Articles tagged with Insulin
A study found that individuals on insulin experienced significantly higher levels of inflammation compared to those living in lower traffic areas. People taking oral diabetes medications did not show the same increase in inflammation, suggesting a potential protective effect.
Researchers at Columbia University Irving Medical Center have found a defect in pancreatic cells that can lead to high blood sugar levels and impaired glucose balance. An experimental drug called Rycal has been shown to stop the leaky channels and normalize glucose levels in mouse models.
A nationwide study found glyburide associated with increased risk of hospitalization, respiratory distress and hypoglycemia in newborns. In contrast, insulin showed lower risk for these outcomes.
Researchers at National Jewish Health found a response in human cells consistent with vaccination response in mice, using a mutated insulin fragment. The finding suggests an immune response in humans could lead to a vaccine and treatment for diabetes.
Researchers at University of British Columbia found a new approach to treating Type 2 diabetes using stem cell transplants and conventional drugs. The study showed mice became glucose tolerant after receiving the transplants, while those without received only drugs, resulting in unexpected weight loss.
A Johns Hopkins study reveals that drug companies have extended patents on insulin for over 90 years, preventing generic versions from entering the market. This has led to costly treatment options, with prices ranging from $120 to $400 per month, and hospitalizations due to uncontrolled diabetes.
Two major diabetes associations, EASD and ADA, jointly recommend a comprehensive overhaul of medical device safety in Europe and the US. The current regulatory framework is criticized for being too lenient, with a lack of follow-up studies and insufficient public availability of adverse event reports.
The American Diabetes Association and European Association for the Study of Diabetes call for a comprehensive safety overhaul of insulin pumps, including greater access to data from manufacturers and funding for independent clinical trials. This is crucial for healthcare teams to educate patients on preventing errors with these devices.
The ISFM Consensus Guidelines on the Practical Management of Diabetes Mellitus in Cats provide evidence-based advice for veterinary teams. Key findings include the importance of weight control, using appropriate diets, and insulin therapy, as well as close monitoring of blood glucose concentrations.
Researchers have identified three ways to predict the development of type 1 diabetes in young children based on autoantibody presence. The presence of these autoantibodies can indicate an autoimmune reaction against the body's own insulin cells, which may be triggered by a viral infection.
A new study published in Diabetologia shows that eating a high energy breakfast and a low energy dinner improves blood sugar control for individuals with type 2 diabetes. The study found significant reductions in post-meal glucose levels and insulin levels when participants followed the high-energy breakfast and low-energy dinner diet.
A new study published in Diabetologia found that lack of sleep can lead to elevated levels of free fatty acids in the blood, causing temporary pre-diabetic conditions in healthy young men. Insufficient sleep also results in increased insulin resistance, a hallmark of pre-diabetes, that persists for nearly five hours.
Researchers are developing an artificial pancreas (AP) to manage pediatric diabetes, aiming to alleviate parents' stress and anxiety. The device will be tailored to consider children's unpredictable eating habits and physical activity, and its safety, efficacy, reliability, and ease of use will be prioritized.
Researchers have developed a long-lasting, glucose-responsive insulin derivative called Ins-PBA-F, which self-activates when blood sugar levels rise. Tests on mouse models show that one injection works for up to 14 hours, automatically lowering blood sugar levels.
A Yale-led research team has discovered the molecular mechanism behind insulin's role in regulating liver glucose production and how it fails in patients with type 2 diabetes. The findings reveal that inflammation in fatty tissue leads to increased hepatic glucose production, highlighting a potential target for new treatments.
Researchers at Stanford University School of Medicine identified limostatin, a hormone that decreases insulin levels during recovery from fasting or starvation, in fruit flies and found a similar protein in humans. This discovery has critical ramifications for understanding metabolism and may inform new efforts to combat diabetes.
A new study identifies a DNA biomarker that can detect β cell death and predict type 1 diabetes risk. Unmethylated insulin DNA levels correlate with reduced β cell function and increased risk of clinical onset.
A study published in Molecular Metabolism found that adropin, a hormone regulating fat and sugar metabolism during feeding and fasting cycles, can improve insulin action in obese mice. This suggests that it may work as a therapy for type 2 diabetes.
Researchers at Saint Louis University have found a way to prevent type I diabetes in an animal model by blocking the autoimmune process that destroys beta cells. The study uses a selective ROR alpha and gamma t inverse agonist to reduce autoimmunity, suggesting a new treatment option for the illness.
A new study reveals that cone snails add a unique form of insulin to their venom cocktail, which disrupts blood glucose levels and causes hypoglycemic shock in fish. The snail insulin may help unlock secrets of insulin function and energy metabolism.
Researchers found that insulin nasal spray improved short-term verbal and visual information retention in adults with mild cognitive impairment and Alzheimer's. The study also showed significant benefits for those carrying the APOE-e4 gene, a risk factor for Alzheimer's.
Researchers discovered that triglyceride production in the liver is independent of insulin action, contributing to health risks in type 2 diabetics. The study's findings provide new insights into non-alcoholic liver disease and potential treatments.
A recent study published in Diabetes Care found that approximately one-third of people with type 1 diabetes produce insulin, as measured by C-peptide, even up to 40 years after diagnosis. This challenges the long-held assumption that these patients lose all ability to produce insulin, highlighting potential implications for clinical pr...
Researchers at Rockefeller University have successfully used electromagnetic waves to remotely control insulin production in diabetic mice, opening up new possibilities for treating diseases. The system, dubbed radiogenetics, uses a natural iron storage particle and heat-activated ion channel to trigger gene expression in cells.
A research team from Instituto Gulbenkian de Ciencia found that the timing of ecdysone synthesis is sensitive to nutrition in fruit flies, regulating final body size. Environmental conditions such as starvation and temperature control ecdysone production, affecting development and growth.
A new study published in Nature Communications reveals that cilia on pancreatic beta cells are covered with insulin receptors, and altered ciliary function is associated with type 2 diabetes. The research found that ciliary defects impaired insulin release, leading to elevated blood glucose levels in mice.
Scientists aim to understand immune system factors that influence insulin production in people with type 1 diabetes. They hope to develop biomarkers and a drug combination to help people live with fewer complications and increased ability to manage their disease.
Diabetic patients using insulin pumps are at risk of dosing errors if they forget to change the clock on their devices. This can lead to severe consequences, including hypoglycemia and hyperglycemia. Researchers call for increased awareness and education to ensure proper pump settings.
Patients treated first with metformin were less likely to require treatment intensification compared to those who started with sulfonylureas, thiazolidinediones, or DPP-4 inhibitors. Metformin also reduced the need for added insulin and was not associated with increased rates of hypoglycemia or cardiovascular events.
A new test developed by researchers at the University of Manchester can identify congenital hyperinsulinism in some patients without known genetic causes. The test measures hormone levels and may influence treatment options, including avoiding pancreatic removal.
Research finds that individuals with a history of depression and hostile marital relationships experience reduced calorie burn and higher insulin levels after consuming high-fat meals, leading to potential weight gain and metabolic syndrome. The study highlights the importance of treating mood disorders in preventing obesity.
A team of scientists has successfully created a light-sensitive sulfonylurea compound that stimulates insulin release only in response to blue light. This breakthrough could lead to more precise control over blood sugar levels and reduce side effects associated with traditional diabetes treatments.
Researchers at Lund University have developed a personalized treatment for type 2 diabetes that targets the disease mechanism itself, rather than just its symptoms. The treatment, which uses a drug called Yohimbin, has shown promising results in improving insulin secretion in patients with the genetic risk variant.
Researchers have discovered a new class of lipids in humans called fatty acid hydroxy fatty acids (FAHFAs) that are linked to reduced inflammation and improved blood sugar levels in diabetes. FAHFA levels are low in humans with a high risk for diabetes, suggesting potential therapeutic opportunities for metabolic disorders.
Researchers at Harvard University have made a breakthrough in producing human insulin-producing beta cells equivalent to normally functioning cells, offering hope for new diabetes treatment. The development involves massive quantities of human embryonic stem cells and could lead to drug discovery and transplantation therapy.
A new study at UC Berkeley found that mice fed a high-fat diet gained 18 percent less weight when drinking clarified grapefruit juice compared to water. The juice also improved glucose, insulin and triacylglycerol levels in mice.
A modified form of a medication called niclosamide may hold the key to battling type 2 diabetes by reducing liver fat and improving insulin function. The research aims to find a safe and practical way to diminish fat content in the liver, which could safely treat patients of all weights.
New research published in the BMJ suggests that long-acting insulin is superior to intermediate-acting insulin for controlling blood sugar levels, preventing weight gain, and treating severe hypoglycemia. Long-acting insulin also showed improved cost-effectiveness compared to intermediate-acting insulin.
Researchers at Karolinska Institutet found that age-dependent reduction of mitochondrial function in beta cells leads to reduced insulin release. Impaired calcium ion dynamics is the molecular mechanism underlying this process.
A nationwide study of over 18,000 patients with type 1 diabetes found that insulin pump treatment reduces all-cause mortality by 29% and fatal cardiovascular disease risk by 43%. Pump use was also associated with an 18% risk reduction for coronary heart disease.
A systematic review and meta-analysis found that combining basal insulin with a GLP-1 agonist resulted in improved blood sugar control, similar rates of hypoglycaemia, and greater weight loss compared to other anti-diabetic treatments. This combination therapy showed a 92% greater likelihood of achieving target blood sugar control.
Researchers found that high insulin levels foster processes leading to obesity, even in mice given insulin to counter diabetes. Suppressing glucagon action may prevent hyperinsulinemia without causing diabetes.
Researchers found that closed-loop insulin delivery systems maintained safe blood glucose levels for 53-82% of the time. The study proposed improvements needed for better design and implementation of these systems in adults and adolescents with type 1 diabetes.
Acute pancreatitis is a severe condition where the pancreas digests itself, leading to abdominal pain, vomiting, and systemic inflammation. Recent research suggests that insulin may prevent toxic effects of alcohol and fatty acid metabolites on pancreatic acinar cells.
A new implantable molecular device measures blood pH and triggers insulin production to regulate metabolic processes. The device, tested in mice with type 1 diabetes, successfully compensated for acidosis and restored normal blood sugar levels.
Researchers have developed a new technique to measure insulin levels in fruit flies with high sensitivity and reproducibility. This breakthrough is expected to transform the field of diabetes research by bringing the power of fruit fly genetics to bear on the devastating condition, enabling rapid testing of diabetes risk factors.
Researchers studying grizzly bears have discovered a natural state of diabetes that serves a biological purpose and is reversible. Grizzlies become diabetic only weeks after hibernation, but then recover when they wake up in the spring. The study reveals how natural biology can teach us about animal coping mechanisms with diseases.
A new study suggests that consuming whey protein before meals can reduce blood sugar spikes and improve the body's insulin response in individuals with type 2 diabetes. Glucagon-like peptide-1 production is increased, stimulating insulin secretion and reducing glucose rise after meals.
Researchers have deciphered how insulin binds to target cells, unlocking a protective hinge that triggers biological signals. This mechanism has attracted international study since the landmark 1969 elucidation of insulin's storage structure, enabling new molecular designs for safer and more effective insulin products.
A single injection of FGF1 protein restores blood sugar levels to a healthy range for over two days, reversing insulin insensitivity and the underlying cause of diabetes. This breakthrough discovery offers a new method to control glucose with a safer and more effective treatment.
Adjusting dietary manipulation may help patients with various conditions by influencing the internal biological clock. Insulin plays a crucial role in resetting the circadian clock, allowing for effective digestion and absorption.
A study published in Diabetologia suggests that consuming whey protein before a regular breakfast can reduce post-meal blood sugar spikes and improve insulin responses. The researchers found that the early insulin response was significantly higher after whey protein, which could be beneficial for individuals with diabetes.
The OpT2mise trial found that insulin pumps result in better blood sugar control than multiple daily injections in people with type 2 diabetes. The study showed that patients using the pumps achieved a significantly greater reduction in average blood sugar levels and spent less time in hyperglycaemia.
A pilot study will evaluate advanced artificial pancreas technology for individuals with type 1 diabetes under real-world conditions. The study aims to test the safety and effectiveness of an unsupervised artificial pancreas system that automatically controls insulin delivery.
A randomized trial found that calcium and vitamin D supplementation significantly reduced fasting plasma glucose, insulin, and LDL cholesterol in pregnant women with GDM. The study also showed improvements in insulin sensitivity and increases in HDL cholesterol.
A new study by Hassan A-R Ibrahim found that diabetic patients who don't know proper injection techniques may administer insulin incorrectly, leading to poor glycemic control and adverse outcomes. The study found that only 31% of patients answered more than half the questions correctly about injection techniques.
A new survey reveals that nearly 70% of adults with Type 1 diabetes do not use their blood glucose self-monitoring devices or insulin pumps to download historical data about their blood sugar levels and insulin doses. Only 12% of patients regularly review their past glucose and insulin pump data at home.
A study found that individuals with growth hormone receptor deficiency have increased insulin sensitivity, preventing Type 2 diabetes and lowering their risk for cancer. Despite higher body fat content, their bodies were more responsive to insulin, suggesting a potential protective effect against these diseases.
A genetic risk component of type 1 diabetes has been shed light on by a study identifying the role of gene Clec16a in faulty cell recycling. Healthy mitochondria are crucial to insulin production and blood sugar control, making this finding a significant step towards treating or preventing both type 1 and type 2 diabetes.
A clinical feasibility study demonstrated that the algorithm was capable of helping maintain glucose above hypoglycemic levels for an average of 99.1 percent of the time. The system's potential to reduce hypoglycemia via a technological approach was underscored by significant differences in insulin dosing response as the aggressiveness...