glucose remained high.
Congenital hyperinsulinism is caused by a genetic mutation that leads to permanent activation of the GDH protein, resulting in excessive insulin production. This triggers chronic hypoglycaemia, brain damage, and intellectual retardation. A new study may pave the way for novel therapies, including a drug that inhibits the GDH accelerator.
New research reveals 30% of type 2 diabetic patients don't begin insulin when initially recommended, with a 2-year average delay. This delay leads to worsening disease progression and increased risk factors.
A global study of over 800 patients with Type 1 diabetes found that dapagliflozin, a Type 2 diabetes medicine, significantly improved blood sugar levels. The results demonstrate the drug's efficacy as an adjunct therapy to insulin, reducing A1C levels by more than 0.5% without severe hypoglycemia.
A low-calorie diet has been shown to reverse Type 2 diabetes by reducing liver and pancreatic fat content, allowing insulin production to resume. The reversal of diabetes remains possible for up to 10 years after onset with sustained weight loss.
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Patients experienced a lower rate of confirmed severe hypoglycemia than observed in patients on placebo and also had weight loss.
Researchers discovered that epicatechin monomers in cocoa enhance beta cells' ability to secrete insulin, improving blood glucose control. The study suggests these compounds could potentially delay or prevent type 2 diabetes onset in patients.
A new study suggests that High-Intensity Interval Training (HIIT) is an efficient way to combat high insulin resistance, a warning sign for diabetes. HIIT improved blood pressure and glucose levels in women at risk of type 2 diabetes, with the greatest benefits seen in those with higher insulin resistance.
Researchers at the University of Wisconsin-Madison have developed a new measurement for the volume and activity of beta cells, which are responsible for producing insulin. The new test uses PET scanning to detect minute levels of a radioactive chemical in the mouse pancreas, providing a more accurate assessment of insulin production.
A phase 3 trial found that biosimilar insulin lispro (SAR342434) has comparable efficacy and safety to Humalog in adults with type 1 diabetes. The study's findings support the use of biosimilars as a cost-effective alternative for insulin treatment.
A study published in The FASEB Journal discovered that a commonly known protein complex can stimulate insulin secretion in pancreatic cells. This finding provides insights into new treatments for conditions where the body produces insufficient insulin, such as diabetes.
Researchers found Epac2A controls insulin release amount and timing at cell membrane sites. Patients with type 2 diabetes have lower Epac2A levels, suggesting a link to reduced insulin secretion.
Two studies found that insulin degludec reduced hypoglycemic episodes and severe hypoglycemia in patients with Type 1 or 2 diabetes, compared to insulin glargine U100. The trials involved over 800 adults and had mixed results.
Researchers found that intranasal insulin improves functional connectivity in brain regions involved in cognitive processes and appetite regulation. The study suggests that insulin in the brain may help regulate eating behavior and facilitate weight loss by suppressing the relationship between adiposity and hunger sensation.
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
A large pragmatic trial found that checking finger-stick blood sugars did not offer significant advantages in blood sugar control or quality of life for non-insulin treated type 2 diabetes patients. The study suggests that the costs of home blood glucose monitoring may outweigh its benefits for this population.
A randomized trial found that self-monitoring of blood glucose levels in patients with non-insulin-treated type 2 diabetes did not improve glycemic control or health-related quality of life after one year. The study suggested that SMBG should not be routine for most patients, contradicting existing practice.
Fatty acid esters disrupt insulin synthesis and lead to beta cell dysfunction in type 2 diabetes. High-resolution mass spectrometry imaging reveals an imbalance in insulin production and secretion, affecting the function of pancreatic islets.
Recent clinical studies support the value of continuous glucose monitoring (CGM) in reducing blood glucose variability and improving patient quality of life. CGM has been shown to be safe and effective, with regulatory approval for nonadjunctive use representing a major advance.
Researchers discovered that a small group of hypothalamus neurons, called POMC, modulate the amount of insulin produced by the pancreas. The study reveals new molecular mechanisms involved in this connection and highlights the importance of mitochondrial dynamics in glucose sensing and insulin release control.
A newly discovered mechanism behind reduced insulin production in type 2 diabetes reveals that insulin-producing cells regress and become immature, reducing their function. The study identifies key genes, including SOX5, which affects disease progression and suggests potential new treatments targeting cellular maturity.
The approved flash glucose monitoring system provides accurate data on demand, reducing the need for calibration, and offers a clinical benefit for individuals with type 1 diabetes. The technology has been shown to improve insulin dosing and overall glycemic control.
Two studies have shown how new potential anti-diabetic drugs interact with their target in the body, reducing blood sugar by increasing sensitivity to insulin and changing metabolism of fat and sugar. Researchers are now designing modified drugs that will work even more efficiently.
Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
A new technique uses modified insulin and red blood cells to regulate blood sugar levels in mice with Type 1 diabetes. The system effectively reduces blood sugar levels for 48 hours and has shown promise in reducing the risk of hypoglycemia.
Researchers at UT Health San Antonio have developed a gene-transfer technique that increases insulin-producing cells, potentially curing Type 1 and improving Type 2 diabetes. The therapy has cured diabetes in mice without side effects, offering a major advance over traditional insulin therapy.
Researchers created custom cells that produce insulin when illuminated by far-red light, allowing for remote control via smartphone application. This innovation enables instant feedback between therapeutic cells and diagnostic devices, promoting stable blood glucose levels in diabetic animals.
Stevia stimulates the ion channel TRPM5, which is involved in taste perception and insulin release, helping to prevent abnormally high blood sugar levels and type 2 diabetes. The study opens up new possibilities for treating diabetes, but further research is needed before new treatments can be developed.
A new study compares blood glucose control and hypoglycemia rates between type 1 diabetes patients using insulin pumps versus multiple daily injections during Ramadan. Researchers report improved glucose variability and reduced hypoglycemic episodes with insulin pump therapy.
The article highlights the link between diabetes and depression, as well as the importance of assessing psychosocial stresses in diabetes management. It also discusses the management goals for patients who engage in self-harming or suicidal behavior, emphasizing the need for frequent glycemic monitoring and a multi-disciplinary approach.
A new study finds that an artificial pancreas system improves blood glucose control better than usual home management for children aged 5 to 8 years with type 1 diabetes. The wearable device uses computer algorithms to track blood sugar levels and adjust insulin dosing, resulting in a longer time in the target range.
Research found disparities in type 1 diabetes care among US military children, with white and officers' kids more likely to use insulin pumps and continuous glucose monitors. These technologies led to better glycemic control, but hospitalizations remained similar between pump users and those using multiple daily injections.
A new study found that intensive medical treatment using oral medications, insulin, and lifestyle therapies can reverse type 2 diabetes in up to 40% of participants. The study's findings support the notion that type 2 diabetes can be reversed, at least in the short term, with medical approaches.
A study published in Annals of Internal Medicine found that Canadians with cystic fibrosis have a significant survival advantage over American patients, with a median age of survival of 50.9 years compared to 40.6 years in the US. The difference is attributed to better healthcare coverage and nutrition in Canada.
A new model of healthcare has shown that nurses can improve patient uptake of insulin treatment, leading to better long-term health outcomes. In a recent Australian study, 70% of patients began treatment under the 'Stepping Up' program, compared to just 22% in traditional approaches.
A new model of care has been associated with a higher uptake of insulin treatment among patients with type 2 diabetes, reports a study published in The BMJ. By focusing on an enhanced role for practice nurses, the model aims to improve outcomes and reduce barriers in clinical practice.
The study focuses on combining SPRA technology with polypseudorotaxane (PPRX) technology to create a sustained and controllable insulin release system. Four types of PPRXs were developed, showing improved blood glucose reduction times and safety profiles.
A fasting-mimicking diet has been shown to reverse diabetes in mice by promoting the growth of new insulin-producing pancreatic cells. In humans, the diet also increased expression of a protein that accelerates insulin production in type 1 diabetes patients, suggesting potential for alleviating symptoms.
Researchers at Linköping University conducted a pilot study showing promising results in treating type 1 diabetes. The study found stable insulin production in six patients who received GAD-alum injections, with significant improvements in blood sugar levels and reduced need for extra insulin.
A pivotal trial demonstrated the safety and efficacy of a hybrid closed-loop insulin delivery system in home use, reducing HbA1c levels and preventing severe hypoglycemic events. The system showed significant improvements in glucose control for both adolescents and adults with type 1 diabetes.
Researchers discovered a subpopulation of beta cells that resists immune attack and acquires stemness to persist despite immune attack. This finding may lead to therapies targeting these cells to restore insulin production in type 1 diabetic patients.
A new study found that high levels of air pollution can make insulin-creating cells less efficient, increasing the risk for type 2 diabetes in obese Latino children. Exposure to poor air quality during childhood increases the risk for obesity and Type 2 diabetes.
Four NIH-funded research projects aim to test and refine fully automated artificial pancreas systems, replacing traditional methods for managing type 1 diabetes. The studies will evaluate safety, efficacy, user-friendliness, and cost, with the goal of bringing these life-changing devices to those who need them.
A new skin patch has been developed to monitor blood glucose levels and release insulin automatically when necessary for people with diabetes. The patch, tested on mice, maintains consistent insulin concentrations in the blood and helps regulate blood sugar levels.
The university will explore a 'molecular diversity' of potential glucose-responsive insulin analogs to develop rapid-acting, glucose-responsive insulins that become active when blood sugar is high and inactive when low. The goal is to mitigate the risk of blood sugar levels being too high or too low for patients with type 1 diabetes.
Chemical modification of insulin enables faster release and improved availability, maintaining efficacy. The study uses computer simulations and experiments to confirm the effect, demonstrating potential for optimizing diabetes treatment.
Insulin resistance is a key mechanism in the pathogenesis of PCOS, leading to metabolic abnormalities and clinical burden. Lifestyle changes and specific medications can improve insulin sensitivity, but personalized treatment approaches are essential.
A new study published in the International Journal of Obesity found that healthy young men who consume sugar, Stevia, monk fruit, or aspartame-sweetened beverages do not experience a significant difference in overall energy intake. However, they did eat more after consuming natural non-nutritive sweeteners.
Researchers at ETH Zurich have created artificial beta cells that can effectively regulate blood sugar levels. These cells work by measuring glucose concentrations in the blood and producing insulin when necessary, making them a promising solution for diabetes treatment.
Researchers found that artemisinins transform glucagon-producing alpha cells into insulin-producing cells by activating GABA receptors, producing insulin. The study uses FDA-approved malaria drugs and has been shown to increase beta cell mass and improve blood sugar homeostasis in animal models.
Researchers used CRISPR/Cas9 to remove an enzyme that regulates the diabetes-associated TXNIP gene, leading to reduced cell death and increased insulin production in genetically modified pancreatic beta cells. The study also found that histone acetyltransferases play a crucial role in regulating the TXNIP gene.
Researchers have successfully reactivated oscillations in insulin-producing pancreatic beta cells using mathematical models and microfluidic devices. By delivering controlled glucose levels to dormant cells, scientists can test how insulin-producing cells get turned off and whether they can be reactivated.
Studies reveal genes respond differently to high insulin levels and sustained low levels, with some expressing quickly and others repressing themselves. Researchers developed a method to control gene expression using temporal patterns and doses of insulin.
Scientists at the University of Michigan are studying protein degradation in pancreatic beta cells to better understand diabetes at the molecular level. They found that proinsulin misfolding can lead to diabetic disease and identified a way to stimulate the degradative pathway to restore normal insulin secretion.
A new study published in Developmental Cell demonstrates that a nerve growth protein plays a crucial role in regulating blood sugar levels by prompting pancreatic cells to release insulin. The research, led by Johns Hopkins University biologist Rejji Kuruvilla, has potential implications for the treatment of type-2 diabetes.
A study published in Diabetologia found that high iron biomarkers are linked to an increased risk of gestational diabetes in pregnant women. Higher iron stores may play a role in developing insulin resistance and oxidative stress, contributing to impaired insulin synthesis and secretion.
A University of Michigan study found that low-carb meals significantly lower insulin resistance by over 30 percent within 24 hours, while high-carb meals sustain it. Exercise before meals also failed to lower insulin resistance, and may even increase blood sugar levels.
A new study found that pulses of glucose can reactivate the insulin clock in beta cells, which regulate blood sugar. The research suggests that controlled glucose solutions may be used to treat Type 2 diabetes.