Articles tagged with Insulin
Researchers at Helmholtz Munich have found that GAD antibody affinity is a key indicator of LADA disease progression. The study used GAD vaccination to examine the impact on antibody affinity in 46 LADA patients, finding no influence from vaccination. Patients with high affinity had low insulin production and required insulin therapy s...
Researchers at Lund University found epigenetic changes in approximately 800 genes of people with type 2 diabetes, which could contribute to reduced insulin production. Epigenetic changes are reversible and can be influenced by factors like age, BMI, and lifestyle.
A new study found that individuals with a history of hypoglycemia are more likely to experience recurrent episodes when using an automatic insulin pump. The ASPIRE study suggests that the 'threshold suspend' feature may not be effective in preventing subsequent events.
A study of 1,358 children found that preterm infants had higher plasma insulin levels at birth and in early childhood, indicating a potential link between preterm birth and insulin resistance. This association may suggest that preterm birth is a risk factor for the development of type 2 diabetes.
Researchers replicated human pancreatic beta cells in a mouse model using a silencing inhibitor, showcasing their ability to replicate while maintaining mature properties. The study's findings have implications for developing treatments to enhance beta-cell mass and insulin production for both type 1 and 2 diabetic patients.
Scientists have discovered that insulin-producing beta cells may fail due to oxygen deprivation, leading to type 2 diabetes. A second study reveals that acinar cells can be converted into functional beta cells, offering a promising new approach for treating the disease.
Wolfgang Peti, a Brown University biochemist, has received a $1.625-million New to Diabetes Research Accelerator Award to tackle type 2 diabetes. He aims to develop medicines that improve on the status quo, potentially making insulin injections unnecessary.
Researchers found that a single gene defect in MADD leads to fasting hyperglycemia and insufficient insulin secretion in mice. The study suggests that type 2 diabetes can be directly caused by the loss of a properly functioning MADD gene, highlighting potential therapeutic targets for treating people with this mutation.
Researchers have made a breakthrough in packaging insulin into tiny sacs that can be absorbed through the gut, overcoming digestive enzyme hurdles. The new delivery system has shown promising results in rats, with blood glucose levels lowered almost as much as injected insulin.
A new technique uses nanoparticles and ultrasound to regulate blood sugar levels in diabetics, potentially eliminating the need for insulin injections. The method involves injecting biocompatible nanoparticles into the skin, which are then activated by a small ultrasound device to release insulin painlessly.
A new study by Intermountain Medical Center has discovered a simple way to further predict a diabetic patient's risk for heart disease: measuring their body mass index or BMI. The findings show that the greater the patient's BMI, the greater their risk for heart disease.
A small proof-of-concept study found that intranasal insulin can improve cognitive function in patients with type 2 diabetes. The treatment worked by improving vascular functions and regulating signaling among neurons, leading to better learning and memory performance.
Researchers have identified a crucial intermediate step in the formation of plaque that causes type 2 diabetes. The protein amylin aggregates into plaques that kill cells, but animals resistant to the disease prevent this by targeting an earlier clumping process.
Researchers at UMD found that fruit flies have similar mechanisms to regulate blood sugar as humans, including the use of insulin. This discovery enables the use of fruit flies in screening tests for new diabetes treatments.
New research suggests that normal glucose regulation depends on a partnership between the pancreas and brain areas regulating blood sugar levels. The brain-centered system enhances insulin-mediated glucose metabolism while stimulating glucose effectiveness, accounting for nearly half of normal glucose uptake.
Researchers at McMaster University discovered that metformin reduces harmful fat molecules in the liver, allowing insulin to work better and lower blood sugar levels. The study found that even obese mice with genetic mutations developed fatty liver and pre-diabetes.
A recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease found that insulin-treated patients experienced higher rates of major adverse cardiovascular events, including death, stroke, and myocardial infarction. CABG was found to reduce mortality and myocardial infarction rates compared...
Researchers found a fat recycling system within pancreatic beta cells that regulates insulin production, providing a promising target for future diabetes treatments. By preventing this system from breaking down unwanted fats, scientists were able to increase insulin secretion.
New technology enabled scientists to prove that most people with type 1 diabetes have active beta cells producing insulin in response to food, contrary to previous thought. This finding has significant implications for understanding the biology of Type 1 diabetes and may lead to new therapies to preserve or replenish beta cells.
People with poorly controlled diabetes are at risk of experiencing hypothermia, frostbite, and dehydration when traveling to high altitudes. Insulin needs may also increase or decrease due to environmental extremes, exercise, and dietary changes.
Scientists at Scripps Research Institute have created a comprehensive roadmap of the protein interactions that enable cells in the pancreas to produce, store and secrete insulin. The finding makes possible a deeper scientific understanding of the insulin secretion process and how it fails in insulin disorders such as type 2 diabetes.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that young women are better equipped to deal with the negative effects of insulin resistance. This biological ability may explain why women typically develop heart disease 10 years later than men.
Researchers found that SLC30A8 zinc transporter is crucial for insulin clearance by the liver and signals to stop releasing insulin. The study also discusses the dynamic regulatory role of zinc in insulin regulation.
The study found that sensor-augmented pump therapy significantly reduced the rate of severe and moderate hypoglycemia among patients with type 1 diabetes, particularly those with impaired awareness. The technology demonstrated potential to reduce the duration and frequency of significant hypoglycemia.
Researchers at Rice University have developed a secure system to protect wireless implantable medical devices from unauthorized access. The technology uses the patient's unique heartbeat as a password, which can only be accessed through touch with a programmer device. This provides a secure way to monitor patients and prevent potential...
A phase II study found that alefacept treatment significantly reduced insulin use and hypoglycemic events in newly diagnosed type 1 diabetics. The therapy targeted memory T-cells, preserving regulatory T-cells.
The new procedure, known as the CIT07 protocol, resulted in significantly improved islet cell function and enabled patients to discontinue daily insulin injections. The approach reduced inflammation and allowed for more efficient use of fewer islet cells.
A recent study found that adding avocado to meals may help reduce hunger and improve insulin response in healthy overweight adults. The research suggests potential weight management benefits, offering promising clues for future studies.
Scientists identified mechanisms necessary to live without insulin, a breakthrough that could lead to alternative treatments against diabetes. Researchers found leptin regulates glucose levels and reduces the risk of hypoglycemia, offering hope for patients.
Researchers found that weight loss significantly improved vascular function in obese individuals, particularly those with high insulin levels. The study suggests that reversing insulin resistance and endothelial dysfunction may represent key therapeutic targets for cardiovascular risk reduction.
Researchers developed a way to change pancreatic cells to produce insulin, reducing the need for two pancreas donations for successful islet cell transplants. This breakthrough could save months of waiting time for Type 1 diabetes patients and make more organs available.
A phase II study tested thymoglobulin, an antithymocyte globulin treatment, in new-onset type 1 diabetic patients. While most younger patients showed decline in beta cell function, older patients experienced little change. The study did not meet its primary endpoint and may have identified biomarkers for safety and efficacy.
A long-term study of insulin pump therapy in children with type 1 diabetes found improved HbA1c control and reduced episodes of severe hypoglycaemia. Pump therapy also led to lower rates of diabetic ketoacidosis compared to injections.
A study published in Clinical Science found that a meal plan prioritizing breakfast intake can reduce insulin resistance, lower testosterone levels, and increase ovulation frequency in women with PCOS. This natural therapy may provide new hope for those struggling with fertility issues associated with the disorder.
Researchers have discovered a protein, Neu1, that regulates insulin signaling in body cells, potentially helping to prevent type 2 diabetes. The study's findings, published in the journal Diabetes, suggest that restoring Neu1 levels and function could improve insulin absorption, reducing the need for insulin therapy.
Researchers developed a drug delivery technique using a sponge-like material that surrounds an insulin core, releasing insulin as needed. The technique also shows promise for targeting cancer cells, with potential applications in smart drug delivery targeting tumors.
Researchers found that adding foods rich in amino and fatty acids, such as leucine and omega-3 fatty acids, may help youth with Type 1 diabetes produce some of their own insulin for up to two years after diagnosis. This approach could benefit the lives of these children by reducing the risk of diabetes complications.
Scientists at Northwestern University have successfully transplanted rat islets into mice, producing insulin for over 300 days without immunosuppressive drugs. This breakthrough method uses a unique approach to control rejection and has significant implications for future interspecies transplants.
A new study by Cincinnati Children's Hospital Medical Center and the University of California Davis has made a significant discovery about insulin's role in lactation. Insulin plays a crucial role in regulating the production of breast milk, particularly for mothers with sub-optimal glucose metabolism.
A new study found that ethnic differences significantly impact insulin response, with East Asians showing improved insulin sensitivity but poorer insulin release. Healthy individuals of all ethnicities maintained normal glucose levels but did so differently, with some groups releasing more or less insulin in response to changes.
Researchers at UC Irvine are working on two groundbreaking projects to treat Type 1 diabetes: islet cell transplantation using ultrapure algae membranes and the development of an accurate insulin sensor for real-time blood sugar monitoring. These innovations aim to improve treatment options and potentially cure the disease.
A clinical trial of a DNA vaccine has delivered promising results, suggesting that it may selectively counter the immune response that causes Type 1 diabetes. The vaccine reduced levels of immune cells believed responsible for the disease and maintained insulin production levels in patients.
Patients with Type 2 diabetes who start on three medications at diagnosis have better glucose control with lower hemoglobin A1c levels and fewer hypoglycemic events compared to conventional therapy. The triple-therapy regimen also promotes weight loss and preserves beta cell function.
The predictive Hypoglycemia-Hyperglycemia Minimizer (HHM) System demonstrated that it can maintain safe glucose levels overnight, with participants spending over 90% of the time within a target range. The system showed encouraging performance in controlling blood glucose values during the critical nighttime period.
Dr. Graeme Bell has been awarded the 2013 Banting Medal for his pioneering work in understanding the role of genetics in diagnosing and treating diabetes. His research focuses on the biology of insulin-secreting pancreatic beta-cells and the use of genetics to personalize treatment.
A meta-analysis study found that insulin degludec has a similar or reduced risk of recurrent hypoglycemia compared to insulin glargine. The study, involving nearly 3,400 adults with type 2 diabetes, suggests that insulin degludec may offer benefits in reducing the major side effect of insulin therapy.
A study by LA BioMed found that men who get more sleep on the weekend can improve their insulin sensitivity, reducing their risk of developing type 2 diabetes. The research, conducted over six months, involved 19 non-diabetic men who slept an average of 6.2 hours per night during the week and caught up on sleep on weekends.
A clinical study found that insulin resistance is associated with weakened bones and a higher risk of bone fractures. The study, presented at The Endocrine Society's annual meeting, showed that bone strength decreased by 10-14% for every doubling of insulin resistance.
A new study has found that skipping breakfast can lead to acute insulin resistance in overweight women, a condition that increases the risk of developing type 2 diabetes. After just one day of skipping breakfast, insulin levels were significantly higher and glucose levels more elevated than after eating breakfast.
Researchers are testing whether a drug called aldesleukin can reduce the number of insulin injections needed for type 1 diabetes patients. The trial aims to slow disease progression and give patients more control over their condition.
Researchers found that sucralose increased insulin and blood sugar levels in severely obese people without diabetes. This study suggests that artificial sweeteners may have more significant effects on metabolism than previously thought.
Researchers at the University of Missouri School of Medicine have discovered a potential cure for Type 1 diabetes by combining adult stem cells with a new drug. The discovery reveals that blood vessels are essential for insulin production and repairing them can help restore insulin-making cells.
The American College of Physicians recommends targeting a blood glucose level of 140-200 mg/dL for surgical and medical intensive care unit patients when using intensive insulin therapy. The guidelines aim to balance the benefits and harms of hyperglycemia management in hospitalized patients.
Australian scientists mapped insulin action in cells with precise detail, providing a comprehensive blueprint for understanding diabetes. The breakthrough study catalogued 37,248 phosphorylation sites on 5,705 proteins, revealing 15% that changed in response to insulin.
Researchers developed an injectable nanogel that can monitor blood-sugar levels and secrete insulin in response, offering a potential solution to Type 1 diabetes. The system consists of nanoparticles with enzyme-loaded dextran spheres that release insulin when glucose levels are high.
Researchers developed a biomaterial that successfully engrafted insulin-producing cells into diabetic mice, reversing symptoms in just 10 days. The material promotes blood vessel formation and allows cells to survive and function within the body.
A team of researchers has developed an innovative injectable nano-network that can effectively control blood sugar levels in diabetics by releasing insulin when needed, maintaining normal levels for over a week. The technology has the potential to improve the health and quality of life of diabetes patients.
Researchers at Harvard University have discovered a hormone called betatrophin that increases insulin-secreting pancreatic beta cells by up to 30 times the normal rate. This could lead to a more natural regulation of insulin and reduced complications associated with diabetes.
A team of researchers from the University of Copenhagen has discovered that PICK1 protein plays a crucial role in regulating hormones such as insulin and growth hormone. This finding has significant implications for understanding diabetes and poor growth, and may lead to better prevention and treatment in the future.
Researchers at Johns Hopkins Children's Center found that a previously minor protein called EPAC2 plays a central role in regulating insulin production. The study suggests that targeting EPAC2 with drugs could potentially restore pancreatic cell function and reverse Type 2 diabetes.