Articles tagged with Insulin
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Researchers have developed an intestinal patch device containing insulin that can be swallowed as a capsule, demonstrating efficacy in managing blood glucose levels in diabetic rats. The patches showed excellent mucoadhesive strength and released insulin within five hours, reducing blood glucose levels significantly.
A pharmacy-led glycemic control program is linked to improved outcomes for surgical patients with diabetes, including fewer complications and readmissions. Patients in the program had better blood sugar control, reduced hospital readmissions, and lower medical costs.
A recent study found that patients with better insulin-producing cells before weight loss surgery are more likely to eliminate diabetes. The research suggests that measuring insulin cells' performance can help doctors predict which patients will benefit from the procedure, emphasizing the importance of early procedures.
A pilot study found early insulin therapy to be as effective as 15 months of oral therapy, improving A1C levels from 10.1% to 6.7% in insulin-treated group and 9.9% to 6.8% in oral therapy group, with no severe hypoglycemia reported
A post-hoc analysis of the ACCORD study found that higher doses of insulin were not associated with increased cardiovascular death. The study's findings provide reassurance for physicians and patients with diabetes, but underscore the need for further research to clarify the potential risks of insulin use.
Researchers at Duke University Medical Center and the University of Alberta have discovered a new biochemical pathway that controls insulin secretion from islet beta cells in the pancreas. The study found that impairing this pathway, known as S-AMP production, disrupts normal glucose-stimulated insulin secretion.
A/Prof Shane Grey's team aims to make significant improvements in islet transplantation therapy, making it a clinically realistic option for more individuals with type 1 diabetes. They focus on calming the immune response of patients to islet transplantation, which could lead to treated individuals living drug-free in the long term.
Researchers at UMMS have discovered a new pathway that triggers regeneration of beta cells in the pancreas. This innovative approach may aid in the development of diabetes treatments by increasing the number of insulin-producing cells in response to increased demand.
A study by University of Alberta researchers discovered a new molecular pathway that manages insulin production, offering hope for restoring the 'dimmer switch' in Type 2 diabetes. The findings suggest that this pathway can be revived to control insulin secretion from islet cells.
Researchers at Karolinska Institutet have discovered a mechanism that explains how insulin-producing cells can be both insulin-resistant and insulin-sensitive at the same time. The study identifies a key factor, PI3K-C2α, that causes a switch in signaling pathways, leading to beta cell proliferation.
Researchers found that brief intervals of exercise during sedentary periods can lower children's blood glucose and insulin levels, and may protect against diabetes, cardiovascular disease, and cancer. The study suggests that even short activity breaks can help overcome negative effects on the body.
Researchers found altered mitochondrial DNA in pre-diabetic individuals with insulin resistance, who had lower amounts of mitochondrial DNA and higher methylation levels. This discovery may help prevent Type II diabetes by identifying a biomarker for early intervention.
Babies diagnosed with diabetes are now immediately tested for all 22 genetic causes, reducing referral time from over four years to under two months. This early comprehensive gene testing provides accurate information on clinical features that haven't yet developed, enabling doctors to anticipate and prevent medical problems.
A recent NIH study found that restricting dietary fat led to a 68% higher rate of body fat loss compared to cutting the same number of carbohydrate calories. The researchers discovered that fat restriction resulted in a greater imbalance between consumed and burned fat, leading to more significant weight loss.
A study published in the British Medical Journal found that insulin pump users had a substantially lower risk of dying from cardiovascular disease than those using multiple daily injections. The researchers believe more frequent monitoring and training may be key to the therapy's benefits.
Researchers discovered insulin delivered via nasal cavity reaches affected brain areas, improving memory in a mouse model. The study suggests potential future treatments using gastrointestinal hormones like insulin to combat Alzheimer's disease.
A new study reveals that skipping breakfast triggers major blood sugar spikes and impairs insulin responses in type-2 diabetics throughout the day. The researchers found that fasting until noon causes extraordinary glucose peaks after lunch and dinner, highlighting the importance of not skipping meals for diabetics.
A gene mutation called ankyrin-B has been found to cause cells to absorb glucose faster, leading to fat storage and type 2 diabetes. The mutations are common among certain populations, including African Americans and Caucasians, and may provide a genetic link to modern diet-related diseases.
Researchers have created an implantable device that continuously measures blood sugar levels and automatically releases insulin as needed, eliminating the need for constant monitoring and daily injections. The artificial pancreas maintained blood glucose within target range nearly 80% of the time in computer simulations.
Researchers at Scripps Research Institute are accelerating development of anti-diabetic compounds, focusing on peroxisome proliferator-activated receptors gamma (PPARG) and overcoming glitazone safety concerns. The new grant aims to inform clinical development and assess effects on bone.
Researchers have created a smart insulin patch that can detect increases in blood sugar levels and secrete doses of insulin, potentially replacing painful injections for diabetes. The patch uses microneedles to administer insulin, which is released when blood glucose levels get too high.
Researchers have discovered a potential target for the treatment of type 2 diabetes by inhibiting the S6K1 protein, which increases insulin sensitivity in mice. In animal models, S6K1 deficient mice displayed improved insulin response and reduced risk of developing diabetes.
Alternative drug-delivery systems are being explored to overcome syringe injection drawbacks, including ointments, dissolvable tablets and micro-needle skin patches. Several promising results have been shown in animal testing, but widespread adoption will require changing the mindset of pharmaceutical companies and regulators.
The study identified urocortin 3 as a key player in regulating insulin production and blood sugar levels. By understanding how this hormone interacts with other cells and systems, researchers hope to develop new treatments for diabetes.
A Montréal research team found that the dual-hormone artificial pancreas provides the most benefits by reducing time spent in nocturnal hypoglycaemia. The study also showed that no participant using the system experienced a nocturnal hypoglycaemia event requiring treatment.
Researchers have identified a gene that may help reactivate insulin-producing beta cells in diabetics. The team, led by Professor Tessem and including four students with Type 1 diabetes, has made significant breakthroughs in understanding the molecular pathways involved.
Diabetes research has made significant progress over the past 50 years, transforming treatment options and patient lives. The development of human insulin, improved glucose testing methods, and advanced delivery systems have greatly enhanced management of the condition.
In a study published in ETH Zurich, researchers discovered that the microRNA-200 family triggers the death of beta cells, leading to type 2 diabetes. By blocking miR-200 production, scientists can guarantee the survival of these vital cells. This finding has significant implications for the development of new treatments for diabetes.
A new study by Ohio State University researchers suggests that skipping meals can lead to insulin resistance and increased abdominal fat gain in mice. Mice on restricted diets who fasted for extended periods developed metabolic issues, including inflammation and plumper fat cells, compared to those who ate regularly.
Researchers found that larger spheres, at least 1.5 millimeters in diameter, triggered lower immune response and developed less scar tissue on their surface. This breakthrough could lead to a viable cure for type 1 diabetes by eliminating the need for lifelong immunosuppressive drugs.
Per capita health care spending for children with diabetes rose 4.1% in 2013, nearly double the 2012 increase, due to higher spending on branded insulin. Out-of-pocket costs for those with diabetes were more than double that of those without the disease.
Five teenagers with Type 1 diabetes will participate in a four-day study to test an 'artificial pancreas,' which automatically monitors and adjusts insulin delivery. The device has the potential to transform diabetes treatment by providing continuous glucose control, reducing anxiety for patients and parents.
Researchers found that eating more protein at breakfast lowered post-meal glucose levels and prompted cells to increase insulin concentrations at the second meal. Consuming 25-30 grams of protein at breakfast may be beneficial for individuals with type 2 diabetes, according to Jill Kanaley.
Researchers have successfully completed the first step in developing an insulin vaccine to prevent type 1 diabetes. The Pre-POINT study showed a positive immune response in children at high risk for the disease, with no adverse reactions observed.
A pilot study found that daily oral insulin administration induced an immune response without hypoglycemia, supporting the need for a phase 3 trial to prevent islet autoimmunity and diabetes. The study enrolled genetically at-risk children and showed varying responses to different doses of oral insulin.
Researchers found that children given daily doses of oral insulin developed a protective immune response to the disease, which could lead to the development of a vaccine against type 1 diabetes. The study showed increased immunity with higher doses of oral insulin, suggesting a potential treatment strategy.
Researchers at UC Davis may have discovered a new way to regenerate beta cells in the pancreas, which could potentially lead to a cure for juvenile diabetes. The study's findings suggest that immature beta cells can arise from alpha cells, offering a new paradigm shift in the treatment of the disease.
A study found that individuals on insulin experienced significantly higher levels of inflammation compared to those living in lower traffic areas. People taking oral diabetes medications did not show the same increase in inflammation, suggesting a potential protective effect.
Researchers at Columbia University Irving Medical Center have found a defect in pancreatic cells that can lead to high blood sugar levels and impaired glucose balance. An experimental drug called Rycal has been shown to stop the leaky channels and normalize glucose levels in mouse models.
A nationwide study found glyburide associated with increased risk of hospitalization, respiratory distress and hypoglycemia in newborns. In contrast, insulin showed lower risk for these outcomes.
Researchers at National Jewish Health found a response in human cells consistent with vaccination response in mice, using a mutated insulin fragment. The finding suggests an immune response in humans could lead to a vaccine and treatment for diabetes.
Researchers at University of British Columbia found a new approach to treating Type 2 diabetes using stem cell transplants and conventional drugs. The study showed mice became glucose tolerant after receiving the transplants, while those without received only drugs, resulting in unexpected weight loss.
A Johns Hopkins study reveals that drug companies have extended patents on insulin for over 90 years, preventing generic versions from entering the market. This has led to costly treatment options, with prices ranging from $120 to $400 per month, and hospitalizations due to uncontrolled diabetes.
Two major diabetes associations, EASD and ADA, jointly recommend a comprehensive overhaul of medical device safety in Europe and the US. The current regulatory framework is criticized for being too lenient, with a lack of follow-up studies and insufficient public availability of adverse event reports.
The American Diabetes Association and European Association for the Study of Diabetes call for a comprehensive safety overhaul of insulin pumps, including greater access to data from manufacturers and funding for independent clinical trials. This is crucial for healthcare teams to educate patients on preventing errors with these devices.
The ISFM Consensus Guidelines on the Practical Management of Diabetes Mellitus in Cats provide evidence-based advice for veterinary teams. Key findings include the importance of weight control, using appropriate diets, and insulin therapy, as well as close monitoring of blood glucose concentrations.
Researchers have identified three ways to predict the development of type 1 diabetes in young children based on autoantibody presence. The presence of these autoantibodies can indicate an autoimmune reaction against the body's own insulin cells, which may be triggered by a viral infection.
A new study published in Diabetologia shows that eating a high energy breakfast and a low energy dinner improves blood sugar control for individuals with type 2 diabetes. The study found significant reductions in post-meal glucose levels and insulin levels when participants followed the high-energy breakfast and low-energy dinner diet.
A new study published in Diabetologia found that lack of sleep can lead to elevated levels of free fatty acids in the blood, causing temporary pre-diabetic conditions in healthy young men. Insufficient sleep also results in increased insulin resistance, a hallmark of pre-diabetes, that persists for nearly five hours.
Researchers have developed a long-lasting, glucose-responsive insulin derivative called Ins-PBA-F, which self-activates when blood sugar levels rise. Tests on mouse models show that one injection works for up to 14 hours, automatically lowering blood sugar levels.
Researchers are developing an artificial pancreas (AP) to manage pediatric diabetes, aiming to alleviate parents' stress and anxiety. The device will be tailored to consider children's unpredictable eating habits and physical activity, and its safety, efficacy, reliability, and ease of use will be prioritized.
A Yale-led research team has discovered the molecular mechanism behind insulin's role in regulating liver glucose production and how it fails in patients with type 2 diabetes. The findings reveal that inflammation in fatty tissue leads to increased hepatic glucose production, highlighting a potential target for new treatments.
Researchers at Stanford University School of Medicine identified limostatin, a hormone that decreases insulin levels during recovery from fasting or starvation, in fruit flies and found a similar protein in humans. This discovery has critical ramifications for understanding metabolism and may inform new efforts to combat diabetes.
A new study identifies a DNA biomarker that can detect β cell death and predict type 1 diabetes risk. Unmethylated insulin DNA levels correlate with reduced β cell function and increased risk of clinical onset.
A study published in Molecular Metabolism found that adropin, a hormone regulating fat and sugar metabolism during feeding and fasting cycles, can improve insulin action in obese mice. This suggests that it may work as a therapy for type 2 diabetes.
Researchers at Saint Louis University have found a way to prevent type I diabetes in an animal model by blocking the autoimmune process that destroys beta cells. The study uses a selective ROR alpha and gamma t inverse agonist to reduce autoimmunity, suggesting a new treatment option for the illness.
A new study reveals that cone snails add a unique form of insulin to their venom cocktail, which disrupts blood glucose levels and causes hypoglycemic shock in fish. The snail insulin may help unlock secrets of insulin function and energy metabolism.
Researchers found that insulin nasal spray improved short-term verbal and visual information retention in adults with mild cognitive impairment and Alzheimer's. The study also showed significant benefits for those carrying the APOE-e4 gene, a risk factor for Alzheimer's.
Researchers discovered that triglyceride production in the liver is independent of insulin action, contributing to health risks in type 2 diabetics. The study's findings provide new insights into non-alcoholic liver disease and potential treatments.
A recent study published in Diabetes Care found that approximately one-third of people with type 1 diabetes produce insulin, as measured by C-peptide, even up to 40 years after diagnosis. This challenges the long-held assumption that these patients lose all ability to produce insulin, highlighting potential implications for clinical pr...