Articles tagged with Insulin
A new implantable molecular device measures blood pH and triggers insulin production to regulate metabolic processes. The device, tested in mice with type 1 diabetes, successfully compensated for acidosis and restored normal blood sugar levels.
Researchers have developed a new technique to measure insulin levels in fruit flies with high sensitivity and reproducibility. This breakthrough is expected to transform the field of diabetes research by bringing the power of fruit fly genetics to bear on the devastating condition, enabling rapid testing of diabetes risk factors.
A new study suggests that consuming whey protein before meals can reduce blood sugar spikes and improve the body's insulin response in individuals with type 2 diabetes. Glucagon-like peptide-1 production is increased, stimulating insulin secretion and reducing glucose rise after meals.
Researchers studying grizzly bears have discovered a natural state of diabetes that serves a biological purpose and is reversible. Grizzlies become diabetic only weeks after hibernation, but then recover when they wake up in the spring. The study reveals how natural biology can teach us about animal coping mechanisms with diseases.
Researchers have deciphered how insulin binds to target cells, unlocking a protective hinge that triggers biological signals. This mechanism has attracted international study since the landmark 1969 elucidation of insulin's storage structure, enabling new molecular designs for safer and more effective insulin products.
A single injection of FGF1 protein restores blood sugar levels to a healthy range for over two days, reversing insulin insensitivity and the underlying cause of diabetes. This breakthrough discovery offers a new method to control glucose with a safer and more effective treatment.
Adjusting dietary manipulation may help patients with various conditions by influencing the internal biological clock. Insulin plays a crucial role in resetting the circadian clock, allowing for effective digestion and absorption.
A study published in Diabetologia suggests that consuming whey protein before a regular breakfast can reduce post-meal blood sugar spikes and improve insulin responses. The researchers found that the early insulin response was significantly higher after whey protein, which could be beneficial for individuals with diabetes.
The OpT2mise trial found that insulin pumps result in better blood sugar control than multiple daily injections in people with type 2 diabetes. The study showed that patients using the pumps achieved a significantly greater reduction in average blood sugar levels and spent less time in hyperglycaemia.
A randomized trial found that calcium and vitamin D supplementation significantly reduced fasting plasma glucose, insulin, and LDL cholesterol in pregnant women with GDM. The study also showed improvements in insulin sensitivity and increases in HDL cholesterol.
A new study by Hassan A-R Ibrahim found that diabetic patients who don't know proper injection techniques may administer insulin incorrectly, leading to poor glycemic control and adverse outcomes. The study found that only 31% of patients answered more than half the questions correctly about injection techniques.
A pilot study will evaluate advanced artificial pancreas technology for individuals with type 1 diabetes under real-world conditions. The study aims to test the safety and effectiveness of an unsupervised artificial pancreas system that automatically controls insulin delivery.
A study found that individuals with growth hormone receptor deficiency have increased insulin sensitivity, preventing Type 2 diabetes and lowering their risk for cancer. Despite higher body fat content, their bodies were more responsive to insulin, suggesting a potential protective effect against these diseases.
A new survey reveals that nearly 70% of adults with Type 1 diabetes do not use their blood glucose self-monitoring devices or insulin pumps to download historical data about their blood sugar levels and insulin doses. Only 12% of patients regularly review their past glucose and insulin pump data at home.
A genetic risk component of type 1 diabetes has been shed light on by a study identifying the role of gene Clec16a in faulty cell recycling. Healthy mitochondria are crucial to insulin production and blood sugar control, making this finding a significant step towards treating or preventing both type 1 and type 2 diabetes.
A clinical feasibility study demonstrated that the algorithm was capable of helping maintain glucose above hypoglycemic levels for an average of 99.1 percent of the time. The system's potential to reduce hypoglycemia via a technological approach was underscored by significant differences in insulin dosing response as the aggressiveness...
A post-hoc analysis of patients with type 2 diabetes found that intensification of insulin therapy with Januvia (sitagliptin) 100 mg once-daily resulted in lower incidence of nighttime hypoglycemia compared to placebo. This is a positive finding for treatment approaches aimed at lowering nocturnal hypoglycemia.
A retrospective cohort study found patients taking JANUVIA and metformin initiated insulin therapy at a slower rate than those taking a sulfonylurea and metformin. The study suggests that real-world data may provide insight into the effects of different oral treatment regimens on the initiation of insulin use.
A recent study found that adding insulin to metformin for diabetes treatment is associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death. The researchers analyzed data from over 178,000 patients with diabetes who received metformin as their primary treatment.
Use of insulin analogs among privately insured patients with type 2 diabetes increased significantly between 2000 and 2010. Out-of-pocket expenditures for insulin prescriptions also rose substantially during this period.
Researchers have discovered a potential therapeutic target for preserving beta cell health in people with type 1 diabetes, according to a new JDRF-funded study. The MANF protein has been shown to reduce beta cell stress and promote regeneration.
Cystic fibrosis contributes to raised diabetes risk due to a mutated gene that inhibits insulin secretion. The mutation affects the early stage of insulin release, leading to insufficient insulin levels when demands increase.
Researchers at the University of Montreal have identified a novel enzyme, ABHD6, that breaks down a fat-like signal involved in insulin release. Inhibiting this enzyme may increase insulin levels in blood and improve sensitivity to insulin, providing a potential new target for type 2 diabetes treatment.
Researchers have found that blocking a pain receptor in mice extends their lifespan and boosts their metabolism, including an improved insulin response. This discovery provides potential insights into treating obesity and diabetes, as well as improving metabolic health.
Scientists at Harvard University have identified a newly discovered compound that can slow the degradation of insulin in animals, potentially leading to a new treatment for diabetes. The compound inhibits insulin-degrading enzyme (IDE), elevating insulin levels and promoting insulin signaling in mice.
A landmark study shows that intensive insulin treatment significantly improves survival in patients with type 2 diabetes who have had a heart attack. The trial, which followed patients for up to 20 years, found that those who received intensified insulin treatment survived an average of 2.3 years longer than those on standard treatment.
Researchers developed a system that predicts and prevents dangerously low overnight blood sugars in patients with type-1 diabetes. The device, which couples a glucose sensor with an insulin pump, reduces cumulative time spent with low blood sugars during sleep by 81%.
A University of Missouri study found that consuming high-protein breakfasts helps healthy women maintain better glucose and insulin control. The study showed that protein-rich breakfasts led to lower spikes in glucose and insulin levels compared to low-protein options.
Researchers at the University of Cincinnati have discovered that gastric bypass surgery leads to excessive post-meal insulin response in a subset of patients, characterized by altered islet cell function and reduced insulin clearance. This study sheds light on mechanisms of glucose metabolism alterations following gastric bypass surgery.
A mathematical model developed by Penn State researchers can accurately predict blood glucose levels of individuals with type 1 diabetes up to 30 minutes in advance. This allows for timely action to be taken and reduces the risk of hypoglycemic events, which can be life-threatening.
A new study provides direct evidence that the fetus's brain response to glucose is associated with the mother's insulin sensitivity. Research found that women with lower insulin sensitivity had fetuses that reacted more slowly to sounds, while those with higher insulin sensitivity had faster reactions.
Dr. Roger Unger has been awarded the 2014 Rolf Luft Award for his groundbreaking research on glucagon, which he identified as a key hormone balancing insulin regulation of blood sugar. His work revealed diabetes is a bihormonal disease with insufficiency of insulin and excess glucagon.
Researchers at Helmholtz Munich have found that GAD antibody affinity is a key indicator of LADA disease progression. The study used GAD vaccination to examine the impact on antibody affinity in 46 LADA patients, finding no influence from vaccination. Patients with high affinity had low insulin production and required insulin therapy s...
Researchers at Lund University found epigenetic changes in approximately 800 genes of people with type 2 diabetes, which could contribute to reduced insulin production. Epigenetic changes are reversible and can be influenced by factors like age, BMI, and lifestyle.
A new study found that individuals with a history of hypoglycemia are more likely to experience recurrent episodes when using an automatic insulin pump. The ASPIRE study suggests that the 'threshold suspend' feature may not be effective in preventing subsequent events.
A study of 1,358 children found that preterm infants had higher plasma insulin levels at birth and in early childhood, indicating a potential link between preterm birth and insulin resistance. This association may suggest that preterm birth is a risk factor for the development of type 2 diabetes.
Researchers replicated human pancreatic beta cells in a mouse model using a silencing inhibitor, showcasing their ability to replicate while maintaining mature properties. The study's findings have implications for developing treatments to enhance beta-cell mass and insulin production for both type 1 and 2 diabetic patients.
Scientists have discovered that insulin-producing beta cells may fail due to oxygen deprivation, leading to type 2 diabetes. A second study reveals that acinar cells can be converted into functional beta cells, offering a promising new approach for treating the disease.
Wolfgang Peti, a Brown University biochemist, has received a $1.625-million New to Diabetes Research Accelerator Award to tackle type 2 diabetes. He aims to develop medicines that improve on the status quo, potentially making insulin injections unnecessary.
Researchers found that a single gene defect in MADD leads to fasting hyperglycemia and insufficient insulin secretion in mice. The study suggests that type 2 diabetes can be directly caused by the loss of a properly functioning MADD gene, highlighting potential therapeutic targets for treating people with this mutation.
Researchers have made a breakthrough in packaging insulin into tiny sacs that can be absorbed through the gut, overcoming digestive enzyme hurdles. The new delivery system has shown promising results in rats, with blood glucose levels lowered almost as much as injected insulin.
A new technique uses nanoparticles and ultrasound to regulate blood sugar levels in diabetics, potentially eliminating the need for insulin injections. The method involves injecting biocompatible nanoparticles into the skin, which are then activated by a small ultrasound device to release insulin painlessly.
A new study by Intermountain Medical Center has discovered a simple way to further predict a diabetic patient's risk for heart disease: measuring their body mass index or BMI. The findings show that the greater the patient's BMI, the greater their risk for heart disease.
A small proof-of-concept study found that intranasal insulin can improve cognitive function in patients with type 2 diabetes. The treatment worked by improving vascular functions and regulating signaling among neurons, leading to better learning and memory performance.
Researchers have identified a crucial intermediate step in the formation of plaque that causes type 2 diabetes. The protein amylin aggregates into plaques that kill cells, but animals resistant to the disease prevent this by targeting an earlier clumping process.
Researchers at UMD found that fruit flies have similar mechanisms to regulate blood sugar as humans, including the use of insulin. This discovery enables the use of fruit flies in screening tests for new diabetes treatments.
New research suggests that normal glucose regulation depends on a partnership between the pancreas and brain areas regulating blood sugar levels. The brain-centered system enhances insulin-mediated glucose metabolism while stimulating glucose effectiveness, accounting for nearly half of normal glucose uptake.
Researchers at McMaster University discovered that metformin reduces harmful fat molecules in the liver, allowing insulin to work better and lower blood sugar levels. The study found that even obese mice with genetic mutations developed fatty liver and pre-diabetes.
A recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease found that insulin-treated patients experienced higher rates of major adverse cardiovascular events, including death, stroke, and myocardial infarction. CABG was found to reduce mortality and myocardial infarction rates compared...
Researchers found a fat recycling system within pancreatic beta cells that regulates insulin production, providing a promising target for future diabetes treatments. By preventing this system from breaking down unwanted fats, scientists were able to increase insulin secretion.
New technology enabled scientists to prove that most people with type 1 diabetes have active beta cells producing insulin in response to food, contrary to previous thought. This finding has significant implications for understanding the biology of Type 1 diabetes and may lead to new therapies to preserve or replenish beta cells.
People with poorly controlled diabetes are at risk of experiencing hypothermia, frostbite, and dehydration when traveling to high altitudes. Insulin needs may also increase or decrease due to environmental extremes, exercise, and dietary changes.
Scientists at Scripps Research Institute have created a comprehensive roadmap of the protein interactions that enable cells in the pancreas to produce, store and secrete insulin. The finding makes possible a deeper scientific understanding of the insulin secretion process and how it fails in insulin disorders such as type 2 diabetes.
Researchers found that SLC30A8 zinc transporter is crucial for insulin clearance by the liver and signals to stop releasing insulin. The study also discusses the dynamic regulatory role of zinc in insulin regulation.
The study found that sensor-augmented pump therapy significantly reduced the rate of severe and moderate hypoglycemia among patients with type 1 diabetes, particularly those with impaired awareness. The technology demonstrated potential to reduce the duration and frequency of significant hypoglycemia.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that young women are better equipped to deal with the negative effects of insulin resistance. This biological ability may explain why women typically develop heart disease 10 years later than men.
Researchers at Rice University have developed a secure system to protect wireless implantable medical devices from unauthorized access. The technology uses the patient's unique heartbeat as a password, which can only be accessed through touch with a programmer device. This provides a secure way to monitor patients and prevent potential...
A phase II study found that alefacept treatment significantly reduced insulin use and hypoglycemic events in newly diagnosed type 1 diabetics. The therapy targeted memory T-cells, preserving regulatory T-cells.
The new procedure, known as the CIT07 protocol, resulted in significantly improved islet cell function and enabled patients to discontinue daily insulin injections. The approach reduced inflammation and allowed for more efficient use of fewer islet cells.
A recent study found that adding avocado to meals may help reduce hunger and improve insulin response in healthy overweight adults. The research suggests potential weight management benefits, offering promising clues for future studies.